The China–Pakistan Economic Corridor (CPEC), as an important part of the Belt and Road Initiative, is of great significance for the promotion of sustainable development in the region through the study of land use change and the simulation of future multi-scenarios. Based on the multi-period land use data of the CPEC, this study firstly analyzed the spatial and temporal land use changes in the CPEC from 2000 to 2020 by using GIS technology, and, secondly, simulated the land use patterns of the CPEC under four scenarios, namely, natural development, investment priority, ecological protection, and harmonious development, in 2040 by using the Markov-FLUS model with comprehensive consideration of natural, socio-economic, and other driving factors. The results show the following: (1) The urban land, forest land, and grassland in the CPEC from 2000 to 2020 show an increasing trend, while the farmland, unutilized land, and water area categories show a decreasing trend. In terms of land use transfer changes, the most frequently transferred out is the conversion of unutilized land to grassland. (2) The FLUS model has high accuracy in simulating the land use pattern of the CPEC, and its applicability in the CPEC area is strong and can be used to simulate the future land use pattern of the CPEC. (3) Among the four different land use scenarios, the harmonious development scenario strikes a better balance between infrastructure construction, economic development, and ecological protection, and can provide a scientific basis for future land management in the CPEC, in order to highlight the importance of promoting economic growth and ecological protection and ultimately realize sustainable development.