The study was conducted to evaluate the production efficiency and to analyze the factors affecting the production efficiency of chili farmers in Tra Vinh Province. The results of the study was based on data collected from 125 farmers growing chili in Tra Vinh Province. Using descriptive statistical methods, cost and benefit analysis, data envelope analysis (DEA) and the Tobit regression model to evaluate various contributing factors such as: financial efficiency, technical efficiency (TE), allocative efficiency (AE), cost efficiency/economic efficiency (CE/EE), and other factors effecting the efficiency of chili production. The results show that the average yield is 16.6 tons/ha, the average profit is 101.1 million VND/ha, the ratio of profit/cost is 1.56 perannum. Factors affecting chili productivity are the amount of seed, nitrogen, phosphate, potassium, electricity and labor. The level of technical efficiency achieved is 77%, with low efficiency due to optimum efficiency andwaste production of about 5.5 tons/ha. The level of production efficiency achieved is 21.5 tons/ha. Factors effecting the economic efficiency of households include education levels, production experience, training andunion participation.