This article examines the subjective antecedents of life satisfaction of workers. Adopting a ‘bottom-up’ perspective, we assessed the unique influence that satisfaction with multiple life domains have on evaluative judgments of overall life satisfaction. Based on a nationwide sample of 530 Chilean workers, we simultaneously tested the effects of seven life domain satisfactions that have been consistently included in extant models of life satisfaction and subjective well-being. These were satisfaction with health, financial situation, social relationships, one’s self-worth, leisure-time, family, and work. Having controlled for age and gender, results showed that satisfaction with one’s financial situation was the dominant predictor of overall life satisfaction of workers, with a weight of .36. Satisfaction with family, work, and health had effects of .25, .14, and .14, respectively. Interestingly, satisfaction with one’s self-worth, leisure-time, and social relationships did not have statistically significant effects on life satisfaction, although the first two showed t values near the critical value.