ABSTRACTThe global pandemic of COVID-19 has created havoc worldwide. By the first week of December 2021, 0.26 billion COVID-19 infected cases and 5.2 million deaths have been reported globally.[1] United Nations Children Fund (UNICEF) reports that more than 10,000 children and adolescents have died from COVID-19, with a case fatality rate of 0.3%. Out of 299 vaccine candidates, 28 are available to the general population in less than 1 year.[2] For children, WHO permitted vaccine Pfizer/BioNTech, Sinovac, and Sinopharm, Drug Controller General of India’s approved ZyCov–D and Covaxin, and the Cuban government approved Soberna 2, and Soberna plus are available.[3] Italy, Germany, France, Norway, Switzerland, Israel, Dubai, Japan, Canada, and the US have already started vaccinating their children. This step may decrease the transmissibility and mutations of the virus and thus restore normalcy. For India, it is a question of “To be or not to be?” Indian researchers have warned of the long-term impact of the pandemic on the health, development, learning, and behavior of children, thus pushing the agenda of vaccination and opening of schools. All attempts at opening schools have failed in the last 2 years. Vaccinating children is not easy as it has taken nearly 1 year to vaccinate half of the adult Indian population. In these circumstances, rather than “vaccine for all,” “vaccine for (chronically) ill” is the only feasible solution for children.