Children's Bone Health Research Articles

Meeting report from the 3rd ISCBH-ERN BOND Achondroplasia Workshop on Long Bone Pathology in Children with Achondroplasia, Salzburg, Austria 22nd June 2024

A pre-meeting workshop on Long Bone Pathology in Children with Achondroplasia was held in Salzburg, Austria at the 11th International Conference on Children's Bone Health (ICCBH) 22–25 June 2024. There remains poor understanding and awareness amongst physicians managing achondroplasia of the underlying pathophysiology, radiology, natural history and orthopaedic procedures available for long bone deformities and restrictions. The structure of the workshop consisted of presentation of the results of a multinational patient survey on views of leg lengthening in achondroplasia, lectures, a debate and an interactive round table discussion. In total 150 attendees from 71 different cities and 31 countries were in attendance.

Abstracts of the 11th International Conference on Children's Bone Health

Abstracts of the 11th International Conference on Children's Bone Health

Effective counseling for children's bone health

Poor bone health is a significant contributing factor to the frequency and severity of many childhood injuries and fractures. Osteoporosis starts in childhood. Therefore, it is important to optimize bone health in children in order to decrease the risk of injury, improve healing and maximize peak bone mass. To do this, pediatricians and pediatric orthopedists need to effectively counsel patients and families to give them the tools necessary to effect lasting change. Bone health is a recipe that requires ingredients including calcium, vitamin D, vitamin C, vitamin K and physical exercise. Required amounts of each component change as children grow and are lifelong requirements. Unfortunately, at this time, there is no uniform consensus on vitamin D supplementation guidelines or optimal serum levels. Current vitamin D dosing guidelines are age-based, but vitamin D is stored in adipose tissue and higher weights/BMIs require higher doses of vitamin D. Routine monitoring of vitamin D is recommended in all patients. However, re-evaluating the dosing guidelines to base them on weight/BMI, rather than age, should be considered. Key Concepts(1)Bone health needs to be prioritized so that peak bone mass is reached by age 30.(2)Patient counseling and patient buy-in are imperative to create lasting impact.(3)Bone health is a recipe and amounts of ingredients needed will vary according to growth and body size.(4)Vitamin D dosing should take weight and body mass into consideration to achieve optimal serum levels.

Meeting Report from 2nd ICCBH-ERN BOND Spinal Complications in Children and Adults with Achondroplasia Workshop, Dublin, Ireland, 2nd July 2022.

A pre-meeting workshop on spinal complications in children and adults with achondroplasia was held in Dublin, Ireland at the 10th International Conference on Children's Bone Health (ICCBH) 2-5 July 2022. The pathophysiology, natural history and medical/surgical management of thoraco-lumbar kyphosis and spinal stenosis remains poorly described in the literature. The structure of the workshop consisted of lectures, a debate and an interactive round table discussion. In total over 100 delegates affiliated to over 70 institutions from 20 countries were in attendance.

Proceedings of the 10th International Conference on Children's Bone Health, Dublin, Ireland, July 2022

JBMR PlusVolume 6, Issue S1 e10676 AbstractsOpen Access Abstracts First published: 24 October 2022 https://doi.org/10.1002/jbm4.10676AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume6, IssueS1Supplement: Proceedings of the 10th International Conference on Children's Bone Health, Dublin, Ireland, July 2022October 2022e10676 RelatedInformation

International Conference on Children's Bone Health Abstracts 2020

JBMR PlusVolume 5, Issue S3 e10458 AbstractsOpen Access Abstracts First published: 26 March 2021 https://doi.org/10.1002/jbm4.10458AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume5, IssueS3Supplement: Abstracts from the International Conference on Children's Bone Health Virtual Forum Meeting on Bone Fragility Disorders in Children, 18–20 November 2020March 2021e10458 This article also appears in:Abstracts from Select Conferences RelatedInformation

Meeting report from the achondroplasia foramen magnum workshop, Salzburg, Austria 22nd June 2019.

A pre-meeting workshop on foramen magnum stenosis in children with achondroplasia was held in Salzburg, Austria at the 9th International Conference on Children's Bone Health (ICCBH) 22-25 June 2019. The screening, monitoring and surgical approach to foramen magnum stenosis still remains controversial with conflicting guidance in the literature. The structure of the workshop consisted of lectures, a debate, expert and delegate discussion and concluded with a research proposal and further next steps. In total, representation by 40 institutions from 22 different countries that care for approximately 1375 children with achondroplasia, were in attendance.

Tracking of bone mass from childhood to puberty: a 7-year follow-up. The CHAMPS study DK.

Bone mass development in childhood varies by sex and age, but also by pubertal stage. The objectives of this study were to (1) describe bone mass development in childhood as it relates to pubertal onset and to (2) determine the degree of tracking from childhood to adolescence. A longitudinal study with 7years of follow-up was initiated in 2008 to include 831 children (407 boys) aged 8 to 17years. Participants underwent whole body dual-energy X-ray absorptiometry (DXA) scanning, blood collection to quantify luteinizing hormone levels, and Tanner stage self-assessment three times during the 7-year follow-up. Total body less head bone mineral content, areal bone mineral density, and bone area were used to describe development in bone accrual and to examine tracking over 7years. Bone mass in pubertal children is higher than that of pre-pubertal children at the same age. Analysing tracking with quintiles of bone mass Z-scores in 2008 and 2015 showed that more than 80% of participants remained in the same or neighbouring quintile over the study period. Tracking was confirmed by correlation coefficients between Z-scores at baseline and 7-year follow-up (range, 0.80-0.84). Bone mass is highly influenced by pubertal onset, and pubertal stage should be considered when examining children's bone health. Because bone mass indices track from childhood into puberty, children with low bone mass may be at risk of developing osteoporosis later in life.

Bone health, activity and sedentariness at age 11-12 years: Cross-sectional Australian population-derived study.

To examine cross-sectional associations of children's bone health (size, density, strength) with moderate-vigorous physical activity (MVPA) and sedentary behaviour by considering: (1) duration of activity, (2) fragmentation, and (3) duration/fragmentation combined. Design: Population-based cross-sectional study. 11-12 year-olds in the Longitudinal Study of Australian Children's Child Health CheckPoint. Exposures: MVPA and sedentary behaviour (7-day accelerometry), yielding (1) daily average durations (min/day) and (2) fragmentations (the parameter alpha, representing the relationship between activity bout frequency and bout length). Tibial peripheral quantitative computed tomography (bone density, geometry, strength). Multivariable regression models including activity durations and fragmentations separately and combined. Of 1357 children attending the CheckPoint, 864 (64%) provided both bone and accelerometry data (mean age 11.4 years (standard deviation (SD) 0.5); 49% male). Mean daily MVPA and sedentary behaviour durations were 34.4 min/day (SD 28.3) and 667.9 min/day (SD 71.9) respectively for boys and girls combined. Each additional daily hour of MVPA was associated with small bone health benefits comprising greater periosteal and endosteal circumference (standardised effect sizes 0.25, 95% CI 0.10 to 0.40 and 0.21, 95% CI 0.03 to 0.39, respectively) and bone strength (0.26, 95% CI 0.14 to 0.38). Sedentary duration and fragmentation of either MVPA or sedentary behaviour showed little association with bone health. In early adolescence, MVPA duration showed associations with better bone health that, while modest, could be of population-level importance. MVPA fragmentation and sedentary behaviour duration and fragmentation seemed less important.

Vitamin D status of Icelandic children and its influence on bone accrual.

The importance of vitamin D for children's bone health has been well established, but the effects of less severe deficiency are not fully known. The main objective of this study was to assess the vitamin D status of Icelandic children at the age of 7, and again at 9years of age, and the association of vitamin D status with bone mineral content and bone accrual over 2 years. We invited 321 children to participate in this study, and 267 (83%) took part; 211 (79%) underwent a DXA scan and 164 were again scanned 2 years later; 159 (60%) vitamin D samples were measured and 119 (75%) were measured again 2 years later. At age 7, 65% of the children had vitamin D concentrations<50nmol/l, and at age 9 this figure was 60%. At age 7, 43% of the children had insufficient amounts of vitamin D (37.5-50nmol/l), and 22% had a vitamin D deficiency (<37.5nmol/l). In linear regression analysis, no association was found between vitamin D and bone mineral content. Furthermore, there was no significant difference in bone accrual over 2 years for the children with insufficient or deficient vitamin D at both ages, compared to those having more than 50nmol/l at both time points. More than 60% of Icelandic children have inadequate concentrations of vitamin D in serum repeatedly over a 2-year interval. However, vitamin D in the range did not have a significant effect on bone mineral content or accrual at ages 7 and 9.

The influence of anthropometry and body composition on children's bone health: the childhood health, activity and motor performance school (the CHAMPS) study, Denmark.

Overweight, physical inactivity and sedentary behaviour have become increasing problems during the past decade. Increased sedentary behaviour may change the body composition (BC) by increasing the fat mass relative to the lean mass (LM). These changes may influence bone health to describe how anthropometry and BC predict the development of the bone accruement. The longitudinal study is a part of The CHAMPS study-DK. Children were DXA scanned at baseline and at 2-year follow-up. BC (LM, BF %) and BMC, BMD and BA were measured. The relationship between bone traits, anthropometry and BC was analysed by multilevel regression analyses. Of the invited children, 742/800 (93%) accepted to participate. Of these, 682/742 (92%) participated at follow-up. Mean (range) of age at baseline was 9.5 years (7.7-12.1). Height, BMI, LM and BF % predicted bone mineral accrual and bone size positively and independently. Height and BMI are both positive predictors of bone accruement. LM is a more precise predictor of bone traits than BF % in both genders. The effects of height and BMI and LM on bone accruement are nearly identical in the two genders, while changes in BF % have different but positive effects on bone accretion in both boys and girls.

Bone status of children born from mothers with autoimmune diseases treated during pregnancy with prednisone and/or low molecular weight heparin.

BackgroundTo evaluate bone status in children born from mothers followed for autoimmune diseases and treated during pregnancy with low molecular weight heparin (LMVH) and/or prednisone.FindingsHistory, physical examination, laboratory tests and phalangeal ultrasonography were performed. Demographic, clinical, and laboratory data were entered into a customized database, and results were analyzed with SPSS software. In children whose mothers were treated with LMWH, we retrieved dried blood spots taken for newborn screening, and analyzed the presence of heparin with tandem mass spectrometry.We enrolled 27 females and 14 males born from 31 mothers with SLE or connective tissue diseases. These women were continuously treated during pregnancy with LMWH (n = 10), prednisone (n = 16), or both (n = 15). Bone ultrasound revealed low values (≤3 centile for age) in ten patients. In a multistep regression analysis, age at examination resulted the single predictor of low ultrasound values (p < 0.004). Tandem mass spectroscopy failed to determine traces of heparin in newborn blood.ConclusionsChildren born from mothers with autoimmune diseases are at risk to develop reduced bone mass. The administration of LMWH and of prednisone seems to be safe with regard to children’s bone health.

The influence of anthropometry and body composition on children's bone health the Childhood Health, Activity and Motor Performance School (The CHAMPS) study, Denmark

The influence of anthropometry and body composition on children's bone health the Childhood Health, Activity and Motor Performance School (The CHAMPS) study, Denmark

The impact on children's bone health of a school-based physical education program and participation in leisure time sports: The Childhood Health, Activity and Motor Performance School (the CHAMPS) study, Denmark

ObjectiveTo evaluate the effect of a school based physical education (PE) program and the amount of leisure time sport (LTS) on children's bone health and to examine if LTS influences the impact of school type on children's bone health. MethodsChildren attending “sports” schools (6×45min PE lessons per week) were compared to children at “traditional” schools (2×45min of PE lessons per week) in Svendborg, Denmark. Whole-body DXA scans were performed at baseline (2008) and at a two-year follow-up (2010). Bone mineral content (BMC), bone mineral density (BMD), and bone area (BA) were measured. Multilevel regression analyses examined the impact of school type and LTS participation on bone. Results742/800 (93%) invited children accepted to participate. 682/742 (92%) participated at two-year follow-up. Mean (SD) age was 9.5years (0.9) at baseline. A positive association between LTS and BMC, BMD (p<0.001) and for BA (p<0.05) (total body less head (TBLH) and lower limb (LL)) was found. All effects regarding school type were insignificant. ConclusionA positive impact of attending LTS on bone traits was found. There was no effect on BMC, BMD and BA (TBLH, and LL) for children attending sports schools compared to traditional schools.

Exposure to sunlight during pregnancy affects children's bone health

Exposure to sunlight during pregnancy affects children's bone health

Winning the Battle Against Childhood Physical Inactivity: The Key to Bone Strength?

Winning the Battle Against Childhood Physical Inactivity: The Key to Bone Strength?

Impact of maternal veiling during pregnancy and socioeconomic status on offspring’s musculoskeletal health

The impact of maternal veiling during pregnancy and of socioeconomic status on offspring's bone mass was investigated in 326 healthy adolescents. Veiling during pregnancy was associated with decreased musculoskeletal parameters in the offspring boys, but not girls. SES was a significant predictor of bone mass in both genders. This study investigates the effects of maternal veiling during pregnancy, a surrogate for low vitamin D level, and socioeconomic status (SES), a surrogate of nutritional status, on their offspring's bone mass at adolescence. Three hundred and twenty-six healthy adolescents aged 13.1(2.0) years and their mothers were studied. The impact of maternal veiling on offspring's bone mass was evaluated through regression analyses. Outcome variables were bone mineral density (BMD) and content (BMC) at the spine, hip, and total body of the children. Predictors were maternal veiling during pregnancy and SES. Covariates were height, body composition, Tanner staging, calcium intake, vitamin D and exercise in children. In boys, adjusted analyses revealed that both maternal veiling during pregnancy and SES were significant predictors of bone mass, at multiple skeletal sites. In girls, SES but not maternal veiling during pregnancy was a significant predictor of bone mass at multiple sites. Maternal veiling during pregnancy was associated with decreased musculoskeletal parameters of boys, but not girls. SES was a significant predictor of bone mass in both genders. These findings may have profound implications on children's bone health.

Genetic study of children's bone health and its therapeutic application

Genetic study of children's bone health and its therapeutic application

WITHDRAWN: 4th International Conference of Children's Bone Health, Montreal, Canada, 2007 growth plate cartilage injury responses and repair mechanisms

This article has been withdrawn consistent with Elsevier Policy on Article Withdrawal ( http://www.elsevier.com/locate/withdrawalpolicy ). The Publisher apologizes for any inconvenience this may cause.

Third International Conference on Children's Bone Health

Third International Conference on Children's Bone Health