To evaluate self-competence, health-related quality of life (HRQOL), and emotional/behavioral functioning in children with Tourette syndrome (TS) compared to normative data and to examine self-competence as a potential protective factor against poorer HRQOL and emotional/behavioral outcomes in this population. Thirty-nine children between the ages of 8 and 17 years and 72 caregivers participated in this study. Participants completed measures of children's HRQOL, emotional/behavioral functioning, and self-competence. Participants reported significantly lower levels of emotional/behavioral functioning and HRQOL compared with norms of healthy children. No significant differences were found in domains of perceived self-competence. Social and general self-competence domains were significantly and positively correlated with most emotional and behavioral outcomes examined. Only social self-competence was significantly correlated with domains of HRQOL. Self-competence, particularly in the social realm, may play a protective role against lower HRQOL and worse emotional and behavioral outcomes in children with TS. Children with this condition may benefit from self-competence-promoting interventions targeting children's perceptions of their own abilities.