Background: Although the consequences of the use of psychoactive substances of abuse are often linked to the media in a subtle way and clarified by the doctor in routine consultations, the use and abuse has been taking uncontrollable growth proportions to the point of generating a problem of the Today's world with immediate needs for interventions in order to minimize the damage caused. Due to this transformation of society's habits, many age groups have been significantly affected. The main and most worrying social group susceptible to drug abuse is the female society, since due to the great coincidence between the reproductive age and the period prone to the use of social attractions, occasionally in a gestation situation, the joint use in any dose generates and potentiates the consequences to fetal maternal life. The little-known social effects go through, when death does not occur, due to malformation of the fetus, nervous compromise, up to the manifestations after birth in the daily life of the child of a user mother. Taking this situation into account and facing this problem of the current world that threatens health, the study will demonstrate the most diverse maternal and fetal manifestations due to the use of substances or drugs of abuse, suggesting as a final objective the creation of information media. capable of keeping the potentially reproductive female society informed about the hidden curses to fetal life in gestation. Material and methods: Systematic review based on searches in the PubMed, Google Scholar, and TripDataBase databases. Scielo and others, with the identification of articles that present the proposed theme as the central theme with the identification of the determinant factors for the development of substance abuse and its different forms of affectation in the gestational period with some scores of the consequences in the puerperal period. Results: With the corresponding search strategies, 73 articles were found in the Pubmed database, 10 articles in the Google Scholar, TripDataBase and Scielo databases. Directing the selection according to criteria, 22 articles were chosen and used for analysis of the systematic review. Conclusion: The problematic use of substances potentially harmful to pregnancy continues to be a challenge for public health. With this, it is of fundamental importance to raise awareness through the creation of health promotion programs based on rational, comprehensive, and multidisciplinary consultations, which guarantee the reduction of consumption and maternal-fetal protection