Auditory hallucinations (AH) are very frequent and disabling symptoms of schizophrenia. In 25% to 30% of these patients, AH will stay refractory to conventional medication, resulting in persistent distress and functional disability. In such cases, evidences suggest that transcranial direct current stimulation (tDCS) could improve AH in adults with schizophrenia. tDCS is a safe noninvasive brain stimulation technique that might modulate brain activity and connectivity in the living Humans. AH are also frequently reported in patients with childhood-onset schizophrenia (COS). While pharmacological treatment of AH in adolescents with COS often leads to multiple side effects, little is known regarding the clinical interest of tDCS in adolescents with AH. The aim of this pilot study is to evaluate the safety and the clinical interest of a tDCS in the treatment of refractory AH in adolescents with COS. In an open-label prospective study, adolescents with COS and refractory AH will received 10 sessions (twice a day for 5 consecutive weekdays) of tDCS (30 minutes, 2 mA). The anode will be placed over the left dorsolateral prefrontal cortex and the cathode over the left temporo-parietal cortex. The severity of AH and the functioning of patients will be assessed 4 times using the Auditory Hallucinations Rating Scale (AHRS), and the Global Assessment of Functioning (GAF): at baseline (V1), after tDCS sessions (V2), one (V3) and 3 months later (V4). Preliminary results in 6 patients showed that tDCS may alleviate AH severity and that tDCS is a safe approach in adolescents with COS. AHRS scores exhibited a 66% decrease (from mean = 25.1 ± standard deviation 3.8 to 8.1 ± 12.8 one month later after tDCS). The Friedman Test for Repeated-Measures indicated a significant effect of tDCS on AH measured with the AHRS; chi square = 9; P = .01. We also observed a significant improvement of functioning measured with the GAF scores in adolescents with COS and refractory AH. Further randomized controlled studies are needed to confirm these preliminary results.