Childhood Background Research Articles

Residential Mobility in Childhood and Union Dissolution Later in Life

The limited existing literature studying the effects of childhood residential mobility suggests that it influences a range of life outcomes, at least in young adulthood. Little is known about how the frequency of moving in childhood is related to later-life demographic behaviour in Europe. Drawing on residential and partnership histories from the Survey of Health, Ageing and Retirement in Europe (SHARE), this paper examines whether moving in childhood relates to union dissolution in adulthood. It empirically addresses two theoretical explanations underlying the potential association: First, according to the confounding hypothesis, effects of childhood residential mobility differ by family background and resources. Second, the family stress model suggests that the accumulated stress and conflicts associated with frequent residential mobility disrupt the family and child’s social ties, resulting in worse relationship skills in later life (mediation hypothesis). Applying discrete-time event history analysis to individuals born between 1945 and 1965 in Sweden, Denmark, and Finland, we find a significant association between childhood moves (prior to age 17) and adult union dissolution. The effect’s strength varies based on the number of childhood moves, demonstrating a clear gradient. Notably, adults with three or more childhood moves exhibit a 55% higher likelihood of union dissolution compared to non-movers. These associations persist even after accounting for childhood background factors, while family stress mediates the link partially. Our findings shed light on the role of spatial mobility in shaping demographic outcomes and underscore its potential contribution to the accumulation and reproduction of life disadvantages.

Risk and protective factors for cognitive decline in Brazilian lower educated older adults: A 15-year follow-up study using group-based trajectory modelling

BackgroundPatterns of cognitive change and modifiable factors for cognitive decline versus stable cognitive trajectories have rarely been described in lower-educated older adults. ObjectivesWe aimed to identify long-term trajectories of cognitive functioning and possible factors associated with cognitive decline. Design and participantsWe used data from 1,042 adults aged ≥ 60 participating in the Health, Welfare and Aging Study (SABE), São Paulo, Brazil, without cognitive impairment at baseline. Data were collected across four waves (2000–2015). Group-based trajectory modelling was used to identify cognitive trajectories. Associations with socioeconomic variables, childhood background, lifestyle, and cardiovascular risk factors were explored using weighted multinomial logistic regressions. MeasurementsThe abbreviated Mini-Mental State Examination was used to measure cognition. ResultsThree cognitive trajectories were identified: stable (n= 754, 68.6%), mild-decline (n= 183, 20.8%), and strong-decline (n= 105, 10.7%). At baseline, respondents in the strong-decline group were more likely to be older than those with stable and mild-decline trajectories. Furthermore, participants in both the mild and strong-decline groups were more likely to have no schooling, be divorced/separated, receive less than 4 monthly wages, and be underweight (BMI < 18.5) compared to the stable group. Finally, the mild-decline group was more likely to have lived in rural areas during childhood than participants located in a stable trajectory. ConclusionsOur findings suggest that interventions to reduce cognitive decline for low-educated older adults might include strategies addressing inequalities and improving modifiable risk factor burden.

ATRT-20. ATYPICAL TERATOID RHABDOID TUMOR: ASSOCIATION OF CLINICAL, HISTOLOGICAL, RADIOLOGICAL, MOLECULAR, AND THERAPEUTIC DATA WITH THE SURVIVAL OF PATIENTS ATTENDED AT IOP/GRAACC/UNIFESP

Abstract BACKGROUND In childhood, Atypical Rhabdoid Teratoid Tumor accounts for 2% of cases of brain tumors. There is no consensus for the treatment, resulting in multiple protocols. METHODS Retrospective study at the Institute of Pediatric Oncology-IOP/GRAACC/UNIFESP, from January 2000 to December 2022. There were 31 patients admitted during this period. The classification of the histological type into rhabdoid/classic, small round and blue cells, epithelial, and mesenchymal was carried out by the same pathologist, and a 50% cutoff characterized the predominant pattern. A neuro-radiologist reviewed the radiological data. Molecular analysis was performed using NGS. RESULTS In patients &amp;lt;3yo, 74.9% of patients died. Overall survival (OS) at 3 years was 24.5%, and progression-free survival (PFS) at 3 years was 13.8%. In patients &amp;lt;3yo, the absence of metastases was associated with a higher OS and PFS (3y-OS 35.6% and 3y-PFS 23.7%, vs 3y-OS 10% and 3y-PFS 0% in patients with M+). The OS was higher in patients who received radiotherapy at the first treatment (3y-OS of 66.6% vs 7.8% in the non-irradiated group). The classic histological pattern had a lower PFS than the epithelial and small cell groups (p=0.021). In patients&amp;gt;3 yo, 57.1% of patients died. The 3y-OS was 38.1% and the 3y-PFS was 53.5%. In this age group, there was no difference in OS and PFS considering metastases, location, histological pattern, and tumor volume. For post-surgical status, only PFS was significantly higher in patients with complete resection (3y-PFS of 75%, p=0.008). The mean survival time in patients &amp;lt;3 yo was 1.9 years, and the mean survival time in patients &amp;gt;3 yo was 2.5 years. The genetic alterations found were SMARCB1, NOTCH1, and KMT2D. CONCLUSION Patients &amp;gt;3yo seem to have a higher OS and PFS than those &amp;lt;3 yo. Early diagnosis of ATRT may corroborate to a better outcome. The radiotherapy in the first treatment can improve the outcome of patients under 3 years of age. The classic histological pattern was associated with worse PFS.

Children’s Character Learning Model Based on Indonesian Local Wisdom: Implemented to Early Childhood Education in Play Centers

Character education can equip young children to become Indonesia's golden generation who are superior and skilled in noble work. This research aims to produce an early childhood character learning model based on local Indonesian wisdom through the Playing Center title which will be implemented at Early Childhood Education Institutions (ECE) in Indonesia. This research method uses the steps of the Borg and Gall research and development model. The subjects in this research were 30 teachers from five ECE institutions in the DKI Jakarta area. The data used as the basis for building a framework for early childhood character learning models based on local intelligence were collected using observation and interview techniques. The findings show that the teacher prepares a learning plan program at the beginning of each semester which is listed in the weekly program and daily program. However, the teacher has not fully prepared a simulation program that leads directly to the introduction of early childhood character. Identification of character values ​​in early childhood is done by providing examples of behavior and speech at school. The media that has been used to identify children's characters is through posters and non-digital story books. The learning environment needs to be improved because teachers have not been optimal in organizing the play environment in providing stimulation to children in class. The results of this research will enrich the character education model following the potential of the institution and the cultural background of early childhood as Indonesia's golden generation. Keywords: character learning model, local wisdom, play center, early childhood

Separating the effects of early and later life body mass index on liver diseases: A Mendelian randomization study

Background and aimThe independent effects of childhood and adult body mass index (BMI) on non-alcoholic fatty liver disease (NAFLD), cirrhosis, and hepatocellular carcinoma (HCC) are lacking assessment. We aimed to separate the effects of childhood and adult BMI on NAFLD, cirrhosis, and HCC. MethodsGenetic variants associated with childhood and adult BMI were selected as instrumental variables. Two-sample univariable and multivariable MR estimated the total and direct effect of childhood and adult BMI on NAFLD, cirrhosis, and HCC. ResultsGenetically predicted each 1-SD increased childhood BMI (OR = 1.30, 95 % CI = 1.12 to 1.51, P = 0.001) and adult BMI (OR = 1.57 95 % CI = 1.33 to 1.84, P = 5.49E-08) was associated with an increased risk of NAFLD. The association between childhood BMI (OR = 0.97, 95 % CI = 0.77 to 1.24, P = 0.825) and NAFLD did not remain significant after adjusting for adult BMI (OR = 1.64, 95 % CI = 1.23 to 2.20, P = 0.001). The direct effects of childhood and adult BMI on cirrhosis and HCC were insignificant after considering their relationship. ConclusionMaintaining a normal BMI in adulthood significantly reduces the adverse effect of a higher childhood BMI on NAFLD. Further investigation is required to clarify the presence of this effect in cirrhosis and HCC.

Understanding compensatory travel

Resources to which people expect to represent their social and personal status influence important traveler decisions. Yet we know little about the antecedents and consequences of travelers' behavior under resource fluctuation. Three studies examined how resource status affects travelers' spending propensities in crisis times from the life-history framework. Results presented that travelers with lower childhood backgrounds increased their willingness to pay for international flights to compensate for their resource deficit when their current income is relatively low and travel restriction is severe. Without resource-scarce cues, travel intentions were associated with travelers' childhood travel habits. The research suggests potential customer relationship strategies by showing how and why travelers' life histories affect compensatory behavior that companies may adopt during the industrial crisis.

Growing older against the background of a traumatic childhood

ZusammenfassungMissbrauchserfahrungen in frühen Lebensjahren können sich bis ins hohe Lebensalter negativ auf die Betroffenen auswirken. Heute existiert vergleichsweise wenig systematisches Wissen im Hinblick auf (un)spezifische Traumafolgen bei älteren Betroffenen. Zusätzlich besteht wenig Wissen bezüglich (relativ) unversehrter langfristiger Verläufe nach traumatischen Kindheitserfahrungen. Um einerseits diesen Forschungsrückstand aufzuholen und andererseits dabei zu helfen, ein dunkles Kapitel der Schweizer Geschichte aufzuarbeiten, wurden am Psychologischen Institut der Universität Zürich mehrere Studien mit ehemaligen Betroffenen von „Fürsorgerischen Zwangsmaßnahmen und Fremdplatzierung“ durchgeführt. Ziel war es herauszufinden, inwieweit solche Erfahrungen mit der körperlichen und psychischen Gesundheit im Alter zusammenhängen.

Association Between Childhood Backgrounds &amp; Mental Health in Middle Age: Findings from the National Social Life, Health, &amp; Aging Project

Abstract Date Presented 04/21/2023 This study focused on examining whether childhood backgrounds were associated with mental health in middle age. The study findings suggest that promoting a happy family life in childhood may contribute to better mental health in middle age. Primary Author and Speaker: Seungju Lim Additional Authors and Speakers: Sangmi Park, Yebin Han, Kiwoong Kim, Su Jeong Jee, Ickpyo Hong Contributing Authors: Ji-Hyuk Park

Dari Ratu Kembang Kacang hingga Berlanggam di Istana: Kiprah Waldjinah sebagai Penyanyi Istana Negara

This study reveals the career path of Waldjinah, a Javanese style singer from Surakarta. The discussion emphasizes the background of childhood, education, and career journey. Waldjinah had an experience that was never forgotten and was also very influential on her career as a singer, namely when she was invited to sing at the state palace by President Sukarno and then continued until the time of President Suharto. Using historical method, this article reveals the childhood that later influenced Waldjinah's life choices. Apart from that, this study also reveals Waldjinah's progress in participating in singing competitions and led her to the State Palace. According to the findings, this study shows that Waldjinah's progress as a famous singer cannot be separated from the family education she received since childhood. In addition, Waldjinah's unyielding attitude brought her to the State Palace to reach the pinnacle of her career. This can be seen from Waldjinah's participation in Bintang Radio approximately three times, even though at the beginning of her participation she did not get the best results.

The Cumulative Effects of Colorism: Race, Wealth, and Skin Tone

Abstract Researchers have long documented a persistent Black–White gap in wealth. These studies, however, often treat race as a discrete category, eluding its socially constructed nature. As a result, these studies assume that the “effect of race” is consistent across all individuals racialized as Black. Studies that make this assumption potentially obscure heterogeneity in the size of the Black–White wealth gap. Research on skin color stratification suggests that it is possible that the Black–White wealth gap varies by the extent to which a racial subgroup is deemed to fit the broader racial umbrella. In turn, I adopt a more complex operationalization of race that is based on both racial and skin tone appraisals. Drawing on data from the National Longitudinal Survey of Youth 1997, I find that the Black–White wealth gap does vary by the Black skin tone subgroup. Generally, the Black–White gap in assets is smallest when focusing on lighter-skin Black people and largest when focusing on darker-skin Black people. These differences are not only the result of initial disadvantage but also cumulative disadvantage in the rate of wealth accumulation. Lastly, the findings suggest that the Black–White wealth gaps grow at a faster rate than the skin tone wealth gaps. I found that differences were robust to adjustments for parental socioeconomic status, childhood background, and interviewer characteristics. I conclude by discussing the theoretical implications for our understanding of the mechanisms undergirding Black–White disparities in wealth attainment.

Patterns of adjustment during the Covid-19 pandemic in Greece: the Resilient, the Rebels and the Internalizers

This study explored the patterns of adjustment to the quarantine restrictions imposed during the first Covid-19 wave in Greece. The sample comprised 1377 respondents from all geographical districts, mostly women (78.9%), with university degrees (80.7%) and an age range between 18-81. The Quarantine Adjustment Questionnaire was designed to assess the reactions of the general population to the lockdown restrictions and three diverse patterns. emerged from the analyses: positive adjustment (the Resilient), confinement stress (the Rebels) and introspection (the Internalizers), which served as the dependent variables in this study. Multiple linear regressions revealed that each profile consisted of characteristic childhood backgrounds, personal attributes, fears and concerns regarding the Covid-19 pandemic. Economic distress and negative childhood experiences differentiated the psychological effects of quarantine restrictions and determined to a large extent the adjustment pattern employed by each group. Women presented the most resilient profile but also the most vulnerable one, depending on the social and personal resources at their disposal. Young people were the most reactive group to the quarantine restrictions, but also the most unprotected to current and future adversity. Implications regarding the impact of sociocultural factors on patterns of adjustment and the need for new policies to support the vulnerable population are discussed.

Peroneus longus tendon transfer; prospective study of treatment outcome of recurrent fixed clubfoot deformities in children after failed surgical treatment

BackgroundIn childhood, for flexible clubfoot deformity, the transfer of the tendon of the tibialis anterior muscle is widely used. In contrast, extensive surgical procedures are required for fixed clubfoot deformities. MethodsWe describe the peroneus longus tendon transfer to the peroneus brevis tendon, additionally to full surgical release, in cases of recurrent fixed clubfoot deformities. The purpose of this surgical technique was to restore and maintain the dynamic balance of foot inversion-eversion during the gait cycle by augmenting the muscular strength of the weak peroneus brevis tendon. We report the prospective study of treatment outcome of twenty recurrent fixed clubfoot deformities in twelve children (20 feet) after failed surgical treatment they had. Anteroposterior and lateral radiographs under full-body weight-bearing and the AOFAS score pre-and postoperatively were used in all patients. For the estimation of the severity of the recurrent clubfoot deformity in each child and to increase the credibility of the AOFAS rating scale, we additionally used a clubfoot sheet score preoperatively and postoperatively (maximum score 100 points for normal foot appearance clinically and radiologically). ResultsThe mean age at surgery was 6,85 (±1,81; 5–11) years. The mean follow-up time was 5,4 (±1,7; 2–8) years. The mean AOFAS ankle-hindfoot rating score increased from 69,85 (±9,51; 53–82) points preoperatively to 94,4 (±2,43; 91–97) points postoperatively. The mean clubfoot sheet rating score increased from 43,00 (±12,18; 15–55) points, preoperatively to 90,0 (±4,58; 80–95) points postoperatively. The two-tailed p-value was < 0,0001. ConclusionsThe transfer of the peroneus longus tendon to the peroneus brevis tendon is a minimal surgical procedure that acts collaboratively in maintaining the correction of foot deformity, achieved by the complete surgical release. Level of Evidence: IV.

Identification and Development of an Age-Related Classification and Signature to Predict Prognosis and Immune Landscape in Osteosarcoma.

Background In childhood and adolescence, the prevailing bone tumor is osteosarcoma associated with frequent recurrence and lung metastasis. This research focused on predicting the survival and immune landscape of osteosarcoma by developing a prognostic signature and establishing aging-related genes (ARGs) subtypes. Methods The training group comprised of the transcriptomic and associated clinical data of 84 patients with osteosarcoma accessed at the TARGET database and the validation group consisted of 53 patients from GSE21257. The aging-related subtypes were identified using unsupervised consensus clustering analysis. The ARG signature was developed utilizing multivariate Cox analysis and LASSO regression. The prognostic value was assessed using the univariate and multivariate Cox analyses, Kaplan-Meier plotter, time-dependent ROC curve, and nomogram. The functional enrichment analyses were performed by GSEA, GO, and KEGG analysis, while the ssGSEA, ESTIMATE, and CIBERSORT analyses were conducted to reveal the immune landscape in osteosarcoma. Results The two clusters of osteosarcoma patients formed based on 543 ARGs, depicted a considerable difference in the tumor microenvironment, and the overall survival and immune cell infiltration rate varied as well. Among these, the selected 23 ARGs were utilized for the construction of an efficient predictive prognostic signature for the overall survival prediction. The testing in the validation group of osteosarcoma patients confirmed the status of the high-risk score as an independent indicator for poor prognosis, which was already identified as such using the univariate and multivariate Cox analyses. Furthermore, the ARG signature could distinguish different immune-related functions, infiltration status of immune cells, and tumor microenvironment, as well as predict the immunotherapy response of osteosarcoma patients. Conclusion The aging-related subtypes were identified and a prognostic signature was developed in this research, which determined different prognoses and allowed for treatment of osteosarcoma patients to be tailored. Additionally, the immunotherapeutic response of individuals with osteosarcoma could also be predicted by the ARG signature.

Market Participation and Moral Decision-Making: Experimental Evidence from Greenland

Abstract The relationship between market participation and moral values is the object of a long-lasting debate in economics, yet field evidence is mainly based on cross-cultural studies. We conduct rule-breaking experiments in 13 villages across Greenland (N = 543), where stark contrasts in market participation within villages allow us to examine the relationship between market participation and moral decision-making, holding village-level factors constant. First, we document a robust positive association between market participation and moral behaviour towards anonymous others. Second, market-integrated participants display universalism in moral decision-making, whereas non-market participants make more moral decisions towards co-villagers. A battery of robustness tests confirms that the behavioural differences between market and non-market participants are not driven by socioeconomic variables, childhood background, cultural identities, kinship structure, global connectedness and exposure to religious and political institutions.

Pancreatic family history does not predict disease progression but connotes alcohol consumption in adolescents and young adults with acute pancreatitis: Analysis of an international cohort of 2,335 patients.

BackgroundIn pediatric acute pancreatitis (AP), a family history of pancreatic diseases is prognostic for earlier onset of recurrent AP (ARP) and chronic pancreatitis (CP). No evidence supports the same association in adult-onset pancreatitis. Age-specific reasons for familial aggregation are also unclear. We aimed to examine the prognostic role of pancreatic family history for ARP/CP and observe possible underlying mechanisms.MethodsWe conducted a secondary analysis of the Hungarian Pancreatic Study Group’s (HPSG) multicenter, international, prospective registry of patients with AP, both children and adults. We compared the positive family history and the negative family history of pancreatic diseases, in different age groups, and analyzed trends of accompanying factors. Chi-square and Fisher exact tests were used.ResultsWe found a higher rate of ARP/CP in the positive pancreatic family history group (33.7 vs. 25.9%, p = 0.018), peaking at 6–17 years. Idiopathic AP peaked in childhood in the positive family history group (75% 0–5 years) and was consistently 20–35% in the negative group. A higher rate of alcohol consumption/smoking was found in the positive groups at 12–17 years (62.5 vs. 15.8%, p = 0.013) and 18–29 years (90.9 vs. 58.1%, p = 0.049). The prevalence of diabetes and hyperlipidemia steadily rose with age in both groups.ConclusionPositive family history most likely signifies genetic background in early childhood. During adolescence and early adulthood, alcohol consumption and smoking emerge—clinicians should be aware and turn to intervention in such cases. Contrary to current viewpoints, positive pancreatic family history is not a prognostic factor for ARP and CP in adults, so it should not be regarded that way.

A global analysis of factors predicting conservationists' values

Abstract There exists a wealth of philosophical, sociological and anthropological literature on environmental values; yet, few studies have investigated the values held by conservationists themselves, and how these shape the conservation movement. Here, we present the first global analysis of the relationships between conservationists' values and a broad range of conservationists' characteristics, categorised into their educational and professional background, geographical context and personal experiences in childhood and adulthood. We draw on survey responses from 9264 conservationists from 149 countries to conduct the broadest analysis to date of what factors are associated with the values of conservationists. Our results demonstrate that 13 characteristics of conservationists' personal and professional backgrounds are statistically related to their values regarding the place of people, science, capitalism and nonhuman entities in conservation. Of these characteristics, educational specialism and continent of nationality had the highest predictive power. We also draw on open‐text responses to uncover other factors that conservationists identify as having been important in shaping their values; travel and religion were the most commonly reported. Our findings have important implications for current debates on diversity and inclusion within the conservation community. In particular, we provide broad empirical evidence that increasing personal and professional diversity in conservation organisations is likely to also increase the range of values represented. We also discuss the implications of our results for interdisciplinarity, the management of disagreement and conflict in conservation, and the training of future generations of conservationists. Read the free Plain Language Summary for this article on the Journal blog.

The concept of pain inventory for children: The reliability and validity study of the Turkish version

Background and purposePain experiences in childhood are very likely to be reflected in adulthood. The early evaluation of the concept of pain in children may eventually lead to.better patient outcomes in the future. Therefore, we aimed to culturally and developmentally adapt the Concept of Pain Inventory for Children (COPI) for Turkish children. MethodsThis descriptive, correlational study was conducted with 239 post-operative children aged 8–12 years between June and December 2021. The research adhered to COSMIN guidelines. The data were collected using a descriptive information form and the COPI. Factor analysis, Cronbach's alpha, and item–total score analysis were used for the data analysis. ResultsThe resulting unidimensional scale consists of 12 items in Turkish. The scale explained 65% of the total variance. The exploratory factor analysis showed that the factor loadings of items ranged from 0.64 to 0.91. The confirmatory factor analysis showed that the factor loadings of items ranged from 0.66 to 0.92. Goodness of fit indexes were found to be as follows: Normed Fit Index >0.90; Incremental Fit Index >0.90; Comparative Fit Index >0.90; and the Root Mean Square Error of Approximation <0.08. The total Cronbach's alpha coefficient of the scale was 0.78 (reliable). ConclusionsThe 12-item Turkish translation of the COPI was deemed valid and reliable in 8–12-year-old children in a post-operative setting. Practice implicationsEvaluation of children's pain concepts during childhood may contribute to the identification of conceptual gaps for pain science education.

Prevalence of acute respiratory infections among children in India: Regional inequalities and risk factors

AimThe high incidence of acute respiratory infection (ARI)-related morbidity and mortality is a major public health concern in developing countries. This study aimed to quantify regional inequalities and the degree of association between childhood ARI and background factors.MethodsThis study utilised information of 238 945 children aged below five years extracted from the Fourth Indian National Family Health Survey conducted in 2015–16. Inter-state and regional inequality in the prevalence of ARI were quantified and presented using a map of India and forest plot. The association of background characteristics and ARI was quantified using bivariate and multivariable binary logistic regression models.ResultsSignificant inequalities in the prevalence of childhood ARI were observed across the six regions of India. Considering the children from north-east region as a reference, those from north, central and east regions were 0.68, 1.02 and 0.57 times more likely to suffer from ARI. Comorbidity, sex, age and nutritional status of children were significantly associated with the prevalence of ARI.ConclusionsARI remains a significant public health concern among Indian children. The results of this study showed that significant regional disparities in the prevalence of ARI exist in India. This study adds value to the better understanding of inequality patterns and quantifies within- and intra-region inequalities in the prevalence of ARI in India.

Does the trauma associated with out-of-home care transmit across generations? Evidence from the 1970 British Cohort Study during a major health pandemic

ObjectivesChildren with experience of out-of-home care (OHC) are at an increased risk of adverse outcomes in later life, including poorer levels of psycho-social adjustment. Less is known about the intergenerational...

Prenatal Drug Exposure in Children With a History of Neuropsychiatric Care: A Nested Case-Control Study.

Background and ObjectivesNeuropsychiatric disorders in childhood after prenatal drug exposure raises concerns. Most of the published studies focused on psychotropic medications. This study investigated which prenatal medication exposure was associated with neuropsychiatric disorders in childhood.MethodsA case-control study, nested in the French POMME cohort, was conducted to compare prenatal medication exposure between children with a history of neuropsychiatric care (ages 0–8 years) and children in a control group. POMME included children born in Haute-Garonne to women covered by the general Health Insurance System, between 2010 and 2011 (N = 8,372). Cases were identified through: (1) reimbursement for neuropsychiatric care; (2) psychomotor development abnormalities specified on health certificates; and (3) reimbursement for methylphenidate or neuroleptics. Controls had none of these criteria. Prenatal exposure to each of the major “Anatomical Therapeutic Chemical” classes was compared between the groups. Class(es) for which there was a statistically significant difference (after Bonferroni adjustment, i.e., p < 0.0033) was(were) compared using logistic regression.ResultsA total of 723 (8.6%) cases and 4,924 (58.8%) controls were identified. This study showed a statistically significant difference in prenatal exposure to nervous system drugs (excluding analgesics) between the groups [ORa: 2.12 (1.55; 2.90)]. Differences (not statistically significant at the 0.0033 threshold) were also observed for the ATC classes: Musculoskeletal, Genito-urinary System and Sex Hormones, Alimentary Tract and Anti-infectives.ConclusionThrough identification of children with neuropsychiatric disorders and of their prenatal medication exposure, this study provides guidance for the assessment of long-term neuropsychiatric effects after prenatal medication exposure, without focusing on psychotropic medications.