Chief Physician Research Articles

On Slavery, Medicine, Speculation, and the Archive

In 1777, word spread along the Amazonian coast that the “cruel contagion of smallpox” was circulating in the Portuguese frontier captaincies of Grão-Pará and Maranhão.1 Rumor often announced the arrival of smallpox before authorities.2 The rumors wound their way along the roads and waterways of Belém, the capital of Grão-Pará, to the ears of thirty-three enslaved Africans, all of them property of Chief Physician Bento Viera Gomes. They were terrified of the ongoing outbreak—and of their enslaver. They knew of Gomes’s attempts to prevent the spread of smallpox by inoculating a group of soldiers stationed nearby. The soldiers refused the inoculations, fearing the disease and the procedure.3 To prove the procedure was safe and effective, Gomes conscripted the thirty-three to serve in an inoculation demonstration for the soldiers. As Gomes remarked, the enslaved people “(although equally fearful)…had no choice but to obey.”4 Each of them, between the ages of three and twenty-five, underwent the procedure. All survived. Nevertheless, this brief chapter in the history of inoculation brings questions of survival, quality of life, and archival objectivity to the fore.The slave trade and slavery established power relations that shaped the terms of scientific and medical knowledge production and practice. European imperial and medical archives naturalize these power relations. It is the historian’s task to unsettle and expose them. The intellectual foundations that presuppose inoculation as an inherent good because it saved lives (and it certainly did) do not prioritize Black people’s healing and well-being. To do so requires affective labor that begins with archival critique and proceeds with speculation.We find this inoculation story buried in a flurry of accounts from medical practitioners around the Portuguese-American colonies discussing plans for the implementation of the Jennerian cowpox vaccine.5 As a show of expertise to the Crown, physicians like Gomes highlighted their prior experiences using inoculation and demonstrated their knowledge of the literature, citing works such as Thomas Dimsdale’s recently translated inoculation manual.6 Vague allusions to inoculations performed in the British colonies, the primary competition for Amazonian industries, also pepper the pages. Perhaps Gomes read the Letters and Essays published by the notorious physician John Quier who experimented with smallpox inoculation on young, pregnant, and elderly enslaved Africans in Jamaica.7Too often, the history of inoculation serves as a prelude to triumphalist narratives of the resounding success of the Jennerian vaccine. Yet in the archival record, undercurrents of exploitation are plain: “they had no choice but to obey.” Enslaved people were the ideal candidates for inoculation demonstrations because colonists and slaveowners viewed them as replaceable commodities, chattels, and units of labor.8 They were expendable, yet essential to the imperial project.9 In Grão-Pará, inoculation would enable the imperial project to proceed despite its health consequences. Most enslaved people survived smallpox outbreaks or inoculation only to die of other causes. Even lifesaving technical and medical advancements can work to maintain the social, environmental, and existential order. Rather than sustaining life, smallpox inoculation reproduced and maintained the intertwined systems of imperialism and slavery, with their violence, pernicious inequity, morbidity, and needless death.Perhaps we might imagine beyond the thirty-three enslaved Africans’ fears and their enslavers’ reputed successes, through wonder, speculation, and questions.10 How much care and tenderness persisted amid the violence? Did parents or siblings hold the three-year-old as they prepared to receive an inoculation? Were mothers forced to hand over their children to strangers in the process? Did they smell the infected, who braced themselves to have smallpox pus removed? Did the infected person look at the recipient reassuringly? Did they exchange words, prayers, hopes, or ask questions about the procedure? Perhaps the twenty-five-year-old assisted, hoisting the small children into their lap and calming them before the incision. Which women (because it was usually women) tended the children until they recovered? Who hovered, feeding them vegetables and broth while their fevers broke, administering treatments, and applying balms and oils to their skin, ensuring they did not scratch and infect their pustules, or worse, disrupt the incision? Even without answers, these questions and errant speculations trouble the foundational liberal narratives of inoculation as progress.Speculation offers a way to divest from autopoiesis in slavery’s afterlife.11 What if we pursued and imagined thriving, not just preserving life? We could then confront our current ontologies of health and healing, and include anti-racist, feminist, environmentalist, and abolitionist collectivist politics that far exceed the neoliberal health care offered by a practitioner–patient dyad. If we want healing to account for Black life and thriving, we will have to reckon with history. We must examine the suffering and death European medical intervention rendered permissible and sustainable for their imperial projects—as well as their enduring legacies in medicine, public health, and science.

Metaverse virtual social center for elderly communication in time of social distancing

BackgroundThe lack of social activities among the elderly due to physical limitations can result in loneliness and depression. The spread of COVID-19 has made it difficult for the elderly to conduct stable social activities, increasing feelings of loneliness. The metaverse is a virtual world that mirrors reality. This allows the elderly to overcome the constraints of reality and perform social activities stably and continuously, providing new ideas for alleviating loneliness. MethodsBy analyzing their needs, a virtual social center framework for the elderly was proposed in this study. In addition, a prototype system was designed according to this framework. The elderly can socialize in virtual reality with metaverse-related technologies and human–computer interaction tools. Additionally, a test was conducted jointly with the chief physician of the geriatric rehabilitation department of a tertiary hospital. ResultsThe results demonstrated that the mental state of the elderly who had used the virtual social center was significantly better than that of those who had not used it. ConclusionsThus, virtual social centers can help relieve loneliness and depression among the elderly with increasing global epidemics and an aging society. Hence, they have promotional value.

Factors associated with the uptake of biosimilars for breast cancer treatment from the perspectives of physicians and patients-Evidence from China.

Objective: To investigate the factors associated with the treatment of breast cancer with biosimilars from the perspectives of physicians and patients, and to generate evidence for promoting the uptake of biosimilars. Methods: This study targeted trastuzumab and its indicated human epidermal growth factor receptor 2 (HER2) positive breast cancer and included female HER2 positive breast cancer patients under treatment of trastuzumab at a provincial oncology medical center in southern China from 1 January 2021, to 31 December 2021. The study extracted patients' demographic, socioeconomic and clinical information and the basic information of their attending physicians from the hospital information system. We performed a bivariate multiple logistic regression analysis of predictive factors of the use of trastuzumab biosimilar. Results: A total of 446 patients (aged ranging between 26 and 74, 51.4 ± 9.06) were included in the analysis, and 19.1% chose biosimilar trastuzumab. Older patients, patients enrolled in the urban and rural resident health insurance program compared with those enrolled in the urban employee health insurance program, patients who initiated treatment after January 2021 when biosimilar entered clinical use compared with those who initiated treatment before, patients with female attending physicians, younger attending physicians and with chief attending physicians compared with deputy chief attending physicians were more likely to adopt biosimilar trastuzumab for treatment (p < 05). Controlling the other factors unchanged, when the patient's attending physician was deputy chief physician, increasing 1year age of the patient was associated with an increased probability of adopting biosimilar by .8% (dy/dx = .008, 95%CI: .002-.01, p = .01). When the patient was aged between 26 and 60, the probability of adopting biosimilar for the patient whose attending physician was a chief physician was higher than for those whose attending physician was a deputy chief physician, and the gap was the largest when the patient was at the age of 45 (dy/dx = .20, 95%CI: .13-.27, p < .01). Conclusion: The uptake rate of biosimilars is still low at its initial development stage in China. Educational policies and physicians making recommendations to the indicated patients at the initiation stage of treatment are helpful to avoid reduced willingness to switch to biosimilars due to non-clinical reasons. Patients with lower ability-to-pay will have better accessibility to biologic regimens through the uptake of biosimilars. Official guidelines and professional training are critical to enhancing physicians' willingness and confidence in adopting biosimilars.

Prescription of potentially addictive medications after a multilevel community intervention in general practice

Objective To evaluate the long-term effects of a multilevel community intervention to improve the quality of prescription practice of potentially addictive medications (PAMs). Design We conducted a retrospective study, using anonymized data from the Norwegian prescription registry. Setting Based on an initiative from the GPs in Molde Municipality in Norway, a multilevel community intervention was initiated by the municipal chief physician in 2018. The intervention targeted GPs, patients, and the public. Subjects We retrieved prescription data from 26 of 36 GPs. Main outcome measures By using the standardized defined daily dose (DDD), we compared prescription of three groups of PAMs from before the intervention (2017) throughout the intervention in 2018, and through 2020 to determine long-term effects. Results Three years after the intervention, the GPs in our study sample prescribed 26% less opioids, 38% less benzodiazepines, and 16% less z-hypnotics. Overall prescription of PAMs decreased by 27%. The number of individuals receiving at least 90 DDD of benzodiazepines and z-hypnotics were reduced from 9 to 7 and 34 to 24 per 1000, respectively. Also, the number of individuals receiving two and three PAMs concomitantly were reduced. Conclusion Addressing prescription practice among GPs in a community as a joint intervention, combined with addressing patients and the public may be a feasible method to obtain long-term reduction of PAM prescriptions. Key points Non-therapeutic prescriptions of potentially addictive medications (PAMs) are both a public health concern and a frequent challenge in general practice. A multilevel community intervention, targeting general practitioners, patients, and the public, led to 27% reduction in prescription of PAMs. Both the number of daily users and concomitant use of several PAMs were reduced. The reduction in prescription persisted for three years.

Automation of health care management system through software

In these modern times, people prefer convenience over traditional methods. This text describes the benefits of implementing a software system in Polyclinic #5. The system enables patients to make online appointments with doctors, eliminating the need to wait in long queues. Additionally, it eliminates the hassle of managing physical medical cards as all records can be accessed digitally. The software also facilitates communication among employees through a chat room and allows for sending reports to the chief physician. For pharmacists, the system provides the ability to check the availability of medicines. Moreover, the software automates tasks, provides schedules for employees, and enables effective management of the team. The system architecture involves subsystems and user access from different devices. Users include the chief physician, doctors, receptionists, nurses, pharmacists, laboratory technicians, and patients. The system development follows an iterative and incremental approach. It concludes with the implementation of off-the-shelf software that simplifies patient appointments, ensures secure medical records, enhances staff communication, and streamlines management and inventory control.

The effect of preoperative fasting time on physiological parameters in patients undergoing thyroid surgery

The research was conducted between January 2022 and June 2022 in the Department of Surgery, Inonu University, Turkey. The sample of the study consisted of 40 consecutive patients who underwent thyroidectomy surgery. After obtaining the necessary permissions from the ethics committee, patients, and the chief physician of the medical faculty hospital, the research was conducted. Research data were collected using the patient diagnosis form, the form for assessing patients; vital signs, the form in which the laboratory values of the patients are determined, and the wound site evaluation form of patients three days after surgery. As a result of the research, it was determined that heart rate, body temperature, and HbA1c value may be affected as the fasting period gets longer. In surgeries performed in other patient groups and in patients with a higher population of thyroid surgery, it was suggested that new research should be done to examine the effect of fasting duration on vital signs, wound site, and blood laboratory values.

КАДРОВОЕ ОБЕСПЕЧЕНИЕ МЕДИЦИНСКИМ ПЕРСОНАЛОМ ЧЕМПИОНАТА МИРА ПО ВОЛЕЙБОЛУ FIVB 2022 В ГОРОДЕ НОВОСИБИРСКЕ

The article touches upon the topic of forming a team of medical staff with higher and secondary professional education to provide highly qualified medical care in the preparation and holding of the 2022 FIVB Volleyball World Championship, which would meet international standards. The practical experience of organizational interaction between the chief physician of the competition, the organizing committee of the World Championship, the Ministry of Health of the Novosibirsk Region, as well as the involved medical organizations and medical staff of the host city is summarized. Considerable attention is paid to the issues of theoretical and practical training of medical professionals, staffing of medical teams with medical and paramedical personnel, their location on the territory of a sports facility for operational interaction both in the provision of planned and emergency medical care to various client groups.

Medical and economic analysis of the effectiveness of the structural units of a medical organization

Medico-economic analysis in a medical organization is a set of techniques and methods for assessing the indicators of medical, industrial and financial activities, the purpose of which is to choose ways to rationally use internal resources. The main objectives of medical and economic analysis is to determine the reserves for the use of the organization's resources; introduction of effective technologies of the treatment process; assessment of the effectiveness of medical care, assessment of the effectiveness of management decisions. The combination of types of analysis, their subordination to management goals can improve the efficiency of the medical organization and its structural divisions. In the context of increasing competition in the medical services market, the importance of medical and economic analysis in medical organizations of various forms of ownership is growing. State medical institutions are no exception. Modern autonomous and budgetary healthcare institutions operate in the status of independent economic entities, while the role of the chief physician as the organizer of the medical and economic process, as well as the role of the head of the structural unit, who must analyze the results and costs, calculate the need for material and financial resources, determine efficiency of medical activity. The subject of the analysis of this article is to determine the optimal algorithm for conducting a medical and economic analysis in the context of the functioning of the structural units of a medical organization.

Disease versus disease: Paolo Zacchia on syphilis and epilepsy.

The lawyer and physician Paolo Zacchia (1584-1659) was the chief physician at the Vatican and an important advisor to the papal court. He is considered a founder of the field of forensic pathology, and the influence of his masterwork, Quaestiones medico-legales, spread throughout Europe. In this essay, we focus on one of Zacchia's consultations, first published posthumously in 1661. Emerging from a cause for beatification, the case features the intriguing medical notion of one disease curing another. Zacchia was to determine if a young man's recovery from epilepsy was miraculous or not. We will briefly review Zacchia's career, examine his argument and the sources on which he based his reasoning in this case, trace the status of the disease-versus-disease notion to the present, and demonstrate that this consultation represents a rare, if not the only example of syphilis being the curative agent - rather than the disease cured.

Clinical decision support system for hypertension medication based on knowledge graph

BackgroundHigh prevalence of hypertension and complicated medication knowledge have presented challenges to hypertension clinicians and general practitioners. Clinical decision support systems (CDSSs) are developed to aid clinicians in decision making. Current clinical knowledge is stored in fixed templates, which are not intuitive for clinicians and limit the knowledge reusability. Knowledge graphs (KGs) store knowledge in a way that is not only intuitive to humans but also processable by computers directly. However, existing medical KGs such as UMLS and CMeKG are general purpose and thus lack enough knowledge to enable hypertension medication. MethodsWe first construct a KG specific to hypertension medication according to the Chinese hypertension guideline and then develop the corresponding CDSS to implement hypertension medication and knowledge management. Current advances in knowledge graph representation and modelling are researched and applied in the complex medical knowledge representation. Traditional knowledge representation and KG representation are innovatively combined in the storage of the KG to enable convenient knowledge management and easy application by the CDSS. Along a predefined reasoning path in the KG, the CDSS finally accomplishes the hypertension medication by applying knowledge stored in the KG. 124 health records of a hypertension Chief Physician from Beijing Anzhen Hospital, Capital Medical University, are collected to evaluate the system metrics on the single drug recommendation task. Results and conclusionThe proposed CDSS has functions of medication knowledge graph management and hypertension medication decision support. With elaborate design on knowledge representation, knowledge management is intuitive and convenient. By virtue of the KG, medication recommendations are highly visualized and explainable. Experiments on 124 health records with 90% guideline compliance collected from hospitals in single class recommendation task achieve 91%, 83% and 77% on recall, hit@3 and MRR metrics respectively, which demonstrates the quality of the KG and effectiveness of the system.

„Er leistete überall Entscheidendes“: Otto Hofer (1892–1972) und seine Rolle in der zeitgenössischen MKG-Chirurgie

The Austrian Otto Hofer is often considered the most important academic student of the Viennese maxillofacial surgeon Hans Pichler. In the years up to 1945, he held professorships at the dental university institutes in Vienna and Berlin—and thus at the two leading addresses in the German-speaking world. This career development contrasts peculiarly with Hofer’s professional activities in the postwar period: in 1945 he accepted a position as chief physician at the General Public Hospital of the City of Linz, where he remained until his retirement in 1964. This article sheds light on Hofer’s role and status in contemporary maxillofacial surgery and examines the background to the career setback outlined above. Special attention is paid to Hofer’s relationship to National Socialism and the background of his departure from Berlin in 1945. Archival files, printed contemporary writings, and selected secondary sources serve as a source base. Otto Hofer’s significance for the discipline lies in his versatility: he described new surgical methods, was a successful and widely known textbook author, and also rendered outstanding services to continuing and further education in dentistry. During the Third Reich, he belonged to the group of Pichler students who served the Nazi regime in terms of party politics and thus recommended themselves for a professorship in the Altreich (Old Reich) after the annexation of Austria to Germany (1938). After 1945, this political orientation became his undoing. Hofer was dismissed from his post in Berlin and found a new position in Austria. But unlike his compatriots Hermann Wolf and Karl Häupl, who had also joined the NSDAP and made a career in the Third Reich, Hofer did not find his way back to the university after the war. Instead, he became involved in professional politics in his home country—with notable success.

"…without avisible sign of protest or at least solidarity from colleagues": the expulsion of neuroscientists from Hamburg

In Hamburg, the National Socialists' racially motivated exclusion principally hit neurologists from two institutions: the Eppendorf Neurological Clinic (director until 1934 Max Nonne) and the Psychiatric and Neurological Clinic of Friedrichsberg State Hospital (director Wilhelm Weygandt). The chief physician of the neurological department of Barmbek Hospital, Heinrich Embden (1871-1941), who had been trained by Nonne, emigrated to Brazil, whereas Friedrich Wohlwill (1881-1958), another Nonne pupil who had been a pathologist at St Georg since 1924, lived for many years in Lisbon, before he found anew scientific home at the Harvard Medical School. The cerebrospinal fluid researcher Victor Kafka (1881-1955), aFreemason and intermittent member of the Communist Party, was briefly in so-called protective custody (Schutzhaft) in Fuhlsbüttel then fled via Norway to Sweden. Hermann Josephy (1887-1960) and WalterR. Kirschbaum (1894-1982), both imprisoned in the Sachsenhausen concentration camp after the November pogroms in 1938, could successfully continue their professional careers in Chicago. Richard Loewenberg (1898-1954) first opted to continue his career in China, then changed his mind and also went to the USA after the Japanese invasion. With the exception of the latter all were full members of the Society of German Neurologists. The broad scope of their research work clearly illustrates that in addition to clinical core competence, former neurologists could intensively follow scientific interests in the neighboring disciplines of pathology, serology, and psychiatry.

Use of Danzhi Xiaoyao Powder in the Treatment of Diseases by Chief Physician Wang Defen: Case Examples

Danzhi Xiaoyao powder was first introduced by Xue Ji, a Ming Dynasty physician, in the “Summary of Internal Medicine.” It is primarily used for treating the syndrome of liver depression transforming into heat and is widely used in the treatment of dermatology, internal medicine, gynecology, and other multi-system diseases. This medical prescription is aptly dispensed, its detoxification effect is strong, and it is a representative medical prescription for soothing the liver, strengthening the spleen and stomach, as well as eliminating heat stagnation. Chief Physician Wang Defen inherited the academic experience of the fifth batch of nationally known Chinese medicine experts, under the guidance of Professor Ji Haiwang, a notable Chinese medicine practitioner in Shaanxi Province and Professor Shi Bingyin, a renowned endocrinologist. Through follow-up studies, the various methods and empirical prescriptions of Danzhi Xiaoyao powder applied by Chief Physician Wang Defen in the treatment of common clinical diseases are summarized. They have been proven to have conclusive efficacy, thus providing guidance and reference for the dialectical treatment using traditional Chinese medicine.

Editorial introductions.

Editorial introductions.

THE EVALUATION OF THE STATUS OF EMERGENCY HEALTH CARE WORKERS ABOUT DISASTER AWARENESS-THE BATMAN EXAMPLE

Amaç: Çalışmada, Batman ilindeki acil sağlık çalışanlarının afetler karşısında acil sağlık hizmeti sunarken yaşadıkları zorlukların ortaya çıkarılması ve afet bilinci bilgi düzeylerinin ölçülmesi amaçlandı.Materyal ve Metot: Araştırma tanımlayıcı tipte gerçekleştirildi. Çalışmanın evrenini, Batman 112 İl Ambulans Servisi Başhekimliği’ne bağlı görev yapan 182 çalışan oluşturdu. Çalışmada örneklem kullanımına gidilmedi, evrenin tamamına ulaşılması hedeflendi. Çalışma, gönüllülük esasına göre katılım gösteren toplam 174 çalışan ile yapıldı. Veriler, araştırmacılar tarafından hazırlanan anket formu ile toplandı. Verilerin değerlendirilmesinde, SPSS 25.0 istatistik paket programı kullanıldı. Analizlerde p&amp;lt;0,05 anlamlı olarak kabul edildi.Bulgular: Çalışmaya alınan 174 kişinin %43,7’si erkek, %56,3’ü ise kadın olarak tespit edildi. Katılımcıların sırasıyla en fazla salgın (%37,6) ve deprem (%30,6 afetlerine maruz kaldığı tespit edildi. Katılımcıların afet eğitimleri durumu sorgulandığında %48,3’ü aldığı eğitimin afet anında etkili olacağını düşündüğü görüldü. Aldığı afet eğitiminin etkili olacağını düşünen katılımcılarda afetzedelere müdahale ederken kendilerini yeterli bulma oranı en yüksek olarak tespit edildi.Sonuç: Çalışmanın yapıldığı Batman İli başta olmak üzere tüm diğer illerde bulunan acil sağlık çalışanlarının afet bilinci ve afet bilgi düzeyi tespit edilerek gerekli eğitimlerin verilmesi sağlanmalıdır. Verilen eğitimler tüm acil sağlık çalışanlarının katılımı olacak şekilde, düzenli tatbikatlar yapılarak tasdik edilmeli ve eksik görülen detaylar üzerinde durulmalıdır.

Analysis of related factors between the occurrence of secondary epidermoid cyst of penis and circumcision

Secondary epidermoid cyst of the penis is a very rare epidermoid cyst that occurs in the penis. The purpose of this study was to investigate the relationship between the occurrence of secondary epidermoid cyst of penis and circumcision-related factors, and to provide possible reasonable and effective suggestions for circumcision. The data of all patients who visited the clinic for epidermoid cysts of the penis from September 2000 to September 2021 in Xiangya Hospital were collected. A retrospective study was carried out on whether the patients had been circumcised and the surgical method, anesthesia method, cyst location, surgical age, postoperative wound infection, whether they were phimosis patients, and the level of the surgeon. Among the 24 patients followed up, 95.8% had a history of circumcision, and only 4.2% had no history of circumcision, and the more traumatic surgical methods developed secondary epidermoid cyst of the penis after surgery the higher the probability. Injecting anesthesia at the base of the penis increases the chances of developing a secondary epidermoid cyst of the penis. Postoperative secondary epidermoid cyst of the penis were mainly located in the anterior segment and posterior segment, and the anterior segment had a higher proportion, followed by the posterior segment. Secondary epidermoid cyst of the penis occur mainly in adults. Postoperative wound infection accelerates the appearance of secondary epidermoid cyst of the penis. Patients with phimosis have an increased probability of developing secondary epidermoid cysts of the penis after surgery. The incidence of secondary epidermoid cysts and postoperative infection after manual circumcision by the attending physician was higher than that of the chief physician. Circumcision, injection of anesthesia at the base of the penis, ligation of the penis, and postoperative wound infection may be the etiologies and triggers of secondary epidermoid cysts of the penis. Adults and phimosis patients may be high-risk groups. Lower-level surgeons may increase the odds of postoperative secondary epidermoid cysts of the penis, and it is recommended that surgery be performed by a clinically-experienced, higher-level surgeon. The indications for circumcision should be strictly evaluated and the operation should be performed as soon as possible, and the less invasive surgical method and anesthesia method should be selected. Reduce irrelevant operations during surgery and avoid wound infection after surgery.

Luigi Mongeri: A reformist and expert on "Oriental Insanity" in the Nineteenth-Century Ottoman Empire

This article focuses on the early career of Luigi Mongeri, who was appointed as the chief physician to the Süleymaniye Mental Asylum in 1856 to treat mental illness and improve the living conditions of mentally ill patients in the nineteenth-century Ottoman Empire. It focuses on Mongeri's early career in Italy, investigates his involvement in Ottoman imperial patronage networks and their subsequent effects on his career, and finally explores the reform program he implemented at Süleymaniye. While in the Ottoman Empire, Mongeri appeared as a reformist who claimed to improve the living conditions and treatment of patients by the use medical statistics, abolishing the use of shackles, etc. At the same time in Europe—and especially in France, which was one of the important centers of alienist medicine at the time— he presented himself as an expert on "oriental insanity,” a claim which gained him access to international medical circles and organizations.

Effect of medium with moderate temperature on patient's body temperature during percutaneous endoscopic lumbar discectomy

PurposeTo explore the influence of irrigating fluid at different temperatures on patients' body temperature and local inflammatory mediators during spinal endoscopy.Methods110 cases of intervertebral foramen surgery in our hospital from January 2019 to October 2021 were randomly divided into control group and observation group. Operations of both groups were performed by the same experienced chief physician. The observation group was irrigated with 37 °C constant temperature saline, while the control group was irrigated at room temperature. The effect was evaluated by monitoring the intraoperative temperature, postoperative VAS score and the levels of inflammatory factors, such as TNF-α, IL-1, IL-6 and IL-10 in drainage fluid.ResultsAfter 30 min of operation, overall temperature of the control group dropped significantly, and 50 cases (90.9%) had hypothermia, P < 0.05. There was no significant difference in preoperative VAS score between the two groups P > 0.05. The VAS score of observation group was significantly lower than that of control group at 6 h and 1 month after operation, P < 0.05. At 0, 3 and 6 h after operation, the values of TNF-α, IL-1, IL-6 and IL-10 in the observation group were significantly lower than those in the control group (P < 0.05).ConclusionsIsothermal flushing solution can reduce the incidence of hypothermia and effectively alleviate local inflammatory reaction.

Valentin Feliksovich VOINO-YASENETSKY - Archbishop, professor-surgeon. To the 145th of birthday

Valentin Feliksovich VOINO-YASENETSKY - Archbishop, professor-surgeon. To the 145th of birthday

Resolution of the Working Meeting of Experts in “Dermatology”: Possibilities of systemic therapy of atopic dermatitis with selective immunosuppressants

On February 19, 2022, a working meeting of experts on the problem of atopic dermatitis was held in Moscow under the chairmanship of the Director of the State Scientific Center for Dermatovenereology and Cosmetology of the Ministry of Health of Russia, Doctor of Medical Sciences, Professor, Corresponding Member of the Russian Academy of Sciences A.A. Kubanov. Also in attendance was the Academician of the Russian Academy of Sciences, Chief Freelance Childrens Specialist in Preventive Medicine, Head of the Research Institute of Pediatrics and Childrens Health of the Central Clinical Hospital of the Russian Academy of Sciences of the Ministry of Science, and Higher Education of the Russian Federation, Doctor of Medical Sciences, Professor, Academician of the Russian Academy of Sciences, L.S. Namazova-Baranova, and also the Deputy Director for Clinical Work ― Chief Physician of the Federal State Budgetary Institution SSC Institute of Immunology FMBA of Russia Doctor of Medical Sciences, Professor N.I. Ilyina.&#x0D; The meeting raised germane issues of providing medical care, reducing the burden of the disease, and improving the quality of life of patients with atopic dermatitis. New possibilities and principles of systemic therapy in patients with moderate and severe atopic dermatitis were discussed. We analyzed data on a new representative of the small molecule class the selective Janus kinase 1 inhibitor, upadacitinib, which was registered in the Russian Federation in June 2021. This analysis aimed to determine its place in atopic dermatitis therapy algorithms and the possibility of the impact of its use as a therapy on the quality of life of patients in relation to the burden of diseases.&#x0D; The article has been published in several journals simultaneously with permission from authors and publishers. The parallel publication is available here: Capabilities of atopic dermatitis systemic therapy with selective immunosuppressors: resolution of the experts workshop of dermatology profile. Pediatric pharmacology. 2022;19(2):209211. DOI: https://doi.org/10.15690/pf.v19i2.2424