Chief Complaint Of Cough Research Articles

Roentgenographic findings in Fanconi's anemia.

Atriad of severe refractory hypoplastic anemia with pancytopenia, brown pigmentation of the skin, and multiple congenital anomalies was first described by Fanconi (9) in 1927. He reported three siblings who presented this triad which is now known as Fanconi's syndrome or Fanconi's hypoplastic anemia. The condition is rare, about 90 cases having been reported up to 1960, according to Nilsson and others (1–11, 14–17, 19–21, 23). Its distribution is world-wide; it has been reported throughout Europe and the United States as well as in Japan, Turkey, South Africa, and South America. There is no racial or geographic preponderance. The disease is somewhat more common in males than in females in a ratio of approximately 2 to 1. The purposes of this report are to present the clinical and roentgenographic findings in 14 cases, with case histories of 4 of them, to review briefly the clinical manifestations, particularly as they relate to roentgenographic findings, and to discuss the roentgenographic diagnosis of this syndrome. Case Reports Case I: This 9-year-old white female was admitted to University Hospitals for the first time on Sept. 25, 1965, with a chief complaint of cough and fever, which had developed two weeks prior to admission. On physical examination she was found to be 51.5 inches in height with a weight of 54 pounds. Height was in the fiftieth percentile for an eight-year-old, and weight was in the fiftieth percentile for a seven-year-old. The head circumference was 18.5 inches, which is in the fiftieth percentile for an 18-month-old (microcephaly). The child was extremely pale but exhibited a generalized bronze pigmentation. She had syndactyly of the second and third toes bilaterally and was unable to bend her left thumb at the distal phalanx. Blood taken on admission revealed white blood cells 3,500, 17 seg-menteds, 2 bands, 70 lymphocytes, and 11 monocytes. The platelet count was 9,000. Hemoglobin was 3 g per 100 cc, and hematocrit, 8.0. An admission chest film showed bronchopneumonia on the left. Findings on intravenous urography were within normal limits. Skull roentgenograms demonstrated microcephaly (Fig. 1). Skeletal films showed minimal shortening of the right first metacarpal and left first proximal phalanx as compared to the opposite sides (Fig. 2). Films of the feet showed only soft-tissue syndactyly. Several transfusions of packed cells were given as soon as possible after admission. The patient improved considerably following the transfusions, and the hematocrit went to 31. Bone-marrow aspiration and subsequent biopsy revealed a moderately hypoplastic marrow, involving chiefly the megakaryocytes and white cell series. A diagnosis of Fanconi's anemia was made. The family history was interesting and pertinent. A 12-year-old sibling had died in 1962 with Fanconi's syndrome. This sibling had aplastic anemia, an absent thumb, microcephaly, and an absent kidney.

Pulmonary Nodules, Fever, and Hepatosplenomegaly in a 2-Month-Old Child

Dr. George F. Zinninger: These roentgenograms were taken of a 2-month-old white girl, who was admitted to the hospital with a chief complaint of cough of two days' duration and diarrhea of approximately one week. The three siblings at home were all well and the family history was essentially normal. The child was pale and lethargic. Physical examination of the chest was unremarkable, but hepatosplenomegaly was noted. The child's temperature was 103.6 F (39.8 C) rectally. The white blood cell count (WBC) was 16,600/cu mm, with 58% polymorphonuclear leukocytes; the hematocrit reading was 28%. A trace of protein was present in the urine along with 3 to 5 WBC. The findings from a lumbar puncture were normal and a few pneumococci were recovered from the sputum. Roentgenograms (Fig 1) were taken the day of admission. They were interpreted as showing patchy infiltrates in the upper-lung fields along with hepatosplenomegaly. The

Cholesterol Pleural Effusion

Cholesterol pleural effusion is a rarely reported condition characterized by a high concentration of lipid and, in most cases, cholesterol crystals in the pleural fluid. Although this entity was first described almost 80 years ago, 1 a total of only 85 cases were found in a comprehensive review of the literature 2 in 1951. Fourteen additional cases have been reported since then, but only one of these reports is in the English literature. 3 The pathogenesis of this condition is unknown. We have recently seen 2 cases of cholesterol pleural effusion and have performed various laboratory studies employing radioisotopes in an attempt to clarify the abnormal physiology involved. Report of Cases Case 1.— A 78-year-old white man, a retired construction worker, was admitted to Denver General Hospital on Nov. 13, 1958, with the chief complaints of cough, vague chest pain, dyspnea, and weakness. Until the onset of these symptoms 6

Loeffler's syndrome following penicillin therapy.

Case Reports1 January 1953LOEFFLER'S SYNDROME FOLLOWING PENICILLIN THERAPYSEYMOUR REICHLIN, M.D., MARY H. LOVELESS, M.D., ERNEST G. KANE, M.D.SEYMOUR REICHLIN, M.D.Search for more papers by this author, MARY H. LOVELESS, M.D.Search for more papers by this author, ERNEST G. KANE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-38-1-113 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis case of Loeffler's syndrome is reported because it demonstrates the production of marked pulmonary infiltration and eosinophilia following sensitizing doses of a penicillin preparation. Although an allergic basis has been postulated for Loeffler's syndrome, there are few cases in the literature which demonstrate clearly a temporal relation to a specific allergen.CASE REPORTA 26 year old white college student first entered New York Hospital on November 18, 1950, with a chief complaint of cough and fever of six hours' duration. He had been in good health prior to this illness. Two years previously he had had a mild...Bibliography1. DamminBukantz GJSC: Modification of biologic response in experimental hypersensitivity, J. A. M. A. 139: 358, 1949. CrossrefMedlineGoogle Scholar2. FalkNewcomer MSVD: Loeffler's syndrome, J. A. M. A. 141: 21, 1949. CrossrefMedlineGoogle Scholar3. HamZimdahl JCWT: Loeffler's syndrome and pulmonary infiltrations accompanied by peripheral eosinophilia, Ann. Int. Med. 29: 488, 1948. LinkGoogle Scholar4. PeckSiegalGlickKurtin SMSAWA: Clinical problems in penicillin sensitivity, J. A. M. A. 138: 631, 1948. CrossrefMedlineGoogle Scholar5. Harkavy J: Personal communication. Google Scholar6. AndersonKeefer DGCS: Penicillin, 1948, J. W. Edwards, Ann Arbor, Michigan. Google Scholar7. Brown EA: Reactions to penicillin, review of the literature, Ann. Allergy 6: 723, 1948. MedlineGoogle Scholar8. Burleson RJ: Anaphylactoid shock due to penicillin, J. A. M. A. 142: 562, 1950. CrossrefMedlineGoogle Scholar9. FelderFelder SLL: Unusual reaction to penicillin, J. A. M. A. 143: 361, 1950. CrossrefMedlineGoogle Scholar10. von Meyenburg H: Die pathologische Anatomie des "Flüchtigen Lungeninfiltrates mit Blut-Eosinophilie," Virchow's Arch. 309: 258, 1942. CrossrefGoogle Scholar11. Bergstrand H: Morphological equivalents in polyarthritis rheumatica, periarteritis nodosa, transient eosinophilic infiltration of the lung, and other allergic syndromes, J. Path. and Bact. 58: 399, 1946. CrossrefMedlineGoogle Scholar12. Harkavy J: Vascular allergy, J. Allergy 14: 507, 1943. CrossrefGoogle Scholar13. BayleyLindbergBaggenstoss ECDOAH: Loeffler's syndrome, Arch. Path. 40: 376, 1945. Google Scholar14. Viswanathan R: Postmortem appearances in tropical eosinophilia, J. Trop. Med. 50: 93, 1947. Google Scholar15. Rich AR: The role of hypersensitivity in periarteritis nodosa, Bull. Johns Hopkins Hosp. 71: 123, 1942. Google Scholar16. ClarkKaplan EBJ: Endocardial, arterial and other mesenchymal alterations associated with serum diseases in man, Arch. Path. 24: 458, 1937. Google Scholar17. Lehmann CF: Loeffler's syndrome with erythema multiforme, South. M. J. 41: 37, 1948. CrossrefMedlineGoogle Scholar18. Engel D: as quoted by Elsom, K. A., and Ingelfinger, F. J.: Eosinophilia and pneumonitis in chronic brucellosis: a report of two cases, Ann. Int. Med. 16: 995, 1942. LinkGoogle Scholar19. Löffler W: Die Flüchtige Lungenfiltrate mit Eosinophilie, Schweiz. med. Wchnschr. 66: 1069, 1936. Google Scholar20. ElsomIngelfinger KAFJ: Eosinophilia and pneumonitis in chronic brucellosis: a report of two cases, Ann. Int. Med. 16: 995, 1942. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication May 11, 1951.From The New York Hospital and the Department of Medicine, Cornell University Medical College, New York, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPenicillinsACTION THROUGH CHANNELS OTHER THAN AIRBORNEPENICILLINANTIBACTERIAL DRUGSPenicillinsDrug-induced eosinophilic lung diseaseDrug-induced Pulmonary DisordersEOSINOPHILIC PNEUMONIASDrug-Induced Hypersensitivity Reactions in the LungEosinophile LungenkrankheitenIatrogenic Thoracic Complications Induced by DrugsPenicillins and CephalosporinsDrug-Induced Interstitial Lung DiseasesAdult Respiratory Distress Syndrome Related to Ampicillin SensitivityPulmonary Infiltrates with Eosinophilia Associated with TetracyclineTransient Eosinophilic Pneumonia Secondary to Use of a Vaginal CreamAcute pulmonary reaction to nitrofurantoinDrug-Induced Lung DiseaseThe Spectrum of Drug-Induced Pulmonary DiseaseE. C. ROSENOW III, M.D., F.A.C.P.PENICILLIN ALLERGY: A REVIEW OF THE IMMUNOLOGICAL AND CLINICAL ASPECTSDrug-induced lung diseaseAllgemeine allergische Reaktionen (eosinophiles Infiltrat)Radiological manifestations of drug-induced diseaseAllergic Pulmonary Complications During Treatment with NitrofurantoinAscaris pneumoniaRespiratory SystemFuradantin AnaphylaxisPulmonary infiltrates, pericarditis and eosinophiliaRecurrent Pulmonary Infiltration and Pleural Effusion Due to Nitrofurantoin SensitivityKrankheiten der GefäßePulmonary Diseases of Allergic OriginLÖFFLER'S SYNDROME: REPORT OF A CASE ASSOCIATED WITH ADMINISTRATION OF MEPHENESIN CARBAMATE (TOLSERAM)*THEODORE RODMAN, M.D., WILLIAM FRAIMOW, M.D., RALPH M. MYERSON, M.D., F.A.C.P.Die eosinophilen LungeninfiltrateFurther Progress in VenereologyDisseminate lung lesionsLÖFFLER'S SYNDROME FOLLOWING USE OF A VAGINAL CREAM*JUNE F. KLINGHOFFER, M.D. 1 January 1953Volume 38, Issue 1Page: 113-120KeywordsAllergensEosinophiliaFeversHospital medicinePenicillin ePublished: 1 December 2008 Issue Published: 1 January 1953 PDF downloadLoading ...

Favorable response of sarcoidosis to cortisone treatment.

Cortisone therapy of pulmonary sarcoidosis has as yet not been reported in the literature.¹Thorn and his co-workers^1areported one case of sarcoidosis, with pulmonary, uveal, and osseous manifestations, treated with 40 mg. of corticotrophin (ACTH) daily for eight days, without significant clinical or roentgen improvement. The patients reported on below were treated with 100 mg. of cortisone daily for four to six weeks and showed such marked improvement in clinical status, roentgen appearance, and pulmonary function that I consider them worth describing. <h3>REPORT OF CASES</h3><h3>Case 1.—History.</h3> —W. K. A., a 28-year-old Negro male veteran, was admitted to Halloran Veterans Administration Hospital on Aug. 14, 1950, with the chief complaints of cough, productive of moderate amounts of clear, mucoid sputum, and substernal pain. He was well until eight months prior to admission, at which time "a cold" developed. In addition to the cough, he experienced at