Chi-square Goodness Of Fit Test Research Articles

(Un)Sustainability of the Time Devoted to Selected Housework—Evidence from Slovakia

Domestic appliances play a vital role in modern households. Appliances help simplify domestic work, but individuals become dependent on them. The present paper aims to contribute to the long-standing dilemma among scholars whether domestic appliances help to shorten the time devoted to household chores or not. The paper focuses on the utilization of various domestic appliances in Slovak households and on the influence of their utilization on the time of men and women in partner households and in the single-person households devoted to routine unpaid work activities. The results of the paper are based on the data from original field research conducted in Slovakia in 2015. A total of 1179 partner households, 182 single-man households and 226 single-woman households were included in the analysis. The jamovi version 1.2 statistical program was used to verify the hypothesis by chi-squared goodness of fit test and nonparametric Mann–Whitney U-test. In partner households and in single-man households, usage of automatic washing machines significantly influences time devoted to preparation and maintenance of the clothes. In single-woman households, usage of dishwasher significantly influences time devoted to food preparation. In partner households, men devote less time to routine unpaid work activities than women, regardless of usage or non-usage of domestic appliances.

The use of 3D printing for osteopathic medical education of rib disorders.

With the advent of increasingly accessible three-dimensional (3D) printing, the possibility to efficiently design and generate prototype innovations is also increasing. This type of manufacturing can potentially enhance medical education by allowing design of models specific to osteopathic manipulative medicine (OMM). To determine the viability of a 3D-printed mechanically moveable rib cage in enhancing the teaching of rib osteopathic principles. A single-blind, qualitative study was conducted to evaluate the use of educating students with this novel 3D-printed, movable rib model vs. a traditional static rib model. A total of 237 first-year medical students participated in the study and received the same standardized lecture on the rib dysfunction. Students were also assigned at random to either a comparison group, which would utilize the 3D printed rib model, or the control group, which would utilize the traditional static model. Students would also complete an entrance and exit surveys assessing subjective scores of overall student satisfaction and objective scores for knowledge of OMM rib dysfunction and treatment. An independent samples t-test was applied to assess potential differences between select student evaluation scores (those with continuous variables) of the rib model in the comparison and experiment groups. Chi-square goodness of fit test was conducted to determine if there were any significant differences in entry and exit survey responses between the two groups. Descriptive statistics of the mean and standard deviation were also reported. For both comparison and control groups, the mean score on an 11-point scale for the evaluation question, "Please rank on a scale of 0-10 how helpful you thought the rib models were to your education," was 9.08 (SD, 1.397). Independent t-test results showed that the comparison group had higher scores than the control group when queried about whether they felt the model accurately depicted the material presented (comparison group mean, 9.55 [SD, 978] vs. control group mean, 9.06[SD, 1.33; t(235)=3.253; p=0.01). Chi-square test of goodness-of-fit showed that the differences between the number of correct answers chosen by participants for Item 3 (a case-based question asking students which rib they would treat for a patient presenting to an OMT clinic) was statistically significantly higher for the comparison group (51.9% correct in comparison group vs. 48.1% in control group), even though both groups scored similarly on this item during the entry survey. The results of this study suggest that utilizing 3D printing to demonstrate somatic dysfunctions of the rib cage may improve understanding and student satisfaction for diagnosis and treatment.

Incidence of insomnia and obstructive sleep apnea in active duty United States military service members.

Epidemiologic studies of obstructive sleep apnea (OSA) and insomnia in the U.S. military are limited. The primary aim of this study was to report and compare OSA and insomnia diagnoses in active duty the United States military service members. Data and service branch densities used to derive the expected rates of diagnoses on insomnia and OSA were drawn from the Defense Medical Epidemiology Database. Single sample chi-square goodness of fit tests and independent samples t-tests were conducted to address the aims of the study. Between 2005 and 2019, incidence rates of OSA and insomnia increased from 11 to 333 and 6 to 272 (per 10,000), respectively. Service members in the Air Force, Navy, and Marines were diagnosed with insomnia and OSA below expected rates, while those in the Army had higher than expected rates (p < .001). Female service members were underdiagnosed in both disorders (p < .001). Comparison of diagnoses following the transition from ICD 9 to 10 codes revealed significant differences in the amounts of OSA diagnoses only (p < .05). Since 2005, incidence rates of OSA and insomnia have markedly increased across all branches of the U.S. military. Despite similar requirements for overall physical and mental health and resilience, service members in the Army had higher rates of insomnia and OSA. This unexpected finding may relate to inherent differences in the branches of the military or the role of the Army in combat operations. Future studies utilizing military-specific data and directed interventions are required to reverse this negative trend.

Oestrogen Receptor Alpha, Beta Genes and CYP17A Gene Polymorphism Analysis in Women with Uterine Leiomyoma

Introduction: Uterine Leiomyoma is a highly morbid condition with an increasing incidence in the Asian Indian ethnicity. The pathogenesis is multifactorial and not clearly delineated, making non-surgical treatment of limited success, thus making surgical intervention prevalent. Derangement of endocrinological parameters is the most evident aspect and cause of this condition. But the root genetic cause of this hormonal imbalance has seldom been explored in Indian women suffering from uterine leiomyoma. Aim: To explore the association of Single Nucleotide Polymorphism (SNPs) rs3020449, rs4986938 and rs743572 of ER alpha, ER beta and CYP17 genes respectively in women having uterine fibroid visiting a Tertiary Care Hospital in North India. Materials and Methods: Hundred patients diagnosed with uterine leiomyoma were selected from Gynaecology Out Patient Department (OPD) of a Tertiary Care Hospital in North India and equal age matched healthy women were taken as controls randomly, with a condition that they have no close blood relative with uterine leiomyoma. The blood was collected for DNA extraction and RFLP based polymorphism detection. Bands were visualised in agarose gel for Estrogen Receptor alpha (ER alpha), ER beta and CYP17 genes. Statistical analysis was performed using Graph Pad Prism 6.0. Hardy Weinberg equilibrium was tested using Chi-square goodness of fit test. Nominal variables were analysed using Fisher-exact test. Data is presented as Mean±SEM and p-value of &lt;0.05 was considered significant. Results: Early age at menarche (cases vs control 11.51±0.19 year vs 12.04±0.12, p=0.03) and less number of previous pregnancies (cases vs control 1.06±0.09 vs 1.41±0.12, p=0.01), which are known risk factors for the uterine fibroids, was reconfirmed in this study. The genotype distribution of all subjects studied in above genes followed Hardy Weinberg equilibrium and there was no significant difference in genotype frequencies between cases and controls [ER alpha rs9322331 C allele (cases vs controls; 62% vs 64%), T allele (38% vs 36%); ER beta rs4986938 G allele (64% vs 59%), A allele (36% vs 41%); CYP17 rs743572 T allele (44.95% vs 46.53%), C allele (55.05% vs 53.47%) p-value not significant in any]. However, there was an increased propensity of TC genotype of CYP17 rs743572 towards obesity (p&lt;0.05). Conclusion: The allelic frequencies of all the three SNPs were similar in cases and controls indicating that they do not affect susceptibility to disease. However, the association of TC allele of CYP17 SNP with higher BMI needs further analysis.

Modeling and Validation of the Hospital’s Ambulatory and Inpatients Operations Using a Non-Homogenous Discrete Time Markovian Chains

Overcrowded hospitals in its different process's levels is a very common issue all over the globe. Research through different works have studied this problem from different angles. Most of those focused on a very specific part of the internal flows. This study presents a mathematical model aiming to reflect patient flow and resources usage. This model presents a new perspective on how it is possible to organize a hospital flow for inpatients of different pathologies. It is based on Non-Homogenous Discrete Time Markovian chains. It takes into consideration the patient's pathology, survival function and the current beds distribution and discharges. To model the different variations of a patient's flow, our work uses an actual case study to validate that our mathematical model based on Markov Chains can represent a real scenario of patients flow in a hospital and can predict the resources occupancy. We used as entry to this model the arrival distribution of patients as represented in the NHS dataset. Served patients and overflowing patients relate proportionally to admission rate based on how much time every diagnosis and preliminary treatment will take, then using the previous beds availability ration will permit, with knowledge of all present patients in the system, calculate the beds occupancy in the actual time. Only based on inputs from the NHS database, bed occupancy can be calculated using our model. Then compare this calculus with published data of the bed's occupancy in the NHS. in the period between March 2020 and February 2021. The results of the simulation model were then compared to the dataset using the chi-square goodness of fit test. Non-homogenous discrete Markovian model, survival function, patient's pathology, time-dependent, pathology, primary allocations, secondary allocations.

Actual Frailty Conditions and Lifestyle Changes in Community-Dwelling Older Adults Affected by Coronavirus Disease 2019 Countermeasures in Japan: A Cross-Sectional Study.

IntroductionBecause of the countermeasures to prevent the spread of coronavirus disease 2019 (COVID-19) in Japan, it is easy to predict that the suspension of local activities and changes in lifestyle that lead to decreased activity will result in increased frailty and prefrailty rates in older adults.ObjectiveTo clarify the actual frailty conditions and lifestyle changes among community-dwelling older adults affected by COVID-19 countermeasures in Japan.MethodsThis cross-sectional study was conducted between May 8 and June 12, 2020. Self-reported questionnaires were distributed to 1,078 older adults aged ≥65 years. We used the frailty screening index to assess frailty status and developed the Questionnaire for Change of Life (QCL) to assess lifestyle changes, the amount of daily movement, leg muscle strength, meal size, worry or anxiety, and opportunities to talk to people. The differences in prevalence rates of frailty, prefrailty, and robustness between this study and the reference based on the Japanese meta-analysis were verified using the chi-square goodness of fit test. We compared each of the QCL results among the frailty, prefrailty, and robust groups using Fisher’s exact test.ResultsOf 680 older adults (63.1%) analyzed, 60 (8.8%) had frailty and 354 (52.1%) had prefrailty. There was a significant difference between the observed and expected prevalence based on the reference (p = 0.018). The frailty status was significantly associated with lifestyle changes. In participants with frailty, the amount of daily movement, leg muscle strength, and meal size significantly decreased (p < 0.001), whereas worry or anxiety significantly increased (p = 0.040). In contrast, regardless of the frailty status, opportunities to talk to people decreased.ConclusionThe prevalence of frailty and prefrailty might have increased due to the effects of COVID-19 countermeasures. Moreover, the lifestyle of community-dwelling older adults affected by COVID-19 countermeasures has changed. Lifestyle changes were more pronounced among older adults with frailty.

Impact of colorectal cancer screening participation in remote northern Canada: A retrospective cohort study.

BACKGROUNDScreening provides earlier colorectal cancer (CRC) detection and improves outcomes. It remains poorly understood if these benefits are realized with screening guidelines in remote northern populations of Canada where CRC rates are nearly twice the national average and access to colonoscopy is limited.AIMTo evaluate the participation and impact of CRC screening guidelines in a remote northern population.METHODSThis retrospective cohort study included residents of the Northwest Territories, a northern region of Canada, age 50-74 who underwent CRC screening by a fecal immunohistochemical test (FIT) between January 1, 2014 to March 30, 2019. To assess impact, individuals with a screen-detected CRC were compared to clinically-detected CRC cases for stage and location of CRC between 2014-2016. To assess participation, we conducted subgroup analyses of FIT positive individuals exploring the relationships between signs and symptoms of CRC at the time of screening, wait-times for colonoscopy, and screening outcomes. Two sample Welch t-test was used for normally distributed continuous variables, Mann-Whitney-Wilcoxon Tests for data without normal distribution, and Chi-square goodness of fit test for categorical variables. A P value of < 0.05 was considered to be statistically significant.RESULTS6817 fecal tests were completed, meaning an annual average screening rate of 25.04%, 843 (12.37%) were positive, 629 individuals underwent a follow-up colonoscopy, of which, 24.48% had advanced neoplasia (AN), 5.41% had CRC. There were no significant differences in stage, pathology, or location between screen-detected cancers and clinically-detected cancers. In assessing participation and screening outcomes, we observed 49.51% of individuals referred for colonoscopy after FIT were ineligible for CRC screening, most often due to signs and symptoms of CRC. Individuals were more likely to have AN if they had signs and symptoms of cancer at the time of screening, waited over 180 d for colonoscopy, or were indigenous [respectively, estimated RR 1.18 95%CI of RR (0.89-1.59)]; RR 1.523 (CI: 1.035, 2.240); RR 1.722 (CI: 1.165, 2.547)].CONCLUSIONScreening did not facilitate early cancer detection but facilitated higher than anticipated AN detection. Signs and symptoms of CRC at screening, and long colonoscopy wait-times appear contributory.

Anxiety and perceptions on the impact of COVID-19 pandemic among orthodontic patients visiting a tertiary care center: A Cross-sectional study

As the COVID-19 pandemic is steadily rising, there is an increase in psychological distress among the orthodontic patients regarding their ongoing treatment. Thus aim of the study was to assess the anxiety and perceptions among orthodontic patients regarding the impact of COVID-19 pandemic on orthodontic treatment. A closed end online questionnaire was sent as Google forms to 300 adult patients’ currently undergoing orthodontic treatment at a tertiary care center. 266 patients answered the survey with a response rate of 88.7%. Online consent was taken before participation in the study and the survey was anonymized and did not contain any identifying information. The descriptive data included the participants' responses using frequency and proportions. The difference in the distribution of responses were compared using Chi-square goodness of fit test and the level of significance was fixed at p &lt; 0.05. Level of anxiety between males and females was compared using independent t-test. Among the respondents, 126 were males and 140 were females. The mean level of anxiety level among males was 4.28 ± 2.28 whereas for females it was 5.85 ± 2.48. The differences in the distribution of responses by the participants were statistically significant. The COVID-19 pandemic showed to have a greater impact on orthodontic appointments and anxiety levels of patients. Females showed greater anxiety than males for visiting the dental clinics. The greatest concern that patients reported was the increase in their treatment duration and they also recognized the importance of monthly orthodontic reviews.

On the possibility of Benfordʼs Law application in accounting fraud detection

Purpose: The purpose of the article is to indicate that, theoretically and practically, Benford’s Law can be applied in order to detect accounting frauds. Methodology/approach: The paper provides an overview of current regulations and experts’ opinions published in the existing literature and internet sources. Moreover, data analysis was used as a research method. Findings: The results of assessing the conformity of the first two significant digits of distribution of foreign revenues from the sales of finished products to Benford’s Law (using the chi-square goodness of fit test) showed that in the case of a proper accounting process, one cannot reject the hypothesis that the data conform to Benford’s Law. On the other hand, the analysis of intentionally falsified foreign revenues led to the conclusion that in the case of an improper accounting process, data, in general, does not conform to Benford’s Law. Research limitations/implications: In the study, it was assumed that the human mind generates false val-ues of accounting entries, and the number of attempts to commit fraud was limited to 10. Originality/value: The article extends the existing knowledge of using Benfordʼs Law in detecting ac-counting fraud in the Polish literature.

Perspectives of Dermatology Faculty Toward Millennial Trainees and Colleagues: A National Survey

ObjectiveTo assess the attitudes and beliefs of faculty dermatologists regarding perceived characteristics of millennial trainees and colleagues. Participants and MethodsWe conducted a cross-sectional survey of dermatology physician-educators listed in the Fellowship and Residency Electronic Interactive Database from August 1, 2019, to October 31, 2019. This survey consisted of 26 items (5-point Likert scales) representing positive, negative, and neutral millennial stereotypes relevant to graduate medical education. Participants’ responses were analyzed using the chi-squared goodness of fit test with dichotomized data. ResultsSeventy-six dermatology physician-educators participated in the national survey. A statistically significant response pattern was seen in 18 of 26 (69%) tested stereotypes. Positive judgments included denial of hesitations about working with millennials (P = .038) and agreement with the notions that millennials are technologically savvy (P < .001), socially just (P < .001), equally capable dermatologists as other generations (P < .001), enjoyable to work with (P < .001), easy to connect with interpersonally (P < .001), and promising future leaders of medicine (P = .039). Negative judgments included perceptions of the word millennial as a pejorative (P < .001) and of millennials being relatively entitled (P < .001), overly sensitive to feedback (P < .001), less polite (P < .001), and less hard-working (P < .001) compared with prior generations. ConclusionThis study represents the first national survey of the attitudes and perspectives of dermatology physician-educators regarding perceived characteristics of millennial trainees and colleagues. Our results suggest that dermatology faculty endorse various positive, negative, and neutral stereotypes regarding Generation Y. Early recognition of implicit biases can inform curricular design and prepare educators to address generational gaps in medical education.

The Distribution of Service Time of Patients

The aim of this research was to study the distribution of service time of patients at the University of Ilorin Health Services Clinic. The distributions of patients’ arrival and their service time were studied. The system was treated as single, time-independent arrivals with multiple service points. Based on the histograms obtained on the arrival process and the service process, appropriate distributions were fitted and tested using Chi-squared goodness of fit test. It revealed that the arrival process follows a Poisson distribution with an arrival rate of 0.8 patient per 2 minutes while the service process follows a gamma distribution with shape and scale parameters equal to 6 and 0.1 respectively. The mean service time was also found to be around 63 minutes. The results of this study may be useful to understand the magnitude of the problem of queue, relationship between resources and waiting times and to find a solution for alleviating the problem.

Patient-Reported Outcomes of Three Different Types of Breast Reconstruction with Correlation to the Clinical Data 5 Years Postoperatively.

The aim of this study was to compare long-term clinical and patient-reported outcomes in terms of satisfaction and health-related quality of life (HRQoL) following postmastectomy breast reconstruction using BREAST-Q in patients undergoing implant-based reconstruction, abdominal-based autologous reconstruction, and combined reconstruction (with implant and LD flap or implant and TDAP flap). A cross-sectional study was conducted. Patients had undergone delayed postmastectomy breast reconstruction and completed the BREAST-Q reconstruction module. The results were related to the clinical data obtained from the clinic's patient record system. A 5-year examination was included. Mean scores and standard deviations were calculated. Kruskal-Wallis test, Chi-square goodness of fit test and Chi-square test were used for the statistical analysis. Overall, 110 patients (n = 24 implant, n = 38 autologous, n = 48 combination) were included. Patients with autologous reconstruction reported greater postoperative satisfaction with breasts (p < 0.001), satisfaction with outcome (p < 0.001), psychosocial well-being (p = 0.001), and sexual well-being (p = 0.051). This study represents a comprehensive long-term examination of postmastectomy breast reconstruction. Autologous reconstruction patients had higher postoperative satisfaction and HRQoL than patients receiving other types of reconstruction despite having more intense oncological therapy and the highest mean number of follow-up surgical procedures. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Sustainable/ Green Product Packaging From the Shoppers Perspective: A Case of Saudi Arabia

Background/Objectives: Global warming, contamination and climate change are some of the problems that have become an increasingly concerning issue internationally. Buyers' concerns about environmental protection have led to the diversification in consumer buying approach towards a green lifestyle. Therefore, firms are taking action to develop potential ecological strategies in the green market industry. This paper aims to explore and determine the insight of Saudi shoppers regarding sustainable (Green) product packaging to maintain a sustainable and green environment.Material and methods: A sample survey of 232 consumers of Saudi Arabia. Descriptive statistical tools were used, for hypothesis testing, Chi-square test/ Chi-Square Goodness of fit test was applied at Alpha 0.05 with 95% of confidence level.Findings: The result conveys that the knowledge and information towards green product packaging are not favorable, the product labels as a source of information for sustainable packaging considered the primary source for the green product.Conclusion: The marketers, and stakeholders having environmental concern, need to have a great call to the campaign of sustainable/ green product packaging. Besides, it is recommended that the marketer of an eco-friendly product need to consider product labels as a good source of information for sustainable packaging at a priority level.Significance of the study: This research will contribute to the related stakeholders to realize the insight of sustainable (green) products packaging. Besides, it will give a better understanding of consumers' behavior regarding sustainable/ green packaging that will lead to achieving their goals in a suitable approach.

Some Statistics in Polar Coordinate System with Uniform Angles

In this study, some bivariate distribution functions are defined in the polar coordinate system and random numbers are generated from these distribution functions. In these definitions, the angular change of the probability density function is taken as constant, and the distance change is performed based on the univariate probability density function. Also, the chi-square goodness-of-fit test is proposed for random numbers generated in the polar coordinates. Four different distribution functions are selected to evaluate the success of the proposed chi-square goodness of fit test for polar distribution functions. Lastly, the validity and the success of the proposed method is shown in the simulation study and the real-life example.

QTL Mapping and Inheritance of Clubroot Resistance Genes Derived From Brassica rapa subsp. rapifera (ECD 02) Reveals Resistance Loci and Distorted Segregation Ratios in Two F2 Populations of Different Crosses

In this study, Brassica rapa subsp. rapifera (ECD 02) which exhibits broad-spectrum resistance to many Canadian Plasmodiophora brassicae isolates was crossed with two clubroot-susceptible B. rapa accessions to produce two F2 populations. The F2 plants were screened against P. brassicae pathotypes 3H, 5X, and 5G. The Chi-square goodness of fit test showed that the vast majority (≈75%) of the crosses that produced the F2 populations showed segregation ratios of 9R:7S, 7R:9S, 13R:3S, 3R:13S, 5R:11S, 11R:5S, and 1R:15S. These were modifications of the 15R:1S ratio expected for the inheritance of two dominant major clubroot resistance (CR) genes from ECD 02. The distorted segregation ratios suggest that the two resistance genes are on different chromosomes and that two genes interact in an epistatic manner to confer resistance. Genotyping was conducted with 144 PCR-based markers in the two F2 populations. Linkage and QTL analysis with the polymorphic markers identified two QTLs on chromosome A03 to be associated with resistance to P. brassicae pathotypes 5X and 5G in Popl#1 while only the second QTL on chromosome A03 was associated with resistance to pathotypes 5X and 5G in Popl#2. The QTLs clustered in genomic regions on the A03 chromosome of B. rapa where the CRa/CRbKato gene(s) are mapped. In addition, the Crr1 gene on the A08 chromosome of B. rapa was detected in the two F2 populations. Therefore, the phenotypic and molecular data confirm the existence of two CR genes in ECD 02. This is the first study that shows that major dominant genes in Brassica interact in a non-additive manner to confer resistance to different P. brassicae pathotypes.Key Message: This study provides knowledge on the inheritance and type of gene action for clubroot resistance derived from Brassica rapa subsp. rapifera (ECD 02). The results indicated that duplicate recessive and recessive suppression epistatic interactions, digenic additivity and complementary gene action between the CRa/CRbKato gene(s) on the A03 and the Crr1 gene on the A08 chromosome of B. rapa controlled clubroot resistance to P. brassicae pathotypes 3H, 5X and 5G.

Testing Procedure for Item Response Probabilities of 2Class Latent Model

This paper presents Hotelling T2 as a procedure for the testing of significance difference between the item response probabilities (ωij′s) of classes in a Latent Class Model (LCM). Parametric bootstrap technique is used in order to generate samples for ωij′s. These samples are based on the estimated parameters of 2-class latent model. The estimation of parameters in either situation is done using the Expectation Maximization (EM) algorithm through Maximum likelihood method. The hypothesis under consideration is whether the response probabilities (ωij′s) are equal against each item in both the classes. { H0 : ωi1 = ωi2. against H1 : =ωi1 ≠ ωi2}. If the test exhibits significant difference between response probabilities in both classes, it will be a clear indication of a presence of latent variable. We consider both training and testing data sets to develop the test. In order to apply Hotelling T2 test the basic assumptions of normality and homogeneity of variance are also checked. Chi-square goodness of fit test is used for assessing normal distribution to be good fitted on the hypothesized (bootstrap samples) based on 2-class latent model parameters for each data and Bartlett test to check heterogeneity of variances in ωij′s. Moreover, our procedure produces a minimum standard error of estimates as compared to those obtained through the package in R.Gui environment

Dietary ecology of Markhor(Capra falconeri cashmiriensis) in winter range of Kazinag National Park, Kashmir, J&amp;K, India

Background/Objective: Understanding winter diet composition of wild ungulates in temperate habitats is of paramount importance for devising conservation measures. The winter diet composition of Markhor (Capra falconeri), one of the least studied ungulate species, was assessed in Kazinag National Park (KNP) of Jammu and Kashmir, India. Methods: Reference slides of 15 available plant species, through micro-histological technique were prepared. Tests like Diet Selection Values (DSV), Ivlev\'s Electivity Index (IEI) and Chi-square tests were applied to study the selection and preference of dietary items. Findings: 80 fecal samples of markhor were analyzed in winter seasons of 2017 & 2018, and compared with reference slides to evaluate the winter diet. Fifteen (15) plant species belonging to 7 families were identified in the diet. Use of Ivlev\'s Electivity Index (IEI), revealed that, shrubs were strongly preferred during this season, besides one graminoid species (Poa pratensis). Among the most preferred species are, Poa pratensis (DSV=6.17) followed by Prunus tomentosa (DSV=2.42), Indigofera heterantha (DSV=2.23), Lonicera spp. (DSV=1.66) and Euonymus hamiltonianus (DSV=1.63). Chi-square goodness of fit test showed that markhor did not feed on all plant species uniformly (p< 0.05). Novelty: Our findings infer that, markhor shows feeding flexibility to adapt to change in forage availability. We recommend that plant species which are the major components of diet of markhor during resource- lean winter be conserved and propagated on priority. Keywords: Diet composition; fecal analysis; Kazinag National Park; markhor; winter

A retrospective analysis of CDK4/6 inhibitors among adult female patients with metastatic breast cancer.

e13028 Background: The aim of this study is to examine the behavior pattern of cyclin-dependent kinase (CDK4/6) inhibitor combinations in adult females with de novo metastatic breast cancer as first therapy or following adjuvant hormonal therapy. Methods: Using United States open health claims and prescription data we analyzed metastatic breast cancer from 2015 Q1 to 2019 Q4, adult female patients (age ≥18). Patients were classified into 3 groups based on their first therapy: Group 1-Hormonal, Group 2-CDK4/6 Inhibitor Combinations, and Group 3-Everolimus Combination. Analysis was completed using the Chi-Squared goodness of fit test assessing the patients moving to next therapy by time period. We also compared the overall CDK4/6 group as a base for probability distribution to study the pattern of therapy change in individual groups. Results: Of 37,351 patients on CDK4/6 inhibitors as first therapy or following adjuvant hormonal therapy for advanced/metastatic diseases, the percentage of patients who moved to next therapy was 3.2% (1,200 patients). For most patients, change in therapy occurred within a 2-year period (87%) and those who remained on their first therapy continued for an extended duration. In both Groups 1 and 2 no statistically significant difference was found in the treatment pattern compared to the overall CDK4/6 inhibitor patient population. However, most patients in Group 3 (90%) compared to the overall patient population on CDK4/6 inhibitors moved to Chemotherapy within the first year of treatment (statistically significant at p-value = 0.02). Further analysis of granularity in individual patient pathways showed about 90% of patients with CDK4/6 inhibitors remained on therapy for about 1 year and, interestingly, about 2% extended beyond 2 years up to 4.5 years. Conclusions: The results show most patients on CDK4/6 inhibitors (95%) had progression free survival (PFS) for the period we analyzed. Overall, patients on CDK4/6 inhibitors behaved similarly when used as first therapy or following adjuvant hormonal therapy.

Dataset on the production of predominantly male tilapia progeny using two malawian tilapias, Oreochromis karongae and Oreochromis shiranus.

A dataset is presented of an experiment that was conducted to compare the proportions of males obtained from hormonal sex reversed pure strain of Oreochromis shiranus and from interspecific hybridization of O.karongae male x O. shiranus female. Part of the data in the dataset were published in a journal article https://doi.org/10.1016/j.aqrep.2020.100274. The data were generated from four SETs of treatments of an experiment that was conducted at the National Aquaculture Center, in Malawi. The first SET of treatment comprised hybrids from interspecific crossing of O.karongae male and O. shiranus female in a pond based breeding hapa 1. SETs 2 and 4 were for fry from hapa spawned pure cross of O.shiranus males and females in a pond based breeding hapa 2. SET 3 comprised fry from pure cross of O. shiranus males and females under controlled temperature (27°C) in an indoor re-circulatory hatchery (Tables 1 to 4). During the first part of the experiment, the fry was raised for 28 days in tanks at three replicates and was fed a fry formulated feed containing 38% crude protein, three times a day. However, for SETs 2 and 3, the feed contained 17α-methyl testosterone at 60mg/kg of feed. The second part of the experiment involved growth performance testing of fry in each SET. The growth experiment was conducted in rearing hapas that were inserted in a common pond for a period of 70 days. The body weight data were collected every 14 days (Tables 1 to 4). On the 70th day, the proportions of males and females in the four SETs was determined using Aceto-carmine staining method (Table 5). The pictures of the stained male and female gonads under compound microscope are presented in the published journal article at https://doi.org/10.1016/j.aqrep.2020.100274. Dataset presented in this paper is for body weights of fish from day 0 to day 70 and proportion of males and females in each SET on the 70th day of the experiment (Tables 1, 2, 3, 4 and 5). The data were analyzed using SPSS version 20.0. Chi-square goodness of fit test was used to investigate if the observed sex ratios significantly deviated from the expected sex ratios at 5% level of significance. The differences among fish body weights were determined using Analysis of Variance and significantly different means were separated using Duncan's multiple range test at the 5% test level of significance. These data are useful for various stakeholders that are interested in sexing juvenile tilapia and for scientists that conduct tilapia sex reversal experiments. This data can also guide hatchery managers during commercial production of all male tilapias which grow faster than those in the mixed sex tilapia culture.

A field survey of hand–arm vibration exposure in the UK utilities sector

PurposeExcessive exposure to HAV can lead to hand–arm vibration syndrome (HAVS) which is a major health and well-being issue that can irreparably damage the neurological, vascular and muscular skeletal system. This paper reports upon field research analysis of the hand–arm vibration (HAV) exposure levels of utility workers in the UK construction sector when operating hand-held vibrating power tools.Design/methodology/approachAn empirical epistemological lens was adopted to analyse primary quantitative data on the management of hand-held tool trigger times (seconds) collected from field studies. To augment the analysis further, an interpretivist perspective was undertaken to qualitatively analyse interviews held with the participating company's senior management team after field study results. This approach sought to provide further depth and perspective on the emergent numerical findings.FindingsThe findings reveal that none of the operatives were exposed above the exposure limit value (ELV) and that 91.07% resided under the exposure action value (EAV). However, the Burr four parameter probability model (which satisfied the Anderson–Darling, Kolmogorov–Smirnov and chi-squared goodness of fit tests at 0.01, 0.02, 0.05, 0.1 and 0.2 levels of significance) illustrated that given the current data distribution pattern, there was a 3% likelihood that the ELV will be exceeded. Model parameters could be used to: forecast the future probability of HAV exposure levels on other utility contracts and provide benchmark indicators to alert senior management to pending breaches of the ELV.Originality/valueHAV field trials are rarely conducted within the UK utilities sector, and the research presented is the first to develop probability models to predict the likelihood of operatives exceeding the ELV based upon field data. Findings presented could go some way to preserving the health and well-being of workers by ensuing that adequate control measures implemented (e.g. procuring low vibrating tools) mitigate the risk posed.