Infestation with the chewing louse (Werneckiella (Damalinia) equi) can be found on horses world-wide. Louse infestations, including clinical signs of louse-derived dermatitis, are known from Icelandic horses. A clinical field investigation was conducted in Iceland using horses with natural louse infestations to evaluate the efficacy of imidacloprid in a 10% solution in comparison with phoxim in a 0.05% solution. A total of 27 horses received a single imidacloprid treatment using 16 ml of the 10% solution along the mane and on the dorso-lateral trunk. A further 43 horses were treated twice, 14 days apart, with phoxim, using 2 x 50 ml solution applied along the mane and the dorso-lateral trunk. At the final evaluation on day 28, complete control of the lice was obtained for the imidacloprid treated horses and only a single moribund louse was found on two horses treated with phoxim.