Research of detailed chemical constituents from the pericarps of Zanthoxylum bungeanum Maxim resulted in the isolation of twenty-two compounds (1–22), including eight alkaloids (1–8), three alkylamines (9–11), five monoterpenoids (12–16), one benzophenone (17), two coumarins (18 and 19) and three lignanoids (20–22). Among them, compounds 2 and 8 were firstly found in the genus Zanthoxylum, while compounds 13–15 and 20 were firstly reported in the Rutaceae family. This work enriches the secondary metabolites of Z. bungeanum and provides valuable information for chemotaxonomic studies on the genus Zanthoxylum.