Division Of Chemistry Research Articles

Applying The Best Practice For Internal Quality Control (IQC) Management, Consolidation And Review Process In Sidra Medicine Clinical Chemistry Division

Abstract Introduction/Objective The management of internal quality control (IQC) in Sidra Medicine Clinical Chemistry Division has been evaluated in order to promote a more consolidated and efficient process of IQC management. The statistical data produced from Cerner QC Module are transferred to IQC review templates consisting of formulas to auto- calculate parameters such as multiple of expected QC failure frequency and desirable comparison limit between analyzers. The IQC review and documentation process using the in-house excel template requires several hours to complete, hence a faster and more efficient IQC management module is required. The main objective of this study is to improve the initial IQC management set up, work flow and review procedures and to implement Biorad Unity Real Time (URT) program to develop a more efficient IQC management system. Methods The URT software has been recently configured and implemented to consolidate and streamline IQC management. URT is built through Sidra Medicine IT Enterprise level which allows multiple users to login. IQC data are downloaded using scripts from Cerner which are filtered through Biorad Unity Connect (UC) software. Additional quality tools are also explored such as various user defined statistical reports, IQC analysis using peer reviewed total allowable error (TeA) and assignment of the most appropriate Westgard rules. Determination of sigma metrics and uncertainty of measurement is also performed using the URT application. Results The generation of any IQC report is less cumbersome and time consuming as compared with the previous process. However, some user defined formulas in the IQC templates are not found on the URT reports. The URT Levey Jennings chart are also more user friendly and directly compares the daily IQC data with Unity inter-laboratory peers enabling the production of instant and monthly reports through QCNet site when assay investigation is required and for IQC report documentation. Conclusion The combination of Cerner IQC, Unity Real-time, QCNet Inter-laboratory reports and in house IQC templates produce a high level and very detailed IQC review which effectively evaluate assay performance to assist on IQC troubleshooting and root cause analysis to be able to apply the most appropriate corrective actions.

Committees

International Web Conference on Advanced Material Science and Nanotechnology(NANOMAT-2020)Organizing Committee• Dr. Alka A. Bhise (Principal)• Dr. Suchita P. Khodke (IQAC Coordinator)• Dr. Anant S. Wadatkar (Organizing Secretary)• Dr. Prashant B. Kharat (Convener)• Mr. Ajay V. Ambhore (Co-convener)Advisory CommitteeProf. K. M. Jadhav, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, India (M.S.) Prof. R. B. Sharma, Hanyang University, Seoul, Republic of KoreaProf. M. D. Shirsat, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, India (M.S.) Dr. F. C. Raghuwanshi, Sant Gadgebaba Amravati University, Amravati, India (M.S.)• Dr. J. V. Yakhmi, Ex-Associate Director, Bhabha Atomic Research Center, Mumbai, IndiaDr. R. S. Shinde, Outstanding Scientist, RRCAT, Indore, India (M.P.)Dr. N. G. Belsare, Former Principal, Brijlal Biyani Science College, Amravati, India (M.S.)Prof. Mahavir Singh, Former Vice-chancellor IEC University, Himachal Pradesh, IndiaProf. P. M. Koinkar, Associate Professor, Tokushima University, Tokushima, JapanProf. T. S. Wasnik, Professor, Vidyabharti College, Amravati (MS), IndiaProf. R. V. Joat, Professor, Vidyabharti College, Amravati (MS), IndiaProf. H. S. Jadhav, Research Associate Professor, Myongji University, Republic of KoreaProf. Dr. A. Mulchandani, University of California, Riverside, United StatesDr. S M Yusuf, Outstanding Scientist, Physics Group,. Bhabha Atomic Research Center, Mumbai, IndiaDr. P. A. Hassan, Scientist, Chemistry Division, Bhabha Atomic Research Center, Mumbai, IndiaDr. R. S. Ningthoujam, Scientist, Chemistry Division, Bhabha Atomic Research Center, Mumbai, IndiaDr. S. S. Meena, Scientist, Physics Group, Bhabha Atomic Research Center, Mumbai, IndiaDr. P. P. Phadnis, Scientist, Chemistry Division, Bhabha Atomic Research Center, Mumbai, IndiaDr. A. B. Lad, Sant Gadgebaba Amravati University, Amravati, India (M.S.)Dr. S. A. Waghule, Sant Gadgebaba Amravati University, Amravati, India (M.S.)Prof. G. K. Bichile, Department of Physics, Dr. B. A. M. U. Aurangabad (MS), IndiaProf. K. B. Modi, Department Of Physics, Saurashtra University, Rajkot, India.Prof. R. L. Raibagkar, Gulbarga University, Karnataka, India.Prof. D. Ravinder, Professor, Osmania University, Hyderabad (TS), India

IIUPAC Awards in Analytical Chemistry—Call for nominations

Abstract The Analytical Chemistry Division of IUPAC has established two awards, including:

A Comparative Study of Imidazolium-Based Ionic Liquid-Single-Walled Carbon Nanotube Composites with Enhanced Conductivity Properties for Supercapacitor Applications

Mixtures of ionic liquids (ILs) containing single-walled carbon nanotubes (SWCNTs) were prepared and characterized to obtain electrolytes with optimized transport properties for the use in energy storage devices such as supercapacitors. Imidazolium ILs bearing cations with side chains of different functionality coupled with bis(trifluoromethylsulfonyl)amide (NTf2 -) or bis(fluorosulfonyl)amide (FSA-) anions were used in mixtures containing up to 5 wt % SWCNTs. It was determined that the ionic conductivities of all ILs studied can be significantly increased with the addition of single-walled carbon nanotubes when the loading of the nanotubes is above 2 wt %. Moreover, higher conductivities were observed for the ILs containing the NTf2 - anion and 5 wt % SWCNTs. These results can significantly contribute to the development of improved energy storage devices. The work at Brookhaven National Laboratory was supported by the U.S. Department of Energy, Office of Basic Energy Sciences, Division of Chemical Sciences, Geosciences, and Biosciences under contract DE-SC0012704. The work at Brooklyn College was supported by the National Science Foundation, Solid State and Materials Chemistry Program, Division of Materials Research, EAGER award #1841398.

Nonadiabatic molecular dynamics simulation of in a strong laser field**Xi Zhao was supported by Chemical Sciences, Geosciences, and Biosciences Division, Office of Basic Energy Sciences, Office of Science, U.S. Department of Energy (Grant No. DE-FG02-86ER13491), the National Natural Science Foundation of China (Grant No. 11904192); Ji-Gen Chen was supported by the National Natural Science Foundation of China (Grant No. 11975012);

We investigate the alignment dependence of the strong laser dissociation dynamics of molecule in the frame of real-time and real-space time-dependent density function theory coupled with nonadiabatic quantum molecular dynamics (TDDFT-MD) simulation. This work is based on a recent experiment study “ultrafast electron diffraction imaging of bond breaking in di-ionized acetylene” [Wolter et al, Science 354, 308–312 (2016)]. Our simulations are in excellent agreement with the experimental data and the analysis confirms that the alignment dependence of the proton dissociation dynamics comes from the electron response of the driving laser pulse. Our results validate the ability of the TDDFT-MD method to reveal the underlying mechanism of experimentally observed and control molecular dissociation dynamics.

REVIEW ARTICLE; ANTICANCER ACTIVITIES OF SOME FUSED HETEROCYCLIC MOIETIES CONTAINING NITROGEN AND/OR SULFUR HETEROATOMS

Cancer cells often have a high demand for antiapoptotic proteins in order to resist programmed cell death. Heterocyclic compounds present themselves as a fundamental division of organic chemistry. Most clinically effective antitumor agents are inhibitors of DNA, RNA or protein synthesis, enzyme inhibition and/or interfere with the metabolism of other cell components, frequently lacking or displaying poor selective antitumor activity. The majority of heterocycle compounds and typically common heterocycle fragments present in most pharmaceuticals currently marketed, alongside with their intrinsic versatility and unique physicochemical properties have poised them as true cornerstones of medicinal chemistry. The S-heterocyclic core (Thiophene) has been reported to possess significant importance in various fields from medicinal chemistry. Many diverse biologically active products were prepared, several of which exhibited antimicrobial, analgesic, anti-inflammatory, antioxidant, antitumor, local anesthetic, anticoagulant and antithrombotic activities. Many N-heterocyclic compounds that are broadly distributed in Nature, possess physiological and pharmacological properties and are constituents of many biologically important molecules, including many vitamins, nucleic acids, pharmaceuticals, antibiotics, dyes and agrochemicals, amongst many others. The base pairs of DNA and RNA (Guanine, cytosine, adenine, and thymine) are also made up of N-heterocyclic compounds, namely purines, pyrimidines, etc. These nitrogen-containing heterocyclic molecules with distinct characteristics and applications have gained prominence in the rapidly expanding fields of organic and medicinal chemistry and the pharmaceutical industry. Finally, many of these compounds have higher activity against cancer cells using the standard MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)assay.

Cover Story: Matters of Perspective: Appreciating Diversity and Promoting Inclusion in Health Technology Professions.

Cover Story: Matters of Perspective: Appreciating Diversity and Promoting Inclusion in Health Technology Professions.

Inorganic Nanoscience Award to Richard Brutchey

, a professor of chemistry at the University of Southern California, is the winner of the 2020 Inorganic Nanoscience Award, presented by the ACS Division of Inorganic Chemistry in recognition of su...

Undergraduate research fellowships awarded

The 2020 recipients of the American Chemical Society Division of Organic Chemistry’s Summer Undergraduate Research Fellowships (SURF) have been announced. They are of the University of Florida; of ...

Grain Zinc Phytic Acid and Nutrient Uptake in Common Bean is Influenced by Sources and Concentrations of Zinc Fertilization

Aim: To study the effect of different sources and levels of zinc fertilization on phytic acid content and nutrient uptake in common beans.
 Design: Randomized complete block design.
 Place and Duration of study: Division of soil science and agricultural chemistry, Faculty of Agriculture, Sheri Kashmir University of agricultural science and technology, Kashmir, between 2017-2018.
 Methodology: A field experiment was conducted to verify the response of common bean (Phaseolus vulgaris L.) to the different sources zinc fertilizer. Three different sources of Zinc Viz:- Zinc Sulphate, Zinc Gluconate and Zinc EDTA were used. Each fertilizer was used in three different amounts. Concentration of Zinc, overall zinc uptake, phytic acid, phytic acid Zinc molar ratio and overall nutrient uptake was estimated.
 Results: The data was analyzed using OPSTAT software at P= 0.05. The application of zinc had a positive impact on increase of zinc concentration from 36.6 to 58.2 mg kg-1 in common bean and overall zinc uptake from 0.43 to 1.02 kg ha-1. It was observed that with the increase in levels of zinc there was a decrease in the concentration of phytic acid from 11.92 to 7.8 mg g-1 hence, phytic acid: Zinc molar ratio also decreased from 31.2 to 13.2. There was a positive correlation between nutrient uptake and zinc concentration in beans.
 Conclusion: Application of Zinc significantly increased the overall nutrient uptake of plants except phosphorus. Among all the sources, Zinc EDTA proved to be most efficient fertilizer followed by zinc Gluconate for enhancing the concentration of zinc and decreasing the concentration of anti- nutritional factor (phytic acid) in beans. Therefore zinc fertilization can be used as an effective method to improve zinc concentration in beans and hence combat zinc deficiency.

NSF names new head of chemistry division

University of Nebraska–Lincoln chemistry professor David Berkowitz has been named the new director of the National Science Foundation’s Division of Chemistry. Berkowitz, who started his new position on May 24, says he’s excited to be returning to the NSF. He spent 3 years there as a program director from 2010 to 2013, followed by a brief stint as interim division director in 2015. During his previous service, he was impressed by the permanent staff and their commitment to high-risk science and basic research, while at the same time considering the health and diversity of chemistry as a field. “I came to know the people, and they were so serious about the mission, I thought I’d like to work with this team” again if the opportunity came along, Berkowitz says. Chemistry plays an important role in some of the NSF’s major initiatives, including quantum computing and artificial intelligence, he says. Work

Changing the Landscape: An Introduction to the Agricultural and Food Chemistry Technical Program at the 258th American Chemical Society National Meeting in San Diego

This special issue of the Journal of Agricultural and Food Chemistry (JAFC) is a highlight of the Agricultural and Food Chemistry Division (AGFD) technical program at the 258th National Meeting of the American Chemical Society (ACS) in San Diego, CA, U.S.A., on August 25-29, 2019. At the conference, AGFD had 44 oral sessions at 19 symposia and 100 poster presentations with more than 400 abstract submissions. The technical program covered a broad range of current research and development topics in agricultural and food chemistry, including bioactive food components, diet and human nutrition, utilization of agricultural materials in food systems, food packaging, nanotechnology, and food safety, as well as several special award symposia. This is the first JAFC special issue that highlights an ACS national meeting program with joint efforts from AGFD.

Society Prizewinner Collection – The Division of Coordination Chemistry of the French Chemical Society

Society Prizewinner Collection – The Division of Coordination Chemistry of the French Chemical Society

Overview of the American Chemical Society Symposium on Metals and Trace Elements in Food Safety, Health, and Food Quality.

A symposium was held at the 2019 American Chemical Society (ACS) Fall National Meeting in San Diego, CA, U.S.A., entitled "Metals Trace Elements in Food Safety, Health, and Food Quality". The 2 day symposium was sponsored by the Division of Agricultural and Food Chemistry (AGFD) and co-sponsored by the Division of Agrochemicals (AGRO). This symposium was convened to broadly cover advances in the detection of metals/trace elements in food and our understanding of how metals and trace elements impact food safety, food quality, toxicology, and human nutrition. There were 21 presentations from speakers from academia, government, and industry. This introduction provides a brief summary of the presentations and serves as a record of the symposium proceedings.

Catalyst: Qubits from the Bottom Up

Yi Liu obtained his PhD degree in chemistry in 2004 from the University of California, Los Angeles, under the direction of Sir J. Fraser Stoddart. After his postdoctoral research with Prof. Barry Sharpless at the Scripps Research Institute, he joined the Molecular Foundry in 2006 as a staff scientist and has been directing the Organic and Macromolecular Synthesis Facility since 2016. Francesca M. Toma obtained a PhD in physics from Scuola Internazionale Superiore di Studi Avanzati with Profs. Scoles and Prato, was a Marie Curie researcher with Profs. Wudl and Stucky at the University of California, Santa Barbara, and was a postdoctoral scholar with Prof. Fischer at the University of California, Berkeley. She has been a staff scientist in the Chemical Sciences Division since 2013 and the Materials Integration Thrust Coordinator at the Joint Center for Artificial Photosynthesis since 2017.

Michael H. Auerbach

Michael H. Auerbach, 76, died on Feb. 11 in Suffern, New York. “Michael did analytical R&D at Monsanto’s polymer and petrochemical division in Springfield, Massachusetts, starting in 1969. He moved to Pfizer’s industrial specialty chemical division in 1976 as manager of applications. He was promoted to senior associate director of regulatory affairs when Pfizer transitioned away from specialty chemicals and formed its food science group. Among his accomplishments, he assisted in the development of a high-pyruvate xanthan gum for enhanced oil recovery and polycarboxylate antiscalants for water desalination and geothermal power; was responsible for a clinical trial of the high-intensity sweetener alitame in Australia; established the generally-recognized-as-safe status of the reduced-calorie fat replacer salatrim; assisted in the development of EverFresh, an antienzymatic browning agent for shrimp; and established worldwide acceptance of the dietary fiber status of the low-calorie bulking agent polydextrose.”—David Auerbach, son Most recent title: Food regulatory affairs scientist,

GIS-GPS based soil fertility maps of macronutrients of village Harnas of Bhor Tehsil in Pune District

Investigation on GPS based soil fertility maps of Harnas Village of Bhor Tehsil of Pune District was undertaken with 120 geo-referenced (GPS) surface soil samples (0-22.5 cm depth) during the year 2017-2018 at Division of Soil Science and Agricultural Chemistry, College of Agriculture, Pune with the object to assess the soil chemical properties with available macro nutrients. The latitude and longitude of the sampling site were recorded with the handheld GPS instrument. It is observed that 97.5% soil samples belong to slightly acidic to acidic in reaction. However, the EC of soils ranged from 0.10 to 0.20 dSm-1 and soils are categorized as normal for emergence of seed. The organic carbon content of soil ranged from 0.21 to 0.71 per cent and categorized as low to high. The calcium carbonate content was medium to high and it ranged from 0.24 to 12.50 per cent.The available nitrogen, phosphorus and potassium ranged 75.26 to 175.60 kg ha-1 (mean 112.43 kg ha-1), 10.16 to 33.84 kg ha-1 (mean 21.11 kg ha-1) and 117.24 to 285.70 kg ha-1 (mean 212.97 kg ha-1), respectively. The available sulphur in soils ranged from 30.38 to 33.42 mg kg-1 (mean 31.91 mg kg-1). The pH of the soil has negative and non-significant correlation with available K and S. however it has positive with significant correlation with P with ‘r’ value 0.164.*. EC of the soils showed negatively but non-significant correlation with available P and S. But positively non-significant correlation with available N and K.Organic carbon showed negatively non-significant correlation with available K. here as it has positively non-significant correlation with available N, P and S. The CaCO3 was negatively and non-significantly correlated with available N, P and K. while it is positively and non-significantly correlated with available S. respectively. The spatial distribution maps of soil were developed with help of Arc GIS 10.2 software.

GIS-GPS based soil fertility maps of micronutrients of village Harnas of Bhor tehsil in Pune district

Investigation on GPS based soil fertility maps of Harnas Village of Bhor Tehsil of Pune District was undertaken with 120 geo-referenced (GPS) surface soil samples (0-22.5 cm depth) during the year 2017-2018 at Division of Soil Science and Agricultural Chemistry, College of Agriculture, Pune with the object to assess the soil chemical properties with available micro nutrients. The latitude and longitude of the sampling site were recorded with the handheld GPS instrument. It is observed that 97.5% soil samples belong to slightly acidic to acidic in reaction. However, the EC of soils ranged from 0.10 to 0.20 dSm-1 and soils are categorized as normal for emergence of seed. The organic carbon content of soil ranged from 0.21 to 0.71 per cent and categorized as low to high. The calcium carbonate content was medium to high and it ranged from 0.24 to 12.50 per cent. Soil pH was non-significant but positively correlated with DTPA extractable Zn but showed negatively significant correlation with Mn and Fe with the r values of -0.189*and -189* respectively, indicating that as soil pH decreases, the availability of Fe, Mn increases. Electrical conductivity had non significantly positive correlation with Cu. While, the organic carbon showed significantly positive correlation with extractable Fe (r = 0.239**) and non-significantly positive correlation with Mn, Zn and Cu. The CaCO3 found negatively and significantly correlated with exchangeable Fe and Mn with the r value of -0.176*, -212** respectively. The spatial distribution maps of soil were developed with help of Arc GIS 10.2 software.

Wacker and Clariant to cut jobs

Wacker Chemie says it will cut more than 1,000 jobs, about 7% of its workforce, by 2022 to save about $270 million anually. The firm hopes to make the cuts, mostly in Germany, without layoffs. “We are preparing for a harsher competitive environment—both in our polysilicon business and at our chemical divisions,” CEO Rudolf Staudigl says. Similarly, Clariant says it will cut 500–600 positions, about 3% of its workforce, in the next 2 years in anticipation of sluggish economic growth and negative effects from currency exchange. The Swiss firm says the cuts will save about $50 million.

Paul C. Scott

Paul C. Scott, 87, died on Nov. 21, 2019, in Arlington, Virginia. “Paul was active in the ACS Fuel Chemistry Division, serving as program secretary from 1974 to 1978 and program chair from 1980 to ...