Department Of Chemistry Research Articles

Spatial Assessment and Variation of Soil Physicochemical Properties and Water Quality in the Tungi Watershed of Maharashtra, India

Aims: To thoroughly evaluate the spatial variability of soil physicochemical properties and groundwater quality of the study area by systematic collection and analysis of geo-referenced soil and groundwater samples to quantify the physical, chemical and biological attributes of the soil. The objective is to gain a comprehensive understanding of soil and water quality in the Tungi watershed, providing valuable insights to guide sustainable land and water management practices in the region.
 Place and Duration of Study: Department of Soil Science and Agricultural Chemistry, College of Agriculture, Latur between 2020 and 2021.
 Methodology: A total of one hundred geo-referenced surface soil samples (0-30 cm) and ten groundwater samples were methodically collected from the surrounding area of soil profiles in the Tungi watershed, situated in Latur, Maharashtra. Physical, chemical and biological properties of soil evaluated using recommended standard methods.
 Results: Bulk density varied from 1.13 to 1.93 Mg m-3, particle density from 2.48 to 2.94 Mg m-3 and porosity from 22 to 58 percent. Soil pH ranged from 7.05 to 8.96 and electrical conductivity was within the permissible range. Organic carbon content of soils ranged from 0.15 to 1.05 percent, with some soils having a calcareous character (0.6 to 22.2 percent). The analysis of nutrient content revealed variable quantities with available nitrogen ranging from 53.31 to 250.88 kg ha-1, available phosphorus from 12.51 to 27.49 kg ha-1, available potassium from 106.9 to 851.5 kg ha-1 and available sulphur from 4.37 to 66.65 mg kg-1. Exchangeable calcium and magnesium quantities revealed ranges of 14.60 to 42.40 cmol(p+) kg-1 and 5.40 to 21.60 cmol(p+) kg-1, respectively. Furthermore, DTPA extractable iron varied from 4.24 to 16.38 mg kg-1, manganese from 4.76 to 25.84 mg kg-1, zinc and copper from 0.5 to 6.56 mg kg-1 and 0.72 to 15.56 mg kg-1, respectively and boron from 0.1 to 3.56 mg kg-1. Microbial population estimates revealed the dominance of bacteria over fungi and actinomycetes in the studied area. Groundwater carbonate and bicarbonate ranged from 0.01 to 0.62 m mol-1 and 6.35 to 10.24 mmol-1 respectively. The dug well, bore well and tube well water RSC ranged from 0.70 to 1.25 mmol-1.
 Conclusion: This extensive study provides helpful insights into the regional variability of physical and chemical properties in both soil and water with help of soil fertility maps, providing better understanding of soil fertilizer input and environmental conditions in the Tungi watershed.

Supramolecular Membrane Chemistry in the Langton Group.

This invited Team Profile was created by the Langton group in the Department of Chemistry, University of Oxford (UK). They recently published an article on a synthetic supramolecular signaling system, in which light is used to initiate the release of diffusible chemical signals from one population of vesicles to another. This triggers transmembrane cation transport in the receiver vesicles and amplifies the signal, in a manner reminiscent of signaling mechanisms in biology. "Inter-Vesicle Signal Transduction Using a Photo-responsive Zinc Ionophore", S. A. Gartland, T. G. Johnson, E. Walkley, M. J. Langton Angew. Chem. Int. Ed. 2023, 62, e202309080.

Supramolecular Membrane Chemistry in the Langton Group

AbstractThis invited Team Profile was created by the Langton group in the Department of Chemistry, University of Oxford (UK). They recently published an article on a synthetic supramolecular signaling system, in which light is used to initiate the release of diffusible chemical signals from one population of vesicles to another. This triggers transmembrane cation transport in the receiver vesicles and amplifies the signal, in a manner reminiscent of signaling mechanisms in biology. “Inter‐Vesicle Signal Transduction Using a Photo‐responsive Zinc Ionophore”, S. A. Gartland, T. G. Johnson, E. Walkley, M. J. Langton Angew. Chem. Int. Ed. 2023, 62, e202309080.

On the History of Developing Catalysis in Ukraine (1850s–1980s)

The article is dedicated to the history of developing highly effective catalysts in the leading scientific institutions of Ukraine and explores the prerequisites for developing theories in physical chemistry, in particular those related to kinetics and catalysis. It highlights the significance of scientific discoveries at the turn of the 19th and 20th century and their application by native scientists to advance theoretical development in the field of chemistry. Special attention is paid to the works of Lev Pisarzhevskii, focusing on his advancements in electronic chemistry and, in particular, the electronic theory of catalysis. The article also outlines current challenges in creating highly efficient catalysts for the chemical and light industry, emphasizing the importance of such indicators of catalysts as activity and selectivity. Drawing on historical, scientific and patent data, the study investigates the process of creating a highly efficient catalyst for obtaining acrylic acid from acrolein. This catalyst holds a great ractical importance for the production of various polymers in industrial conditions. It is shown that, as a result of research conducted by native scientists of the Institute of Physical Chemistry of the Academy of Sciences of the Ukrainian SSR and the Chemistry Department of Kyiv State University, the catalyst K-2-5 was developed. The catalyst has good indicators for the industrial production of acrylic acid from acrolein. The authors also highlight works studying the properties of the obtained catalyst, specifically its porous structure, which is an important factor in catalytic processes. They extensively focus on the kinetic indicators of catalytic reactions that occur when using this catalyst. The article also emphasizes the relevance of these developments for advancing research in catalysis and chemical industrial production.

The Effect of the RADEC Model on Conceptual Understanding of Polycyclic Aromatic Hydrocarbons (PAHs) Topic

This study was conducted to analyze the conceptual understanding of students and their struggle on Polycyclic Aromatic Hydrocarbons (PAHs) compounds topic through the implementation of the RADEC Model. Respondents consisted of 37 students from Chemistry Education Department and 33 students from the Chemistry Department at a university in Bandung, Indonesia. This study is an experimental study with a pre-experimental type. Data on conceptual understanding were obtained through pre-tests and post-tests, while data on students’ difficulties were obtained through survey. The data were analyzed using SPSS 24. It was found that there was an increase in the conceptual understanding of the students of Chemistry Education and Chemistry Department in the medium category with n-gain values of 0.33 and 0.38, respectively. The results of inferential analysis through the Wilcoxon Test with Asymp. Sig. (2-tailed) were <0.05 for the two groups of students indicating differences in the pre-test and post-test results with a higher average post-test score. Friedel-Crafts acylation is a concept that is difficult to understand by students from the Chemistry Education Department and the Chemistry Department with the same percentage of 33%. Chemistry Department students also have difficulty understanding the electrophilic substitution concept with a percentage of 33%. As a practical implication, this study successfully showed the effective implementation of the RADEC model, serving as an innovative and beneficial learning approach. The model offered substantial support to students in grasping complex topic such as PAHs compounds.

Celebrating 100 Years of University of Delhi (1922–2022)

AbstractUniversity of Delhi (DU) has attained global recognition for its research and teaching in Chemistry. This Guest Editorial introduces the research showcased in the “Institute Feature: Celebrating 100 Years of University of Delhi (1922–2022)” ‐ a joint special collection from the European Journal of Organic Chemistry (EurJOC), European Journal of Inorganic Chemistry (EurJIC) and ChemistrySelect The collection highlights the contributions to the field of chemistry through research articles and reviews authored by faculty members from the Department of Chemistry, alumni of the department and faculty members of chemistry department of various colleges affiliated with the university, celebrating 100 years of DU.

Learning, Teaching, and Demonstration of Unique Chemistry for the Indonesian Generation at Sanggar Bimbingan Mulia, Kuala Lumpur Malaysia

As a form of concern for the issues faced by the descendants of Indonesian nationals in Malaysia, especially for the Human Resources, we provide the unique theoretical and practical chemistry mentorship for future capability. Sanggar Bimbingan Sungai Mulia 5 is an organization that offers educational services for Indonesian descendants whose citizenship status is still unclear due to administrative reasons. Based on the Chemistry Department UM and Sanggar Bimbingan Mulia cooperation, It is important to enhance the nation's intellectual capacity, especially in ensuring the success of the mandatory 9-year education program. This community service aims to combat illiteracy, in still character education, and prepare students for higher education. The expected outcomes of this program is a unique chemistry Massive Open Online Course (MOOC), a service article published, a service report, and a poster. Our program successfully developed the interest of children to love a simple chemistry experiment and improved for reading and learning through various MOOC, books, and educational materials.

Two Teams Are Better Than One: Where Theory and Experiment Successfully Interact

AbstractThis invited Team Profile was created by Prof. Judy I. Wu, Department of Chemistry, University of Houston (USA) and Prof. Michael M. Haley, Department of Chemistry & Biochemistry and the Materials Science Institute, University of Oregon, Eugene (USA). The X‐ray structure of tetra‐t‐butyl‐s‐indacene was reported in 1986 to possess a symmetric, delocalized D2h geometry, which went against conventional wisdom that this antiaromatic should exhibit a bond‐localized C2h structure. Computational studies over the ensuing 35+ years yielded conflicting outcomes as to the preferred geometry. A computational reexamination of this structure by our team found experimental proton chemical shifts matched best with a computed C2h symmetry, confirming a bond‐localized geometry. “Tetra‐tert‐butyl‐s‐indacene is a Bond‐Localized C2h Structure and a Challenge for Computational Chemistry”, L. J. Karas, S. Jalife, R. V. Viesser, J. V. Soares, M. M. Haley, J. I. Wu, Angew. Chem. Int. Ed. 2023, 62, e202307379.

Two Teams Are Better Than One: Where Theory and Experiment Successfully Interact.

This invited Team Profile was created by Prof. Judy I. Wu, Department of Chemistry, University of Houston (USA) and Prof. Michael M. Haley, Department of Chemistry & Biochemistry and the Materials Science Institute, University of Oregon, Eugene (USA). The X-ray structure of tetra-t-butyl-s-indacene was reported in 1986 to possess a symmetric, delocalized D2h geometry, which went against conventional wisdom that this antiaromatic should exhibit a bond-localized C2h structure. Computational studies over the ensuing 35+ years yielded conflicting outcomes as to the preferred geometry. A computational reexamination of this structure by our team found experimental proton chemical shifts matched best with a computed C2h symmetry, confirming a bond-localized geometry. "Tetra-tert-butyl-s-indacene is a Bond-Localized C2h Structure and a Challenge for Computational Chemistry", L. J. Karas, S. Jalife, R. V. Viesser, J. V. Soares, M. M. Haley, J. I. Wu, Angew. Chem. Int. Ed. 2023, 62, e202307379.

The evaluation of biochemistry practicum based on several parameters of laboratory services in chemistry department Universitas Negeri Surabaya during the even semester

This study was conducted to evaluate laboratory management during biochemistry practicum activities and to build laboratory information for the internal and external community of Universitas Negeri Surabaya (Unesa) in 2023 through several aspects, namely infrastructure, tools, materials, and PLP/laboratory services. A descriptive-qualitative approach is used with a questionnaire for all biochemistry practitioners. The result shows that all aspects of biochemistry practicum activities obtain percentages sequentially of 89%, 90%, 93%, and 90%, which are included in the excellent category, so it can be concluded that all practitioners are highly satisfied with laboratory services during practicum. However, improvements to the deficiencies still need to be made so that the following practicum activities run better and optimally.

Peer Review Statement

All papers published in this volume have been reviewed through processes administered by the Editors. Reviews were conducted by expert referees to the professional and scientific standards expected of a proceedings journal published by IOP Publishing.• Type of peer review: Double Anonymous• Conference submission management system: Morressier• Number of submissions received: 167• Number of submissions sent for review: 126• Number of submissions accepted: 113• Acceptance Rate (Submissions Accepted / Submissions Received × 100): 67.7• Average number of reviews per paper: 1.63• Total number of reviewers involved: 38• Contact person for queries: Name: Robby Gus Mahardika Email: robby@ubb.ac.id Affiliation: Department of Chemistry, Universitas Bangka Belitung

Effect of Integrated Nutrient Management on Yield, Uptake and Soil Properties of Pearl Millet (Pennisetum glaucum L.) in Alluvial Soil of Gird Region of Madhya Pradesh

Aims: Effect of Integrated nutrient management onyield, uptake and soil properties of pearl millet (Pennisetum glaucum L.) in alluvial soil of Gird region of Madhya Pradesh.
 Study Design: Randomized block design.
 Place and Duration of Study: Department of Soil Science and Agricultural Chemistry, R.V.S.K.V.V., CoA, Gwalior, Districts of Madhya Pradesh during kharif, 2022.
 Methodology: There were 12 treatments T1 – Control, T2 -50% NPK, T3-75% NPK, T4 -100% NPK, T5 - 150% NPK, T6 -100% NPK-S, T7 -100% NPK ZnSO4, T8 -100% NPK + FeSO4, T9 -50% NPK + FYM, T10 -75% NPK + FYM, T11 -100% NPK + FYM and T12-100% NPK + FYM + {PSB+ Azotobacter (Seed treatment)} and were replicated thrice under RBD and were statistically analyzed by the Fishher the analysis of variance technique was adopted as suggested by Panse and Sukhatme (1984) for Randomized Block Design. The pH , EC, OC, N, P, K and S content before creation of treatments were 7.72, 0.23 dSm-1, 0.39 %, 170 kgha-1, 12.04 kg ha-1 and 180 kg ha-1 respectively.
 Results: The results indicated that yield, uptake of nutrients and soil properties pH, EC, OC, Available Nitrogen, Phosphorus, Potassium and Sulphur were found highest in the treatment T12-100% NPK + FYM + {PSB+ Azotobacter (Seed treatment)} and was found lowest in the treatment T1 – Control.
 Conclusion: Based on experimental findings it can be concluded that application of100% NPK + FYM + {PSB+ Azotobacter (Seed treatment)} is beneficial in terms of yield, uptake of nutrients and Soil chemical properties pearl millet.

Assessment of Physicochemical Parameters of Drinking Water in the Schools of Bagnashkali, Palpa, Nepal

This study aims to assess the physicochemical parameters of drinking water in schools in the Bagnashkali Rural Municipality in Nepal according to standard methods. Physicochemical analysis was performed at the Department of Chemistry at Tribhuvan Multiple Campus, Palpa, in March 2022 using samples collected randomly from different schools. The study found that water samples from schools in Bagnashkali meet NDWQS and WHO guidelines as pH (7.28- 7.98), hardness(60-140 mg/L), conductivity (65.3-173.2 µs/cm), alkalinity (46-96.6 mg/L), chloride (0.3-0.7 mg/L), dissolved oxygen (9.12-12.6 mg/L), total dissolved solids (9.12-12.6 mg/L), free CO2 (7.04-10.56 mg/L) and iron (0.017-0.068 mg/L) which were all except for temperature within acceptable limits. The temperature of the water samples in this study ranged from 21°C to 28°C. The study found that the water quality in the selected schools was good and met the acceptable standards in terms of physicochemical parameters.

Improvement of Acid-Base Materials Understanding SMAI Gumukmas Students with Simple Practicum

SMAI Gumukmas is a privately-funded high school situated in Purwoasri Village, Gumukmas District, Jember, with a B accreditation status. The absence of laboratory resources challenges devising inventive, uncomplicated, and pragmatic classroom learning, such as Chemistry. Collaboration between SMAI Gumukmas and the Chemistry Department lecturers to conduct community service is a mutually beneficial initiative that fosters curriculum innovation and practicum subjects. Acid-base is a chemistry topic with material relevant to all grade levels and can be easily visualized through practical examples from everyday life. The methodology involves delivering a lecture or theoretical framework on acid-base, followed by practical work. The acid-base practical is designed to commence with comprehension of the acid-base concept, including everyday life examples, before progressing to classroom implementation. The acid-base theme learning activities and practicum at SMAI Gumukmas proceeded seamlessly and successfully. The initial class consisted of 40 students from grades 11 and 12, while the subsequent consisted of 33 grade 10 students. The students exhibited a positive response as their studies progressed with exemplifications derived from everyday life.

Guest Editor’s Note

The process of writing review articles originally materialized as a component of the student evaluation process during the final year of their research projects, coinciding with the closure of universities due to the COVID-19 pandemic. In these challenging times, final-year honors degree students dedicated themselves to extensive literature research from their homes. As the evaluation phase concluded, it became evident to the Chemistry department that several of the review articles had reached a remarkable level of quality, making them suitable for publication in a reputable scientific journal.
 Thus, the idea emerged to compile and publish these outstanding articles in a special edition of our esteemed journal, Current Scientia, formerly known as the Vidyodaya Journal of Science. This endeavor involved meticulous scrutiny and enhancement of both the content and coverage of the articles, a collaborative effort between the students and their dedicated supervisors. The contributions of the supervisors were invaluable in this process.
 Reflecting upon the circumstances, one might consider the period of house arrest during the pandemic as a blessing in disguise. It provided an opportunity for students and supervisors to invest more time and effort into refining their work. The synergy that emerged between them during this challenging time is truly commendable.
 With the publication of this special issue, we hope that it will set a new precedent and ignite the academic curiosity of scholars from various departments within the faculty. We aspire to encourage academics to craft their own high-quality review articles in their respective fields for potential publication in this journal in the future, fostering a culture of scholarly contribution and collaboration.
 Dr. Mahesh KarunarathneGuest EditorSpecial Issue Current Scientia (formerly Vidyodaya Journal of Science Special Issue)

Pharmacokinetics of a New Dimethylamineethanol Derivative Administered Orally to Laboratory Animals

A new derivative of dimethylaminoethanol, butanedioic and trans-butenedioic acids (laboratory code ADK-17) was synthesized at the Organic Chemistry Department of the Saint Petersburg State Chemical and Pharmaceutical University (SPSPU). This promising nootropic and anti-asthmatic agent is planned for use in an oral dosage form. The aim was to calculate the pharmacokinetic parameters of the synthesized compound and to determine its possible biotransformation pathways. Rabbits of the Soviet Chinchilla breed were used as a test system in the preclinical study of the compound pharmacokinetics. In accordance with the designed schedule, blood was taken from the marginal vein of the ear, and urine samples were taken. Quantitative determination in biological media was carried out using an Ultimate 3000 liquid chromatograph with a Q-Exactive mass-selective detector with electrospray ionization in accordance with OFS 1.2.1.100015 (Chromatography) of the State Pharmacopoeia by ultra-performance liquid chromatography–mass spectrometry (UPLC-MS). To study the pharmacokinetics of the ADK-17 preparation, a measurement procedure was developed with a detection limit in biological media ranging from 10-6 to 10-3 mg/ml. The determined harmacokinetic parameters show that the absorption of ADK-17 into the systemic circulation from the gastrointestinal tract occurs at an average rate, with its maximum concentration in blood plasma during the oral route of administration being observed between 60–90 min. The elimination half-life from the systemic circulation comprises 4.3 h. Urinary excretion in the first 4 h proceeds at a high rate; however, the compound is detected in the urine within 3 days and in the blood within 2 days from the moment of administration.

CONFORMATIONAL STUDY OF MOLECULES IN A BIOLOGICAL ENVIRONMENT, DESIGN OF INHIBITORS OF HUMAN AMINOPEPTIDASE M1 IMPLICATED IN CANCER THERAPY

Objective: A novel subnanomolar anticancer hydroxamic acid containing drug candidates, inhibitors of human M1 aminopeptidase (APN) a recent validated target and has reached the predicted subnanomolar range of inhibitory potency. Methods: A quantitative structure activity relationships (QSAR) complexation model has been developed from a compounds of 37 hydroxamic acid derivatives (AHD1-37 as training set, TS) to establish a linear correlation between the calculated relative Gibbs free energies (GFE: ΔΔGcom) of APN-AHDx complex formation and the experimental inhibition potency (Kiexp). The predictive power of the QSAR model was then validated first with 9 other AHDs not included in the TS and thereafter with the generation of a 3D-QSAR-PH4 pharmacophore (PH4) model to screen the AHD chemical subspace built as a virtual combinatorial library of more than 58,644 AHD analogs). Finally the best PH4 hits were evaluated with the initial QSAR model for predicted potency (Kipre) and pharmacokinetic profile. Results: The QSAR model linear correlation equation: pKiexp=-0.1901×∆∆Gcom + 8.2886 , R2=0.94, the subsequent PH4 model linear correlation between experiment and PH4-estimated Ki: pKiexp=1.0006× pKipre + 0.0028, R2=0.79 documents the high predictive power of this approach. Finally the screening of the virtual library of AHD analogs yielded 95 orally bioavailable candidates the best reaching a predicted potency (Kipre) of 50 pM and displaying favorable pharmacokinetic profile. Conclusion: The combined use of molecular modeling (QSAR) and in silico PH4-based screening of the hypothetical combinatorial library has resulted in proposed and predicted potent anticancer candidates with a suitable pharmacokinetic profile. Peer Review History: Received: 3 August 2023; Revised: 12 September; Accepted: 25 October, Available online: 15 November 2023 Academic Editor: Dr. Nuray Arı, Ankara University, Turkiye, ari@ankara.edu.tr Received file: Reviewer's Comments: Average Peer review marks at initial stage: 7.0/10 Average Peer review marks at publication stage: 9.0/10 Reviewers: Prof. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye Prof. Dr. A. Hakan AKTAŞ, Süleyman Demirel University, Faculty of Science and Art, Department of Chemistry, Isparta-Turkey, hakanaktas@sdu.edu.tr

Impact of Long-term Use of Fertilizers and Manure on Distribution of Soil-inorganic Phosphorus Fractions in a Vertisol

The field experiment was conducted during the kharif season under the AICRP on Long-Term Fertilizer Experiment at the Research Farm, Department of Soil Science and Agricultural Chemistry, JNKVV, Jabalpur (M.P.), India. The investigation was carried out to assess the distribution of P fractions in Vertisol after the harvesting of the soybean crop. Eight treatments were imposed with four replications in a simple randomized block design. The treatments were applied in combination with different doses of fertilizer viz., T1 (50% NPK), T2 (100% NPK), T3 (150% NPK), T4 (100% N), T5 (100% NP), T6 (100% NPK+FYM), T7 (100% NPK-S), and T8 (control). Through the findings, the soil pH and electrical conductivity (dS m-1) did not show significant changes even after the long-term application of various fertilizer levels compared to their initial values. The treatment with 100% NPK + FYM exhibited the highest organic carbon (g kg-1) content and available N, P, and K (kg ha-1) content over the control. The various forms of phosphorus in the soil were observed in the following order: Ca-P > Fe-P > Al-P > Occluded-P > Saloid-P . The Ca-P content was highest when 100% NPK fertilizer and farmyard manure (FYM) were used together. The analysis showed that the presence of saloid-P significantly influences the availability of phosphorus in Vertisol soil. Based on the current investigation, it is recommended to use integrated nutrient management, which includes both 100% NPK fertilizer and FYM, to prevent phosphorus deficiency in soybean cultivation in Vertisol.

End-to-end Standardization of Original Medicines when Determining Related Impurities

Introduction. For tablets “Malоben, 60 mg” and “Etmaben, 300 mg”, permission was received to conduct phase I clinical trials, so they required a full cycle of research and standardization.Aim. Development of a unified analytical procedure for the determination of related impurities in samples (RS, API, FPP) of Malоben and Ethmaben.Materials and methods. RSs were obtained at the Department of Organic Chemistry of the St. Petersburg State Chemical and Pharmaceutical University; the synthesis of APIs and the production of FPP were carried out on an industrial scale in pharmaceutical production. The studies were carried out on a Flexar liquid chromatograph (PerkinElmer, USA), equipped with a pump (formation of a gradient on the low-pressure side), an autosampler, a column thermostat, a UV detector and a chromatographic column Intersil® ODS-3V, 5 µm, 100 Å, 250 × 4, 6 (Phenomenex, Japan).Results and discussion. In the research, uniform optimal chromatographic conditions were selected using the HPLC method to determine the RP in RS, API and FPP of Maloben and Ethmaben. Column C18 250×4.6 mm, mobile phase 0.1% phosphoric acid and acetonitrile (gradient elution), flow rate 1 ml/min, sample volume 10 µl, UV detector (270 nm). They were validated in terms of specificity, linearity, detection limit, precision, robustness, and solution stability. Analytical concentration levels were selected for the formation of draft regulatory documents. Using the developed analytical technique, samples of RS, API and tablets of malоben and ethmaben were analyzed.Conclusion. A full cycle of research was carried out, an analytical methodology was developed and related impurities were identified in RS, API and FPP of Maloben and Ethmaben.

Reaction Engineering and Comparison of Electroenzymatic and Enzymatic ATP Regeneration Systems

AbstractInvited for this issue's Front Cover are the group of Bioprocess Engineering at TU Dortmund University, Department of Chemistry at Johannes Gutenberg University Mainz, and the Biotechnology Group at Constructor University. The front cover illustrates the electroenzymatic regeneration of ATP. The electrons of an enzymatically catalyzed redox reaction necessary for the ATP regeneration cascade are transferred to an electrode mediated by ferrocenyl‐methanol. Regenerative and green energy can therefore be used to drive the reaction. Cover design by Tobias Prenzel and Finn Moeller. Read the full text of the Research Article at 10.1002/celc.202300332.