Today, there is a trend of intensive growth of chemical protection of plants by pesticides, potentially hazardous to the environment and humans. Accordingly, the risks of poisoning and occupational diseases associated with the use of pesticides in agricultural production are increasing. In Ukraine, a number of laws and regulations on safety regulations have been adopted to regulate legal relations associated with the use of pesticides in agricultural production. State sanitary rules DSP 8.8.1.2.001-98 are the basic normative document, regulating the requirements to transportation, storage and use of pesticides in production. The standards are being developed and approved for more than a quarter of a century, are out-of-date and do not take into account the peculiarities of new technologies. Therefore, taking into account modern requirements of hygienic rationing and new data on toxicological properties of pesticides, the need to harmonize domestic regulations with the requirements of the European Community is growing. Some existing regulations need revision and modernisation. Recommendations for use of personal protective equipment at spraying are analyzed according to DSP 8.8.1.2.001-98 and the safety data sheet of fungicide Akanto® Plus by DuPont International Operations CH-1218 Le Grand Saconnex/GE. Switzerland, designed in accordance with Regulation (EC) No.1907/2006 as amended. Analysis of safety equipment, namely eye and respiratory protection, showed that application of DSP 8.8.1.2.001-98 recommendations for workers of chemical spraying operations is contradictory, which can create hazardous working conditions. For some types of work it is too high requirements, which are difficult to fulfill in real field conditions. Therefore, in Ukraine, the need arose to revise the current regulations and harmonize them with European standards in terms of safety requirements for transportation, storage and use of pesticides.