Lignocellulosic wastes are valuable feedstock in biorefinery thanks to their high sugars content and low level of fibers intricacy. However, their massification is often a limiting parameter in the development of industrial projects. Hence, this study aims to develop an efficient process enabling the conversion of several waste streams within the same process line. Several pretreatment and enzymatic hydrolysis parameters were firstly evaluated with Old Corrugated Cardboards (OCC) as a model substrate. A chemical free pretreatment followed by an enzymatic hydrolysis (Cellic Ctec 3 enzymatic cocktail at 0.06 g of cocktail per g of Total Sugars (TS)) efficiently depolymerized OCC into monomeric sugars (0.50 g/gTS) consequently fermented into ethanol (0.24 g/gTS). Then, the suitability of this process was validated for sugars production from Pulp and Paper (P&P) sludge (0.48 g/gTS), sieved toilets papers (0.40 g/gTS), the Organic fraction of municipal solid waste (0.37 g/gTS) and Waste Wood B (0.08 g/gTS).