Chemical Peels Research Articles

A Comprehensive Bibliographic Review Concerning the Efficacy of Organic Acids for Chemical Peels Treating Acne Vulgaris.

Acne vulgaris stands out as the most prevalent skin disorder among teenagers and young adults, causing physical discomfort and considerable economic and psychological burdens on individuals and society. A wide range of topical and systemic therapies are available in acne treatment. Chemical peeling is a skin resurfacing technique designed to rebuild healthy skin using exfoliating substances, a simple and affordable process with various dermatological uses. Chemical peels, classified as superficial, medium, and deep, have been utilized for acne vulgaris and multiple other skin issues. In these chemical peels, a diverse range of chemical substances is employed, each with its unique mode of action. Among these, α-hydroxy and β-hydroxy acids have gathered attention for their efficacy in reducing acne lesions and enhancing overall skin appearance. Acids, such as salicylic acid, glycolic acid, or lactic acid, are commonly used in chemical peels due to their exfoliating and sebum-regulating properties. Despite the widespread use of these acids, there exists a lack of consensus regarding the most effective acid type and concentration for treating acne-prone skin. This review aims to bridge this knowledge gap by evaluating the effectiveness and safety of various organic acids used in chemical peels specifically for acne-prone skin. The findings of this comprehensive bibliographic review indicate that organic acid-based chemical peels represent effective and safe treatment options for individuals with acne-prone skin. Their adaptability sets these treatments apart; the choice of organic acid can be tailored to meet individual patient needs and tolerability levels. This personalized approach ensures that patients receive optimal care while minimizing the risks associated with the treatment. As research in this field progresses, it is anticipated that a more nuanced understanding of the ideal acid type and concentration will emerge, further enhancing the efficacy and safety of chemical peels for acne-prone skin.

Comparative Efficacy of Chemical Peeling Agents in the Treatment of Melasma.

Melasma is a complex skin disorder characterized by brown or dark patches, primarily affecting facial areas. Despite numerous treatment options, the effective management of melasma remains challenging. This study aims to fill a gap in the literature by rigorously comparing the effectiveness of three prevalent chemical peeling agents, 15% trichloroacetic acid (TCA), 15% phenol, and 2% glycolic acid, in treating melasma. A randomized controlled trial was conducted involving patients who were clinically diagnosed with melasma. Participants were divided into three groups, each receiving one of the chemical peeling treatments. The primary measure of efficacy was the Melasma Area and Severity Index (MASI) score, recorded before and after the treatment series. Side effects were also documented and analyzed. Preliminary findings suggest a significant reduction in MASI scores in the group treated with 15% TCA peel. The average MASI score reduction was 8.5 points for the TCA group, 6.0 points for the phenol group, and 5.2 points for the glycolic acid group. Side effects such as redness and mild irritation were noted but were least prevalent in the TCA group. Our study indicates that 15% TCA peel is not only effective but also comparatively safer in treating melasma. It shows a more rapid and significant improvement in reducing melasma symptoms than 15% phenol and 2% glycolic acid peels. However, further research is warranted to validate these findings over a larger population.

Chemical Peeling with Trichloroacetic Acid in Skin Treatment: Review Study

Chemical Peeling with Trichloroacetic Acid in Skin Treatment: Review Study

Effectiveness of various organic peels in facial rejuvenation and treatment of sensitive skin

The problems with adverse effects of conventional treatments for a range of dermatological conditions have led scientists to search for new compounds of therapeutic value. Efforts have included the evaluation of natural products such as manuka honey, black olives, citrus extracts , pumpkin enzyme extracts for example, has been scientifically recognized for its anti-microbial and skin rejuvenation properties and is now used clinically as a part of medi-facials or as basic low strength peels for skin rejuvenation and for those with sensitive skin. We evaluated the effects of various organic peels on sixty patients over a period of six months by using a grading scale for following skin characteristics post peel procedure; smoothness, firmness, even coloration, normal texture and absence of active skin infections. The overall score in current study was showed that the effectiveness of mandelic peel was more when compared with other organic peels which showed significant difference (p value 0.033). Keywords: sensitive skin; organic peels; medifacials; black olive; manuka honey; pumpkin peel; citrus peel; chemical peels

Effect of the use of foam for skin regeneration "SUN-EKT®" on the processes of skin regeneration after cosmetic procedures and removal of tumors

The study was conducted to evaluate the effectiveness of foam for skin regeneration "SUN-EKT®" in cosmetology practice after removal of neoplasms, exposure to chemical peeling or the irritating effect of cosmetology and hardware procedures. 107 patients were examined after the removal of neoplasms and/or irritating procedures, who were divided into 3 groups: І included 38 patients who used "SUN-EKT®" for skin regeneration, ІІ – 33 patients who used "Panthenol", ІІІ – 36 patients who used other regenerative means or expected self-healing of injuries. The indicators of hydration of the stratum corneum, the 10-point scale of pain sensation (Numerical Rating Scale), applied dermatoscopy and skin analyzer were studied in comparison. In the І group, the intensity of pain was 5.9 points on the 1st day from the start of using "SUN-EKT®", 4.3 – on the 3rd day, 2.8 – on the 7th day. For comparison, in the II group this indicator was 6.8, 6.1 and 3.7; and in the III group – 7.7, 7.1 and 5.9 points in the corresponding terms. The average value of the "hydration of the stratum corneum" indicator in the I group on the 1st day from the start of using "SUN-EKT®" was 23.2; after 3 days – 27.6; after 7 days – 32.1, i.e. increased by 38.4% over 7 days. For comparison, in II and III groups it was 21.1; 22.3; and 27.1, as well as 18.4; 19.6; and 22.7 in the corresponding periods, and increased by 28.4% and 23.4%, respectively. Non-invasive skin monitoring revealed a gradual decrease in manifestations of hyperemia, edema, and hypervascularity within 7 days in all three groups, but the rate of recovery was the fastest in group I and the slowest in group III. It was concluded that according to all indicators, the healing process was the best in the I group, which allows us to recommend "SUN-EKT®" for wide use. Keywords: wounds, burns, laser epilation, healing, injection and hardware cosmetology.

Using pectinase enzymatic peeling for obtaining high-quality Huyou (Citrus changshanensis) segments

Huyou (Citrus changshanensis) is a toothsome and nutritious fruit, but its consumption is hindered due to the nonedible segment membranes. The use of pectinase in citrus peel hydrolysis has proven to be an effective strategy for obtaining high-quality citrus segments. In this study, Huyou segments were obtained by three different methods: hand peeling (HP), enzymatic peeling (EP), and chemical peeling (CP). The analysis focused on evaluating the chemical constituents, bitter substances, and color properties of the segments following various treatments. Scanning electron microscopy characterization and molecular docking assays verified the enzyme-substrate interaction during the enzymatic hydrolysis of segment membranes. Notably, the EP treatment maintained the natural color of the segments (∆E ≤ 2) and preserved more than 97% of the total soluble sugars. Furthermore, EP treatment exhibited greater advantages in preserving the major flavonoids without increasing the concentration of the bitter-causing compound, limonin. Conversely, CP treatment resulted in the decline of flavonoids. Hence, EP treatment had little effect on the physicochemical quality of citrus segments, which signifies its potential as a promising alternative to the traditional CP method for producing high-quality citrus segments.

41113 The use of chemical peels for nail surface rejuvenation

41113 The use of chemical peels for nail surface rejuvenation

The Relation between the Perception of Medical Skin Care and the Treatment of Skin Problems: The people with medical skin care experience in Harbin, China

Medical skin care is a system that treats problematic skin as a specialized management by performing medical treatment and skin care at the same time through correct skin diagnosis, and has a high degree of reliability in surgical methods. Therefore, the relationship between problematic skin conditions and treatment methods according to the perception of medical skin care was verified for those with experience in medical skin care. The study consisted of a total of 69 questions, including 8 questions on general characteristics, 23 questions on perceived problem skin conditions, 6 questions on treatment methods for problematic skin, 11 questions on medical skin care awareness, and 21 questions on medical skin care satisfaction. A total of 410 questionnaires were used from December 21, 2020 to January 9, 2021 were anaiyzed WeChat and the Wenjuanxing program. Data analysis was performed using SPSSWIN 21.0 program with Frequency analysis, Reliability test, Cronbach's  coefficient, Descriptive statistical analysis, and one-way ANOVA was also conducted. Among the subjects of the survey, female (67.8%), university (first degree), married (51.7%), students(occupation). Recognition of problematic skin conditions acne (25.6%), melasma pigmentation (24.4%), sensitivity and telangiectasia (18.6%). The self-awareness of problematic skin conditions, acne (25.6%) is the hightest, problematic skin surgical methods MTS (31.0%) for acne, chemical peeling (29.1%) for pores and scars, laser (36.5%) for pigmentation, and injection therapy (20.5%) for wrinkles and skin elasticity. The degree of awareness of medical skin care high awareness (31.2%), medium awareness (38.5%), low awareness (30.2%). The difference in perceived problem skin condition according to medical skin care awareness was high in the high group and normal group for melasma and pigmentation skin, and the lower group has a higher awareness of acne skin. According to different awareness of medical skin care the awareness of physical peeling for acne, laser treatment for pores, scars and pigmentation, injection therapy for wrinkles and skin elasticity, laser treatment for sensitivity skin, and MTS for extremely dry skin was found to be more higher. As for the difference in medical skin care satisfaction according to the recognition of medical skin care, there was no difference in satisfaction of facilities and environment, effects, services, and economic costs. With the awareness of medical skin care, the difference in satisfaction with medical skin care is higher in the group, and the satisfaction with products and surgery is significantly higher. The above results showed that in the group with higher awareness of medical skin care, melasma pigmentation and acne skin, the surgical method was melasma pigmentation skin laser, and the MTS of acne skin was higher. In addition, medical skin care has high satisfaction in terms of products and surgery.

Comparison of mechanical dermabrasion and CO2 laser in cultured epithelial sheets transplantation in the treatment of refractory stable vitiligo: A multicenter, prospective and self‐controlled comparative study

AbstractBackgroundVitiligo is an acquired depigmented disorder that causes great damage to patient's appearance and mental health. Surgical treatment plays a vital role in patients with refractory vitiligo. Recipient‐site preparation (such as liquid nitrogen, mechanical dermabrasion, chemical peeling and laser) is a key step in surgical treatment. Among them, mechanical dermabrasion and CO2 laser can achieve accurate ablation in different parts and depths.ObjectivesTo compare the advantages and disadvantages of mechanical dermabrasion and CO2 laser and their preference for different parts in cultured epithelial sheets transplantation for the treatment of vitiligo.MethodsWe used a self‐controlled study to compare the efficacy of mechanical dermabrasion and CO2 laser in 120 stable vitiligo patients of different parts at different time points after cultured epithelial sheets transplantation.ResultsNo overall difference between the mechanical dermabrasion group and the CO2 laser group. While the recovery rate of different parts of the mechanical dermabrasion group was significantly different (p < 0.05). Two methods have distinct efficacy for different parts, and CO2 laser is better at treating uneven parts.ConclusionsBoth mechanical dermabrasion and CO2 laser have good results in cultured epithelial sheets transplantation for the treatment of vitiligo.

A multicentric, prospective, observational study evaluating the use patterns of Sebium night peel for acne-prone skin and associated conditions

Background: Acne is a common skin disorder that affects both adolescents and adults and is categorized as an inflammatory dermatosis. Persistent adult acne is prevalent in more than 80% of cases. Chemical peels are widely used in acne therapy due to their various benefits, including exfoliation, acne lesion reduction, complexion radiance improvement, and scar repair. The procedure, consisting of 2 to 8 sessions, is ideal for adult women with oily skin, acne breakouts, and concerns about photoaging and complexion radiance. Methods: A cohort of Indian dermatologists were provided a questionnaire related to the quantum of weekly acne patients seen and their clinical expertise regarding the use of Sebium Night Peel containing 15% glycolic acid, the Fluidactiv™ patented complex & D-panthenol. These results were later analyzed using a standardised visual analogue scale. Results: The study enrolled 826 patients, and complete responses were received from 73 dermatologists practicing clinical and aesthetic dermatology across major cities in India. The study revealed that 97% of dermatologists would recommend the Sebium Night Peel as a chemical peel for patients with acne and acne-related complications. The majority of dermatologists rated the peel's tolerability and safety as "good" across various evaluation criteria. Additionally, 97% of dermatologists reported no safety concerns associated with the Sebium Night Peel. Conclusions: This study establishes the Sebium Night Peel as a preferred and effective chemical peel for managing acne-prone skin and associated conditions, as endorsed by dermatologists across India.

Comparative Study of Polydioxanone Monofilament (PDO) Threads Combined with Scar Subcision versus Fractional CO2 Laser Combined with Scar Subcision in Management of Atrophic Post Acne Scars

Abstract Background Acne is an inflammatory disorder of the pilosebaceous unit characterized by comedones, inflammatory papules, pustules, and nodules of the face, chest, and back. The inflammatory response in some acne patients results in permanent, disfiguring scars from either increased tissue formation or due to loss or damage of tissue. Many treatments have been attempted in order to improve acne scarring such as: chemical peels, surgical excision, subcision, punch grafting, dermabrasion, fillers and laser have been used to ameliorate atrophic acne scars with varying degrees of success Objectives The aim of this work was to study the efficacy of polydioxanone (PDO) monofilament threads combined with scar subcision versus fractional Co2 laser combined with scar subcision in management of atrophic acne scars. Patients and Methods This is a split-face pilot study included 10 patients with atrophic acne scars. The patients recruited from the Outpatient Dermatology Clinic at Ain Shams University Hospitals. Fractional CO2 laser sessions were done for the right side of the face (2 sessions - one month apart), and Polydioxanone (PDO) threads were inserted to the left side of the face (2 sessions - one month apart), each treatment modality was preceded by scar subcision. The patients were followed up for 3 months. The response of treatment was evaluated by Antera 3D camera. Results Our study revealed that treatment of the right side of the face with fractional CO2 Laser led to statistically significant improvement more than what was achieved by PDO threads on the left side. It was also found that both PDO monofilament threads and Fractional Co2 laser improved the skin texture. Conclusion .The current study confirmed the superiority of fractional CO2 laser for the management of atrophic post acne scars. Polydioxanone threads had an effect in improving the skin texture but their overall effect is not comparable to the effect of fractional CO2 laser. To the best of our knowledge, we were the first to compare between Fractional Co2 laser and poydioxanone threads regarding there efficacy in management of atrophic acne scars and to evaluate the response using Antera 3D camera.

Treatment of actinic keratoses in older adults

Actinic keratoses (AKs) are common precancerous skin lesions that primarily affect older adults due to cumulative sun exposure. Given the increased vulnerability of older adults to developing AKs, appropriate therapeutic strategies are crucial to prevent their progression to invasive squamous cell carcinoma. This comprehensive review aims to explore the various treatment modalities available for AKs in the elderly population, focusing on their efficacy, safety, and suitability for this specific age group. The article discusses topical treatments, cryotherapy, photodynamic therapy, chemical peels, and surgical interventions, providing adetailed analysis of their mechanisms of action, benefits, limitations, and considerations in geriatric patients. Furthermore, the importance of individualized treatment plans, considering factors such as comorbidities, medication interactions, and patient preferences, are highlighted.

Cosmetic therapies for Chinese patients with acne taking concomitant or recent intake of oral isotretinoin: A retrospective study.

The current standard recommendation is to initiate the cosmetic therapies after discontinuing taking oral isotretinoin for at least 6 months. However, this recommendation has been questioned in several recent publications, and it is difficult to operate in clinical practice as early initiation of effective treatment is desirable for patients with acne sequelae. The purpose of this study is to evaluate the efficacy and safety of chemical peeling and light/laser or radiofrequency treatments combined with oral isotretinoin for patients with acne vulgaris and acne scars. A retrospective study of 511 patients on/or recently administered with isotretinoin treated with glycolic acid, intense pulsed light, nonablative fractional laser, fractional radiofrequency, and ablative carbon dioxide laser. A total of 1352 interventions were performed. The medical follow-up lasted for at least 1 year. The efficacy and safety of different procedures were evaluated. A total of 511 patients, who were treated with isotretinoin orally or stopped for <6 months, received 477 sessions of glycolic acid chemical peeling treatment, 588 sessions of intense pulsed light treatment, 61 sessions of nonablative fractional laser treatment, 101 sessions of fractional radiofrequency treatment, and 125 sessions of ablative fractional carbon dioxide laser treatment. No hypertrophic scars and keloids were found, and the incidence of serious adverse reactions such as scarring, erythema, blisters, and postinflammatory hyperpigmentation did not increase. It is safe to perform skin procedures in patients with acne and acne scars during or after discontinuation of isotretinoin for <6 months. Invasive treatments such as ablative fractional carbon dioxide laser treatment can be performed, as appropriate, by an experienced physician. The guideline of avoiding chemical and physical procedures in such patients taking oral isotretinoin should to revised.

Melasma: A Homoeopathic Approach

Melasma is an acquired pigmentary disorder. Its Pathogenesis is complex and involves the interplay of various factors, such as genetic predisposition, UV radiations, hormonal factors &amp; drugs. It is characterized by symmetrical hyperpigmented macules on face. Tropical bleaching agents, chemical peels have been shown to provide only minimal improvement in condition. It can generally affect a patient’s quality of life by causing embarrassment, fear of negative appraisal, frustration by discoloration. There are numerous effective homoeopathic treatments for melasma, but the choice is specific to the patient and takes into account both the patient's physical and mental symptoms. Homoeopathy has an individualistic and holistic approach prescription according to a different type of clinical presentation of cases. Keywords: Hyperpigmentation, Melasma, Pigmentary disorders, Chloasma, Homoeopathy.

Insights on in-office scar revision and resurfacing procedures.

Many facial plastic surgery procedures can be performed in an office-based setting, ranging from simple chemical peels to reconstructive surgeries to assist with scar revision. The aim of this review is to summarize the current state of facial plastics in-office surgical procedures, including scar revision, dermabrasion, lasers, and chemical peels. A literature review was conducted with the PubMed search engine with the following keywords: facial plastics, scar revision, dermabrasion, lasers, chemical peels, face, office, and outpatient. The literature was surveyed for relevance, with a focus on realistically which procedures were performed in a facial plastics surgery outpatient clinic. These were then used to compile a review of the current state of this field. There are various scar revision procedures that can be performed in the office setting, including z-plasty, w-plasty, and geometric broken line closure techniques, as well as various nonmedical treatment options to improve the appearance of a scar. Dermabrasion can also be performed to assist with elevated scars. Various lasers are available to enhance cell turnover in the field of facial rejuvenation, scarring, and sun damage. Chemical peels are also available to assist with facial rejuvenation. With the appropriate counseling of the patient and medical staff, these can be safely performed in the office.

Skin of color repigmentation after phenol-croton oil chemical peel

Skin of color repigmentation after phenol-croton oil chemical peel

Practice Patterns: An American Society of Plastic Surgeons (ASPS) Member Survey, 2000 and 2020-How Much Has Brow Lifting Changed?

In 2001, Elkwood and Matarasso published an American Society of Plastic Surgeons (ASPS) member survey detailing brow lift practice patterns. Interval changes in practice patterns have not been studied. The previous survey was revised to elucidate current trends in brow lift surgery. A 34-question descriptive survey was distributed to a random group of 2360 ASPS members. Results were compared to the 2001 survey. A total of 257 responses were collected (11% response rate; ± 6% margin of error at 95% CI). The most frequent technique for the correction of brow ptosis in both surveys was the endoscopic approach. The use of hardware fixation has increased in endoscopic brow lifting, whereas the use of cortical tunnels has decreased. Although coronal brow lifting has decreased in frequency, hairline and isolated temporal lift have increased. Neuromodulators have replaced resurfacing techniques as the most common nonsurgical adjunct. Frequent use of neuromodulators has risen from 11.2% to 88.5%. Nearly 30% of current surgeons feel that neuromodulators have replaced formal brow lifting procedures to a significant degree. In comparing the 2001 and current ASPS member survey there has been a clear transition to less invasive procedures over time. Although the endoscopic approach was the most popular means of forehead correction in both surveys, coronal brow lifting has decreased in frequency and the hairline and temporal approaches have increased. Neurotoxins have replaced laser resurfacing and chemical peeling methods as an adjunct, and in some cases replaced the invasive procedure entirely. Possible explanations for these findings will be discussed.

The Role of Chemical Peels in Trauma Patients: Accelerating Skin Healing and Restoring Confidence

The Role of Chemical Peels in Trauma Patients: Accelerating Skin Healing and Restoring Confidence

Treatment of acne in the aesthetic patient: A round table update.

The popularity of social media appears to be increasing the acceptance of cosmetic treatments, prompting more consumers to seek cosmetic treatments. As the estimated prevalence of acne vulgaris among adult women may be as high as 54%, acne is commonly observed among patients presenting for cosmetic treatments. Concomitant treatment of acne in the aesthetic patient population will improve overall clinical outcomes. The goal of this work was to deliver a high-quality ethical and evidence-based educational program to physicians and adjunctive health care providers to advance patient care. This paper is based on a webcam presentation with roundtable discussion by several notable experts in their field. A range of topical medications, injectable products, chemical peels, and energy-based devices are available for treating acne vulgaris. In most instances, these are compatible with rejuvenation procedures in the aesthetic patient. The growth of social media is raising awareness of aesthetic procedures and appears to be increasing the number of patients seeking aesthetic treatment. Educating patients about the importance of treating acne vulgaris can improve overall treatment outcomes. In most instances, the presence of acne is not a barrier to aesthetic care.

Unveiling the mystery of Riehl's melanosis: An update from pathogenesis, diagnosis to treatment.

Riehl's melanosis is a hyperpigmentation disorder that has a significant psychological and social impact on individuals. In the past 10 years, new categories have been developed, raising questions about how to classify Riehl's melanosis. The mechanism of this disease remains unclear, although the type IV hypersensitivity response caused by allergic sensitization, as well as genetic, ultraviolet radiation, and autoimmune factors, is to blame. Clinical manifestation, dermoscopy, reflectance confocal microscopy, patch/photopatch testing, histopathology, and a novel multimodality skin imaging system have been used for the diagnosis. A variety of therapies including topical skin-lightening agents, oral tranexamic acid, glycyrrhizin compound, chemical peels, and lasers and light therapies (intense pulsed light, 1064-nm Q-Switched Nd: YAG laser, 755-nm PicoWay laser, nonablative 1927-nm fractional thulium fiber laser, new pulsed-type microneedling radiofrequency), with improved effectiveness. The latest findings on possible biomarkers and their relationship to other autoimmune diseases were also summarized.