This paper presents a general chlorine metabolic model at industrial parks' level and takes one chemical industrial park in China as a case study. The general metabolism model of chlorine in industrial parks consists of 4 subgroups. Subgroup-1 is mainly composed of industries utilizing NaCl as the major chlorine source. Subgroup-2 includes chemical industries with Cl2 as the major chlorine source. Subgroup-3 uses HCl as the major chlorine source and subgroup-4 implies the effluent treatment engineering. The chlorine metabolic pattern illustrates the main flow routes of chlorine in chemical industrial parks and demonstrates that Cl2 and HCl are the key nodes in these routes. The model is employed to investigate the Cl stream of a typical chemical park in China. The maximum flux route of chlorine is the polyvinyl chloride (PVC) production path: NaCl→Cl2→HCl→PVC. The relatively low resource efficiency (RE) of chlorine for the whole park (55.47%) indicates huge chlorine losses during production, which may be due to the outflow of by-products and effluents containing Cl. Four scenarios, direct utilization of HCl, conversion of HCl, Cl− recycle and the integrated scenario, are proposed to raise the RE of the park, achieving the maximum rise of RE from 55.47% to 83.69%.