The synergistic interaction between Polypyrrole/Molybdenum disulfide at the interface makes their nanocomposites ideal for gas sensing applications. In this work, PPy/MoS2 (1wt%, 5wt%, 10wt%, 20wt% and 30wt%) based nanocomposites have been prepared by in-situ chemical oxidative polymerization of pyrrole. In these nanocomposites, pyrrole acts as a matrix component and MoS2 as filler, which is finally loaded on interdigitated electrodes. In a significant development for large-scale production, the gas sensor fabrication process was designed to be both cost-effective and easy to operate. This paves the way for wider commercialization. The optimized sensor made from PPy and MoS2 with 5wt% of MoS2, demonstrates excellent sensing performance. It has a sensitivity of 21.65% for 100 ppm gas exposure, along with fast response and recovery times of 340seconds and 680seconds, respectively. It also shows a high response towards NH3 compared with pure PPy. In addition, high repeatability and long-term stability of prepared nanocomposites have also been observed over a concentration range of 10-200 ppm. This material stands out for its strong response to ammonia gas compared to other detectable gases. These results render the PPy/MoS2 nanocomposite a promising candidate for high-performance NH3 sensing at 28 ̊C. The underlying sensing mechanism of the PPy/MoS2 sensing device towards NH3 gas was systematically discussed which is attributed to the synergistic effect of binary nanocomposites.