The H-abstraction reaction between methoxyflurane (CH3OCF2CHCl2) and OH radical is studied by employing the DFT-based M06-2X/6-311++G(d,p) method along with kinetic calculations by using the transition state theory (TST) and Eckart’s tunneling correction. The H-abstraction from the –CHCl2 group is found to be the most favorable reaction channel both kinetically and thermodynamically at lower temperature region. The rate coefficients for the title reaction are computed over a temperature range of 250–500 K and found to agree well with the available experimental values. Atmospheric lifetime, Radiative efficiency and Global Warming Potential (GWP) of CH3OCF2CHCl2 are also reported to highlight its atmospheric impact.