Introduction. The presidency of Emmanuel Macron during 2017–2023 was marked by the crisis of the regime of the Fifth Republic in France. The authors propose an analysis of the origins and development of this crisis. They emphasize the complex nature of the crisis, which is not opportunistic but systemic. Materials. The research is based on the data of sociological surveys, periodical materials, and electronic sources that allow us to characterize the course and current state of the political crisis of the regime of the Fifth Republic during the presidency of Emmanuel Macron, as well as the processes accompanying it. Analysis. The authors identify and analyze the manifestations of Gaullism as an anti-crisis strategy in the policy of E. Macron. The authors are describing and analyzing the growing political crisis under the leadership of E. Macron and the causes of his government failure. The authors compare the policy of E. Macron and the political strategy of Charles de Gaulle. Results. The authors conclude that E. Macron’s selective use of elements of the Gaullist strategy in order to further legitimize and strengthen the regime of personal power does not bring final success and that French society’s trust in the current government is gradually decreasing, which contributes to the deepening of the systemic crisis of the regime of the Fifth Republic. Author’s contribution. Ahmad Mulyadi prepared a material on the use of elements of Gaullism in the politics of E. Macron, S. V. Biryukov, and S. N. Chirun – on the political process and the crisis in France.