Characterization Of Novel Ionic Liquid Research Articles

The Development and Characterization of Novel Ionic Liquids Based on Mono- and Dicarboxylates with Meglumine for Drug Solubilizers and Skin Permeation Enhancers.

In this study, we synthesized a family of novel ionic liquids (ILs) with meglumine (MGM) as cations and tartaric acid (TA), azelaic acid (AA), geranic acid (GA), and capric acid (CPA) as anions, using pharmaceutical additives via simple acid-base neutralization reactions. The successful synthesis was validated by attenuated total reflection-Fourier transform infrared (ATR-FTIR) and powder X-ray diffraction (PXRD). Thermal analysis using differential scanning calorimetry confirmed the glass transition temperature of MGM-ILs to be within the range of -43.4 °C--13.8 °C. We investigated the solubilization of 15 drugs with varying pKa and partition coefficient (log P) values using these ILs and performed a comparative analysis. Furthermore, we present MGM-IL as a new skin permeation enhancer for the drug model flurbiprofen (FRP). We confirmed that AA/MGM-IL improves the skin permeation of FRP through hairless mouse skin. Moreover, AA/MGM-IL enhanced drug skin permeability by affecting keratin rather than stratum corneum lipids, as confirmed by ATR-FTIR. To conclude, MGM-ILs exhibited potential as drug solubilizer and skin permeation enhancers of drugs.

Synthesis and characterization of novel ionic liquids based on imidazolium for acid corrosion inhibition of aluminum: Experimental, spectral, and computational study

Three newly ionic liquids namely, 1-bnzyl-2-methyl-3-octyl-1H-imidazol-3-ium bromide, 1-bnzyl-3-decyl-2-methyl-1H-imidazol-3-ium bromide, and 1-bnzyl-3-dodecyl-2-methyl-1H-imidazol-3-ium bromide are synthesized and their chemical structures characterized via different spectra techniques (FT-IR, elemental analysis,and 1H NMR). The corrosion inhibition of newly ionic liquids was evaluated on aluminum alloy in 1 M HCl at varied exposure temperatures (298–318 K) and varied concentrations via various experimental and theoretical methods for example mass loss, electrochemical, spectral, and computational calculations. The results illustrate that these types of ionic liquids inhibit corrosion of aluminum in acid solution with maximum inhibition efficiency was reached 83.2 % at 298 K. The inhibition efficiency increases with the addition of zinc sulfate which has a synergistic impact which was reached to 92.7%. Also, the concentration of ionic liquids and the kind of cation have an impact on the obtained results. The existence of these inhibitors in the acidic solution improves the charge transfer resistance and lessens the double-layer capacitance. The Langmuir adsorption isotherm governs the adsorption of these inhibitors' molecules on the aluminum alloy surface, and they behave as mixed-type inhibitors. The outputs reveal that the computational calculations match the experimental data rather well.

Synthesis and Structure modification of Ionic Liquids to optimize their Thermoelectric Properties

Ionic Liquids (IL) are organic salts with melting temperature typically below 100 °C. The unique properties of ionic liquids such as their excellent chemical and thermal stabilities, their low vapor pressure, their important ionic conductivity makes them interesting compounds in material science and especially in thermoelectric generators (TEGs) for medical, pharma, or electronic applications. A big advantage of ILs is the endless number of cation/anion combinations, which allows synthesizing task-specific ionic liquids for TEG applications. This paper describes the synthesis, physical and electrochemical characterization of novel IL for application in thermoelectric generators (TEGs). We discuss the optimization of the chemical structure of IL regarding their thermoelectric properties via a structure-activity relationship approach. The best ionic liquids are the protic ones with a Seebeck coefficient of 570.24 µV/K for methylammonium trifluoroacetate and -1424.56 µV/K for ethylammonium formate.

Imidazolium-based Mono and Dicationic Ionic Liquid Sodium Polymer Gel Electrolytes

The synthesis and characterization of novel ionic liquid (ILs) based gel polymer electrolytes for application in sodium-ion (Na+) batteries is reported. It comprises a 0.2M solution of NaN(CF3SO2)2 (sodium bis(trifluoromethylsulfonyl) imide) in mono and dicationic imidazolium-based ionic liquids immobilized in a poly(vinylidene fluoride)-hexafluoropropylene copolymer matrix. The membranes offer acceptable ionic conductivity, up to 2.2×10−4 S cm−1 at room temperature, with excellent thermal and electrochemical stabilities. The useful thermal stability reached up 150 °C and decomposition only starts at about 400 °C, while electrochemical stability window comprises from 1.5 V to 5.0 V vs. Na/Na+. Na+ transference values (tNa+) are in the range of 0.1 to 0.5, indicating a contribution of anionic transport (TFSI− anion) and component ions of ionic liquid to the total ionic conductivity. The nature of Na+ coordination and the formation of Na+-complexes were elucidated through Raman spectroscopy. The average number of TFSI coordinated to Na+ (n) allowed to know the contribution of the formed complexes in ionic mobility mechanism in the gel electrolytes. The effect of side chain length in oxyethylene-functionalized imidazolium mono and dicationic RTILs on both structural and electrochemical properties were discussed. Results obtained demonstrate promising characteristics of the membranes, being suitable candidates to be used in rechargeable sodium batteries.

ChemInform Abstract: Synthesis and Characterization of Novel Ionic Liquids: N‐Substituted Aziridinium Salts.

AbstractSome representative compounds of a new family of room‐temperature ionic liquids built from aziridinium cations are prepared.

Synthesis and Characterization of Novel Ionic Liquids: N‐Substituted Aziridinium Salts

Ionic liquids based on three‐membered ring aziridinium cations have been synthesized for the first time using a straightforward synthetic route. N‐butyl‐N‐methylaziridinium bis(trifluoromethanesulfonyl)imide, N‐propyl‐N‐ethylaziridinium bis(trifluoromethanesulfonyl)imide, N‐butyl‐N‐[2‐(2‐methoxyethoxy)ethyl]aziridinium bis(trifluoromethanesulfonyl)imide, N‐butyl‐N‐methylaziridinium dicyanamide, and N‐butyl‐N‐ethylaziridinium dicyanamide were thus obtained in good yields and satisfactory purity and fully characterized.

Preparation and Characterization of Novel Ionic Liquids Based on Schiff Base Cation

AbstractTwo novel ionic liquids, N,N′‐disalicylideneethylenediaminium acetate and N,N′‐disalicylideneethylenediaminium trifluoroacetate, were prepared and characterized by IR, 1H NMR, DTA‐TG and elemental analysis. The experimental results indicate that the new ionic liquids possess lower melting point and higher electrical conductivity. It is noteworthy that the ionic liquids reported herein are the first member of the ionic liquid family with the Schiff base functional group in the cation.

Preparation and characterization of novel ionic liquid based on benzotriazolium cation

Six novel ionic liquids based on benzotriazolium ion were synthesized by an improved method. These ionic liquids were characterized by IR, 1H NMR, and elemental analysis. Their melting point, thermal stability, conductivity, electrochemical window and solubility properties in common solvents were investigated. The results indicate that these ionic liquids show the higher thermal stability (up to 345 °C), the larger electrochemical window of 3 V, the peculiar solubility in traditional solvents and the excellent electrochemical medium in the electrochemical oxidation of naphthalene and ferrocene.