Recording Characteristics Research Articles

Wavelet-Detected Changes in Nocturnal Brain Electrical Activity in Patients with Non-Motor Disorders Indicative of Parkinson's Disease.

Background/Objectives-Parkinson's disease (PD) is the second most common neurodegenerative disorder caused by the destruction of neurons in the substantia nigra of the brain. Clinical diagnosis of this disease, based on monitoring motor symptoms, often leads to a delayed start of PD therapy and control, where over 60% of dopaminergic nerve cells are damaged in the brain substantia nigra. The search for simple and stable characteristics of EEG recordings is a promising direction in the development of methods for diagnosing PD and methods for diagnosing the preclinical stage of PD development. Methods-42 subjects participated in work, of which 4 female/10 male patients were included in the group of patients with non-motor disorders, belonging to the risk group for developing PD (median age: 62 years, height: 164 cm, weight: 70 kg, pulse: 70, BPsys and BPdia: 143 and 80)/(median age: 68 years, height: 170 cm, weight: 73.9 kg, pulse: 75, BPsys and BPdia: 143 and 82). The first control group of healthy participants included 6 women (median age: 33 years, height: 161 cm, weight: 66 kg, pulse: 80, BPsys and BPdia: 110 and 80)/8 men (median age: 36.3 years, height: 175 cm, weight: 69 kg, pulse: 78, BPsys and BPdia: 120 and 85). The second control group of healthy participants included 8 women (median age: 74 years, height: 164 cm, weight: 70 kg, pulse: 70, BPsys and BPdia: 145 and 82)/6 men (median age: 51 years, height: 172 cm, weight: 72.5 kg, pulse: 74, BPsys and BPdia: 142 and 80). Wavelet oscillatory pattern estimation is performed on patients' nocturnal sleep recordings without separating them into sleep stages. Results-Amplitude characteristics of oscillatory activity in patients without motor disorders and the prodromal PD stage are significantly reduced both in terms of changes in the number of patterns and in terms of their duration. This pattern is especially pronounced for high-frequency activity, in frequency ranges close to 40 Hz. Conclusions-The success of the analysis of the electrical activity of the brain, performed over the entire duration of the night recording, makes it promising to further use during daytime monitoring the concept of oscillatory wavelet patterns in patients with non-motor disorders, belonging to the risk group for developing PD. The daytime monitoring system can become the basis for developing screening tests to detect neurodegenerative diseases as part of routine medical examinations.

Time-series clustering of raw recordings of 24-hour ambulatory blood presssure for risk stratification in general population

Abstract Objective 24-hour ambulatory blood pressure measurements (ABPM) is the best out-of-office BP measurement used to refine cardiovascular (CV) risk stratification. Currently, only summary ABPM indexes are used in the clinical practice while the temporal characteristics of the raw BP recordings have not been explored. Therefore, in this study we employed an unsupervised machine learning (ML) algorithm suitable for multivariate time-series analysis to identify distinct BP and heart rate (HR) profiles associated with the incidence of adverse CV events. Design and Method In 1391 community-dwelling individuals (mean age, 46.9 years; 50.97% women), we acquired 24-hour ABPM and clinical data and collected CV events (n=399) on average 22 years later. We employed multivariate dynamic time warping and k-medoids algorithm on the raw recordings of systolic and diastolic BP and HR. To assess the clinical significance of the derived clusters, we compared the clinical characteristics and the incidence of adverse events. We validated the trained model using 24-hour ABPM obtained from external population cohort (n=1137). Results The silhouette score and Dunn index showed that the optimal number of clusters was 4. Across all clusters we observed significant difference in age and sex distribution. Cluster 4 had the worst CV risk factors profiling, with higher office BP and anti-hypertensive medication intake compared to the other clusters. We observed differences in the incidence of adverse events between clusters (Figure), with cluster 1 representing the lowest risk group and cluster 4 the highest. After adjusting for traditional CV risk factors, including office systolic BP, cluster 1 had the lowest risk (HR:0.92; 95%CI:0.84-0.99; P=0.036) and cluster 4 the highest (HR:1.13; 95%CI:1.03-1.24; P=0.006) as compared to the average population risk. The analysis of the external validation cohort revealed similar ABPM patterns and clinical characteristics. Conclusion Employing an unsupervised ML model on the raw ABPM recordings we identified clinically meaningful clusters associated with an increasing cumulative incidence of CV events. This ML analysis paves the way towards utilization of temporal BP and HR information and subsequently optimization of CV risk stratification.

Brunnipila calyculiformis (Schumach.) Baral: A Novel Record for Türkiye

The research subject of this study is a specimen of Brunnipila collected from the Biga (Çanakkale) district in 2024. The specimen, which is characterised by outward facing brown hairs and densely septate hairs with crystals on top, was identified as B. calyculiformis (Schumach.) Baral, as a new record for members of the Ascomycota in Türkiye, based on morphological characters in accordance with the data obtained from field studies and laboratory analyses. In this manuscript the macro- and micromorphological characteristics of the new record were described and illustrated. This new record will contribute to the macrofungal diversity of Türkiye and the distribution of the genus Brunnipila

Development And Application of Magnetic Storage Technology

Magnetic storage technology plays an important role in modern information storage and is the main way of modern information storage. The basic principle is to define the different magnetization states of the magnetic medium as "1" and "0" in the binary, and to realize the storage of information by changing the magnetization state of the magnetic medium. This paper summarizes the basic principle of magnetic storage technology, the characteristics of longitudinal magnetic recording and perpendicular magnetic recording, and their respective advantages. At the same time, this paper also studies the structure, advantages, and development trend of hard disk drives and magnetic random-access memory based on magnetic storage technology. For the frontier of magnetic memory technology, this paper focuses on the physical properties of magnetic Skyrmions and the possibility of magnetic Skyrmions in magnetic memory devices. For the memory using magnetic Skyrmions, topological Hall effect and magnetoresistive effect can be used to complete the writing and reading of information. Finally, this paper is expected to review the importance of magnetic storage technology.

Quantifying and mitigating recorder-induced variability in ecological acoustic indices

Due to the complexity of soundscapes, Ecological Acoustic Indices (EAI) are frequently used as metrics to summarize ecologically meaningful information from audio recordings. Recent technological advances have allowed the rapid development of many audio recording devices with significant hardware/firmware variations among brands, whose effects in calculating EAI have not yet been determined. In this work, we show how recordings of the same landscape with different devices effectively hinder reproducibility and produce contradictory results. To address these issues, we propose a preprocessing pipeline to reduce EAI variability resulting from different hardware without altering the target information in the audio. To this end, we tested eight EAI commonly used in soundscape analyses. We targeted three common cases of variability caused by recorder characteristics: sampling frequency, microphone gain variation, and frequency response. We quantified the difference in the probability density functions of each index among recorders according to the Kullback-Leibler divergence. As a result, our approach reduced up to 75% variations among recorders from different brands (AudioMoth and SongMeter) and identified the conditions in which these devices are comparable. In conclusion, we demonstrated that different devices effectively affect EAI and show how these variations can be mitigated.

Can Patient-centered Education and Pain Management Delivered by Coaches Improve Pain Outcomes After Orthopaedic Trauma? A Randomized Trial.

Pain after orthopaedic trauma is complex, and many patients who have experienced orthopaedic trauma are at increased risk for prolonged opioid utilization after the injury. Patient-centered interventions capable of delivering enhanced education and opioid-sparing pain management approaches must be implemented and evaluated in trauma care settings to improve pain outcomes and minimize opioid-related risks. Does personalized pain education and management delivered by coaches (1) improve pain-related outcomes, (2) reduce opioid consumption, and (3) improve patient-reported outcome measures (Patient-Reported Outcomes Measurement Information System [PROMIS] scores) compared to written discharge instructions on pain management and opioid safety? This clinical trial aimed to examine the effect of a personalized pain education and management intervention, delivered by paraprofessional coaches, on pain-related outcomes and opioid consumption compared with usual care (written discharge instructions on pain management and opioid safety). Between February 2021 and September 2022, 212 patients were randomized to the intervention (49% [104]) or control group (51% [108]). A total of 31% (32 of 104) and 47% (51 of 108) in those groups, respectively, were lost before the minimum study follow-up of 12 weeks or had incomplete datasets, leaving 69% (72 of 104) and 53% (57 of 108) for analysis in the intervention and control group, respectively. Patients randomized to the intervention worked with the paraprofessional coaches throughout hospitalization after their orthopaedic injury and at their 2-, 6-, and 12-week visits with the surgical team after discharge to implement mindfulness-based practices and nonpharmacological interventions. Most participants in the final sample of 129 identified as Black (73% [94 of 129]) and women (56% [72 of 129]), the mean Injury Severity score was 8 ± 4, and one-third of participants were at medium to high risk for an opioid-use disorder based on the Opioid Risk Tool. Participants completed surveys during hospitalization and at the 2-, 6-, and 12-week follow-up visits. Surveys included average pain intensity scores over the past 24 hours measured on the pain numeric rating scale from 0 to 10 and PROMIS measures (physical functioning, pain interference, sleep disturbance). Opioid utilization, measured as daily morphine milligram equivalents, was collected from the electronic health record, and demographic and clinical characteristics were collected from self-report surveys. Groups were compared in terms of mean pain scores at the 12-week follow-up, daily morphine milligram equivalents both during inpatient and at discharge, and mean PROMIS scores at 12 weeks of follow-up. Additionally, differences in the proportion of participants in each group achieving minimum clinically important differences (MCID) on pain and PROMIS scores were examined. For pain scores, an MCID of 2 points on the pain numeric rating scale assessing past 24-hour pain intensity was utilized. We found no difference between the intervention and control in terms of mean pain score at 12 weeks nor in the proportions of patients who achieved the MCID of 2 points for 24-hour average pain scores (85% [61 of 72] versus 72% [41 of 57], respectively, OR 2.2 [95% confidence interval (CI) 0.9 to 5.3]; p = 0.08). No differences were noted in daily morphine milligram equivalents utilized between the intervention and control groups during hospitalization, at discharge, or in prescription refills. Similarly, we observed no differences in the proportions of patients in the intervention and control groups who achieved the MCID on PROMIS Physical Function (81% [58 of 72] versus 63% [36 of 57], respectively, OR 2.2 [95% CI 0.9 to 5.2]; p = 0.06). We saw no differences in the proportions of patients who achieved the MCID on PROMIS Sleep Disturbance between the intervention and control groups (58% [42 of 72] versus 47% [27 of 57], respectively, OR 1.4 [95% CI 0.7 to 3.0]; p = 0.31). The proportion of patients who achieved the MCID on PROMIS Pain Interference scores did not differ between the intervention and the control groups (39% [28 of 72] versus 37% [21 of 57], respectively, OR 1.1 [95% CI 0.5 to 2.1]; p = 0.95). In this trial, we observed no differences between the intervention and control groups in terms of pain outcomes, opioid medication utilization, or patient-reported outcomes after orthopaedic trauma. However, future targeted research with diverse samples of patients at increased risk for poor postoperative outcomes is warranted to ascertain a potentially meaningful patient perceived effect on pain outcomes after working with coaches. Other investigators interested in this interventional approach may consider the coach program as a framework at their institutions to increase access to evidence-based nonpharmacological interventions among patients who are at increased risk for poor postoperative pain outcomes. Smaller, more focused programs connecting patients to coaches to learn about nonpharmacological pain management interventions may deliver a larger impact on patient's recovery and outcomes. Level I, therapeutic study.

Benchtop Performance of Novel Mixed Ionic-Electronic Conductive Electrode Form Factors for Biopotential Recordings.

Background: Traditional gel-based (wet) electrodes for biopotential recordings have several shortcomings that limit their practicality for real-world measurements. Dry electrodes may improve usability, but they often suffer from reduced signal quality. We sought to evaluate the biopotential recording properties of a novel mixed ionic-electronic conductive (MIEC) material for improved performance. Methods: We fabricated four MIEC electrode form factors and compared their signal recording properties to two control electrodes, which are electrodes commonly used for biopotential recordings (Ag-AgCl and stainless steel). We used an agar synthetic skin to characterize the impedance of each electrode form factor. An electrical phantom setup allowed us to compare the recording quality of simulated biopotentials with ground-truth sources. Results: All MIEC electrode form factors yielded impedances in a similar range to the control electrodes (all <80 kΩ at 100 Hz). Three of the four MIEC samples produced similar signal-to-noise ratios and interfacial charge transfers as the control electrodes. Conclusions: The MIEC electrodes demonstrated similar and, in some cases, better signal recording characteristics than current state-of-the-art electrodes. MIEC electrodes can also be fabricated into a myriad of form factors, underscoring the great potential this novel material has across a wide range of biopotential recording applications.

Acute to long-term characteristics of impedance recordings during neurostimulation in humans

Objective. This study aims to characterize the time course of impedance, a crucial electrophysiological property of brain tissue, in the human thalamus (THL), amygdala-hippocampus, and posterior hippocampus over an extended period. Approach. Impedance was periodically sampled every 5–15 min over several months in five subjects with drug-resistant epilepsy using an investigational neuromodulation device. Initially, we employed descriptive piecewise and continuous mathematical models to characterize the impedance response for approximately three weeks post-electrode implantation. We then explored the temporal dynamics of impedance during periods when electrical stimulation was temporarily halted, observing a monotonic increase (rebound) in impedance before it stabilized at a higher value. Lastly, we assessed the stability of amplitude and phase over the 24 h impedance cycle throughout the multi-month recording. Main results. Immediately post-implantation, the impedance decreased, reaching a minimum value in all brain regions within approximately two days, and then increased monotonically over about 14 d to a stable value. The models accounted for the variance in short-term impedance changes. Notably, the minimum impedance of the THL in the most epileptogenic hemisphere was significantly lower than in other regions. During the gaps in electrical stimulation, the impedance rebound decreased over time and stabilized around 200 days post-implant, likely indicative of the foreign body response and fibrous tissue encapsulation around the electrodes. The amplitude and phase of the 24 h impedance oscillation remained stable throughout the multi-month recording, with circadian variation in impedance dominating the long-term measures. Significance. Our findings illustrate the complex temporal dynamics of impedance in implanted electrodes and the impact of electrical stimulation. We discuss these dynamics in the context of the known biological foreign body response of the brain to implanted electrodes. The data suggest that the temporal dynamics of impedance are dependent on the anatomical location and tissue epileptogenicity. These insights may offer additional guidance for the delivery of therapeutic stimulation at various time points post-implantation for neuromodulation therapy.

E-band telecom-compatible 40 dB gain high-power bismuth-doped fiber amplifier with record power conversion efficiency

Multi-band transmission is one of the key practical solutions to cope with the continuously growing demand on the capacity of optical communication networks without changing the huge existing fiber base. However, ultra-broadband communication requires the development of novel power efficient optical amplifiers operating beyond C- and L-bands, and this is a major research and technical challenge comparable to the introduction of the seminal erbium-doped fiber amplifiers that dramatically changed the optical communication sector. There are several types of optical fibers operating beyond C- and L-bands that can be used for the development of such amplifiers, specifically the fibers doped with neodymium, praseodymium, thulium, and bismuth. However, among these, Bi-doped fibers are of special interest as the most promising amplification medium because, unlike the others, different Bi-associated active centers allow amplification in an enormous band of overall width of 700 nm (1100–1800 nm). Such spectral coverage can be obtained by using different host materials, such as aluminosilicate, phosphosilicate, silica, and germanosilicate glasses. Here, we report a novel Bi-doped fiber amplifier with record characteristics for E-band amplification, including the highest power conversion efficiency among telecom-compatible E-band amplifiers reported to date. This bismuth-doped fiber amplifier (BDFA) features a maximum gain of 39.8 dB and a minimal noise figure of 4.6 dB enabled by 173 m Bi-doped fiber length. The maximum achieved power conversion efficiency of 38% is higher than that of L-band Er-doped fiber amplifiers. This performance demonstrates the high potential of BDFA for becoming the amplifier of choice in modern multi-band optical communication networks.

New fossil woods (upper Pleistocene) from the lower-middle Uruguay river basin (South America) reveal the past distribution of Aspidosperma (Apocynaceae)

The present work describes the taxonomic and paleobiogeographic study of two fossil woods related to extant Aspidosperma. The silicified specimens come from the fossil localities of Santa Ana (30°54′S, 57°55′W) and Concordia (31°19′S, 57°59′W), Entre Ríos Province, Argentina, belonging to the El Palmar Formation (Late Pleistocene). This unit represents the sedimentary body of the upper fluvial terrace generated by the Uruguay River in its middle basin in eastern Argentina. The anatomical features that distinguish the woods are growth rings delimited by axial parenchyma and fibers, semi-ring to-diffuse-porous woods; mainly solitary vessels; simple perforation plates; alternate, bordered, and vestured intervessel pits; scarce paratracheal and diffuse apotracheal axial parenchyma; homocellular, and uniseriate to-triseriate rays; non-septate fibers. Climate reconstruction modelled at the regional scale (Ecological Niche Modeling) revealed variations in macroecological diversity patterns of the nearest living relatives (Aspidosperma australe and A. polyneuron) over the last ca. 130,000 years. Optically stimulated luminescence dating of sediments from the upper part of the El Palmar Formation in the type area reveals that the unit spans from the Last Interglacial period (warm substage, MIS marine isotope stage 5a), to the penultimate interglacial (MIS 7). This period was characterized by warmer and wetter conditions than those observed today. The eco-anatomical characteristics of the fossil record reflect this type of environment. The modern analogues of the fossils studied here are now part of the forests that integrate the Atlantic forest and Araucaria forest biogeographic provinces in South America.

Mdpg: a novel multi-disease diagnosis prediction method based on patient knowledge graphs.

Diagnosis prediction, a key factor in enhancing healthcare efficiency, remains a focal point in clinical decision support research. However, the time-series, sparse and multi-noise characteristics of electronic health record (EHR) data make it a great challenge. Existing methods commonly address these issues using RNNs and incorporating medical prior knowledge from medical knowledge bases, but they neglect the local spatial characteristics and spatial-temporal correlation of the data. Consequently, we propose MDPG, a diagnosis prediction model based on patient knowledge graphs. Initially, we represent the electronic visit records of patients as a patient-centered temporal knowledge graph, capturing the local spatial structure and temporal characteristics of the visit information. Subsequently, we design the spatial graph convolution block, temporal self-attention block, and spatial-temporal synchronous graph convolution block to capture the spatial, temporal, and spatial-temporal correlations embedded in them, respectively. Ultimately, we accomplish the prediction of patients' future states through multi-label classification. We conduct comprehensive experiments on two real-world datasets independently and evaluate the results using visit-level precision@k and code-level accuracy@k metrics. The experimental results demonstrate that MDPG outperforms all baseline models, yielding the best performance.

Embracing unity at OMERACT: Valuing equity, promoting diversity, fostering inclusivity

ObjectiveTo increase awareness and understanding of the principles of Equity, Diversity, and Inclusivity (EDI) within Outcome Measures in Rheumatology's (OMERACT) members. For this, we aimed to obtain ideas on how to promote and foster these principles within the organization and determine the diversity of the current membership in order to focus future efforts. MethodsWe held a plenary workshop session at OMERACT 2023 with roundtable discussions on barriers and solutions to increased diversity within OMERACT. We conducted an anonymous, web-based survey of members to record characteristics including population group, gender identity, education level, age, and ability. ResultsThe workshop generated ideas to increase diversity of participants across the themes of building relationships [12 topics], materials and methods [5 topics], and conference-specific [6 topics]. Four hundred and seven people responded to the survey (25 % response rate). The majority of respondents were White (75 %), female (61 %), university-educated (94 %), Christian (42 %), spoke English at home (60 %), aged 35 to 55 years (50 %), and did not report a disability (64 %). ConclusionOMERACT is committed to improving its diversity. Next steps include strategic recruitment of members to the EDI working group, drafting an EDI mission statement centering equity and inclusivity in the organization, and developing guidance for the OMERACT Handbook to help all working groups create actionable plans for promoting EDI principles.

Evaluation of mechanically stabilized earth retaining walls for different soil–structure interaction methods: A review

Abstract The method for soil preservation has been completely revolutionized thanks to internally reinforced walls. Although such walls have gained significant awareness in many parts of the globe, this construction technique has only been extensively utilized lately. The primary reason may be that the costs associated with constructing such walls are likely higher than those associated with constructing conventional externally reinforced walls. The construction methods involved may be excessively time demanding. The term “mechanically stabilized Earth systems” refers to an internally stabilized fill structure that is made up of an unreinforced concrete levelling pad, precast concrete face panel units and coping units, selected granular backfill (reinforced backfill), a subsurface drainage system, and reinforcing elements (high-strength, metallic, or polymeric inclusions) to create a reinforced soil mass which is utilized to stabilize the backfill. The purpose of this article is to provide a historical overview of the mechanically stabilized Earth retaining walls by focusing on the necessary aspects required for their design, as well as to discuss how the change of the characteristics of the soil influences lateral displacements and stress responses that occur under various ground movements. The results of this study lead to the conclusion that the dynamic behaviour of the cantilever wall is very sensitive to the frequency characteristics of the seismic record and the interaction between the soil and the structure.

New Distribution Record and Habitat Characteristics of Stinging Catfish (Heteropneustes nani Hossain, Sarker, Sharifuzzaman and Chowdhury, 2013) from Nepal

New Distribution Record and Habitat Characteristics of Stinging Catfish (Heteropneustes nani Hossain, Sarker, Sharifuzzaman and Chowdhury, 2013) from Nepal

Paleoenvironmental changes during the Late Pleistocene in Buenos Aires province (Argentina), using foraminifera fauna as proxy data

This paper describes the lithological and micropaleontological characteristics of a new record corresponding to the last interglacial for Buenos Aires province. Foraminifera were analyzed from an artificial outcrop 4 m thick (36°34′0.97″ S and 57°22′54.43″ W), from the quarry situated in the town of General Conesa, Buenos Aires province at an approximate elevation of 4 m a.s.l. Benthic foraminifera fauna was constituted by a predominance of calcareous forms represented mostly by the species Buccella peruviana and Ammonia parkinsoniana. The micropaleontological and lithological characteristics of all the sedimentary units involved in this locality suggest deposits associated with a transition from a low-energy shallow intertidal or subtidal zone to a higher-energy beach or supratidal environment. Although, the topographic height does not enable conclusive assignment of the age of this coastal deposit (>79.500 kyr), the environmental conditions could be correlated with the penultimate transgressive event that occurred at the beginning of the Late Pleistocene (MIS 5), which would have occurred in a shallow environment with changes in the marine influence. These findings provide new information that contributes to better understanding of the paleoenvironmental evolution of this region where two marine transgressions and two wind deposits have been recognized.

Simultaneous Dry and Gel-Based High-Density Electroencephalography Recordings.

Evaluations of new dry, high-density EEG caps have only been performed so far with serial measurements and not with simultaneous (parallel) measurements. For a first comparison of gel-based and dry electrode performance in simultaneous high-density EEG measurements, we developed a new EEG cap comprising 64 gel-based and 64 dry electrodes and performed simultaneous measurements on ten volunteers. We analyzed electrode-skin impedances, resting state EEG, triggered eye blinks, and visual evoked potentials (VEPs). To overcome the issue of different electrode positions in the comparison of simultaneous measurements, we performed spatial frequency analysis of the simultaneously measured EEGs using spatial harmonic analysis (SPHARA). The impedances were 516 ± 429 kOhm (mean ± std) for the dry electrodes and 14 ± 8 kOhm for the gel-based electrodes. For the dry EEG electrodes, we obtained a channel reliability of 77%. We observed no differences between dry and gel-based recordings for the alpha peak frequency and the alpha power amplitude, as well as for the VEP peak amplitudes and latencies. For the VEP, the RMSD and the correlation coefficient between the gel-based and dry recordings were 1.7 ± 0.7 μV and 0.97 ± 0.03, respectively. We observed no differences in the cumulative power distributions of the spatial frequency components for the N75 and P100 VEP peaks. The differences for the N145 VEP peak were attributed to the different noise characteristics of gel-based and dry recordings. In conclusion, we provide evidence for the equivalence of simultaneous dry and gel-based high-density EEG measurements.

An Examination of the Historiographic Record in Light of Emperor Wuzong’s Military Defense of Yingzhou, as well as an Assessment of the Special Characteristics of the Veritable Records of the Wuzong Reign

&lt;p&gt;正德十二年，明武宗親征應州，逼退蒙軍。《明武宗實錄》的修纂者認為此戰所費不償、戰功甚少且「乘輿幾陷」。但綜合《實錄》的自相矛盾及各方材料所記，可知「乘輿幾陷」並非事實，其傷亡情況亦有諸多疑點。由於武宗等人要為正德朝的「失德」負責，且應州封功確有冒濫，加上京城曾有皇帝被俘的訛言，於是文官們順此思路，淡化了前者的功績。而世宗為塑造新政及其父子的權威，文臣們又欲借此清洗政敵、重拾威望，使得《明武宗實錄》以揭露武宗的負面形象、批判各類「改制」之事、強調文官的正直與遠見為主要傾向。這體現《實錄》主、客觀性交織的特點，也反映出正、嘉兩朝的政治變動，以及世宗和文官集團所欲塑造的前朝記憶。&lt;/p&gt; &lt;p&gt;&amp;nbsp;&lt;/p&gt;&lt;p&gt;In the twelfth year of the Zhengde reign, the Wuzong Emperor personally led his troops to Yingzhou in defense against the nomadic tribes. However, the editors of the Veritable Records of the Wuzong Reign thought that this war was unremunerative, presented few achievements, and put the emperor in danger. After a comprehensive investigation of the contradictions in the Veritable Records of the Wuzong Reign and other historical sources, we can conclude that the assertion, &amp;ldquo;Emperor Wuzong was nearly captured by the enemy&amp;rdquo; is not factual and that there remain many doubts about the level of casualties. Moreover, Emperor Wuzong was deemed responsible for the &amp;ldquo;lack of moral governance&amp;rdquo; during his reign, and there were rumors in the capital that the emperor had been captured. Thus, the compilers followed this line of thinking and downplayed Wuzong&amp;rsquo;s accomplishments.&lt;br /&gt;In shaping new policies and assuming power from his father, Emperor Shizong directed his ambitious officials who themselves desired to purge their political opponents, to expose Wuzong&amp;rsquo;s negative image and criticize his every reform in their writing of the Veritable Records, during which they emphasized their own integrity and vision. In this respect, the Veritable Records embody the simultaneous interweaving of subjective and objective views and reflect the political changes of the Zhengde and Jiajing reign as well as the attempts of Emperor Shizong and his officials to shape the memory of the previous reign.&lt;/p&gt; &lt;p&gt;&amp;nbsp;&lt;/p&gt;

Dupilumab in chronic rhinosinusitis with nasal polyps: Real life data in a multicentric Sicilian experience

ObjectiveThis study aimed to evaluate the effectiveness and safety of dupilumab during the first year of treatment in a real-life setting, focusing on improvement in nasal polyp score (NPS) as well as specific symptoms, quality of life and olfactory function. Methodology/principalA multicentric observational cohort study was carried out. A total of 170 patients were enrolled in the Otorhinolaryngology Unit of the three University Hospitals and considered for dupilumab therapy. All recorder characteristics were age (at the first dupilumab application visit), sex, smoke habits, previous local and systemic corticosteroid therapy, history of endoscopic sinus surgery, number of previous endoscopic sinus surgery, concomitant asthma, history of an allergic condition, immunoglobulin E (IgE), allergy to nonsteroidal anti-inflammatory drugs (NSAIDs), Aspirin Exacerbated Respiratory Disease (AERD), other comorbidities associated, blood eosinophils, nasal polyp score, sinonasal outcome test 22 (SNOT 22), sniffin' stick test, the start date of dupilumab therapy and number of doses of dupilumab and eventually, Dupilumab's adverse events related to administration. The Wilcoxon test for dependent samples was performed to compare variables. Statistical significance was assumed for p values < 0.05. ResultsA statistically significant reduction in SNOT-22 and NPS was shown at the 6th and 12th month compared to baseline values (p < 0.001 for both comparisons). A statistically significant increase value at the Sniffin' sticks test was shown in the 6th and 12th month compared to baseline values (p < 0.001 for both comparisons).At the 12-month follow-up, according to EUFOREA indications, all patients were considered to remain in treatment with dupilumab and continued the treatment because of a reduced NPS, improved quality of life and a reduced need for system corticosteroids.Dupilumab seemed to be well tolerated by all patients. Any adverse effect of the drug led to the quit of biological treatment. ConclusionsThis multi-centric real-life study supported the effectiveness of dupilumab as an add-on therapy to intranasal corticosteroids in patients with severe uncontrolled CRSwNP in improvement of quality of life, severity of symptoms, polyp size reduction and smell function. Furthermore, our data support the safety profile of monoclonal therapy with dupilumab.

Dorsal subthalamic nucleus targeting in deep brain stimulation: microelectrode recording versus 7-Tesla connectivity.

Connectivity-derived 7-Tesla MRI segmentation and intraoperative microelectrode recording can both assist subthalamic nucleus targeting for deep brain stimulation in Parkinson's disease. It remains unclear whether deep brain stimulation electrodes placed in the 7-Tesla MRI segmented subdivision with predominant projections to cortical motor areas (hyperdirect pathway) achieve superior motor improvement and whether microelectrode recording can accurately distinguish the motor subdivision. In 25 patients with Parkinson's disease, deep brain stimulation electrodes were evaluated for being inside or outside the predominantly motor-connected subthalamic nucleus (motor-connected subthalamic nucleus or non-motor-connected subthalamic nucleus, respectively) based on 7-Tesla MRI connectivity segmentation. Hemi-body motor improvement (Movement Disorder Society Unified Parkinson's Disease Rating Scale, Part III) and microelectrode recording characteristics of multi- and single-unit activities were compared between groups. Deep brain stimulation electrodes placed in the motor-connected subthalamic nucleus resulted in higher hemi-body motor improvement, compared with electrodes placed in the non-motor-connected subthalamic nucleus (80% versus 52%, P < 0.0001). Multi-unit activity was found slightly higher in the motor-connected subthalamic nucleus versus the non-motor-connected subthalamic nucleus (P < 0.001, receiver operating characteristic 0.63); single-unit activity did not differ between groups. Deep brain stimulation in the connectivity-derived 7-Tesla MRI subthalamic nucleus motor segment produced a superior clinical outcome; however, microelectrode recording did not accurately distinguish this subdivision within the subthalamic nucleus.

Prognostic value and predictors of the alteration of the diffusing capacity of the lungs for carbon monoxide in systemic lupus erythematosus.

SLE is a systemic autoimmune disease characterized by heterogeneous manifestations and severity, with frequent lung involvement. Among pulmonary function tests, the measure of the diffusing capacity of the lungs for carbon monoxide (DLCO) is a noninvasive and sensitive tool assessing pulmonary microcirculation. Asymptomatic and isolated DLCO alteration has frequently been reported in SLE, but its clinical relevance has not been established. This retrospective study focused on 232 SLE patients fulfilling the 2019 EULAR/ACR classification criteria for SLE. Data were collected from the patient's medical record, including demographic, clinical and immunological characteristics, while DLCO was measured when performing pulmonary function tests as part of routine patient follow-up. At the end of follow-up, DLCO alteration (<70% of predicted value) was measured at least once in 154 patients (66.4%), and was associated with a history of smoking as well as interstitial lung disease, but was also associated with renal and neurological involvement. History of smoking, detection of anti-nucleosome autoantibodies and clinical lymphadenopathy at diagnosis were independent predictors of DLCO alteration, while early cutaneous involvement with photosensitivity was a protective factor. DLCO alteration, at baseline or any time during follow-up, was predictive of admission in intensive care unit and/or of all-cause death, both mainly due to severe disease flares and premature cardiovascular complications. This study suggests a link between DLCO alteration and disease damage, potentially related to SLE vasculopathy, and a prognostic value of DLCO on death or intensive care unit admission in SLE.