Mass Characteristics Research Articles

The dilemma of recalling well-circumscribed masses in a screening population: A narrative literature review and exploration of Dutch screening practice.

In Dutch breast cancer screening, solitary, new or growing well-circumscribed masses should be recalled for further assessment. This results in cancers detected but also in false positive recalls, especially at initial screening. The aim of this study was to determine characteristics of well-circumscribed masses at mammography and identify potential methods to improve the recall strategy. A systematic literature search was performed using PubMed. In addition, follow-up data were retrieved on all 8860 recalled women in a Dutch screening region from 2014 to 2019. Based on 15 articles identified in the literature search, we found that probably benign well-circumscribed masses that were kept under surveillance had a positive predictive value (PPV) of 0-2%. New or enlarging solitary well-circumscribed masses had a PPV of 10-12%. In general the detected carcinomas had a favorable prognosis. In our exploration of screening practice, 25% of recalls (2133/8860) were triggered by a well-circumscribed mass. Those recalls had a PPV of 2.0% for initial and 10.6% for subsequent screening. Most detected carcinomas had a favorable prognosis as well. To recognize malignancies presenting as well-circumscribed masses, identifying solitary, new or growing lesions is key. This information is missing at initial screening since prior examinations are not available, leading to a low PPV. Access to prior clinical examinations may therefore improve this PPV. In addition, given the generally favorable prognosis of screen-detected malignant well-circumscribed masses, one may opt to recall these lesions at subsequent screening, if grown, rather than at initial screening.

A Damage Constitutive Model for a Jointed Rock Mass under Triaxial Compression

Due to the different structural characteristics and in situ environment, jointed rock masses encounter different failure mechanisms. Because of the joints, jointed rock masses show peculiar characteristics such as anisotropy and weakening. To describe the deformation and failure mechanism in jointed rock masses, a novel damage constitutive model of rock mass is proposed here considering the geometric parameters and mechanical properties of joints. A total damage variable is derived on the basis of the strain equivalence hypothesis, which combines the Weibull statistical damage theory for the strength of the rock elements and the fracture mechanics model for joints. This new damage variable reflects the coupled damage inflicted by two damage states, one is initial damage induced by prefabricated joints and the other is joint damage and rock mesoscopic damage under loading. The damage evolution path revealed by the new damage variable corresponds to the evolution of mechanical properties and behaviors induced by changes in the rock mass structure. Afterward, the computational formulation scheme for the model parameters is deduced using the extremum method. The model parameters, m and F0, have a clear physical meaning. The parameter m describes the ductility–brittleness characteristics of jointed rock masses, and F0 reflects the level of strength. This model describes the effect of joints and strain on the evolution of rock mass damage, model parameters, deformation, and failure characteristics. The mechanical behavior of rock mass described by the damage model and the change law of model parameters are consistent with the published experimental results.

Shrimp community structure and influence of environmental variables in the East China Sea and Yellow Sea in spring.

Based on data collected from research vessel cruises performed in May 2020 off the East China Sea (ECS) and the southern Yellow Sea (YS) (26°30'-35°00' N, 120°30'-127°00' E), we analyzed the shrimp community and its relationships with environmental variables by using index of relative importance, biodiversity indices, and multivariate techniques. A total of 29 species were recorded, belonging to 11 families and 19 genera. The dominant species were Metapenaeopsis longirostris, Leptochela gracilis, Solenocera melantho, Crangon hakodatei, Parapenaeus fissuroides, Plesionika izumiae, and Trachypenaeus curvirostris, which together accounted for 82.9% of the total biomass and 90.8% of the total abundance of shrimps. Results of Cluster and NMDS analyses showed that three groups were identified for the shrimp community in the ECS and YS in spring, including group A (inshore of northern ECS and YS group), group B (offshore of northern ECS group) and group C (southern ECS group). ANOSIM and SIMPER analysis showed significant differences between group A and B, gourp A and C, and group B and C, with the dissimilarity of 92.2%, 95.8% and 91.6%, respectively. The typical species were T. curvirostris, C. hakodatei, L. gracilis and Palaemon gravieri in group A, and S. melantho in group B, and M. longirostris, P. fissuroides, P. izumiae and Solenocera alticarinata in group C. Significant differences were also detected in biomass, diversity index, species richness index and evenness index among groups, with significantly greater values in group C than those in A and B. Environmental variables and the substrate also displayed significant differences among groups. Results of canonical correspondence analysis showed that bottom temperature, bottom salinity, depth, and the substrate were the main environmental variables affecting spatial structure of shrimp community. Water mass characteristics and substrate type had important influences on the distribution of shrimp community in the ECS and YS in spring.

Jointed rock masses as metamaterials – Implications for railway tunnel vibrations

Vibrations from underground railways are known to affect receptors located close to the tunnel. Understanding the transmission pathway between these tunnels and receptors is important in determining the magnitude of vibrations which can be transmitted. Rail tunnels can be excavated in a range of geological conditions, including jointed rock masses. Jointed rock masses have been found to display certain resonant characteristics, namely spring resonance. Therefore, this paper studies the resonant characteristics of jointed rock masses using a series of models solved using the combined discrete element-finite difference method and the finite difference method. Modelling assumptions are tested as well as different equivalent material models. It is found that spring resonances occur at the same frequencies as predicted by analytical functions when different modelling assumptions are used. This indicates that the spring resonance effect will prevail in complex rock masses under a range of geological settings. The spring resonance mechanism is found to cause jointed rock masses to behave like periodic metamaterials in respect to the transmission of stress waves, which can operate as a band-pass or low pass filter, depending on the number of joints within the material. New evidence is presented showing that periodic metamaterials exhibit spring resonance. Results for metamaterials in laboratory scale frequency sweep tests are shown to feature high transmission zones occurring at the predicted spring resonant frequency for that material. Finally, the effects of the spring resonance mechanism operating within the jointed rock masses are appraised in the context of vibrations from railway tunnels.

Experimental Study of Single Structure Surface Dangerous Rock Mass Dynamic Characteristics Based on Constant Micromotion

The dynamic parameters of a dangerous rock mass reflect the degree of damage of the structure of its surface. There is still an urgent problem to identify the dynamic parameters of a dangerous rock mass based on the characteristics of the constant micromotion at its site. To address this problem, a method is proposed to identify the dynamic characteristics of a dangerous rock mass undergoing excitation caused by constant micromotion: (1) the vibration of a dangerous rock mass undergoing excitation from constant micromotion is classified as forced undamped structural vibration with a single degree of freedom. The ratio of the amplitude of the spectrum of the dangerous rock mass to the amplitude of the spectrum of the bedrock is defined as the relative amplitude spectrum. The first-order natural frequency is identified from the relative amplitude spectrum. (2) Bedrock is the source of excitation of a dangerous rock mass. When a mechanical wave propagates to a dangerous rock mass, it crosses the porous surface of media with structural damage, and mechanical wave scattering occurs. The frequency domain of the mechanical wave changes. The center frequency shifts to a low frequency. By means of laboratory model tests, the changes in the dynamic parameters of models of a cantilevered dangerous rock mass and a sliding dangerous rock mass with structural surface damage are analyzed. It is concluded that (1) based on the theory of vibration mechanics, the first-order natural frequencies of dangerous rock masses can be obtained from their relative amplitude spectra. The first-order natural frequencies of dangerous rock masses undergoing constant micromotion are measurable. (2) The damage of the structural surface of a dangerous rock mass with macroscopic fractures can be identified by its first-order natural frequency. The center frequency cannot reflect the development of fractures. The damage of the structure of the surface of a dangerous rock mass with microscopic fractures can be identified by the change in the center frequency in its high-frequency band. The first-order natural frequency cannot reflect the development of fractures. (3) There are limitations in using single vibration mechanics theory or elastic wave scattering theory to analyze the damage of the structure of the surface of a dangerous rock mass; it is more effective to integrate both methods.

EVALUATION OF THE RESULTS OF TESTING THE HARDWARE COMPARTMENT OF SUBORBITAL ROCKETS FOR RELIABILITY

Nowadays, the issue of creating modern models of rocketry is becoming more and more popular due to the constant development of technologies and competition in the domestic market. This paper describes the results of the behavior of on-board electronic equipment during launches of ultra light suborbital rockets of the «Meteo» series manufactured by the Rocketry agency project. When designing the hardware compartment
 and further improving it in subsequent rocket models, the first place is occupied by its level of reliability, which should in turn take into account the economic part for the development and manufacture of further products. Such improvements included the use of new materials, increased strength and resistance to negative impacts, improved thermal management and elimination of structural defects. Tests have shown that to overcome higher altitudes, such as the Karman Line, more fuel is used and the mass and size characteristics of the rockets change, which leads to increased complexity of their control and navigation. One of the key challenges is the lack of an effective control system. Without a proper control system, a missile's flight becomes unpredictable and dangerous for the area where it is flying. One way to solve this problem is to develop and test a proper control system for the missile on a special test bed that will allow testing and debugging the control system in a controlled environment that ensures its functioning in real-world conditions without the risk of sending an untested missile into the air.

Study on the crack propagation behaviour of eccentric uncoupled blasting in a deep-level rock mass

ABSTRACT To explore the dynamic crack propagation behaviour in the fracture zone and the damage characteristics of the rock mass around the blasthole during eccentric uncoupled blasting of a deep-level rock mass, theoretical analysis, model experiments and numerical simulation studies have been described in this paper. Firstly, the stress state of the crack and the stress distribution state and failure mechanism of the rock mass around the blasthole under the influence of the in-situ stress, and the pressure distribution of blast shock wave on the blasthole were analysed. Secondly, with the help of a new digital laser caustics experimental system, the eccentric uncoupled blasting model experiment under the action of the in-situ stress was carried out. The fractal damage theory is used to quantitatively evaluate the damage degree of the rock mass in different areas around the blasthole, and the blast-induced crack propagation mechanical behaviour characteristics in the fracture zone are analyzed from the perspective of dynamics. Then, based on the LS-DYNA software, a numerical simulation study was conducted on the eccentric blasting of deep rock mass. Finally, some discussions and suggestions are provided for the analysis of blasting mechanisms in a deep-level rock mass.

Association between characteristics of swallowing-related muscles and trunk muscle mass

Swallowing function is associated with systemic factors. Whether trunk or appendicular skeletal muscle mass is a better indicator of swallowing-related muscle characteristics in community-dwelling older adults is not clear. Hence, we investigated the association between the characteristics of swallowing-related muscles (e.g., mass and quality) and trunk muscle mass. Community-dwelling older adults aged ≥ 65 years (n = 141; men: n = 45, women: n = 96) were recruited for this cross-sectional observational study via a health survey conducted in 2018. Trunk muscle mass index (TMI) and appendicular skeletal muscle mass index (SMI) were measured using bioelectrical impedance analysis. Cross-sectional areas (CSAs) and echo intensity (EI) of the geniohyoid muscle (GHM) and tongue were evaluated using an ultrasonic diagnostic apparatus. Multiple regression analysis was used to examine the relationship of the characteristics of swallowing-related muscle with TMI and SMI. Multiple regression analysis showed that CSA of the GHM was positively associated with both TMI (B = 24.9, p < 0.001) and SMI (B = 13.7, p = 0.002). EIs of swallowing-related muscles were not associated with TMI and SMI. Trunk muscle mass was associated with swallowing-related muscle mass and not muscle quality. The results of this study shed light on the elucidation of association of dysphagia with TMI and SMI.

Prediction of Ultimate Bearing Capacity of Oil and Gas Wellbore Based on Multi-Modal Data Analysis in the Context of Machine Learning

As important research for drilling engineering, the prediction of oil and gas shaft lining conditions is changing from the traditional method based on the mechanism model to the intelligent prediction method combining the mechanism model with the data model. Therefore, this paper establishes a stacking integrated model for predicting the uniaxial compression strength (UCS) of rock based on four basic parameters that can reflect the characteristics of rock mass. At the same time, the expectation-maximation (EM) algorithm is used to optimize the hidden Markov models (HMM), and a fuzzy random model of the ultimate bearing capacity of oil and gas shaft lining is established. The uncertain distribution of main parameters of rock mass is analyzed, and the corresponding fuzzy random distribution law is obtained. The experimental results show that the stacking integration algorithm is of great help to improve the prediction effect of rock mass compressive strength. The EM-HMM model has the advantages of small error, high efficiency, and fast convergence after two fuzzy random processes. Using this algorithm is helpful to analyze the stress state and parameter response mechanism of the shaft lining, dynamically generate optimized parameters, and provide technical support for reducing the incidence of complex drilling accidents, shortening the well construction period and lowering the drilling cost.

Rockfall feature investigation and kinematic simulation based on nap-of-the-object photogrammetry and GIS spatial modeling

On-site investigation and numerical simulation are the main methods for assessing the risk of rockfall disasters. Unmanned aerial vehicles (UAVs) have been widely used because they can quickly obtain geospatial data. However, in a complex terrain environment, it is difficult to ensure reliable positioning accuracy and resolution of geospatial data collected or constructed at the same flight altitude. Therefore, it is difficult to complete the detailed investigation of rock mass characteristics, and the reliability of the simulation results of rockfall motion characteristics will also be affected. This article summarizes a new image acquisition method and three-dimensional (3D) modeling ideas. Furthermore, in this study a risk assessment is conducted of a slope where a rockfall disaster has occurred. Through this method, the real-world 3D model with a positioning accuracy of less than 5 cm and digital surface model (DSM) data with sub-centimeter resolution of the research area are obtained. Using these data, the rock mass characteristics and the mechanism of disaster formation are analyzed, and the motion characteristics of potential rockfall are numerically simulated in a geographic information system (GIS). After comparing and analyzing the simulated superior trajectory with the on-site terrain, it is found that the trajectory simulated using high-resolution terrain data can better represent the actual movement of falling rocks. The method and process summarized in this paper can provide technical reference for the investigation and evaluation of the risk of rockfall disasters under complex terrain conditions.

Production and characterization of an AAV1-VP3-only capsid: An analytical benchmark standard

Adeno-associated viruses (AAVs) are non-enveloped ssDNA icosahedral T= 1 viruses used as vectors for clinical gene delivery. Currently, there are over 200 AAV-related clinical trials and six approved biologics on the market. As such new analytical methods are continually being developed to characterize and monitor the quality and purity of manufactured AAV vectors, these include ion-exchange chromatography and Direct Mass Technology. However, these methods require homogeneous analytical standards with a high molecular weight standard comparable to the mass of an AAV capsid. Described here is the design, production, purification, characterization, and the cryo-electron microscopy structure of an AAV1-VP3-only capsid that fulfills this need as a calibrant to determine capsid mass, charge, homogeneity, and transgene packaging characteristics.

The individual and combined effect of ozone and UV-C on mass loss, respiration, texture and colour changes of fresh-cut lettuce

The aim of this study was to investigate the effect of UV-C and ozonation as individual and combined treatments on the quality characteristics (mass loss, colour, texture and respiration rate) of fresh-cut lettuce, employing three different UV-C fluences and one O3 concentration that have been reported in the literature to have a positive effect on disinfection of fresh-cut lettuce. Fresh-cut ‘Romaine’ lettuce (Lactuca sativa L. var. longifolia) was exposed to three fluences 0.20, 0.40 and 0.80 kJ/m2 of ultraviolet-C (254 nm) radiation, to gaseous O3 concentration of 5 mg/L for 5 min, and their combination. The produce was stored unpackaged for 5 days at 5.7oC and 91.95%. The applications of O3, UV-C and their combinations (UV-C+O3) gave good results in terms of quality characteristics preservation. Individual or combined treatments prevented mass loss throughout the cold storage compared to control samples. The combined treatment of UVC with O3 achieved more than 25% less mass loss (maximum values) compared to the other tested treatments and control samples. The respiration rate was increased in individual and combined treatments, especially in the UV-C treatment. The UV-C fluence &lt; 0.80 kJ/m2 and O3 concentration 5 mg/L for 5 mins applications achieved improved texture quality in terms of positive peaks (crispness). The crispness of the treated samples was increased by 35% compared to control samples, especially for the UV-C+O3 combination. Limited colour degradation was noted since the UV-C fluence and O3 concentration and dosage were kept below the limits of UV-C fluence &lt; 5 kJ/m2 and O3 concentration &lt; 5 mg/L for which quality degradation has been reported in the literature.

Multi-parameter adaptive online energy management strategy for concrete truck mixers with a novel hybrid powertrain considering vehicle mass

Given the characteristics of dynamic vehicle mass, multi-operation scenes, and multi-energy-source and multi-energy-consumption-source, the energy optimization problem of concrete truck mixers remains a challenge. To this end, in this paper, a novel hybrid powertrain with a single-shaft parallel for the upper-part system and extended-range for the driving system is utilized and an adaptive online energy management strategy with multi parameters including the driving cycle, vehicle mass, battery state of charge (SOC), and remaining mileage is presented. First, a driven-data clustering method with fuel consumption differentiation is adopted. Then, using the parallel computing genetic algorithm-optimized rule-based method, a driving condition knowledge base, including optimal control models of the various typical driving conditions under multi-parameter combinations, is built to realize the adaptability and robustness. Parameter identifiers are designed, including a sparrow search-optimized-based deep mixed kernel extreme-learning machine recognizer and a vehicle mass recognizer based on sensor and working scene fusion for obtaining corresponding information online. Finally, simulation experiments are conducted to validate the performance and robustness of the presented control strategy. Results indicate it can reduce fuel consumption by an average value of 15.17% and performs better in the convergence level of terminal SOC in five real composite driving conditions.

AIUM Practice Parameter for the Performance and Interpretation of Diagnostic Ultrasound of the Thyroid and Extracranial Head and Neck.

AIUM Practice Parameter for the Performance and Interpretation of Diagnostic Ultrasound of the Thyroid and Extracranial Head and Neck.

Primary hepatic Epstein–Barr virus-positive diffuse large B-cell lymphoma associated with azathioprine immunosuppression: a case report

BackgroundHepatic masses are relatively common findings, and the diagnostic approach often begins by identifying patient and mass characteristics that are risk factors for malignancy. Chronic immunosuppression is a known risk factor for various malignancies, and azathioprine in particular has been reported in association with solid and hematologic malignancies, including diffuse large B-cell lymphoma.Case presentationA 46-year-old white woman presented to clinic with several weeks of gastrointestinal symptoms and was found to have a hepatic mass on imaging. Her history was notable for neuromyelitis optica spectrum disorder on chronic immunosuppression with azathioprine. It was initially thought to be an inflammatory adenoma. On 6-month follow-up imaging, the mass had grown rapidly in size and was surgically resected. Further workup determined the mass to be an iatrogenic immunodeficiency-associated Epstein–Barr virus-positive diffuse large B-cell lymphoma confined to the liver. Azathioprine was discontinued and the patient underwent treatment with rituximab with no evidence of recurrence 2 years after the initiation of treatment.ConclusionsThis case report describes the first time hepatic Epstein–Barr virus-positive diffuse large B-cell lymphoma has been reported with azathioprine, which highlights the unique sequelae of chronic immunosuppression, including atypical hematologic malignancies, and the importance of considering chronic immunosuppression in the diagnostic evaluation of a hepatic mass.

Retrospective Evaluation and Characteristics of Bilateral Adrenal Masses Followed Up in the Endocrinology Clinic of Ondokuz Mayıs University Hospital Between 2008 and 2022

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Method for Converting the Energy Characteristics of Alternative Fuels

The article analyzes the reasons hindering the mass use of alternative fuels in the field of energy consumption of domestic transport, which for the most part have lower energy and kinetic indicators of combustion in comparison with traditional fuels. A new approach to solving the problem of improving the environmental and energy-saving indicators of combustion of alternative fuels based on their preliminary thermochemical processing - conversion on board a vehicle is presented. The results of a preliminary analytical study of the parameters of the on-board conversion process for a number of potentially acceptable types of alternative fuels are presented in order to assess the efficiency of this process. The possibility of practical implementation of the proposed process for improving the combustion indicators of alternative fuel with an assessment of its efficiency was tested based on the results of experimental approbation in the conditions of full-scale engine tests. According on the results of the study, the expediency of using this process in transport technologies is justified due to the technical simplicity of its implementation and efficiency. Thermocatalytic reactor is the simplest design of a heat exchanger, the mass and dimensional characteristics of which (in the volume of a conventional muffler) ensure the convenience of its installation in the engine exhaust system. The component composition of these products contains reactive compounds that contribute to the improvement of environmental and energy-saving indicators of the fuel combustion process, and an increase in the efficiency of the engine's operating cycle.

Simulation modeling of the lifting and assembly module of the supports of the structural coating

The materials of the article are devoted to the issue of simulation modeling of construction mechanized technological equipment, in particular, modeling of the lifting and assembly module for the installation of a structural coating. Today, an urgent task in the construction market is the construction of large-scale structures, the life cycle of which is shortened, but the construction terms are reduced. Such a need exists in the construction of shelter hangars, field hospitals, warehouses, etc. As a rule, for urgent needs, buildings with light construction structures are erected, the covering of which is formed by structural blocks. A feature of such structures is multi-element support elements. A lifting assembly module is proposed for the installation of such structures.&#x0D; It is essential that the mounted structural coating is assembled on the heads of the lifting and collecting modules in blocks, and the lifting of the structural block to the design mark occurs thanks to the module while simultaneously raising/assembling the supporting elements of the coating. Simulation computer modeling tools were used to study the possibility of implementing the assembly process using the lifting assembly module. It is proposed to use the parametric formation of sketches and 3D models when forming the design features of the module. The dissection of the elements of the new assembly module, support elements and structural coating to the level of simple parts made it possible to determine their mass characteristics with sufficient accuracy. The basic technical indicators of the assembly module and building structures, which can be used in the development of the assembly technology, were obtained.&#x0D; Approaches to the use of cloud databases when using unified elements during design are defined.The use of simulated geometric modeling data allows to analyze the strength properties of the components of the technical system and, together with the visual observation data, to create a common information model of the building object with the possibility of qualitative analysis of the indicators of the specified elements of building structures.

A novel coal-rock cutting state identification model based on the Internet of Things

The sudden change in the interface between coal-rock mass can lead to the increased abrasion of picks and the failure rate of mining machinery. The safe and efficient coal-rock identification technology is the key to realize the intelligent control of coal mining machinery. To realize the real-time perception and accurate recognition of coal-rock cutting state information, a novel coal-rock cutting state identification model based on the Internet of Things (IoT) is explored. Specifically, by using the virtual prototype technology, multi-source heterogeneous data from acquisition, processing and identification of coal-rock cutting state information are fused and analyzed. First, the paper analyzes the physical and mechanical characteristics of coal-rock mass, and takes the cutting drum of bolter miner as the research object to theoretically analyze its load, which provides a foundation for the research on coal-rock cutting state identification. Second, a rigid-flexible coupling virtual prototype model of the cutting drum and coal-rock models under different cutting conditions are established. The simulation process is implemented by employing the discrete element method (DEM) to ensure the real-time transmission of motion information and state characteristic signals. Ultimately, the dynamic information of drum load during the coal-rock cutting process is obtained. Finally, LVQ (Learning Vector Quantization) and PSO-BP (Particle Swarm Optimization-Back Propagation) neural networks are created, and the variation coefficient, waveform factor, and peak factor of load curves of cutting drums in the coal-rock mass with different firmness coefficients are input into the neural networks as feature vectors for state recognition. The experimental results show that LVQ and PSO-BP neural networks can be used for coal-rock cutting state identification, and PSO-BP network has faster convergence speed and higher recognition efficiency, which provides a new scheme for coal-rock cutting state identification to improve the safety and efficiency of coal mining machinery.

The technology of forming a backfill mass with the specified geotechnical characteristics

Introduction. To reduce ore loss and impoverishment, high-value non-ferrous metal reserves are commonly developed by the mining methods with worked-out area backfilling. Regardless of the type and methods of backfill mass formation, worked-out area backfilling, being a way to control the rock state, is highly labor intensive and incurs additional costs, therefore increasing the cost of stoping. During field exploitation, mining and geological conditions tend to constantly deteriorate, and complex mining conditions form, which is accompanied by decreased content of the commercial component. The more complex the mining conditions are, the higher goaf maintenance costs is and the lower the mining intensity is. So, as mining develops, production cost constantly grows while the commercial component content decreases, which negatively affects total production performance indicators. Therefore, searching for ways to solve the problem of backfill cost reduction remains an urgent practical task of mining. It is possible to optimize backfill costs under changing and constantly deteriorating mining and geological conditions without reducing mining productivity by means of the underground geotechnology with artificial industrially-modified mass formation with the required geotechnical characteristics. The technology is presented in this work and is aimed at the effective development of the field reserves. Research objective is to develop and substantiate the parameters of underground geotechnology with worked-out area backfilling, which controls geotechnical characteristics of an artificial industrially-modified mass during the stoping. Methods of research. A room-and-pillar mining method was designed and its parameters were substantiated, taking into account natural mining and geological conditions and mining technical conditions formed in the course of stoping. The research was based on theoretical calculations and geomechanical modeling. Results. A variant of a room-and-pillar mining method has been developed with worked-out area backfilling with dry rock and further consolidation with a hardening mixture and compaction by breaking reserves in a compressive medium. The results obtained showed the mining method’s effectiveness. The study substantiates the rational values of the mining method structural element parameters. In particular, the size of the chamber wall is determined, located at an angle of 80°, with the reinforced layer up to 5 m thick and 1.5 MPa strong. Conclusions. A variant of the mining method can be used when mining inclined and steeply pitching ore bodies in difficult mining and geological conditions.