Characteristics Of Vitamin Research Articles

Microstructures and anti-osteoporosis effects of vitamin D3/calcium phosphate microparticles prepared by multiple emulsion micro-reaction method

Calcium and vitamin D are essential for combating osteoporosis. However, enhancing the anti-osteoporosis effects of the supplements remains a challenge. This study introduced an optimized multiple emulsion micro-reaction method for preparing vitamin D3/calcium phosphate microparticles. The microstructure and characteristics of vitamin D3/hydroxyapatite microparticles (VD3@HAP) and vitamin D3/calcium hydrophosphate microparticles (VD3@CHP) were analyzed using Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and stress testing. The calcium absorption and anti-osteoporosis effects of VD3@HAP and VD3@CHP were evaluated in situ and in vivo, respectively. FTIR and XRD analyses confirmed that the microparticles retained the spectral characteristics of calcium phosphates, while VD3@HAP exhibited randomly distributed pores on its surface, enhancing both the loading capacity and photostability of vitamin D3 compared to VD3@CHP. Additionally, the vitamin D3/calcium phosphate microparticles prepared by this method significantly increased bone mineral density and decreased serum alkaline phosphatase levels. Notably, VD3@HAP demonstrated superior calcium absorption, reduced marrow cavity area, and improved osteoporosis symptoms in the rat model compared to VD3@CHP, as evidenced by absorption assay, X-ray analysis, and HE staining. Thus, the multiple emulsion micro-reaction method effectively prepared vitamin D3/calcium phosphate microparticles that enhanced the anti-osteoporosis effects of supplementation, particularly VD3@HAP. We anticipate that VD3@HAP could serve as a safe and effective calcium supplement with significant potential for preventing and treating osteoporosis.

Characteristics of Vitamin D Concentration in Elite Israeli Olympic Athletes.

The prevalence of vitamin D deficiency has been a growing concern in recent years. Vitamin D is important in many of the body's physiological systems, such as the musculoskeletal, cardiovascular and immune functions. A deficiency of vitamin D in athletes may negatively impact both muscle functions and recovery and, thus, affect performance and increase the risk of injury. Many studies assessed the prevalence of vitamin D deficiency in athletes; however, as of today, there are no official recommendations/protocols for screening vitamin D levels in athletes, and only a few studies were performed in male and female elite athletes (i.e., Olympic level), in different sport disciplines. We investigated the prevalence of vitamin D deficiency among athletes entering the Israeli Olympic team. A total of 761 samples of Vitamin D(OH)25 from 334 athletes were analyzed. For this analysis, we used the first test the athlete had performed when joining the Olympic team. The prevalence of vitamin D deficiency (<50 nmol/L, as defined by the Endocrine Society Committee) was investigated according to gender, types of sports and outdoor vs. indoor sports through the different seasons of the Israeli Olympic team athletes. Twenty-five athletes (7.5%) were diagnosed with vitamin D deficiency. One hundred and thirty-one athletes (39.2%) had insufficient levels of vitamin D (50-75 nmol/L). The highest incidence of vitamin D deficiency was found amongst gymnastics and combat sport athletes. A significant difference was also found in vitamin D concentration between seasons. Vitamin D average concentration in the winter was 74.1 nmol/L compared to 86.4 nmol/L in the Summer (p < 0.0005). Due to the importance of vitamin D to athletic performance and the high prevalence of deficiency and insufficiency, we suggest careful and frequent monitoring of groups at risk, including elite athletes, especially in susceptible sports and during the winter. Future studies are necessary to investigate the effectiveness of Vitamin D supplementation in athletes with low baseline vitamin D levels.

Risk of Vitamin D Deficiency in Medical Students Based on The Characteristics of Food Intake and Sun Exposure

Introduction. The need for Vitamin D can be fulfilled through direct synthesis from Vitamin D stores in the skin with the help of ultraviolet B rays. Therefore, sufficient Vitamin D intake and sun exposure are needed. Most of the activities of medical students on campus are indoors from morning to evening, so it is suspected that there is a risk of Vitamin D deficiency. The purpose of this study was to identify the risk of Vitamin D deficiency based on the characteristics of Vitamin D from food intake and sun exposure in Faculty of Medicine students, Universitas Sriwijaya. Methods. This research was a descriptive study using a questionnaire and observation. Age, sex, BMI and use of related drugs were recorded. The food survey method used was the repeated food recall which was then analyzed using Nutrisurvey 2007. Subjects filled out a questionnaire to obtain data on exposure scores and sun protection scores. The research subjects were students of the Faculty of Medicine, Universitas Sriwijaya who were willing to sign informed consent and were present at the time of sampling. Results. The results from the data of 259 subjects showed that 98.8% of the subjects did not meet their vitamin D intake needs, with an average consumption of 123 ± 142 IU. Types of food that contribute the most Vitamin D are catfish (40%) and eggs (20%). None of the subjects took supplements containing Vitamin D. Sun exposure was sufficient for most subjects (62.9%), but most subjects were at risk of deficiency due to the use of sun protection (62.2%) Conclusion. There is a risk of deficiency in most medical students due to a lack of Vitamin D intake and the use of sun protection.

Characteristics of Vitamin A Deficiency Retinopathy at a Tertiary Referral Center in the United States

To explore the risk factors and fundus imaging features of vitamin A deficiency retinopathy (VADR) in an academic tertiary referral center in Atlanta, GA, United States, and to propose guidance regarding diagnostic workup and management of affected patients. Single-center retrospective case series. Nine patients seen between 2015 and 2021 at the Emory Eye Center diagnosed with VADR. Retrospective chart review. Baseline serum retinol level, Snellen visual acuity, multimodal fundus imaging findings, and electroretinography findings. Nine patients, 4 (44.4%) female, with a median (range) age of 68 (50-75) years were identified. The most common underlying etiologies for vitamin A deficiency included history of gastrointestinal surgery (55.6%), liver disease (44.4%), and nutritional depletion due to low-quality diet (44.4%). Only 1 (11.1%) patient had a history of bariatric surgery. Four (44.4%) patients were on some form of vitamin A supplementation before the diagnosis of VADR. Median (range) serum retinol level was 0.06 (< 0.06-0.19) mg/L. All patients had macular subretinal hyperreflective deposits resembling subretinal drusenoid deposits, although in some cases, these were scant and sparsely distributed. Six eyes of 3 patients with longstanding deficiency had defects in the external limiting membrane (ELM). Three of these eyes additionally had macular areas of complete retinal pigment epithelium and outer retinal atrophy (cRORA). Full-field electroretinography demonstrated severe rod dysfunction and mild to moderate cone system dysfunction. Many findings of VADR were reversible with vitamin A repletion. However, all eyes with ELM defects or cRORA had persistence or continued growth of these lesions. Vitamin A deficiency retinopathy is uncommon in the developed world. However, given that early intervention can lead to dramatic visual improvement and avoid potentially permanent retinal damage, retina specialists should be familiar with its clinical presentation. The presence of nyctalopia and subretinal hyperreflective deposits in a patient with a history of gastrointestinal surgery, liver disease, and/or poor diet can be suggestive of this diagnosis, even in the presence of ongoing vitamin A supplementation. Vitamin A supplementation can vary in route and dosage and can be tailored to the individual with serial testing of serum retinol. The authors have no proprietary or commercial interest in any materials discussed in this article.

Effect of Inulin Concentration and Cooking Time on the Quality of Aloe Vera Jam

This study aims to determine effect of inulin concentration and cooking time on the quality of aloe vera jam. This study used factorial randomized block design. The first factor was concentration of inulin (I): (I1) 2%, (I2), 4% and (I3), 6%, the second factor was cooking time (L): (L1) 30 minutes (L2), 40 minutes and (L3) 50 minutes. Statistical analysis using analysis of variance and further test BNJ 5%. The results showed that there was significant interaction between inulin concentration and cooking time on the water content and lightness of aloe vera jam. Inulin concentration and cooking time had significant effect on the organoleptic characteristics of greasing power, texture and taste. Inulin concentration had significant effect on water content and lightness. Cooking time has significant effect on the vitamin C content, water content and lightness of aloe vera jam. The best treatment was aloe vera jam with I1L1 treatment (2% inulin concentration and 30 minutes of cooking time) with characteristics of vitamin C content 0.32%, water content 36.41%, lightness 44.97, redness 2.44 , yellowness 20.01 and the organoleptic of greasing power 3.03 (easy to spread-very easy to smear), texture 3.70 (smooth-very smooth), aroma 2.83 (slightly flavorful-fairly flavorful), and taste 3.40 (sweet-very sweet).

Causal Links between Hypovitaminosis D and Dysregulation of the T Cell Connection of Immunity Associated with Obesity and Concomitant Pathologies

Subclinical inflammation in morbid obesity is associated with immune activation and the development of concomitant diseases. Impaired immune homeostasis and immune cell dysregulation in adipose tissue are associated with phenotypic and functional changes in the pool of T lymphocytes and the development of chronic hypovitaminosis D. Low vitamin D levels in obesity lead to the activation, proliferation and production of pro-inflammatory mediators by T cells. Hypovitaminosis D is the cause of a decrease in the functional potential of regulatory and anti-inflammatory lymphocytes and the maintenance of the inflammatory response. The exact molecular genetic mechanisms of the effect of vitamin D on T lymphocytes have not been fully elucidated. Therefore, uncovering the functional role of T cells and their relationship to vitamin D homeostasis in the context of obesity development may contribute to the development of new pathogenetic methods for clinical prediction of the risk of metabolic, oncologic, autoimmune and infectious complications. The review presents the molecular genetic mechanisms of the effect of vitamin D on adipose tissue resident T lymphocytes and the characteristics of vitamin D receptor expression, and analyzes the phenotypic and functional characteristics of potentially pathogenic T lymphocytes in relation to the development of obesity and its associated complications.

Pleiotropic effects of vitamin D3

Introduction: Vitamin D belongs to the group of fat-soluble vitamins. cholecalciferol (D3) and ergocalciferol (D2) are the most important forms. Vitamin D is associated with a regulatory role in calcium and phosphate metabolism. In recent years, there has been attention to its pleiotropic action. Aim: The aim of the study was to present the general characteristics of vitamin D and explore its relation with polycystic ovary syndrome (PCOS), endometriosis, pain management, insulin resistance, influenza and chronic kidney disease (CKD).Description: VDR receptor has been detected in the cells of the intestines, bones, kidneys, heart, brain, prostate, breast, ovaries, skin. In the ovaries, vit. D3 affects the production of progesterone, estradiol or estrone which suggest its important role in the folliculogenesis and ovulation. Women with PCOS have significantly lower levels of vitamin D3 compared to healthy women. It has been suggested that the deficiency of this vitamin may be related to infertility. Research show that vit. D3 may affect the mechanisms of the inflammatory and nocyceptive pain perception. A significant connection has also been found between vit. D3 and the metabolism of the adipose tissue and insulin secretion. Vitamin D3 deficiency may increase the risk of development of obesity and insulin resistance as well as CKD.Summary: The observation of statistically significant correlation between the reduced level of vit. D3 and occurrence of numerous diseases indicates the need for further research to explain the mechanisms in which D3 deficiency may contribute to development of these diseases. This knowledge is important for the development of new prevention and treatment methods of the diseases mentioned in this article.

Vitamine D supply in girls of puberty age with autoimmune hepatitis

Vitamin D undergoes important biotransformation and inactivation in the liver. Because vitamin D is metabolized in the liver, abnormal vitamin D metabolism can be expected to be associated with chronic liver disease, including autoimmune hepatitis (AIH). The prevalence of vitamin D deficiency in puberty was the justification for the objective of the study– to determine the characteristics of vitamin D supply in girls of puberty age with AIH with autoimmune hepatitis during this period. Materials and methods. To solve this goal, a comprehensive clinical and paraclinical examination of 66 girls withAIH and 180 relatively healthy girls of the control group aged 12-17 years. The complex included clinical and anamnestic data, biochemical study of liver function, determination of serum autoantibodies and markers of viral hepatitis, the level of 25- (OH) D in blood serum, ultrasound and elastography of the hepatobiliary system organs, liver biopsy. Results. The mean level of vitamin 25 (OH) D in the serum of girls with AIH of pubertal age was 17.14 ± 1.06 vs. 23.27 ± 0.53 ng / ml in the control (p&lt;0,01). In 66.67% of patients with AIH there was a deficiency of 25 (OH) D, in 22.73% – insufficiency, in 10.61% – the optimal level. The supply of vitamin D depended on the histological activity of AIG. Among girls with AIH and histological activity index&gt; 9 points, the share of patients with vitamin D deficiency was 79.41% compared with 53.13% of cases among girls with AIH, where the histological activity index was &lt;9 points (χ2=5.13; p&lt;0,02). Conclusions. Cytolysis, cholestasis, mesenchymal-inflammatory syndrome, hepatocellular insufficiency in AIH in girls of puberty agedevelops against the background of reduced vitamin D supply, which depends on the histological activity of the disease.

Vitamin D deficiency in association with endothelial dysfunction: Implications for patients with COVID-19.

There is emerging evidence to suggest that vitamin D deficiency is associated with adverse outcomes in COVID-19 patients. Conversely, vitamin D supplementation protects against an initial alveolar diffuse damage of COVID-19 becoming progressively worse. The mechanisms by which vitamin D deficiency exacerbates COVID-19 pneumonia remain poorly understood. In this review we describe the rationale of the putative role of endothelial dysfunction in this event. Herein, we will briefly review (1) anti-inflammatory and anti-thrombotic effects of vitamin D, (2) vitamin D receptor and vitamin D receptor ligand, (3) protective role of vitamin D against endothelial dysfunction, (4) risk of vitamin D deficiency, (5) vitamin D deficiency in association with endothelial dysfunction, (6) the characteristics of vitamin D relevant to COVID-19, (7) the role of vitamin D on innate and adaptive response, (8) biomarkers of endothelial cell activation contributing to cytokine storm, and (9) the bidirectional relationship between inflammation and homeostasis. Finally, we hypothesize that endothelial dysfunction relevant to vitamin D deficiency results from decreased binding of the vitamin D receptor with its ligand on the vascular endothelium and that it may be immune-mediated via increased interferon 1 α. A possible sequence of events may be described as (1) angiotensin II converting enzyme-related initial endothelial injury followed by vitamin D receptor-related endothelial dysfunction, (2) endothelial lesions deteriorating to endothelialitis, coagulopathy and thrombosis, and (3) vascular damage exacerbating pulmonary pathology and making patients with vitamin D deficiency vulnerable to death.

Study progress of vitamin D in respiratory diseases in children

Vitamin D is an active derivative of fat-soluble steroid, which can promotes the absorption of Ca in the intestine and maintains the concentrations of serum Ca in blood as well as phosphate.Recent researches found that the lack of vitamin D would increase the risk of respiratory diseases, cardiovascular diseases, autoimmune diseases, neuropsychiatric diseases, tumors and other metabolic diseases in addition to affecting the development of bones.More stu-dies have shown that low vitamin D levels is related to respiratory diseases in children.In this review, the physiological characteristics of vitamin D and the relationship with respiratory diseases in children were discussed. Key words: Vitamin D; neonatal respiratory distress syndrome; Bronchiolitis; Asthma; Recurrent respiratory infections

Profitability of Investment and Farm Level Efficiency Among Groups of Vitamin A Cassava Farmers in Oyo State Nigeria

Biofortified (vitamin A) cassava was developed through convectional breeding similar to most other improved varieties cultivated by Nigeria farmers. Despite its potential in addressing the increasing food demand and malnutrition in the country, lack of empirical knowledge about its yield and return on investment has been a major barrier to the uptake of this technology among farmers in Nigeria. This study examined the socio-economic characteristics of vitamin A cassava farmers; analyzed farm level efficiency and return on investment from vitamin A cassava in the study area; determined the factors affecting farm level efficiency and productivity, and examined the constraint to productivity and profitability among vitamin A cassava farmers. A multistage random sampling was used to select a total of 100 vitamin A cassava farmers in the study area. The data collected were analyzed using descriptive statistics, stochastic frontier production function (SFPF), profitability ratio and regression analysis. The results indicated that investing in vitamin A cassava as a business was very profitable. The result showed that 82% of the respondents were male, the mean age of the farmers was 53.25, 49% had only primary school certificate education, 66% farmed on the land between 1-2 hectares. The result further showed that on the average, total revenue was N261511.90, the total variable cost was N87754, gross margin was N173757.9, total cost was N179828.8, and net income was N81683.05. Mean technical efficiency was 78.73%. The study concluded that vitamin A cassava production in the study area was efficient and profitable. These results have implications for the design of effective advocacy strategies to attract more farmers into vitamin A cassava production in Nigeria.

KARAKTERISTIK SENYAWA BIOAKTIF EKSTRAK SELADA LAUT (Ulva lactuca L.) PADA KONSENTRASI PELARUT ETANOL DAN LAMA EKSTRAKSI

Ulva lactuca L. is a type of Chloro phyta or green algae. Ulva lactuca L. contains many chemical compounds that are useful to be developed. This study were determine the effect of ethanol solvent concentration and duration of extraction on the characteristics of extract bioactive compounds. This study used Factorial Randomized Block Design (RAK) with 2 factors as treatment. Factor I is the concentration of ethanol solvent which consists of 3 levels there are 70%, 80% and 90%. Factor II is the length of extraction consisting of 4 levels there are 3 hours, 4 hours, 5 hours, and 6 hours. The results showed that ethanol solvent concentration and extraction time were very influential on total phenolic content of sea lettuce extract. While the interaction treatment of ethanol concentration and extraction time greatly affect the levels of vitamin C and ?-tocopherol levels. Ethanol concentration of 90% and 5 hours extraction time resulted in the best extract of Ulva lactuca L. with characteristics of vitamin C content of 35.64 mg / 100g., Total phenolic 694.57 mg GAE / 100 g, and ?-tocop herol content of 308.54 mg / 100g.&#x0D; Keywords : Ulva lactuca L, solvent concentration, extraction time, vitamin C, phenolic ?-tokoferol

What are the characteristics of vitamin D metabolism in opioid dependence? An exploratory longitudinal study in Australian primary care

ObjectiveCompare vitamin D levels in opioid dependence and control population and adjust for relevant confounding effects. Nuclear hormone receptors (including the vitamin D receptor) have been shown to be key...

Characteristics of Vitamin D supplementation programs for the prevention of rickets in infants and young children in Europe: Factors influencing compliance

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Vitamin D deficiency and its characteristics among patients with acute stroke at a national referral hospital in Kampala Uganda.

BackgroundVitamin D deficiency has been associated with acute stroke and other cardiovascular diseases in the developed world. Low 25-hydroxyvitamin D (25OHD) has been described in some populations in Sub-Saharan Africa (SSA) in spite of adequate sunshine all year round. There is no information on the magnitude of vitamin D deficiency among patients with stroke and other cardiovascular diseases in Uganda or SSA. The aim of this study was to determine the burden and characteristics of vitamin D deficiency among patients with acute stroke, the most common form of cardiovascular events in SSA.MethodsWe conducted a cross-sectional study between October 2012 and March 2013. We consecutively recruited 142 subjects with acute stroke admitted to the medical wards of Mulago hospital. We administered a pre-tested questionnaire to the study participants, and did a detailed physical examination and laboratory evaluation. Serum levels of 25OHD were determined using an electrochemiluminescence assay. Data were analyzed using STATA version 12 software.ResultsThe prevalence of vitamin D deficiency (25OHD < 20 ng/ml) was 15 %. Longer hours of sunshine exposure decreased the likelihood vitamin D deficiency significantly (adjusted OR 0.85, p = 0.03). Higher HDL cholesterol had a significant inverse association with vitamin D deficiency (adjusted OR 0.15, p = 0.02). In addition, the likelihood of vitamin D deficiency increased with rising age (adjusted OR 1.03, p = 0.05).ConclusionsThere was a relatively low burden of vitamin D deficiency among patients with acute stroke in Uganda. With increasing longevity and indoor lifestyles vitamin D deficiency may assume a greater role in stroke and other cardiovascular diseases in tropical sub Saharan Africa. Future studies on the mechanisms of vitamin D deficiency and its relationship to outcomes among patients with stroke may be necessary.Electronic supplementary materialThe online version of this article (doi:10.1186/s12902-015-0053-y) contains supplementary material, which is available to authorized users.

Incidence and characteristics of vitamin D deficiency rickets in New Zealand children: a New Zealand Paediatric Surveillance Unit study

Objective:To investigate the incidence and characteristics of vitamin D deficiency rickets in New Zealand (NZ). Methods:Prospective surveillance among paediatricians of Vitamin D Deficiency Rickets was conducted by the New Zealand Paediatric Surveillance Unit (NZPSU) for 36 months, from July 2010 to June 2013, inclusive. Inclusion criteria were: children and adolescents <15 years of age with vitamin D deficiency rickets (defined by low serum 25‐hydroxyvitamin D and elevated alkaline phosphatase levels, and/or radiological rickets). Results:Fifty‐eight children with confirmed vitamin D deficiency rickets were identified. Median age was 1.4 (range 0.3–11) years, 47% were male, and 95% of the children were born in NZ; however, the majority of the mothers (68%) were born outside NZ. Overall annual incidence of rickets in children aged <15 years was 2.2/100,000 (95%CI 1.4–3.5); with incidence in those <3 years being 10.5/100,000 (95%CI 6.7–16.6). Skeletal abnormalities, poor growth and motor delay were the most common presenting features, with hypocalcaemic convulsion in 16% of children. Key risk factors identified were: darker skin pigment, Indian and African ethnicity, age <3 years, exclusive breast feeding, and southern latitude, particularly when combined with season (winter/spring). Of the patients reported, none had received appropriate vitamin D supplementation. Conclusions:Vitamin D deficiency rickets remains a problem for NZ children. Key risk factors remain similar to those identified in the international literature. Preventative targeted vitamin D supplementation, as per existing national guidelines, was lacking in all cases reported. Implications:Vitamin D deficiency rickets is the most significant manifestation of vitamin D deficiency in growing children. To reduce the incidence of this disease among those at high risk, increasing awareness and implementation of current public health policies for targeted maternal, infant and child supplementation are required.

Incidence and characteristics of vitamin D deficiency rickets in New Zealand children: a prospective New Zealand paediatric surveillance unit study

Vitamin D deficiency rickets is the most significant manifestation of vitamin D deficiency in growing children. Concerns have been raised in New Zealand (NZ), and worldwide, that cases continue to present, and may be possibly increasing. We undertook a prospective study to investigate the incidence and characteristics of vitamin D deficiency rickets in NZ children. Prospective surveillance of Vitamin D Deficiency Rickets was conducted by the NZ Paediatric Surveillance Unit (NZPSU), for 36 months, from July 2010 – June 2013 inclusive. Inclusion criteria were: children aged <15 years with vitamin D deficiency rickets (defined by low 25-hydroxyvitamin D and elevated alkaline phosphatase levels, and/or radiological rickets). 58 children with confirmed vitamin D deficiency rickets were identified. Median age was 1.4 years (range 0.3 – 11), male gender 47%, 95% of children were born in NZ, as opposed to 22% of mothers. Overall annual incidence in those aged <15 years was 2.2/100,000, while incidence in the south of NZ peaked at 6.8/100,000. Overall NZ incidence in children aged <5 years was higher at 6.6/100,000. Skeletal abnormalities, poor growth and developmental delay were the most common presenting features, with hypocalcaemic convulsion in 16%. Key risk factors identified were: dark skin pigment, Indian/South Asian and African ethnicity, age ≤2 years, exclusive breast feeding, and southern latitude, particularly when combined with season (winter/spring). Vitamin D deficiency rickets remains a health problem for New Zealand children, with significant associated morbidity. Public health policy, utilising infant supplementation, for at minimum the above identified risk factors, should be considered to reduce the incidence of this disease among those at high risk.

Vitamin D enrichment of bakery products of special purpose

Nowadays such diseases of bony tissue as osteoporosis are more often invaded. Osteoporosis is disease that occurs as a result of violations in the human body, proliferation and differentiation of osteoblasts, the synthesis of specific proteins, enzymes, bone mineral metabolism, which in turn regulates the activity of metabolites of vitamin D, which decrease bone resorption, promote the Ca mobilization in bone. Important problem is increasing the consumption of vitamin D, enriching food by them. The comparative characteristics of vitamin D usage in Ukraine and in other countries are conducted in the article. During research it is found that the bakery is the most appropriate product for the enrichment of vitamin D. Because of bakery products in Ukraine are the most used, it was considered the bread as an object for the enrichment of vitamin D. The use of this product will significantly increase the intake of vitamin D in the body and thus reducing the osteoporosis.

Profiles of vitamin D insufficiency and deficiency in Japanese men and women: association with biological, environmental, and nutritional factors and coexisting disorders: the ROAD study

Assessments of serum 25-hydroxyvitamin D levels in 1,683 Japanese from a population-based cohort revealed prevalences of vitamin D insufficiency and deficiency were 81.3 and 1.2%, respectively. Vitamin D deficiency was significantly associated with female sex, examined month, current smoking, lack of regular walking, higher intact parathyroid hormone (iPTH), and poor daily vitamin D intake. To clarify the characteristics of subjects with vitamin D insufficiency and deficiency among men and women in the general Japanese population. We initiated research on osteoarthritis/osteoporosis against disability (ROAD), a large-scale population-based cohort study, in 2005-2007. Blood examination was performed to measure serum 25-hydroxyvitamin D (25D) and iPTH levels and biochemical markers of bone turnover in 1,683 participants (595 men, 1,088 women). Participants completed an interviewer-administered questionnaire, measurements of bone mineral density, and x-ray examination. Vitamin D deficiency and insufficiency were defined by serum 25D levels <10 and ≥10 but <30 ng/mL, respectively. The prevalence of vitamin D insufficiency and deficiency was 81.3 and 1.2%, respectively. Multinominal logistic regression analyses using potentially confounding variables revealed vitamin D insufficiency was significantly associated with age (+1 year, relative risk ratio, 0.98; 95% confidence interval, 0.96-0.99), gender (women vs. men, 2.28; 1.59-3.30), residing areas (coastal area vs. mountainous area, 0.58; 0.41-0.81), examined month (October, November, December vs. January, 0.51; 0.34-0.76), and serum levels of iPTH (+1 pg/mL, 1.02; 1.01-1.03). Vitamin D deficiency was significantly characterised by female sex (20.5; 3.1-136.7), examined month (0.28; 0.09-0.95), current smoking habit (6.39; 1.78-23.0), lack of regular outside walking (3.96; 1.34-11.7), higher iPTH (1.02; 1.01-1.03) and poor daily vitamin D intake (+10 μg/day, 0.48; 0.24-0.93). A high prevalence of vitamin D insufficiency and a low prevalence of vitamin D deficiency were found in Japanese men and women, and the characteristics of vitamin D status were clarified.

Assessing the Prevalence and Characteristics of Vitamin D Deficiency in Patients on Hemodialysis in a Long Term Acute Care Hospital

Assessing the Prevalence and Characteristics of Vitamin D Deficiency in Patients on Hemodialysis in a Long Term Acute Care Hospital