Based on disturbance observer, this paper develops a nonsingular terminal sliding mode control method for uncertain chaotic gyroscope system. Firstly, fuzzy logic system (FLS) is used to estimate the unknown function; then disturbance observer (DOB) is constructed to estimate the mixed disturbance, which consists of the fuzzy estimation error, external disturbance, and dead-zone input error. Subsequently, by using a nonsingular terminal sliding mode function, the control method proposed in this paper can achieve the sliding mode variable approaching a small neighborhood of zero and reduce chattering phenomenon of the tracking error and controller. Finally, comparative simulation results confirm the effectiveness of the method proposed in this paper.