In this paper, a robust control design of chaos suppression is considered for generalized four-dimensional (4D) Lorenz–Stenflo systems subjected to matched/mismatched uncertainties and input nonlinearity. It is implemented by using rippling sliding mode control (SMC). A proportional-integral (PI) type scalar switching surface is designed such that the controlled dynamics in the sliding manifold becomes easy to analyze. Furthermore, only by using single rippling SMC even with input nonlinearity can we ensure the existence of the sliding mode for the controlled dynamics and suppress the chaotic behavior in a manner of rippling. Under the proposed control scheme, the chaos behavior in uncertain generalized 4D Lorenz–Stenflo systems subjected to mismatched uncertainties can be robustly suppressed to predictable bounds, which is not addressed in the literature. The numerical simulation results including matched/mismatched uncertainties and nonlinear inputs are presented to verify the robustness and validity of the rippling sliding mode controller.