We have developed the novel Fuzzy Set Chaos Algorithm (FSCA) to regulate tissue histology. If serum quantities of molecules that activate the expression of genes and proteins are at fuzzy levels, then histologi- cal regulation could be accomplished by iterative ON/OFF expression programming cycles and the resulting plot-pattern would render a depiction of chaos. We tested this hypothesis on metastasized cancer cells that pro- liferate rapidly and migrate into adjacent tissues and organs. Using a basic flow chart of histological regulation, we searched various databases to identify effective molecules. These molecules were then used for gene expres- sion programming to envelop metastasized tumor cells by commanding fibroblasts to surround the target cells in the tissue. The ON commands we used were 1) switch on transcription of collagen genes by ascorbic acid (VC), 2) increase collagen mRNA translation by supplying collagen-enriched food or by amino acids Pro Gly and Cys, 3) envelop metastasized cancer cells by combining collagen with elastin which is activated by calcium, and 4) proliferate fibroblastic cells by thiamin (VB1), riboflavin (VB2), pyridoxine (VB6), and cobalamin (VB12) dur- ing the fibrogenesis. Elimination of the supply of individual molecules constituted the OFF command. The com- mands were transmitted via the blood flow; their delivery to the area of interest was possible because permeability of the walls of blood vessels around metastasized cancer cells is increased by IL-1, IL-6, TNF-α, PAF, prostacy- clin bradykinin and VEGF. Cytokines and chemokines around metastasized cancer cells served to inform fibro- blasts of the location of metastasized cancer cells. Successful of fibrogenesis was conformed by rat liver fibrosis and the effectiveness of the therapy by patient viability.