Much of the literature available on heat transfer enhancement from rough surfaces concerns flat plates or channels. Studies on protruding concave surfaces are surprisingly rare though they have the potential to enhance heat transfer. Therefore, three-dimensional steady-state simulations and corresponding experimental validation is carried out for an air jet impinging on a concave surface projected with semi-spherical protrusions. By providing multiple protrusions, various geometrical configurations are studied by considering the dimensions, angular positions, and pitch between the protrusions. Each individual configuration has its own unique flow pattern which makes prediction of heat transfer complex. This motivates present study to consider entire geometrical parameters affecting heat transfer characteristics with the help of networking tool. Past investigations on protruded flat surfaces concerns random allocation of protrusions. Hence artificial neural network is employed in this study to easily predict the corresponding heat transfer value with set of few input data. Simulation results give detailed flow physics which helps in understanding the heat transfer behavior. It is observed that each protrusion is marked with high-pressure region around its uphill and negative pressure around the downhill. As the flow moves downstream, the protrusions obstruct the flow path and flow separates away as soon as it reaches center of the protrusion. A maximum heat transfer enhancement of 11% is obtained over a corresponding smooth surface.