Changes In Flow Structure Research Articles

Experimental study on the unsteady characteristics of flow evolution for two vehicles with ventilated partial cavitation

The object of this article is two parallel underwater vehicles with ventilated partial cavitation, which results in partial deformation of the ventilated cavity and is accompanied by nonlinear changes in the internal flow structure. In our experiments, a high-speed camera system was used to observe transient cavity evolution, and dynamic pressure measurement systems were employed to measure pressure fluctuations under different ventilation flow rates and parallel distances. The results indicated that cavity evolution goes through three stages after ventilation begins: the growth stage, the shortening stage, and the periodic shedding stage, with their periods being influenced by different variables. The dominant frequencies of grayscale variation in the three stages are significantly different, as are the pressure variations. Moreover, the dominant frequency of periodic shedding in the two cavities decreases as ventilation flow rates increase. A critical distance of d* = 1.6 was identified under the experimental conditions, which differentiates the pressure fluctuation characteristics at different parallel distances. Furthermore, the two main mechanisms of pressure fluctuation during the periodic shedding stage were clarified.

Future Changes in the Vertical Structure of Severe Convective Storm Environments over the U.S. Central Great Plains

Abstract The effect of warming on severe convective storm potential is commonly explained in terms of changes in vertically integrated (“bulk”) environmental parameters, such as CAPE and 0–6-km shear. However, such events are known to depend on the details of the vertical structure of the thermodynamic and kinematic environment that can change independently of these bulk parameters. This work examines how warming may affect the complete vertical structure of these environments for fixed ranges of values of high CAPE and bulk shear, using data over the central Great Plains from two high-performing climate models (CNRM and MPI). To first order, projected changes in the vertical sounding structure are consistent between the two models: the environment warms approximately uniformly with height at constant relative humidity, and the shear profile remains relatively constant. The boundary layer becomes slightly drier (−2% to 6% relative humidity) while the free troposphere becomes slightly moister (+1% to 3%), with a slight increase in moist static energy deficit aloft with stronger magnitude in CNRM. CNRM indicates enhanced low-level shear and storm-relative helicity associated with stronger hodograph curvature in the lowest 2 km, whereas MPI shows near-zero change. Both models strongly underestimate shear below 1 km compared to ERA5, indicating large uncertainty in projecting subtle changes in the low-level flow structure in climate models. The evaluation of the net effect of these modest thermodynamic and kinematic changes on severe convective storm outcomes cannot be ascertained here but could be explored in simulation experiments. Significance Statement Severe thunderstorms and tornadoes cause substantial damage and loss of life each year, which raise concerns about how they may change as the world warms. We typically use a small number of common atmospheric parameters to understand how these localized events may change with climate change. However, climate change may alter the weather patterns that produce these events in ways not captured by these parameters. This work examines how climate change may alter the complete vertical structure of temperature, moisture, and wind and discusses the potential implications of these changes for future severe thunderstorms and tornadoes.

Experimental study of hydrodynamic characteristics in three-phase coarse particle fluidized flotation column

Understanding multiphase flow regimes and hydrodynamic characteristics in the three-phase coarse particle fluidized flotation column (TFC) is crucial in mineral processing. This study systematically investigated the influence of gas velocity (Ug) and water velocity (Uw) on the flow regimes in TFC, focusing on the identification and hydrodynamic characteristics of different flow regimes in the freeboard and bulk fluidized bed regions. Three distinct flow regimes (heterogeneous flow, pseudo-homogeneous flow and mono-homogeneous flow) and two transition water velocities (transitions from a heterogeneous flow regime to a pseudo-homogeneous flow (Ut1) and transitions from a pseudo-homogeneous flow to a mono-disperse homogeneous flow regime (Ut2)) were identified in the freeboard region based on the visual observation and bubble characteristic parameter acquisition system (BVW-2) monitoring the variations in the bubble size distribution. Visual observation combined with electrical resistance tomography (ERT) monitoring the solid concentration variations facilitated accurate determination of three flow regimes (fixed bed regime, agitated bed regime, and complete fluidization regime) and two transition points (minimum agitation water velocity (ULma) and minimum fluidization water velocity (ULmf)) in the bulk fluidized bed region. Furthermore, statistical and spectral methods were used to analyze pressure fluctuation signals and characterize fluidization behavior across different flow regimes, including the average pressure fluctuation (ΔP¯), the probability density function (PDF), normalized standard deviation (δ), kurtosis (K), skewness (S), autocorrelation function (ACF), power spectral density (PSD) and average cycle frequency (fc). The results indicated that it is the changes in dominant flow structures within the three-phase fluidized bed, such as variations in bubble behavior and particle movement under different Ug and Uw, that lead to differences in flow characteristics, thereby forming distinct flow regimes.

Numerical Analysis of Flow Structure Evolution during Scour Hole Development: A Case Study of a Pile-Supported Pier with Partially Buried Pile Cap

This study numerically investigates a pile-supported pier, which comprises a column with a partially buried pile cap and a group of piles, recognizing that partially buried pile caps lead to the highest scour depth. Most research has focused on equilibrium scour conditions in laboratory settings, overlooking the detailed dynamics of horseshoe vortices around pile groups. This study aims to clarify the flow structure and vortex dynamics at a pile-supported pier during local scour hole development stages using an in-house developed numerical model. The model’s accuracy is validated against flat-channel and compound pier reference cases. For the pile-supported pier, fixed bed geometry was used in flow simulations at selected scouring stages. Results show significant changes in flow structure and vortex formation with scour hole time development, particularly as the bed surface moves away from the pile cap. The study reveals variations in vortex size, number, and positioning, alongside turbulent kinetic energy and Reynolds shear stress distributions over time. High positive Reynolds shear stress near the bed during intermediate scouring stages highlights the complex interactions within the flow field. This research provides the first detailed visualization of flow structure evolution within a scour hole at a pile-supported pier.

Towards Sustainable Energy Development: Integrating Traditional and Renewable Energy in Azerbaijan’s Energy Policy

The article examines the formation of Azerbaijan's energy policy and the multivector development of its fuel and energy complex. In the context of global transformations and changes in energy flow structures, the author emphasizes the balanced development of both hydrocarbon and carbon-free segments of energy. The proposed concept of sustainable energy development envisages the harmonious coexistence of traditional and renewable energy, enhancing Azerbaijan's economic stability and geopolitical influence. The significant role of the oil and gas sector, demonstrated by successful projects and substantial foreign investments, is reinforced by the active development of renewable energy sources. Azerbaijan implements large-scale projects in wind and solar energy, as well as initiatives for the production of «green» hydrogen, which contributes not only to the reduction of emissions but also to the expansion of the country's export potential. The article highlights the importance of balanced FEC development, focusing on emission minimization through the application of carbon capture and utilization (CCUS) technologies, as well as the need for infrastructure modernization to improve energy efficiency. Azerbaijan demonstrates a unique case where traditional and renewable energy do not compete but complement each other, strengthening its positions in international cooperation and within the framework of the Greater Eurasian Partnership.

Effect of emergent vegetation on riverbank erosion with sediment mining

The present work investigates the combined effects of the upstream sediment mining pit and vegetation on the riverbank using emergent rigid vegetation beyond the toe on the flow structure and morphological changes due to fluvial erosion. A steep gradient of streamwise velocity and other turbulence parameters such as Reynolds shear stress (RSS), transverse RSS, and turbulent kinetic energy (TKE) at the interface of the vegetated and unvegetated part of the test segment was observed. The cross-sectional analysis showed that vegetation increased the velocity of the unvegetated main channel, and the sandpit increased even the near-bed velocity with a similar trend in its longitudinal variation at the center line of the main channel. The abrupt variation in RSS and transverse RSS at the location of the berm induces instability and erodes the berm present at the toe of the riverbank. The combination of the vegetation and sandpit led to increased TKE of the flow at the near-bed and berm locations. The morphological analysis showed complete riverbank erosion in both cases of the unvegetated riverbank, i.e., without or with an upstream pit. The installed stems of rigid vegetation on the riverbank helped decrease the fluvial erosion of the riverbank, and its profile observed minimal changes over the length of the test segment. However, the main channel erosion was amplified due to the vegetation (in no-pit case) at the beginning of the test segment, which eroded the bed of the main channel by about 67% of the bed thickness. Also, in the vegetated riverbank cases, the upstream pit caused an increase in erosion by 7.66% at the center of the main channel. The study helps establish the hypothesis of negating the effects of sediment mining on bank erosion by using the rigid vegetation on the riverbank beyond its toe location, which performed well by maintaining the riverbank profile.

A Computational Investigation of the Influence of Seafloor Conditions on the Turbulent Flow Characteristics of an Autonomous Underwater Vehicle

The effect of the seabed on the hydrodynamics of three-dimensional autonomous underwater vehicles (AUVs) varies according to the physical conditions of the place where AUVs interact with the environmental conditions. This study examines the hydrodynamics of an AUV resembling a torpedo model while taking the influence of the seabed surface as a function of the dimensionless distances (G/D) between the torpedo and the seabed. Reynolds numbers, varying from 1 × 104 to 8 × 104, were considered. These Reynolds numbers were associated with various seabed distances falling within 0.25 ≤ G/D ≤ 1.5. To perform the simulations, governing equations were utilized and incorporated with the k–ω SST turbulence model. It has been observed that when AUVs or torpedo models operate in close proximity to the seabed surface, several key hydrodynamic parameters and flow characteristics are affected. These include the pressure coefficient (Cp), drag coefficient (CD), overall flow structures, maneuverability, and performance of the torpedo model. As the AUV or torpedo model approaches the seabed surface, the symmetrical flow pattern deteriorates. This deterioration is associated with changes in vortical flow structures under the influence of seabed surfaces. Additionally, the intensity of the shear stress (τ) near the seabed surface gradually increases as the AUV or torpedo model gets closer to it. In summary, the proximity of AUVs or torpedo models to the seabed surface causes disruptions in the flow patterns, increased shear stress, and alterations in key hydrodynamic parameters, ultimately affecting the system's performance and behavior.

FLUJO PULSÁTIL DE FLUIDOS VISCOELÁSTICOS EN TUBOS

In this study, we present an experimental investigation of the flow structure changes in non-Newtonian fluids subjected to periodic variable fluxes inside rigid-walled tubes. We employ a liquid mixture composed of water and polyacrylamide to account for various rheological properties. We obtain the velocity fields for each experimental case using the Particle Image Velocimetry (PIV) technique and we analyse their variations based on different properties of the pulsatile input signal. Reynolds numbers between 200 and 350 are considered, with a 10% variation in amplitude.

Two-phase flow visualization experiments in variable-aperture fractures: The correlation between flow structure, displacement efficiency and relative permeability

The correlation of flow structure, displacement efficiency and relative permeability for two-phase flow in variable-aperture fractures is critical for many fractured rock applications. A systematic visualization method for two-phase flow experiments was developed and four transparent variable-aperture fracture samples were duplicated by epoxy casting method. A total of 112 times two-phase flow experiments of nitrogen displacing water under various gas flow rates were performed and the corresponding results of images and pressure data during flow process were recorded and analyzed based on optical principles. On the basis of the competition between capillary resistance and inertia force of gas, the flow structure can be generally divided into four states including capillary resistance dominant (CR) state with few flow paths in two lateral sides without fingering flow, competitive (CP) state with the occurrence of clear fingering flow phenomenon, inertia force of gas dominant (IF) state showing more chaotic gas distributions, and steady (SD) state that has few changes in flow paths. The growth of displacement efficiency is greatly affected by the four transition states, in which the increment of displacement efficiency in Frac-1 that has gone through the three states of flow structure approaches 30%, and that of Frac-2 and Frac-3 are about 15%, while Frac-4 with little change of flow structure is less than 10%. As a consequence, the relationship between saturation and relative permeability of gas becomes steeper from Frac-1 to Frac-4 with greater deviation from X, V–C and Corey models due to the smaller variation range of gas saturation, and an improved v-type model is obtained where the exponent n shows a positive correlation to fracture mean aperture.

Effects of wall cavity and fuel injection pressure on the performance of a non-reacting supersonic combustor

This study numerically investigates the flow field of a non-reacting cavity-configured scramjet (Supersonic Combustion Ramjet) combustor at various fuel injection pressures by solving the 2D Reynolds-Averaged Navier-Stokes (RANS) equations, species transport equations, and Menter SST k-ω model. The aim of this research is to reveal the effects of wall cavity insertion and fuel injection pressure (FIP) on the crucial performance parameters i.e., fuel-air mixing efficiency (MxE), total pressure recovery (TPR), and mass-averaged Mach number (MAMN). Accordingly, two trapezoidal cavities of aspect ratio 7 are introduced on the opposite walls of a rectangular combustor. The combustor entrance is configured with rearward-facing steps and it intakes finite parallel air streams through finite-width inlets. Gaseous hydrogen jets are injected 30 mm downstream from the combustor entrance and 10 mm upstream from the cavity leading edge. FIP is varied according to the fuel-to-freestream pressure ratios (FFPR) of 4.5, 9.0, 13.5, and 18.0. The results of the cavity-configured combustor are then compared with the performance of the combustor in the absence of the wall cavities. The results delineate the change in flow structures with the inclusion of wall cavities and variation in FIP. Insight physics of mixing, total pressure loss, and MAMN in different regions of the combustor are studied and the results are quantified for comparison. MxE in a cavity-configured combustor does not monotonically increase with decreasing FFPR as found in the combustor without wall cavities. The shock-shear layer interactions (SSLIs) play a dominant role in mixing inside the cavity-configured combustor. The results also demonstrate that the insertion of wall cavities can increase fuel-air MxE through the formation of cavity recirculation zones. In the cavity-configured combustor, a maximum of 45% MxE is achieved for FFPR 4.5, which is 4% higher than the value obtained from the combustor without the cavities with an expense of 3% greater total pressure loss.

Longitudinal Change in Flow Structures and Energy Loss of Free Jumps and Submerged Jumps of Flows over an Embankment-type Weir

This study numerically investigates the longitudinal changes in the flow structures and energy loss of the free jumps and the submerged jumps. The hydraulic jumps from flows over an embankment-type weir are considered. For the numerical simulations, the 2D Unsteady Reynolds-Averaged Navier-Stokes equations are solved using the k–ω SST turbulence model. Flow structures and their longitudinal changes are compared with the available experimental data, showing moderate agreement. The simulation results indicate that the decaying patterns of the flow structures for the free jump are roughly similar to those for the submerged jump. The decaying rate decreases with increasing submergence ratio, in which process the adverse pressure gradient plays a key role. It is also confirmed that the loss of the kinetic energy increases with decreasing submergence ratio. For both free jump and submerged jump, the process of dissipating the kinetic energy terminates within the developed zone, with the decaying process of the flow structure unfinished.

Modulation of Rayleigh–Bénard convection with a large temperature difference by inertial nonisothermal particles

This study investigates the modulation by inertial nonisothermal particles in two-dimensional Rayleigh–Bénard (RB) convection with non-Oberbeck–Boussinesq effects due to a large temperature difference. Direct numerical simulations combined with a Lagrangian point-particle method are performed for 1×106≤Ra≤1×108 and 6.1×10−3≤Stf≤1.2, where the Rayleigh number Ra and Stokes number Stf measure the vigor of convection and particle response time, respectively. The typical aspect ratio Γ = 1 is of primary concern. We find that a horizontally arranged double-roll flow pattern prevails at intermediate Stokes numbers with optimal heat transfer efficiency, which has never been reported before. Compared to the single-phase cases, the heat transfer efficiency is enhanced by a factor of two or three. For micro Stokes numbers, unlike cases in the Oberbeck–Boussinesq limit where the addition of particles causes a small amount of flow structure changes, in this study, it is observed that a tiny volume load of particles could actually induce significant flow oscillations or trigger fluid instability for Ra=106; conversely, for medium Rayleigh numbers (Ra=107), it is found that flow reversal is slightly suppressed by small particles. For intermediate Stokes numbers, where particle–fluid couplings are strongest and a wealth of new phenomena emerge, special attention is paid. Considering different aspect ratios, after the addition of particles, it is found that closed RB systems tend to contain an even number of convection rolls rather than odd ones. Quantitatively, heat transfer also improves significantly for various aspect ratios for intermediate Stokes numbers. Subsequent investigations reveal that the narrowing of the horizontal size of convection rolls cannot fully explain the significant enhancement; instead, it should also be attributed to strong couplings between particles and fluid dynamics. Moreover, it is found that both momentum and thermal couplings play crucial roles in enhancing heat transfer efficiency.

Karakteristik Aliran Turbin Hidrokinetik Savonius Susunan Inward dan Outward Overlap dengan Dua Semicircular Blade-Flat Leading Edge

This current investigation was conducted to study the flow field through Savonius hydrokinetic turbine with flat blade leading edge. The influences of blade thickness, overlap, and freestream velocity were simulated using ANSYS FLUENT with k-w SST model. The results show that the flow structure changes with increasing turbine rotation flow complexity is formed at a larger rotation angle. Both inward and outward overlap lead to a more complex pattern of the flow. The coefficient of torque and power for thin blades is higher than for thicker turbine blades and its values increase with the increase in the freestream velocity.

Bi-stability of the Wake Flow of a Hatchback Car under Zero Yaw Angle Condition

<div>The aerodynamic performance of automobile especially drag and lift was largely determined by the wake flow, which is three-dimensional, unsteady, and turbulent. The styling of the rear back of the vehicle body has much influence on the wake flow structure, typically including squareback, notchback, and hatchback. Bi-stability of the wake flow of vehicle body makes the aerodynamic force oscillating, which affects the energy consumption and driving stability. This article investigates the bi-stability of wake flow of a hatchback SUV in full-scale automotive wind tunnel. Both aerodynamic force and surface pressure on the rear back of the vehicle were measured. Time series of aerodynamic force and pressure footprint are used to confirm the existence of bi-stability. The effects of some sensitive factors on the bi-stability have been analyzed. The results show that for the given condition with bi-stability phenomenon existing, the change of drag and lift can be 6.36% and 111%, respectively. The bi-stability of wake of the tested hatchback SUV is related to the change of flow structure in the wake of the vehicle, which can be explained by the drag crisis of hatchback vehicle under critical slant angle.</div>

Non-Boussinesq effect on the internal solitary wave propagation under a Lagrangian-like description for various pycnocline thickness conditions

The Dubreil–Jacotin–Long (DJL) equation is an exact model for the steady propagation of internal solitary waves (ISWs) under Boussinesq approximation. The aim of this study is to discuss the non-Boussinesq effect on ISWs initialized by DJL equation for various pycnocline thickness conditions. The simulated results show that the non-Boussinesq effect can indeed lead to instability of DJL equation, and the pycnocline thickness will affect the amplitude of re-stable ISWs and the separation process of tail waves. Moreover, in order to extract features of the non-Boussinesq instability and the location of the tail wave separation, we propose an effective analytical approach for the quasi-traveling wave problem inspired by the definition of classical Lagrangian coherent structure (LCS). The improved finite-time Lyapunov exponent with a moving window (FTLEmw) is a Lagrangian-like description with considering the prior information of physical phenomenon. For a steady ISW propagation in the Boussinesq system, the repelling and attracting FTLEmv fields are symmetrical and the field ridge behaves as a continuous spiral topology, which suggests that particles on different streamlines in the flow structure have different rotation periods, while the streamlines are not actually completely closed due to the forward propagation of the wave. During the main unstable stage of non-Boussinesq effect, the topology of separated tail wave which is disconnected from the ISW main part can be clearly distinguished. The tail wave separation locations identified by the improved FTLEmv field and the classical FTLE field are not the same, which illustrates the difference between the two perspectives of flow structure change and fluid particle motion. In addition, the leading edge, trailing edge and main part of ISWs will gradually be divided into three-part FTLEmv topologies in the thicker pycnocline conditions.

Thermodynamic investigation of the secondary flow inside centrifugal compressor for compressed air energy storage based on local dissipation

Centrifugal compressors are critical components of compressed air energy storage (CAES) systems and are of great interest to understanding internal secondary flows and their resulting energy losses. While previous studies have primarily described these secondary flows using empirical correlation equations, this paper conducts numerical simulations of a high-loading centrifugal compressor after performing an experimental validation. The changes in the secondary flow structure in the impeller are analyzed for different operating conditions using a specific identification method based on the simulation results. The local dissipation coefficient is used as a weighting to analyze the enthalpy losses due to different sources during the impeller's thermodynamic process. The variations of the loss proportions from different sources with the dimensionless operating parameters (flow coefficient, impeller machine Mach number, and loading coefficient) are discussed. The reasons for the trends of different loss types correlate with the flow structure, and three different loss regions in the whole operation range are distinguished. The energy loss inside an optimized impeller is compared with the baseline, and the results demonstrate that different losses can be controlled by adjusting the secondary flow structure within the impeller. This study provides a reference for enhancing the understanding of thermodynamic processes within a centrifugal impeller and aims to further the development of advanced centrifugal compressors.

Structure of the streaming flow generated by a sphere in a fluid undergoing rectilinear oscillation

A solid body in a viscous fluid undergoing oscillatory motion naturally produces a steady secondary flow due to convective inertia. This phenomenon is embodied in the streaming flow generated by a sphere in an unbounded fluid executing rectilinear oscillations. We review the considerable literature on this canonical problem and summarise exact and asymptotic formulas in the small-amplitude limit. These analytical formulas are used to explore the characteristic flow structure of this problem and clarify previously unreported features. A single, toroidal-shaped vortex exists in each hemisphere regardless of the oscillation frequency, which can drive a counter-flow away from the sphere. The vortex centre moves monotonically away from the sphere with decreasing oscillation frequency, and engulfs the entire flow domain for $\beta \equiv \omega R^2/\nu < 16.317$ , where $\omega$ is the angular oscillation frequency, $R$ the sphere radius, and $\nu$ the fluid kinematic viscosity. This seemingly abrupt change in flow structure at the critical frequency $\beta _{critical} =16.317$ , and its quantification, appear to have not been reported previously. We perform a direct numerical simulation of the Navier–Stokes equations, to (1) confirm existence of this critical frequency at finite amplitude, and (2) examine its variation with amplitude. This reveals a universal relationship between the critical frequency and oscillation amplitude, clarifying previous reports on the structure of this streaming flow. The critical frequency is shown to be identical for the streaming flow and the cycle-averaged particle paths, establishing that the critical frequency is accessible directly using standard measurements.

Surface Roughness in RANS Applied to Aircraft Ice Accretion Simulation: A Review

Experimental and numerical fluid dynamics studies highlight a change of flow structure in the presence of surface roughness. The changes involve both wall heat transfer and skin friction, and are mainly restricted to the inner region of the boundary layer. Aircraft in-flight icing is a typical application where rough surfaces play an important role in the airflow structure and the subsequent ice growth. The objective of this work is to investigate how surface roughness is tackled in RANS with wall resolved boundary layers for aeronautics applications, with a focus on ice-induced roughness. The literature review shows that semi-empirical correlations were calibrated on experimental data to model flow changes in the presence of roughness. The correlations for RANS do not explicitly resolve the individual roughness. They principally involve turbulence model modifications to account for changes in the velocity and temperature profiles in the near-wall region. The equivalent sand grain roughness (ESGR) approach emerges as a popular metric to characterize roughness and is employed as a length scale for the RANS model. For in-flight icing, correlations were developed, accounting for both surface geometry and atmospheric conditions. Despite these research efforts, uncertainties are present in some specific conditions, where space and time roughness variations make the simulations difficult to calibrate. Research that addresses this gap could help improve ice accretion predictions.

Modeling Gas Flows in Packed Beds with the Lattice Boltzmann Method: Validation Against Experiments

This study aims to validate the lattice Boltzmann method and assess its ability to accurately describe the behavior of gaseous flows in packed beds. To that end, simulations of a model packed bed reactor, corresponding to an experimental bench, are conducted, and the results are directly compared with experimental data obtained by particle image velocimetry measurements. It is found that the lattice Boltzmann solver exhibits very good agreement with experimental measurements. Then, the numerical solver is further used to analyze the effect of the number of packing layers on the flow structure and to determine the minimum bed height above which the changes in flow structure become insignificant. Finally, flow fluctuations in time are discussed. The findings of this study provide valuable insights into the behavior of the gas flow in packed bed reactors, opening the door for further investigations involving additionally chemical reactions, as found in many practical applications.

Single vascular insult exacerbates disease pathology in APPswe Mice.

AbstractBackgroundVascular insults, such as microinfarcts play a major role in mixed dementia including Alzheimer’s disease (AD). Neuroimaging from longitudinal studies have shown involvement of white matter hyperintensities due to blood brain barrier (BBB) breakdown. In patients with AD the combined neurotoxic effects of amyloid‐β (Aβ) converge on brain vasculature synergistically leading to neuronal and synaptic dysfunction, which in turn leads to cognitive impairment. In the present study we examined the effect of vascular insult induced by enothelin‐1 (ET‐1, a vasoconstrictor peptide) on Aβ pathology in mouse models of AD. We further studied behavioral deficits during reduced cerebral blood flow changes and structural changes in BBB components.MethodWe injected 2µg/2μl of ET‐1 bilaterally into lateral ventricles APPswe mice carrying point mutation for APP. Behavioral assays were performed to compare associative learning and spatial memory deficits, if any after 30 days of ET‐1 injection. Immunohistochemistry for markers of endothelial cells and pericytes were done to look at the structural changes in BBB. Aβ ELISA and plaque load were tested to understand the effect of vascular insult on AD pathology.ResultVasoconstriction following ET‐1 injection after 30 days leads to memory deficits in AD mice while wildtype mice recovered. There were structural changes in BBB showing decreased expression of endothelial and pericyte marker, however these changes were not observed in wildtype mice. Aβ levels were increased in brain lysates of APPswe mice injected with ET‐1.ConclusionSingle vascular insult was adequate to bring about impairment in learning and memory in APPswe mice and structural changes in BBB, which were not seen in WT type mice indicating that ET‐1 induced cerebral hypoperfusion accelerated AD pathogenesis.