AbstractWe investigate the projected climate change over Mainland Southeast Asia (also known as the Indochina Peninsula) and the Lancang‐Mekong River basin, a region with complex topography and unique weather and climate systems, but limited availability of published high‐resolution regional climate model (RCM) studies. The study is based on an unprecedented ensemble of 21st century projections with the RegCM4 RCM driven by five different general circulation models (GCMs) at a grid spacing of 25 km under the representative concentration pathways RCP4.5 and RCP8.5. We focus on mean temperature and precipitation in the dry season November–March (NDJFM), the wet season May–September (MJJAS), and the whole year. Intercomparison between the RegCM4 simulations with the driving GCMs is provided to illustrate the added value of the RegCM4 experiments. RegCM4 reproduces greater and more realistic spatial detail of the present day temperature and precipitation distribution compared to the driving GCMs, but some biases are found, such as an overestimation of precipitation over high topography regions. The spatial pattern of biases shows some consistencies across the GCMs and, for NDJFM the RegCM4, although weak correlation is found between the GCM and nested RegCM4 biases. A generally lower warming is projected in the future by the RegCM4 in different seasons and the whole year. For precipitation, while prevailing increases are found in the GCM projections, large areas of decrease occur in the RegCM ones, in particular during the wet season, possibly due to the more detailed topographical representation. The change patterns of precipitation show consistencies across the GCMs and the RegCM4, especially in MJJAS. The projected changes of extreme indices indicate a general decrease/increase of extreme cold/warm events. Drought events are projected to be more frequent over the southwestern, while a general increase of heavy rain events prevails over most parts of the region.