Changes In Asymmetry Research Articles

Effects of Successive Annual Training on Young Swimmers’ Strength Asymmetries and Performance

This study aimed to compare changes in swimmers’ performance, biomechanical variables, and strength asymmetries within two successive training years. Eight competitive age-group swimmers (four males and four females; age: 14.8 ± 1.3 years) were tested before and after the same 12-week mesocycle period within two successive years (Year-1, Year-2). The swimmers were timed in 50, 200, and 400 m, and the stroke rate (SR), stroke length (SL), and stroke index (SI) were calculated. SI was calculated by the product of SL with swimming speed. Dryland shoulder isometric strength (ISO), hand grip isometric strength test (HG), and in-water maximum 30 s tethered swimming force (TF) were evaluated. The asymmetry index was calculated using ISO, HG, and TF tests as [(Fd − Fnd)/0.5 × (Fd + Fnd)] × 100, where Fd is strength in the dominant hand and Fnd is strength in the non-dominant hand. Performance time improved in 200 and 400 m, while the asymmetry indices calculated by the ISO, HG, and TF tests were similar after 12 weeks of training in both Year-1 and Year-2 (p = 0.01). Changes (Δ) in HG strength asymmetries correlated with Δ in 200 and 400 m in Year-2 (r = 0.78–0.87, p = 0.01). The asymmetry index does not change after two successive years of training but may be connected to performance changes in 200 and 400 m front crawl.

Mobile Spatiotemporal Gait Segmentation Using an Ear-Worn Motion Sensor and Deep Learning.

Mobile health technologies enable continuous, quantitative assessment of mobility and gait in real-world environments, facilitating early diagnoses of gait disorders, disease progression monitoring, and prediction of adverse events like falls. Traditionally, mobile gait assessment predominantly relied on body-fixed sensors positioned at the feet or lower trunk. Here, we investigate the potential of an algorithm utilizing an ear-worn motion sensor for spatiotemporal segmentation of gait patterns. We collected 3D acceleration profiles from the ear-worn sensor during varied walking speeds in 53 healthy adults. Temporal convolutional networks were trained to detect stepping sequences and predict spatial relations between steps. The resulting algorithm, mEar, accurately detects initial and final ground contacts (F1 score of 99% and 91%, respectively). It enables the determination of temporal and spatial gait cycle characteristics (among others, stride time and stride length) with good to excellent validity at a precision sufficient to monitor clinically relevant changes in walking speed, stride-to-stride variability, and side asymmetry. This study highlights the ear as a viable site for monitoring gait and proposes its potential integration with in-ear vital-sign monitoring. Such integration offers a practical approach to comprehensive health monitoring and telemedical applications, by integrating multiple sensors in a single anatomical location.

Negative Asymmetric Response of Pantropical Gross Primary Productivity to Precipitation Anomalies

AbstractThe carbon sink in pantropical biomes play a crucial role in modulating the inter‐annual variations of global terrestrial carbon balance and is threatened by extreme climate events. However, it has not been carefully examined whether an increase in tropical gross primary productivity (GPP) can compensate the decrease during precipitation anomalies. Using the asymmetry index (AI) and multiple GPP products, we assessed responses of pantropical GPP to precipitation anomalies during 2001–2022. Positive AI indicates that GPP increases are greater than GPP decreases during precipitation anomalies, and vice versa. Our results showed an average negative pantropical GPP asymmetry, that is, GPP decreases exceeded the GPP increases during precipitation anomalies. In addition, a positive AI was found in tropical hyper‐arid and arid regions, which is opposite to the negative AI observed in tropical semi‐arid, sub‐humid, and humid regions. This suggest that tropical GPP asymmetry changes from positive to negative as the moisture increases. Notably, a significant decreasing trend of negative AI was observed over the entire tropical region, indicating that the negative effect of inter‐annual precipitation variations on pantropical vegetation productivity has enhanced. Considering the model predicted increasing climate variability and extremes, the negative impact of precipitation variability on tropical carbon cycle may continue to intensify. Lastly, the divergence in AI estimates among multiple GPP products highlight the need to further improve our understanding of the response of tropical carbon cycle to climate changes, especially for the tropical humid regions.

Serial engagement of distinct motor learning mechanisms to alter walking after stroke

This study asked if combining different motor learning mechanisms—adaptation and reinforcement—could produce immediate improvements in over ground walking after stroke. Fifteen adults with stroke engaged in three conditions: (1) reinforcement following adaptation, (2) reinforcement alone, and (3) adaptation alone. Adaptation involved split-belt treadmill walking to produce after-effects that reduce step asymmetry. Reinforcement involved the use of real-time auditory feedback about step length asymmetry. Auditory feedback was binary, signaling whether steps were asymmetric or equal, but not whether to shorten or lengthen either step. Change in step length asymmetry was the outcome assessed during over ground walking. Reinforcement following adaptation led to reductions in step length asymmetry that persisted into an immediate retention period. Importantly, it led to the desired pattern of lengthening the shorter step in a majority of participants. Reinforcement alone led to no significant change in step length asymmetry, and sometimes produced a non-optimal pattern of shortening the longer step. Our control condition of adaptation alone led to more transient reductions in step length asymmetry. These findings reveal the potential for utilizing serial delivery of adaptation and reinforcement to influence a complex movement in the real-world context of over ground walking, in people with stroke.

German infants’ discrimination of the English /æ/-/ɛ/ contrast: Evidence from a cross-sectional and a longitudinal study

Young infants can discriminate many non-native sounds, but the discrimination ability is thought to decrease within the first year of life due to perceptual attunement. However, most studies tested infants’ perception cross-sectionally, without examining within-group change. To this end, the current study tested German infants’ discrimination of the English /æ/-/ɛ/ contrast both cross-sectionally and longitudinally using the visual habituation technique. In Experiment 1, 96 German-learning infants were tested cross-sectionally at 5–6, 8–9 and 12–13 months. Linear mixed-effects models revealed that while the 5–6-month-olds did not discriminate the contrast, the 8–9- and 12–13-month-olds showed signs of discrimination only when they were habituated with /ɛ/, in line with previous findings suggesting that changes from central to peripheral vowels in the F1/F2 vowel space are more noticeable than in the reverse direction. Moreover, the 8–9-month-olds showed a novelty preference, while the 12–13-month-olds showed a familiarity preference. In Experiment 2, the infants tested at 5–6 months in Experiment 1 were tested again at 8–9 and 12–13 months. Fifteen infants completed the three experiments. Here, only the 12–13-month-olds discriminated the contrast by showing a novelty preference but only when habituated with /æ/. Overall, both experiments showed gradual development of discrimination ability across the first year, which challenges the assumptions of perceptual attunement. We propose that the perceptual sensitivity for a non-native vocalic contrast can improve during development. The change in perceptual asymmetry tells us that the direction of asymmetry is not universal and can be altered by linguistic experience. The change from novelty to familiarity preference may be due to the emerging preference for the more native-like vowel as well as the effect of repeating experiments with the same infants. In sum, our cross-sectional and longitudinal results overlap broadly, but the potential effect of repeating experiments must be considered when interpreting longitudinal studies.

Changes in Lower Limb Asymmetry following Intensive Balance Training in adults with Chronic Stroke

Changes in Lower Limb Asymmetry following Intensive Balance Training in adults with Chronic Stroke

Comparing the effects of resistance and aerobic exercise on mood-related symptoms and EEG activity in young healthy adults: A non-randomized pilot study

Background and aimsExercise offers several benefits in combating mood-related symptoms in humans. Participation in various types of physical activity improves brain and mental health. However, the different effects and mechanisms depending on the type of exercise on an individual's mood and brain remain unclear. This pilot trial aimed to reveal the feasibility of the effects of resistance and aerobic exercise on mood-related symptoms and explain the different patterns of brain waves. MethodsThis 15-week single-arm pre-test/post-test trial including 3 measurement periods was held in Seoul, Republic of Korea. Overall, 18 healthy participants aged 19–29 years were recruited. After 6 weeks of respective aerobic and resistance exercise, anxiety/depression-related questionnaire scores and electroencephalography (EEG) changes were measured (single blinded outcome assessment). Specifically, changes in frontal alpha asymmetry (FAA), absolute band power of beta waves, and theta waves were measured in the prefrontal and frontal regions, which play a critical role in regulating mood and cognition. ResultsResistance exercise resulted in a significant reduction in Beck Depression Inventory-II scores (p = 0.002, effect size = 0.76) while significant improvement was shown in Beck Anxiety Inventory scores (p = 0.01, effect size = 0.77) after aerobic exercise. In regarding EEG analysis, ten participants completed the assessment. After resistance exercise, there was a significant elevation in frontal beta waves (p = 0.01, effect size = 0.81). Aerobic exercise did not result in significant EEG changes. There were no adverse events related to study participation. ConclusionOur findings suggest that resistance and aerobic exercises may be feasible for the alleviation of mood-related symptoms and EEG activities. As our pilot trial has a small sample size and did not include a control group, future research that accurately reflects the effects of different types of exercises on mood symptoms and changes of EEG activities is required.

From tweets to tensions: exploring the roots of political polarization in Turkish constitutional referendum

ABSTRACT This study examines between-group and within-group polarization in online social networks to uncover latent factors and ideological changes over time. The study used 2017 Turkish constitutional referendum as a case focusing on Twitter dynamics between the yes-vote and no-vote communities, examining divergence of worldviews and partisan responses. We examined how changes in partisan asymmetries over time shape echo-chambers in opinion, network, and user polarization providing evidence of polarization at group, sub-group, and individual levels. Findings show differences in polarization between groups at different time periods. Before the referendum, yes-voting users are main drivers of polarization and more inward-looking than no-voting users. In contrast, considering the gap between winners and losers of the referendum and associated mood swings, in the days following the referendum no-voting users are main drivers of polarization. This demonstrates fine-grained details of polarization and changes in users’ sentiment as a latent factor behind seasonal behavior differences observed between two groups. Overall, yes-voting community was ideologically more coherent with a relatively denser network structure and more polarized body of users.

Longitudinal changes in brain asymmetry track lifestyle and disease.

Human beings may have evolved the largest asymmetries of brain organization in the animal kingdom. Hemispheric left-vs-right specialization is especially pronounced in our species-unique capacities. Yet, brain asymmetry features appear to be strongly shaped by non-genetic influences. We hence charted the largest longitudinal brain-imaging adult resource, yielding evidence that brain asymmetry changes continuously in a manner suggestive of neural plasticity. In the UK Biobank population cohort, we demonstrate that asymmetry changes show robust associations across 959 distinct phenotypic variables spanning 11 categories. We also find that changes in brain asymmetry over years co-occur with changes among specific lifestyle markers. Finally, we reveal relevance of brain asymmetry changes to major disease categories across thousands of medical diagnoses. Our results challenge the tacit assumption that asymmetrical neural systems are highly conserved throughout adulthood.

Raman spectra of oxidized sulfur species in hydrothermal fluids

Raman spectroscopic determination of sulfur species molalities in hydrothermal fluids requires correct assignment and knowledge of the scattering efficiencies of Raman bands. Therefore, we studied the Raman spectra of NaHSO4 and H2SO4 solutions experimentally to 700 °C, and of Na2SO4, NaHSO4, H2SO4, and H2SO3 solutions by ab initio molecular dynamics simulation at 727 °C. The results indicate that the scattering efficiencies of the νs(SO3), νas(SO3), and ν(S–OH) Raman bands of HSO4−(aq) depend on the H+ activity. The asymmetric shape of the νs(SO3) Raman band of HSO4−(aq) becomes more symmetric with increasing temperature, which correlates with decreasing hydrogen bonding in the molecular environment. Proton activity and ion pairing do not have a large effect on the change in the band asymmetry with temperature, and a resonance effect on the band shape is not observed. Therefore, we attribute the asymmetric shape of the νs(SO3) Raman band of HSO4−(aq) mostly to hydrogen bonding of the proton in the H–OSO3− molecule with water in its environment. The AIMD simulations clarify assignments of Raman bands of H2SO40, specifically to νs(SO2) and νas(SO2) at ∼1140 cm−1 and ∼1370 cm−1, to νs(SO4) and νas(SO4) at ∼970 cm−1 and ∼1220 cm−1, and to νs(S–(OH)2) and νas(S–(OH)2) at ∼750 cm−1 and ∼840 cm−1. In addition, the experiments showed that diamond is not inert to H2SO4 at high temperatures as reduction of S(VI) to S(IV) produces SO20 and oxidation of diamond generates CO20.

Comprehensive analysis of alar base inclination and lip line cant following orthognathic correction of maxillomandibular asymmetry: A retrospective study

This paper examines the relationship between roll rotation of the jaws and changes in alar base or lip line asymmetry in the coronal plane following orthognathic correction. The study involved patients with preoperative frontal alar base and lip line asymmetries greater than 0.5° (because it corresponds to the minimum asymmetry perception threshold) and underwent bimaxillary orthognathic surgery without (Group I) or with (Group II) genioplasty. The alar base angle (ABA), lip line cant angle (LLCA), maxillary cant angle (MxCA), and mandibular cant angle (MnCA) were measured using preoperative and 12 months postoperative cone beam computed tomography (CBCT) images. Thirty-four patients were included in the study. Significant correlations were found between changes in MxCA and ABA besides between changes in MnCA and LCA in Groups I (P = 0.016, P˂0.001, respectively) and II (P = 0.002, P˂0.001, respectively). The mean of the change in ABA/the change in MxCA and the change in LLCA/the change in MnCA ratios for Group I were 0.59 ± 1.57 and 0.73 ± 0.94, respectively, while those for Group II were 0.46 ± 3.70 and 0.39 ± 2.00, respectively. Angular measurements from jugular and mental foramina points, aligned with the bony midline, offer a convenient tool for predicting alar base and lip symmetry during bimaxillary orthognathic surgery planning.

OO Leo: An Active Contact Binary with Possible Solar-like Differential Rotation

With Transiting Exoplanet Survey Satellite (TESS) high-precision photometry and Large Sky Area Multi-object Fiber Spectroscopic Telescope medium-resolution spectra, we present the first light and radial velocity curve analyses for the eclipsing binary OO Leo. The simultaneous solution suggests that OO Leo is a W-subtype contact binary with a relatively low mass ratio (1/q = 0.173) and a moderate degree of contact (f = 28.1%). The asymmetry and continuous changes observed in the TESS light curve were properly modeled by one retrograde cool spot on its secondary surface. A detailed investigation of the Hα line also confirmed that the secondary star had a high level of magnetic activity. The retrograde longitudinal motion of the spot can be explained by a solar-like differential rotation in the secondary component. The orbital period investigation revealed that OO Leo is undergoing a secular decrease and a cyclic variation in its orbital period. The secular decrease may be mainly caused by mass transfer from the more massive secondary star to the less massive primary star. The cyclic period variation can be explained by the light–time effect of an invisible third body or the cyclic magnetic activity of the secondary star. The long-lived spot migration in the longitudinal direction makes OO Leo an excellent target for investigating the differential rotations of contact binaries.

Crescent Mastopexy With Augmentation and Hemi-Interlocking Circumareolar Mersilene Suture: An Innovative Approach

Introduction: Safety and patient satisfaction of crescent mastopexy and concurrent primary or revisional augmentation mammoplasty is controversial owing to secondary asymmetry and potential complications involving breast tissue and the nipple-areolar complex (NAC). The primary objective of this case series was to present a new technique that can achieve anatomic integrity and natural morphology of the NAC, while avoiding complications and minimizing scarring and hypertrophic alterations. Materials and Methods: Using white nonabsorbable 3-0 polyester mersilene suture for tension-free closure, the procedure was completed via intradermal insertion of the needleless end of the suture into the circumareolar NAC-skin junction at the inferior segment and an interlocking purse-string or spoke-wheel configuration in the superior segment, juxtaposing the NAC and cutaneous margin, thereby redistributing the tension line from the crescent scar to a circumareolar, cranially repositioned site. Patients were followed at 24 hours, 1, 3, 6, and 12 weeks, and 6 and 12 months. Postoperative pain was patient-measured using the Visual Analog Scale (possible scores ranged from 0 to 10), and esthetic satisfaction was determined by patient surveys (scores 0-5). Follow-up visits involved evaluation of scars, nipple sensation, nipple-areolar perfusion by capillary refill, asymmetry, and hypertrophic and pigmentation changes. Results: Six patients (ages 32-46) underwent 2 primary procedures and 4 revisions between January 2020 and March 2023 and were chosen retrospectively based on inclusion and exclusion criteria. One revision was completed using the traditional method while the rest were completed with the new technique. Surgical times ranged from 15:34 to 17:35 minutes, with patients reporting minimal initial and postoperative pain, high patient satisfaction, and reduced scar visibility. All patients reported postoperative pain assessments as negligible initial pain on days 0 to 3 (0) and 1 to 2 on days 4 to 7, with 1 patient scoring pain as 2 to 3. Scar visibility was minimal (<0.5 mm), although 1 patient experienced 1.5 mm at 12 months. Shape of the NAC was maintained in all cases at 6 months, with 1 patient evolving to oval shape at 12 months. Patient satisfaction was scored at 4 and 5 at 6 and 12 months. No complications, scarring, or alterations in NAC shape or position were noted. Conclusion: This technique avoided resection of the mammary gland, achieved minimal tension and thereby preserved the crescent scar, corrected preoperative asymmetry and mild ptosis, proved superior aesthetic enhancement, and reduced complications compared with traditional methods. These promising results warrant further evaluation in a larger cohort.

Radial halo substructure in harmony with the Galactic bar

ABSTRACT Overdensities in the radial phase space $(r,v_{\rm r})$ of the Milky Way’s halo have previously been associated with the phase-mixed debris of a highly radial merger event such as Gaia Sausage–Enceladus. We present and test an alternative theory in which the overdense ‘chevrons’ are instead composed of stars trapped in resonances with the Galactic bar. We develop an analytic model of resonant orbits in the isochrone potential, and complement this with a test particle simulation of a stellar halo in a realistic barred Milky Way potential. These models are used to predict the appearance of action space $(J_\phi ,J_{\rm r})$ and radial phase space in the Solar neighbourhood. They are able to reproduce almost all salient features of the observed chevrons. In particular, both the analytic model and simulation predict that the chevrons are more prominent at $v_{\rm r}\ \lt\ 0$ when viewed near the Sun, as is observed by Gaia. This is inconsistent with formation by an ancient merger event. We also associate individual chevrons with specific resonances. At a bar pattern speed of $\Omega _\mathrm{b}=35$ km s$^{-1}$ kpc$^{-1}$, the two most prominent prograde chevrons align very closely with the corotation and outer Lindblad resonances. The former can be viewed as a highly eccentric extension of the Hercules stream. Finally, our model predicts that the $v_{\rm r}$ asymmetry changes sign as a function of Galactic radius and azimuth, and we find evidence that this is indeed the case in the Milky Way.

The relationship between asymmetry changes in the slope frequency of bioelectrical activity of the gluteus maximus muscles and experience in short track speed skating athletics

BACKGROUND: In short track speed skating, there is asymmetric fatigue of the gluteus maximus (GM) muscle resulting from the technique of skating. Scientific reports confirm the relationship between muscle fatigue and its change in the slope frequency of bioelectrical activity. OBJECTIVE: To investigate whether athletic experience in elite short track speed skating can distinguish the asymmetry change in slope frequency of the raw electromyographic signal (EMG) of the GM muscle, influenced by the disparity in experience between junior and senior athletes. METHODS: In the research, an elite group of short track speed skating national team athletes Junior and Senior, participated. Isometric tension GM muscle was tested using the Biering-Sorensen test. RESULTS: The study confirmed differences in the asymmetry of slope frequences EMG signal in GM muscle between juniors and seniors in short track speed skating (p⩽ 0.001). Senior athletes showed greater slope frequences in the right GM muscle (p⩽ 0.002), while juniors showed greater in the left GM muscle (p⩽ 0.008). Intergroup analysis revealed significantly meaningful differences (p⩽ 0.001) in the level of slope frequences of the right GM muscle (juniors vs. seniors), highlighting the asymmetry resulting from experience. CONCLUSIONS: Statistically significant differences in the level of slope frequences of the right gluteus maximus muscle juniors vs. seniors were demonstrated, suggesting asymmetry due to experience and skating technique.

Natural reversal of cavefish heart asymmetry is controlled by Sonic Hedgehog effects on the left-right organizer.

The direction of left-right visceral asymmetry is conserved in vertebrates. Deviations of the standard asymmetric pattern are rare, and the underlying mechanisms are not understood. Here, we use the teleost Astyanax mexicanus, consisting of surface fish with normal left-oriented heart asymmetry and cavefish with high levels of reversed right-oriented heart asymmetry, to explore natural changes in asymmetry determination. We show that Sonic Hedgehog (Shh) signaling is increased at the posterior midline, Kupffer's vesicle (the teleost left-right organizer) is enlarged and contains longer cilia, and the number of dorsal forerunner cells is increased in cavefish. Furthermore, Shh increase in surface fish embryos induces asymmetric changes resembling the cavefish phenotype. Asymmetric expression of the Nodal antagonist Dand5 is equalized or reversed in cavefish, and Shh increase in surface fish mimics changes in cavefish dand5 asymmetry. Shh decrease reduces the level of right-oriented heart asymmetry in cavefish. Thus, naturally occurring modifications in cavefish heart asymmetry are controlled by the effects of Shh signaling on left-right organizer function.

Evidence of bottom-up homeostatic modulation induced taVNS during emotional and Go/No-Go tasks.

Bilateral transcutaneous auricular vagus nerve stimulation (taVNS) - a non-invasive neuromodulation technique - has been investigated as a safe and feasible technique to treat many neuropsychiatric conditions. such as epilepsy, depression, anxiety, and chronic pain. Our aim is to investigate the effect of taVNS on neurophysiological processes during emotional and Go/No-Go tasks, and changes in frontal alpha asymmetry. We performed a randomized, double-blind, sham-controlled trial with 44 healthy individuals who were allocated into two groups (the active taVNS group and the sham taVNS group). Subjects received one session of taVNS (active or sham) for 60min. QEEG was recorded before and after the interventions, and the subjects were assessed while exposed to emotional conditions with sad and happy facial expressions, followed by a Go/No-Go trial. The results demonstrated a significant increase in N2 amplitude in the No-Go condition for the active taVNS post-intervention compared to the sham taVNS after adjusting by handedness, mood, and fatigue levels (p = 0.046), significantly reduced ERD during sad conditions after treatment (p = 0.037), and increased frontal alpha asymmetry towards the right frontal hemisphere during the emotional task condition (p = 0.046). Finally, we observed an interesting neural signature in this study that suggests a bottom-up modulation from brainstem/subcortical to cortical areas as characterized by improved lateralization of alpha oscillations towards the frontal right hemisphere, and changes in ERP during emotional and Go/No-Go tasks that suggests a better subcortical response to the tasks. Such bottom-up effects may mediate some of the clinical effects of taVNS.

Improving Earth-like planet detection in radial velocity using deep learning

Context. Many novel methods have been proposed to mitigate stellar activity for exoplanet detection as the presence of stellar activity in radial velocity (RV) measurements is the current major limitation. Unlike traditional methods that model stellar activity in the RV domain, more methods are moving in the direction of disentangling stellar activity at the spectral level. As deep neural networks have already been proven to be one of the most effective tools in data mining, in this work, we explore their potential in the context of Earth-like planet detection in RV measurements. Aims. The goal of this paper is to present a novel convolutional neural network-based algorithm that efficiently models stellar activity signals at the spectral level, enhancing the detection of Earth-like planets. Methods. Based on the idea that the presence of planets can only produce a Doppler shift at the spectral level while the presence of stellar activity can introduce a variation in the profile of spectral lines (asymmetry and depth change), we trained a convolutional neural network to build the correlation between the change in the spectral line profile and the corresponding RV, full width at half maximum (FWHM) and bisector span (BIS) values derived from the classical cross-correlation function. Results. This algorithm has been tested on three intensively observed stars: Alpha Centauri B (HD 128621), Tau ceti (HD 10700), and the Sun. By injecting simulated planetary signals at the spectral level, we demonstrate that our machine learning algorithm can achieve, for HD 128621 and HD 10700, a detection threshold of 0.5 m s−1 in semi-amplitude for planets with periods ranging from 10 to 300 days. This threshold would correspond to the detection of a ~4 M⊕ in the habitable zone of those stars. On the HARPS-N solar dataset, thanks to significantly more data, our algorithm is even more efficient at mitigating stellar activity signals and can reach a threshold of 0.2 m s−1, which would correspond to a 2.2 M⊕ planet on the orbit of the Earth. Conclusions. To the best of our knowledge, it is the first time that such low detection thresholds are reported for the Sun, but also for other stars, and therefore this highlights the efficiency of our convolutional neural network-based algorithm at mitigating stellar activity in RV measurements.

UV‐Triggered Optical Asymmetry Modification of Gold Nanorods Helical Assemblies in a Cholesteric Liquid Crystal Host

AbstractThe creation and modulation of chirality innanomaterials is a well‐established and widely applied concept. Nevertheless, the direct approach of dynamically tuning their morphological asymmetry at thenanoscale to reveal their optical asymmetry variations is yet less well‐implemented. The helical templating of nanomaterials within a cholesteric liquidcrystal (CLC) host and the exploitation of their optical asymmetry change inconjunction with the host represent a means of circumventing technological limitations. In this study, a blending approach is employed to investigate the helical assemblies of gold nanorods (Au NRs) within a photo‐tunable CLC host, followed by their morphological asymmetry modulation through the use of UV irradiation. The results demonstrated that the optical asymmetry of the Au NR shelical assemblies increased in response to a reduction in pitch and the distance between the Au NRs, regardless of the azimuthal variations.Furthermore, the Au NRs blended with CLCs exhibited excellent and stable reflective properties comparable to those of conventional CLCs. Additionally,they can modulate the light flux of incident light at NIR wavelengths. The integrated modulation of reflection and transmission by Au NRs helical assemblies and CLC hosts represents a promising avenue for future research inthe field of multi‐level information encryption.

Dual-task gait has prognostic value for cognitive decline in Parkinson’s disease

IntroductionCognitive decline frequently occurs in individuals with Parkinson’s disease (PD), but the clinical methods to predict the onset of cognitive changes are limited. Given preliminary evidence of the link between gait and cognition, the purpose of this study was to determine if dual task (DT) gait was related to declines in cognition over two years in PD. MethodsA retrospective two-year longitudinal study of 48 individuals with PD using data from the Parkinson’s Progression Markers Initiative of the Michael J. Fox Foundation. The following data were extracted at baseline: spatiotemporal gait (during single and DT), demographics (age, sex), PD disease duration (time since diagnosis), motor function (Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS)), and cognition (Montreal Cognitive Assessment (MoCA)), with MoCA scores also extracted after two years. ResultsA binomial logistic regression was conducted, with all covariates (above) in block 1 and DT effect (DTE) of gait characteristics in block 2 entered in a stepwise fashion. The final model was statistically significant (χ2(6) = 23.20, p < 0.001) and correctly classified 78.7 % of participants by cognitive status after two years. Only DTE of arm swing asymmetry (ASA) (p = 0.030) was included in block 2 such that a 1 % decline in DTE resulted in 1.6 % increased odds of cognitive decline. ConclusionsIndividuals with greater change in arm swing asymmetry from single to DT gait may be more likely to experience a decline in cognition within two years. These results suggested that reduced automaticity or poor utilization of attentional resources may be indicative of subtle changes in cognition and indicate that DT paradigms may hold promise as a marker of future cognitive decline.