Changes In Taste Research Articles

Fires of Joy and Anticipation Wedding Firework Displays of the Central European Habsburgs in the Second Half of the 17th Century

Early modern firework illuminations and displays formed part of festivities in both secular and sacred contexts from the end of the 14th century. During the 15th and 16th centuries their designers, often high-ranking artillery officers, became an increasingly important part not only of army but also of court life. The development of fireworks, and especially rockets, gave prominence to intricately conceived displays, which were gradually developed according to the changing tastes of musical theatre productions and the skills of masters of pyrotechnics. In Central Europe, several performances were staged at the Habsburg court from the middle of the 17th century onwards which were clearly among the most costly, complex and, above all, the highest-quality pyrotechnical displays of their kind in the history of human culture. They were instruments of the complex patterns of contemporary propaganda and courtly representation, and their stories reflected the reality, desires, visions and concerns of the ruling dynasty. We can deduce their forms, stories and messages from surviving synopses and printed illustrated sheets.

Problems of trade and provision in the daily life of rural regions residents of Central Kazakhstan during 1964-1985

The article discusses the place of trade and supply in the Soviet system, based on a planned economy, and the impact of changes in the daily life of rural regions. The research paper used archival documents and interview materials that were first introduced into scientific circulation. Since the Soviet trade and supply system, which did not take into account demand, could not fully provide the common population with types of goods, the qualities of the “Soviet man” in everyday life always helped to find a way out of the difficult, and the solution of the problem was carried out in the system of institutional and beyond structures. The article takes into account the disadvantages and advantages of providing local differences between districts and types of goods, reflects changes in taste and innovations in human needs. Nomenclature with low interest and zeal for the cause in Soviet institutions, as in other fields of activity of the Soviet era, the most important thing is an ordinary “Soviet man” with the desire to satisfy his basic needs in a rigid state and ideological system are given by examples of rural areas. The primary sources of the habits formation, which in most life situations first give importance to informal contacts, are indicated by clear evidence. In conclusion, it was concluded that the supply of the rural population with consumer goods was completely subordinated to the state, the place of shortages was covered by informal contacts and relations on the local ground, and the common people fought the deficit through the methods of “silent resistance”

Authenticity and Commodification of Creative Industry Products in The Tourism Sector, Bali


 The creative industry places an emphasis on the creativity of a product, the understanding that the creator is known and has a copyright. In addition, the creative industry has links with the cultural industry, because its products are components of culture. When market tastes lead to post-industry, it is found that creative industry products consumed by tourism experience a change from homogeneous to heterogeneous with mass production. Changes in market tastes encourage the emergence of highly varied creative art products, as a result of the creative economy industry. The entry of the creative economy industry into the realm of culture, which then develops into the cultural industry, apart from growing the local and national economy, also has an impact on cultural components, especially from the aspects of authenticity and commodification. The areas affected include performing arts, tourism, entertainment, fashion, craft products, and culinary. In order to increase the competitiveness of Indonesian tourism, especially from the cultural pillar, the aspects of authenticity and commodification can increase its contribution to the local and national economy through the implementation of internationalization, traditionalization, and sacred versus profane.

Escalation of alcohol intake is associated with regionally decreased insular cortex activity but not changes in taste quality.

Intermittent access to ethanol drives persistent escalation of intake and rapid transition from moderate to compulsive-like drinking. Intermittent ethanol drinking may facilitate escalation of intake in part by altering aversion-sensitive neural substrates, such as the insular cortex (IC), thus driving greater approach toward stimuli previously treated as aversive. We conducted a series of experiments in rats to examine behavioral and neural responses associated with escalation of ethanol intake. First, taste reactivity analyses quantified the degree to which intermittent brief-access ethanol exposure (BAEE) alters sensitivity to the aversive properties of ethanol. Next, we determined whether pharmacological IC inhibition facilitated ethanol escalation. Finally, given that the IC is primary gustatory cortex, we employed psychophysical paradigms to assess whether escalation of ethanol intake induced changes in ethanol taste. These paradigms measured changes in sensitivity to the intensity of ethanol taste and whether escalation in intake shifts the salient taste quality of ethanol by measuring the degree to which the taste of ethanol generalized to a sucrose-like ("sweet") or quinine-like ("bitter") percept. We found a near-complete loss of aversive oromotor responses in ethanol-exposed relative to ethanol-naïve rats. Additionally, we observed significantly lower expression of ethanol-induced c-Fos expression in the posterior IC in exposed rats relative to naïve rats. Inhibition of the IC resulted in a modest, but statistically reliable increase in the acceptance of higher ethanol concentrations in naïve rats. Finally, we found no evidence of changes in the psychophysical assessment of the taste of ethanol in exposed, relative to naïve, rats. Our results demonstrate that neural activity within the IC adapts following repeated presentations of ethanol in a manner that correlates with reduced sensitivity to the aversive hedonic properties of ethanol. These data help to establish that alterations in IC activity may be driving exposure-induced escalations in ethanol intake.

Xerostomia and dysgeusia in the elderly

Xerostomia is defined as the perception of dry mouth, and dysgeusia, as a change in taste. Both are common complaints in the elderly, especially among those making use of polypharmacy drug combinations. Aim: This study aimed to determine the prevalence of xerostomia and dysgeusia and to investigate their association with polypharmacy in the elderly. Methods: older people under follow-up at the Multidisciplinary Elderly Center of the University Hospital of Brasília were interviewed and asked about health problems, medications used, presence of xerostomia and dysgeusia. Descriptive statistics were used to determine the prevalence of the symptoms surveyed. The chi-square test was used to investigate the relationship between xerostomia and dysgeusia and polypharmacy. Secondary associations were performed using binomial logistic regression. Results: Ninety-six older people were evaluated and of these, 62.5% had xerostomia and 21.1%, had dysgeusia. The average number of medications used was 4±3 medications per individual. Polypharmacy was associated with xerostomia but not dysgeusia. It was possible to associate xerostomia with the use of antihypertensive drugs. Conclusion: Xerostomia was a frequent complaint among elderly people making use of polypharmacy, especially those using antihypertensives. Antihypertensives and antidepressants were used most drugs by the elderly and exhibited interactions with drugs most prescribed in Dentistry. Two contraindications were found between fluconazole and mirtazapine; and between erythromycin and simvastatin.

Nutritional and Lifestyle Behaviors Reported Following One Anastomosis Gastric Bypass Based on a Multicenter Study

This study aimed to describe nutritional and lifestyle parameters following one-anastomosis gastric bypass (OAGB). A multicenter study among OAGB patients across Israel (n = 277) and Portugal (n = 111) was performed. Patients were approached according to the time elapsed since surgery. An online survey with information regarding demographics, anthropometrics, and nutritional and lifestyle aspects was administered in both countries simultaneously. Respondents from Israel (pre-surgery age of 41.6 ± 11.0 years, 75.8% females) and Portugal (pre-surgery age of 45.6 ± 12.3 years, 79.3% females) reported changes in their appetite (≤94.0% and ≤94.6%), changes in their taste (≤51.0 and ≤51.4%), and intolerance to specific foods (i.e., red meat, pasta, bread, and rice). Bariatric surgery-related eating recommendations were generally followed well, but a trend toward lower adherence was evident in groups with longer time elapsed since surgery in both countries. Most respondents from Israel and Portugal reported participation in follow-up meetings with a surgeon (≤94.0% and 100%) and a dietitian (≤92.6% and ≤100%), while far fewer reported participation in any follow-up meeting with a psychologist/social worker (≤37.9% and ≤56.1%). Patients following OAGB might experience changes in appetite, taste, and intolerance to specific foods. Adherence to bariatric surgery-related eating recommendations is not always satisfying, especially in the longer term post-surgery.

Oral Health of Diabetic Patients

According to the American Dental Association (ADA), diabetes can increase the risk of oral diseases and other symptoms in the oral cavity. About one-fifth of tooth loss can be attributed to diabetes. Periodontal diseases include gingivitis and periodontitis. Gingivitis is the acute or chronic inflammation of the gums, which is usually caused by dental plaques. Five major impacts on oral health by diabetes include gum disease, dry mouth or change in taste, infection, slow healing and periodontal disease. In addition, beside affecting blood sugar; periodontal disease is also closely related to cardiovascular disease. Omega-3 polyunsaturated fatty acids (PUFA) are not only beneficial to cardiovascular and metabolism, but also can inhibit inflammation and diabetic patients.

Modelling India. Unfired clay figurines and the East India Company's collections: from devotional icons to didactic displays

AbstractA well-known series of miniature figures produced in India from unfired clay, appropriately clothed and in many instances represented carrying out their respective secular or ritual duties, enjoyed a period of particular popularity on the world stage in the nineteenth century when they were appropriated as illustrative devices in museum displays and international exhibitions. Over the previous half-century or more they had emerged as products of a dynamic industry that responded to changes in taste as well as religious and artistic practice within Indian society, before being taken up by the West to serve new colonial imperatives. There they received perhaps their most enthusiastic reception at the India Museum, established in the headquarters of the East India Company in London in the early 1800s, and surviving beyond the suppression of the Company itself until they were dispersed to a number of other institutions in 1879. From an early appearance at the Great Exhibition in 1851, the figures also became a regular feature of the international exhibitions of the latter part of the century. Initially they celebrated the traditional crafts and practices of India but gradually were recruited to communicate other messages of Western industrial dominance and perceived artistic and industrial superiority. Although comparatively few of these figures survive intact in Western collections, the history of their considerable impact on the European stage can be enlarged upon with the aid of the documentary record.

Sensory evaluation of the bitterness of asenapine using D-sorbitol pretreatment: single-blind, placebo-controlled, crossover trial

BackgroundAntipsychotics are essential in the acute treatment of and maintenance therapy for schizophrenia, but medication adherence and long-term treatment continuity are needed to maximize their effectiveness. Each antipsychotic has various side effects, which may affect adherence. Some patients with schizophrenia are reluctant to take asenapine because of its unique oral-related side effects, such as the bitter taste caused by sublingual administration. Our previous basic research found that D-sorbitol lowered the bitterness parameters of the taste sensors. However, whether D-sorbitol has the same effect in patients remains unclear. Therefore, using a D-sorbitol solution, we aim to evaluate changes in the bitterness of asenapine among patients with schizophrenia.MethodsIn this single-blind, placebo-controlled, crossover trial, we plan to recruit 20 adult patients with schizophrenia spectrum disorder who take sublingual asenapine tablets. The participants will be divided into two groups (n = 10 each). Each group will be given a D-sorbitol or placebo solution on the first day for rinsing before taking the sublingual asenapine tablets. After a 1-day interval, the participants will rinse their mouths again with a different liquid. Questionnaires regarding changes in taste and the willingness to continue asenapine will be conducted before the start of the study and after each rinse. The primary and secondary end points will be a taste evaluation of bitterness, and the willingness to continue asenapine, respectively. Differences in questionnaire scores between the D-sorbitol and placebo solutions will be calculated and analyzed using a McNemar test.DiscussionThis study aims to determine the efficacy of D-sorbitol in masking the bitter taste of asenapine. To our knowledge, it is the first intervention study using D-sorbitol for bitter taste of asenapine in patients with schizophrenia. Evidence of the efficacy of D-sorbitol could result in D-sorbitol pretreatment being an easy and inexpensive means of improving adherence to asenapine.Trial registrationThis study was registered in the Japan Registry of Clinical Trials jRCTs041210019, on May 14, 2021. Ethics approval was obtained from the Nagoya University Clinical Research Review Board.

Impact of COVID-19 on Portuguese Dental Students: A Cohort Study

The goal of this study was to assess the impact of COVID-19 on Portuguese dental students on their depression, anxiety, temporomandibular dysfunction, academic degree, and oral behaviors. The target of this population study was to enroll third-, fourth-, and fifth-year students of the Integrated Master's degree in Dental Medicine at the Universidade Católica Portuguesa-Faculty of Dental Medicine (Viseu, Portugal) in the academic year 2021-2022. Temporomandibular disorders (TMD) symptoms, oral behaviors, anxiety, and depression were assessed using validated questionnaires. The variables under study were (a) age, gender, marital status, academic level, academic degree, medication, and any existing pathologies; (b) questions related to taste changes or thoughts that would indicate (or not) worsening psychological conditions (anxiety and depression). After data collection (Google Forms®), data were transferred to an Excel file and entered into SPSS® software. A chi-square test allowed the independence between ordinal or nominal variables. The Spearman correlation test was used to analyze the relationship between variables in the study (significant if p ≤ 0.05). 98.2% of the students answered the questionnaire. TMD had a prevalence of 35%, and anxiety and depression a prevalence of 29% and 24%, respectively. The results showed that the female gender was the most affected by psychological and temporomandibular disorders. Statistically significant correlations were identified between variables, such as gender and anxiety, TDM, and depression (respectively, p = 0.0001, p = 0.014, and p = 0.026); between TDM and anxiety and depression (respectively, p = 0.001 and p < 0.001); and between performing oral behaviors and TMD, anxiety, and depression (respectively, p = 0.0001, p = 0.0001, and p = 0.006). The variables, such as age and academic degree, did not establish a statistically significant relationship with TMD, oral behaviors, and the two psychological conditions. It was possible to conclude that there was a moderate prevalence of TMD, anxiety, and depression in the period studied. Moreover, a statistically significant relationship was found between TMD, anxiety, and depression with gender and frequency of OBs; however, no significant association was found for TMD, anxiety, and depression with the age of students and with the academic degree.

Market Conditions and Speed of Innovation on Increasing Sales of Micro and Small Entrepreneurs in Ternate City

The decline in people's purchasing power can be caused by market conditions, which of course, has an impact on decreasing the income of Micro and Small Enterprises (MSE) actors. This research was conducted to determine the ability to understand market conditions and the speed of innovation of MSME entrepreneurs toward increasing their sales in the City of Ternate. Research data was collected through a questionnaire on MSE actors in 5 sub-districts across Ternate. A total of 339 questionnaires were collected. Research data were analyzed using SEM-PLS analysis. The results show that market conditions and the speed of innovation directly affect the increase in sales. The level of innovation can mediate the influence of market conditions on sales. This finding has implications for MSEs to have the ability to understand market conditions and the pace of innovation in managing their business amid rapidly changing market conditions. Another interest for the Regional Government of the City of Ternate is to conduct training and policy assistance related to very rapid changes in market conditions due to changes in consumer tastes.

Prevalence of taste and smell dysfunction in mild and asymptomatic COVID-19 patients during Omicron prevalent period in Shanghai, China: a cross-sectional survey study

ObjectivesCOVID-19, which is caused by SARS-CoV-2, is a severe threat to human health and the economy globally. This study aimed to investigate the prevalence of taste and/or smell dysfunction and...

Survival in a Collapsed Stable for 37 Days After Avalanche Burial in 1755.

In 1755 in Bergemoletto, Italy, an avalanche buried 4 people (2 women, a girl, and a boy) and several animals in a stable. After 37 d in a pitch-dark confined space, 3 of the 4 people were rescued alive. The 3 survivors had only goat milk, a few chestnuts, a few kg of raw kid meat, and meltwater for nutrition. We describe the longest-known survival in an avalanche burial and discuss the medical and psychological problems of the survivors. The boy died. When they were extricated, all 3 survivors were exhausted, cachectic, and unable to stand or walk. They were severely malnourished and were experiencing tingling, tremors, and weakness in the legs; constipation; changes in taste; and amenorrhea. One of the women had persistent eye problems and developed symptoms consistent with post-traumatic stress disorder. The survivors were given slow refeeding. It took from 1 to 6 wk before they could walk. We compare this case to other long-duration burials, especially mining accidents, and describe the rescue and patient care after long-duration burials. This case demonstrates that people can overcome extremely adverse conditions and survive.

The Efficacy of GLP-1 Analogues on Appetite Parameters, Gastric Emptying, Food Preference and Taste Among Adults with Obesity: Systematic Review of Randomized Controlled Trials.

Obesity is an epidemiological issue that negatively affects public health and has led to a high global burden on the healthcare system. Several approaches to control and overcome the obesity crisis have been established. However, Nobel discoverers found that glucagon-like peptide-1 analogues (GLP-1 analogues) positively regulate appetite and food intake, eventually leading to weight loss. The present systematic review aims to summarize the currently available evidence of the impact of GLP-1 analogues on appetite, gastric emptying, taste sensitivity, and food preferences among adults with obesity without other chronic diseases. A systematic literature search was conducted from October 2021 to December 2021 from three electronic databases (PubMed, Scopus, and ScienceDirect), including only randomized clinical trials (RCTs). Studies were based on the use of GLP-1 analogues, of any dosage and duration among adults with obesity without other medical diseases; studies measured appetite, gastric emptying, food preferences, and taste as a primary or secondary outcome. The risk of publication bias in each study was assessed independently using the updated Cochrane risk-of-bias tool (RoB2). Twelve studies met the inclusion criteria with a total sample size of 445 participants. All the included studies measured at least one or more of the primary outcomes. The promising effect was evidenced by most studies showing appetite suppression, delayed gastric emptying, and changes in taste and food preferences. GLP-1 analogues are effective obesity management therapy that could decrease food intake and eventually reduce weight by suppressing appetite, reducing hunger, decreasing gastric emptying, and altering food preferences and taste. However, high-quality, long-term, large sample size studies are crucial to examine the efficacy and effective dose of GLP-1 analogues intervention.

The ultimate control tower is the gateway to more dynamic supply chain agility

Strains on global supply chains have exposed more than ever the need for global businesses to have greater visibility, control and a chameleon-like ability to adapt to any new situation rapidly. Organisations need an in-built ability to reconfigure to unforeseen disruptions arising from anything from geo-political events to a sudden change in consumer taste. Over the years, companies have tried different approaches to this challenge, hoping to gain that elusive level of consistency in a unified view of their supply chain data that will support all their needs. Each has run into problems, with the current shortage of data science expertise a difficulty all must overcome. This paper explains how the ultimate control tower has emerged as a highly effective approach, providing the connective tissue that global organisations need. It enables them to exploit data from their dynamic supply chain to better-inform decisions with immediate positive impact. Based on the four pillars of see, understand, optimise and act, this approach is already delivering for major companies with extended global supply chains. Using real-world examples, the paper explains how organisations deploying the ultimate control tower are achieving resilience and shape-shifting agility that enable them to excel in highly dynamic markets amid many challenges. Organisations are able to move from linear to much more supple digital and collaborative models. They can embed on-demand analytics capabilities and machine learning (ML), making it faster and easier to gain new insights and intelligent predictive and prescriptive capabilities.

스탕달과 문학적 야망

Stendhal, who is well known as art critic and romantic and realist novelist, was fascinated by the theater and often engaged in writing theatrical works without succeeding. His early vocation was to live in Paris by making comedies like Molière. He strengthened himself in critical reading and philosophical studying of the English, Italian and Spanish theatre. He took important theatrical works and developed them into his own immortal theatrical works. Selmours, Les deux Hommes and Letellier were advanced but were not finished. He failed to be a comic playwright because of his too much literary ambition, the change of literary circumstance and viewer's taste, and the lack of literary genius. The ambition to be the greatest comedy-writer did not come true, but he declared himself as a novelist and left his mark in novels.

English

This study describes the influence of chemotherapy on patients&#39; eating habits in the context of resource-limited countries. This is a descriptive and analytical cross-sectional study of patients who have been prescribed chemotherapy and followed throughout this treatment at the Yalgado Ouedraogo University Hospital. We collected data on the initial eating habits and dietary coping strategies during chemotherapy during medical oncology consultations. One hundred and two patients were collected, aged 49.19 years on average. We compared the food consumption and dietary diversity scores before and during chemotherapy, the usual diet of our patients is local cereals and tubers accompanied by vegetables and animal proteins. During chemotherapy, 81.4% of patients experienced both quantitative and qualitative taste and olfactory changes. The mean food consumption score was 58.5 before and 57.5 during chemotherapy (p = 0.005). The mean dietary diversity score during chemotherapy is 5.27 versus 4.9 before chemotherapy (p &lt; 0.0001). During chemotherapy, 50 patients had fewer meals, and 20 had increased their dietary intake. Making nutritionists and dieticians available to cancer patients would improve their food experience during chemotherapy. Key words: Cancer, nutrition, chemotherapy, diet.

Nutrition impact symptoms: Noteworthy prognostic indicators for lung cancer

Nutrition impact symptoms (NIS) in head and neck cancer are well-studied and are found to be heavy contributors of poor outcome. However, the prevalence and role of NIS in other cancer are less addressed. In this study, we investigated the incidence and prognostic role of NIS in patients with lung cancer. NIS, evaluated by patient-generated subjective global assessment (PG-SGA) in a multicenter real-world prospective study, included loss of appetite, nausea, vomiting, mouth ulcer, constipation, diarrhea, dry mouth, taste change, altered smell, dysphagia, early satiety, and pain. The endpoints were the patients' overall survival (OS) and quality of life (QoL). The COX analysis was used to investigate the relationship between NIS and OS. Interaction analysis and mediation analysis were performed to determine the modifiers and mediator. 3634 patients with lung cancer were enrolled in this study, of which 1533 patients had NIS. During the average follow-up of 22.65 months, 1875 deaths occurred. The OS of patients with lung cancer with NIS was lower than that of patients without NIS. NIS (HR, 1.181, 95% CI, 1.073-1.748), loss of appetite (HR, 1.266, 95% CI, 1.137-1.409), vomiting (HR, 1.282, 95% CI, 1.053-1.561), and dysphagia (HR, 1.401, 95% CI, 1.079-1.819) were independent prognostic factors in patients with lung cancer. There were interactions between chemotherapy and primary tumor on NIS . In the relationship between different types of NIS (NIS, loss of appetite, vomiting, dysphagia) and prognosis, the mediating effects of inflammation accounted for 15.76%, 16.49%, 26.32%, and 18.13%, respectively. Meanwhile, these three NIS were closely associated with the occurrence of severe malnutrition and cancer cachexia. 42% patients with lung cancer experienced different types of NIS. NIS were independent indicators of malnutrition, cancer cachexia and shorter OS, and closely related to QoL. NIS management is of clinical significance.

Development of a microfluidic-based taste sensor using lipid polymer membrane

This study aims to develop a microfluidic-based taste sensor for detecting time-dependent human taste sensations. Lipid polymer membranes were welded to perforated polycarbonate films with organic solvents to monitor the adsorption and desorption of taste substances to lipid polymer membranes and to physically immobilize lipid polymer membranes to withstand the pressure of a pumped liquid. A polydimethylsiloxane flow channel was bonded chemically to the polycarbonate film with the lipid polymer membrane using 3-aminopropylethoxysilane. A fabricated microfluidic-based taste sensor could measure the membrane potential change with time due to the adsorption and desorption of tannic acid, an astringency substance, onto a lipid polymer membrane. The proposed sensor could be useful as a tool for assessing the time-course changes in human taste.

The late Goethe: New directions

The late Goethe: New directions