Detailed assessment of smoking topography (puffing and post-puffing metrics) can lead to a better understanding of factors that influence tobacco use. Research suggests that portable mouthpiece-based devices used for puff topography measurement may alter natural smoking behavior. This paper evaluated the impact of a portable puff topography device (CReSS Pocket) on puffing & post-puffing topography using a wearable system, the Personal Automatic Cigarette Tracker v2 (PACT 2.0) as a reference measurement. Data from 45 smokers who smoked one cigarette in the lab and an unrestricted number of cigarettes under free-living conditions over 4 consecutive days were used for analysis. PACT 2.0 was worn on all four days. A puff topography instrument (CReSS pocket) was used for cigarette smoking on two random days during the four days of study in the laboratory and free-living conditions. Smoke inhalations were automatically detected using PACT2.0 signals. Respiratory smoke exposure metrics (i.e., puff count, duration of cigarette, puff duration, inhale-exhale duration, inhale-exhale volume, volume over time, smoke hold duration, inter-puff interval) were computed for each puff/smoke inhalation. Analysis comparing respiratory smoke exposure metrics during CReSS days and days without CReSS revealed a significant difference in puff duration, inhale-exhale duration and volume, smoke hold duration, inter-puff interval, and volume over time. However, the number of cigarettes per day and number of puffs per cigarette were statistically the same irrespective of the use of the CReSS device. The results suggested that the use of mouthpiece-based puff topography devices may influence measures of smoking topography with corresponding changes in smoking behavior and smoke exposure.