Background: The coronavirus disease 2019 (COVID-19) pandemic and containment strategies employed to limit its spread have profoundly impacted daily life. Emerging evidence shows that mental health worsened compared to pre-pandemic trends. In this study, we examine associations of self-reported changes in physical activities and sedentary behaviors with mental health changes during the COVID-19 pandemic among older Irish adults. Methods: This study used data from Wave 5 (2018) and the COVID-19 study (July–November 2020) of the Irish Longitudinal Study on Ageing (TILDA). Depressive symptoms were measured using the 8-item Centre for Epidemiological Studies Depression Scale; Perceived stress, using the 4‐item Perceived Stress Scale. Participants reported perceived changes in participation in physical activities and sedentary behaviours before and after the outbreak of COVID-19. Linear regressions examined separate associations between changes in physical activities and sedentary behaviours and changes in perceived stress/depressive symptoms. Adjustment included demographics, body mass index, smoking, alcohol, chronic diseases and stress/depressive symptoms at Wave 5. Results: Among 2,645 participants (mean age, 68.2yrs; 56% female), 19.5% (95%CI: 18.2–20.9) reported clinically significant depressive symptoms during the COVID-19 pandemic. Compared to before the pandemic, reduced and no exercise at home and walking were associated with increased depressive symptoms and stress. A reduction in home DIY (do it yourself) was also associated with both depression and stress while doing no DIY at all was associated with increased stress but not depressive symptoms (all p<.05). Reduced hobbies and reading were associated with higher depressive symptoms, and both reduced and increased screen time were associated with increased depressive symptoms. Conclusions: Greater decreases in mental health were seen among those who reported negative changes in their physical and sedentary activities. These findings have important implications for mental health care both as we transition back to normal life and for responses to future pandemics.