Related Changes Research Articles

Do mean platelet volume and platelet count vary on a daily or gender basis?

Aims: Mean platelet volume (MPV) is a measurement based on platelet morphology. We aimed to investigate whether MPV and platelet count exhibit a daily change in relation to the days and gender. Methods: Healthy blood donors aged 18–55 years with no history of the disease and/or drug use participated in the study. MPV values and platelet counts were analyzed with respect to the date of the blood test and the gender of the participant based on a 29–day calendar. Results: A total of 14718 participants (7772 female) were included. The median age of the females and males was similar (38 [range 18–54], and 36 [18–55], p=0.254, respectively). Median platelet count was 278 × 109/L (range 152–448) in females and 244 × 109/L (range 151–439) in males, with a significant difference (p<0.01). The median MPV was 8.9 (range 5.7–12.2) fL in females and 8.4 (range 5.9–12.8) fl in males (p<0.01). MPV and platelet counts were higher in females on all days of the month compared to males. Decreases in MPV values were observed in both females and males on days 9th, 12th, 20th, and 26th, whereas increases in both occurred on days 5th, 15th, 23rd, and 29th. Conclusion: We demonstrated that MPV and platelet count exhibited a daily fluctuating in healthy individuals; MPV values and platelet count were overall higher in females. This study may give a different perspective on future studies of MPV and a lead for evaluating daily changes on other blood parameters.

Modulating Driver Alertness via Ambient Olfactory Stimulation: A Wearable Electroencephalography Study.

Poor alertness levels and related changes in cognitive efficiency are common when performing monotonous tasks such as extended driving. Recent studies have investigated driver alertness decrement and possible strategies for modulating alertness with the goal of improving reaction times to safety critical events. However, most studies rely on subjective measures in assessing alertness changes, while the use of olfactory stimuli, which are known to be strong modulators of cognitive states, has not been commensurately explored in driving alertness settings. To address this gap, in the present study we investigated the effectiveness of olfactory stimuli in modulating the alertness state of drivers and explored the utility of electroencephalography (EEG) in developing objective brain-based tools for assessing the resulting changes in cortical activity. Olfactory stimulation induced a significant differential effect on braking reaction time. The corresponding effect to the cortical activity was characterized using EEG-derived metrics and the devised machine learning framework yielded a high discriminating accuracy (92.1%). Furthermore, neural activity in the alpha frequency band was found to be significantly associated with the observed drivers' behavioral changes. Overall, our results demonstrate the potential of olfactory stimuli to modulate the alertness state and the efficiency of EEG in objectively assessing the resulting cognitive changes.

Salinity change evokes stress and immune responses in Atlantic salmon with microalgae showing limited potential for dietary mitigation.

Smoltification was found to impact both immune and stress responses of farmed Atlantic salmon (Salmo salar), but little is known about how salinity change affects salmon months after completed smoltification. Here, we examined (1) the effect of salinity change from brackish water to seawater on the stress and immune responses in Atlantic salmon and (2) evaluated if functional diets enriched with microalgae can mitigate stress- and immune-related changes. Groups of Atlantic salmon were fed for 8weeks with different microalgae-enriched diets in brackish water and were then transferred into seawater. Samples of the head kidney, gill, liver and plasma were taken before seawater transfer (SWT), 20h after SWT, and 2weeks after SWT for gene-expression analysis, plasma biochemistry and protein quantification. The salmon showed full osmoregulatory ability upon transfer to seawater reflected by high nkaα1b levels in the gill and tight plasma ion regulation. In the gill, one-third of 44 investigated genes were reduced at either 20h or 2weeks in seawater, including genes involved in cytokine signaling (il1b) and antiviral defense (isg15, rsad2, ifit5). In contrast, an acute response after 20h in SW was apparent in the head kidney reflected by increased plasma stress indicators and induced expression of genes involved in acute-phase response (drtp1), antimicrobial defense (camp) and stress response (hspa5). However, after 2weeks in seawater, the expression of antiviral genes (isg15, rsad2, znfx1) was reduced in the head kidney. Few genes (camp, clra, c1ql2) in the gill were downregulated by a diet with 8% inclusion of Athrospira platensis. The results of the present study indicate that salinity change months after smoltification evokes molecular stress- and immune responses in Atlantic salmon. However, microalgae-enriched functional diets seem to have only limited potential to mitigate the related changes.

Engaging men in women’s empowerment: impact of a complex gender transformative intervention on household socio-economic and health outcomes in the eastern democratic republic of the Congo using a longitudinal survey

BackgroundIn the Democratic Republic of the Congo, women in (peri-)urban areas are commonly engaged in small trade, which allows them to meet the basic needs of their families. Microsaving approaches are a low-risk option to obtain financing for economic activities. A project combining men’s sensitization on gender equity and women’s empowerment through village savings and loan associations were implemented in North and South Kivu to raise the household economic level.ObjectiveThis study assessed how involving men in gender equity affects women’s health and socio-economic outcomes, including food security.MethodsA cohort study was conducted with 1812 women at the baseline; out of them 1055 were retrieved at the follow-up. Baseline data collection took place from May to December 2017 and the follow-up from July 2018 to January 2019. To identify socio-economic changes and changes of gender relations, linear and logistic regressions were run.ResultsResults showed that the household income improved with intervention (coefficient = 0.327; p = 0.002), while the capacity to pay high bills without contracting debts decreased (coefficient = 0.927; p = 0.001). We did not find enough statistically significant evidence of the influence of the intervention on skilled birth attendance (coefficient = 0.943; p = 0.135), or family planning use (coefficient = 0.216; p = 0.435) nor women’s participation in the decision-making (coefficient = 0.033; p = 0.227) nor on couple’s cohesion (coefficient = 0.024; p = 0.431). Food insecurity levels decreased over time regardless of being in the intervention or control area.ConclusionEmpowering women while sensitizing men on gender aspects improves financial well-being (income). Time, security, and strong politics of government recognizing and framing the approach are still needed to maximize the benefit of such projects on social factors such as women’s participation in decision-making and social cohesion.

Connexins 30 and 43 expression changes in relation to age-related hearing loss

Age-related hearing loss (ARHL), also known as presbycusis, is the number one communication disorder for aging adults. Connexin proteins are essential for intercellular communication throughout the human body, including the cochlea. Mutations in connexin genes have been linked to human syndromic and nonsyndromic deafness; thus, we hypothesize that changes in connexin gene and protein expression with age are involved in the etiology of ARHL. Here, connexin gene and protein expression changes for CBA/CaJ mice at different ages were examined, and correlations were analyzed between the changes in expression levels and functional hearing measures, such as ABRs and DPOAEs. Moreover, we investigated potential treatment options for ARHL. Results showed significant downregulation of Cx30 and Cx43 gene expression and significant correlations between the degree of hearing loss and the changes in gene expression for both genes. Moreover, dose-dependent treatments utilizing cochlear cell lines showed that aldosterone hormone therapy significantly increased Cx expression. In vivo mouse treatments with aldosterone also showed protective effects on connexin expression in aging mice. Based on these functionally relevant findings, next steps can include more investigations of the mechanisms related to connexin family gap junction protein expression changes during ARHL; and expand knowledge of clinically-relevant treatment options by knowing what specific members of the Cx family and related inter-cellular proteins should be targeted therapeutically.

Biofilm producing plant growth promoting bacteria in combination with glycine betaine uplift drought stress tolerance of maize plant.

The escalating threat of drought poses a significant challenge to sustainable food production and human health, as water scarcity adversely impacts various aspects of plant physiology. Maize, a cornerstone in staple cereal crops, faces the formidable challenge of drought stress that triggers a series of transformative responses in the plant. The present study was carried out in two sets of experiments. In first experiment, drought stress was applied after maintaining growth for 45 days and then irrigation was skipped, and plant samples were collected at 1st, 3rd and 6th day of drought interval for evaluation of changes in plant growth, water relation (relative water content) and antioxidants activity by inoculating indigenously isolated drought tolerant biofilm producing rhizobacterial isolates (Bacillus subtilis SRJ4, Curtobacterium citreum MJ1). In the second experiment, glycine betaine was applied as osmoregulator in addition to drought tolerant PGPR to perceive modulation in photosynthetic pigments (Chlorophyll a and b) and plant growth under varying moisture stress levels (100, 75 and 50% FC). Results of the study revealed upsurge in root and shoot length, fresh and dry biomass of root and shoot besides increasing chlorophyll contents in water stressed inoculated plants compared to uninoculated plants. Glycine betaine application resulted in an additional boost to plant growth and photosynthetic pigments, when applied in combination with bacterial inoculants. However, both bacterial inoculants behaved differently under drought stress as evident from their biochemical and physiological attributes. Isolate SRJ4 proved to be superior for its potential to express antioxidant activity, leaf water potential and relative water contents and drought responsive gene expression while isolate MJ1 showed exclusive increase in root dry biomass and plant P contents. Though it is quite difficult to isolate the bacterial isolates having both plant growth promoting traits and drought tolerance together yet, such biological resources could be an exceptional option to be applied for improving crop productivity and sustainable agriculture under abiotic stresses. By exploring the combined application of PGPR and glycine betaine, the study seeks to provide insights into potential strategies for developing sustainable agricultural practices aimed at improving crop resilience under challenging environmental conditions.

A comparative study on anterior teeth retraction-related hard and soft tissue changes with physiologic anchorage control technique

Aim of this comparative cross-sectional study was to evaluate the effect of anterior teeth retraction and related hard and soft tissue change under physiologic anchorage control in patients with chief complain of protrusive teeth. 68 Class I or II orthodontic patients undergoing four-premolar extraction and requiring maximum or medium anchorage were included. Patients were treated with physiologic anchorage control technique (PASS group, n = 34, 18.6 ± 7.7 years, 10 male and 24 female) and self-ligation technique (Damon group, n = 34, 17.5 ± 5.4 years, 13 male and 21 female), respectively. TADs were used for anchorage reinforcement in Damon group. Pre- and post-treatment cephalograms were collected. Twenty-six skeletal, dental and soft tissue items were measured and analyzed using a blinded method. T test and paired rank-sum test were used for statistical analysis. The baseline characteristics were similar between groups (P > 0.05). After treatment, inter-group comparison showed statistically significant differences in the decrease of skeletal measurements ∠ANB (− 0.73 ± 1.05° in PASS group and − 0.25 ± 0.84° in the Damon group), Wits value (− 2.56 ± 2.29 mm in PASS group and − 0.47 ± 2.15 mm in Damon group) and soft tissue measurement UL-E (− 2.75 ± 1.36 mm in PASS group and − 2.03 ± 1.30 mm in Damon group) and the increase of FCA and Z angle, which was 2.03 ± 2.12°and 9.52 ± 4.78°in PASS group and 0.97 ± 2.12°and 6.96 ± 4.43°in Damon group, respectively (P < 0.05). Our results indicated that significant anterior teeth retraction and profile improvement could be achieved with PASS technique without additional anchorage devices. Appropriate application of physiologic anchorage control could reduce the dependence of TADs for anterior teeth retraction.

Carry-Over of Exercise-Related Self-Regulation to Eating-Related Self-Regulation in Women Participating in Behavioral Obesity Treatments

ABSTRACT Purpose: Because obesity has not responded well to instructing affected adults in healthier eating behaviors and increased physical activity/exercise, enhanced research on psychosocial determinants of those behavioral changes is needed. Intervention foci on self-regulation have been suggested, but targeted research is required. Method: Women with obesity participated in community-based treatments that were either self-regulation-focused (self-regulation emphasis group; n = 52) or typical instruction-based (education [treatment-as-usual] group; n = 54). Results: There were overall significant increases in exercise-related self-regulation, physical activity/exercise, exercise-related self-efficacy, and eating-related self-regulation that were each significantly more pronounced in the self-regulation emphasis group. Increase in exercise-related self-regulation over 3 months predicted eating-related self-regulation over 6 months; however, sequential entry of changes in physical activity and exercise-related self-efficacy significantly mediated that relationship. However, only the path from changes in exercise-related self-regulation to exercise self-efficacy to eating-related self-regulation was significant. In a revised model where change in exercise self-efficacy was the sole mediator, treatment group did not significantly moderate the exercise self-regulation to eating self-regulation change relationship, but full mediation of that relationship occurred. Conclusion: Findings indicated salience for perceived ability/self-efficacy for physical activity, over actual physical activity progress, and its role in the transfer of self-regulatory skills from an exercise to eating context. Increased eating self-regulation significantly predicted weight loss over 6, 12, and 24 months. In the self-regulation emphasis group that translated to meaningful weight loss/weight-loss maintenance of greater than 5% of initial weight. Findings contributed to an increased understanding of psychosocial-change processes within obesity treatment research.

Sex- and region-specific cortical and hippocampal whole genome transcriptome profiles from control and APP/PS1 Alzheimer's disease mice.

A variety of Alzheimer's disease (AD) mouse models has been established and characterized within the last decades. To get an integrative view of the sophisticated etiopathogenesis of AD, whole genome transcriptome studies turned out to be indispensable. Here we carried out microarray data collection based on RNA extracted from the retrosplenial cortex and hippocampus of age-matched, eight months old male and female APP/PS1 AD mice and control animals to perform sex- and brain region specific analysis of transcriptome profiles. The results of our studies reveal novel, detailed insight into differentially expressed signature genes and related fold changes in the individual APP/PS1 subgroups. Gene ontology and Venn analysis unmasked that intersectional, upregulated genes were predominantly involved in, e.g., activation of microglial, astrocytic and neutrophilic cells, innate immune response/immune effector response, neuroinflammation, phagosome/proteasome activation, and synaptic transmission. The number of (intersectional) downregulated genes was substantially less in the different subgroups and related GO categories included, e.g., the synaptic vesicle docking/fusion machinery, synaptic transmission, rRNA processing, ubiquitination, proteasome degradation, histone modification and cellular senescence. Importantly, this is the first study to systematically unravel sex- and brain region-specific transcriptome fingerprints/signature genes in APP/PS1 mice. The latter will be of central relevance in future preclinical and clinical AD related studies, biomarker characterization and personalized medicinal approaches.

Discovery of anticancer compound possessing potential to bind γ-secretase catalytic subunit and inhibit notch promoter activity

Gamma secretase (GS) is an important therapeutic target in anticancer drug discovery. Increased GS activity activates notch signaling pathway which is associated with cancer stemness and drug resistance in cancer cells. A total of 69,075 natural and their derivative compounds were screened to identify the lead compound on the basis of in silico GS catalytic domain binding potential and in vitro selective anticancer efficacy. STOCK1N-23234 showed higher dock score (−11.82) compared to DAPT (−9.2) in molecular docking experiment and formed hydrogen bond with the key amino acid (Asp385) involve in catalysis process. Molecular dynamics (MD) simulation parameters (RMSD, RMSF, Rg, SASA and hydrogen bond formation) revealed that the STOTCK1N-23234 formed structurally and energetically stable complex with the GS catalytic domain with lower binding energy (−22.79 kcal/mol) compared to DAPT (−16.22 kcal/mol). STOCK1N-23234 showed better toxicity (up to 60%) against colon and breast cancer cells (HCT-116 and MDA-MB-453) at 1–70 µM concentration. Interestingly, STOCK1N-23234 did not showed cytotoxicity against human normal breast cells (MCF-10A). STOCK1N-23234 treatment significantly decreased sphere formation, notch promoter activity, and transcription of notch target genes (Hes-1 and Hey-1) in HCT-116 cells derived colonosphere. Confocal microscopy revealed that STOTCK1N-23234 treatment at test concentration induced apoptosis related morphological changes, reduced mitochondria membrane potential and increased reactive oxygen species production in HCT-116 cells compared to non-treated cells. In conclusion, STOCK1N-23234 is a novel lead natural anticancer compound which requires in depth validation in cancer preclinical models. Communicated by Ramaswamy H. Sarma

Gas Temperature Distribution in the Combustion Chamber of a GTM400 MOD Turbojet Engine Powered by JET A-1 Fuel and Hydrogen

Research on engine operation using hydrogen may enable appropriate optimization of thrust, and therefore performance, related to its potential use in aircraft. It is particularly important as the share of hydrogen in combustion affects the reduction of combustion products such as carbon dioxide, carbon monoxide, nitrogen oxide, hydrocarbons, and solid matter. This is in line with the new requirements regarding the increased supply of sustainable aviation fuels (SAFs) and the related changes in emissions, i.e., reducing the harmful impact of exhaust gases on the environment. This paper presents the results of measurements carried out in the GTM400 MOD turbojet engine. Based on the research performed, the impact of hydrogen and aviation kerosene combustion on selected engine parameters is presented. The paper shows changes in the rotational speed and volume flow of JET A-1 fuel as a function of engine operation time. Changes in temperature measured at the edge of the flame tube were also examined. The tests confirmed that the combustion chamber worked correctly in the selected area in the range of the tested fuel mixtures. After incorporating hydrogen into the combustion process, the consumption of traditional JET A-1 fuel was significantly reduced.

B-GOS alleviates olanzapine-induced lipid disturbances in mice by enriching Akkermansia and upregulation of PGRMC1-Wnt signaling

Although olanzapine (OLZ) remains one of the most efficacious antipsychotic medications for the treatment of schizophrenia, there are significant tolerability issues related to its metabolic profile such as weight gain and dyslipidemia. Our previous studies have demonstrated that progesterone receptor membrane component 1 (PGRMC1) plays a key role in antipsychotic-induced metabolic side effects. Prebiotics showed positive effects on lipid metabolism, however, limited studies focused on their therapeutic potential and mechanisms in treating antipsychotic-induced lipid metabolic disorders. Herein, our study aims to explore the effects of the prebiotic B-GOS on lipid disturbances induced by OLZ and elucidate its underlying mechanisms via PGRMC1 pathway. In an 8-week study, long-term intraperitoneal administration of OLZ at a dosage of 8 mg/kg/day in mice induced lipid disturbances as manifested by significantly increased lipid indexes in plasma and liver. B-GOS effectively alleviated the OLZ-induced abnormal lipid metabolism by enhancing the diversity of the gut microbiota, with a 100-fold increase in Akkermansia abundance and a 10-fold decrease in Faecalibaculum abundance. Followed by the B-GOS related changes of gut microbiota, OLZ-induced substantial hepatic inhibition of PGRMC1, and associated protein factors of Wnt signaling pathway (Wnt3a, β-catenin, and PPAR-γ) were reversed without affecting plasma levels of short-chain fatty acids. Taken together, prebiotics like B-GOS enriching Akkermansia offer a promising novel approach to alleviate antipsychotic-induced lipid disturbances by modulating the PGRMC1-Wnt signaling pathway.

The change of Chinese elements in Hollywood films from a cross-cultural perspective

As a kind of visual communication art, a movie is a product of the fusion of modern science and technology and art, as well as a medium for reflecting social phenomena and spreading multiculturalism. The mainstream Hollywood films naturally represent the ideological characteristics and value orientation of the field or country it belongs to. As a heterogeneous culture, Chinese elements in Hollywood movies have experienced a long and tortuous change, which is not only related to the enhancement of China's comprehensive national power and the change of international relations, but also inextricably linked to the Western core cultural values behind Hollywood. The overall change of the image of Chinese elements in Hollywood movies can be summarized as a shift from negative stereotypes to the inclusion of Chinese characteristic elements and the gradual export of Chinese stories and culture, showing a positive and diversified development trend, and behind this trend change is the refraction and effect of cross-cultural communication between Chinese and Western.

New forms of family care in cultural and institutional contexts. Introduction to the Special Collection

Objective: This special collection aims to contribute to theory and research on the cultural and institutional contexts of care and on the relationship between care policies, gender and the family. Background: Since the 1990s, many European welfare states have not only extended social rights and infrastructure related to extra-familial care, but have also expanded support for care by family members. So far, research on family care in the context of contemporary care policies remains scarce. Method: The special collection’s seven articles present theoretical debates related to family care and apply research on cross-national differences and intergroup differences using a variety of quantitative and qualitative methods. Results: By taking a multidimensional perspective on family care for older people, the special collection offers new insights into institutional and cultural family care contexts, the social risks and scope of action connected with family care and the consequences of the development of care policies for the relationship between family, gender and care. Conclusion: The special collection demonstrates that the systematic analysis of the development of family care in its institutional and cultural contexts, as well as the consequences for the development of social risks and scope of action connected with family care, enhances our understanding of the changing relationship between family, gender and care.

Ontological transformations: the Kawaiwete's shifting relations with spirits as seen through changing ideas of conception

AbstractDrawing on the insights of the ontological turn, this article explores how human and nonhuman social relations have changed over a thirty‐year period for a community of Tupian Kawaiwete people in Brazil's Xingu Indigenous Territory. Changes in human‐spirit relations are discussed through a focus on people's changing understandings of human conception and the relative importance and roles of maternal and paternal substances, shamanic practitioners, and spirit beings. While changes in relations with nonhuman others are usually understood in lowland literature in terms of the impact of outside forces, such as conversion to Christianity, in this article, we look at the agency of one particular shaman in restructuring humans’ relations with spirits, bringing these entities much closer than they used to be three decades ago. We argue that this shaman is responding to his historical context, and look at how his agency is entangled with the agency of nonhumans. Ultimately, we suggest that cosmology and ideas of conception are more variable and transformable than they are often portrayed.

Coupling input and output intensity to explore the sustainable agriculture intensification path in mainland China

Sustainable intensification (SI) of agriculture is widely regarded as an important way to alleviate the contradiction between the food gap and ecosystem health. Correlate input intensity and output intensity have been regarded as an important dimension in most estimation frameworks of SI. But in practice, this correlation is generally expressed in terms of efficiency metrics and calculated as the ratio of output intensity to input intensity, which cannot quantitatively explain the impact of input intensity on output intensity and provide a threshold value for estimating the suitability of SI. This study's goals are to propose an input—output coupled method to explain the impact of input intensity on output intensity and thereby estimate the suitability of provincial SI. Provincial annual input intensity and output intensity were estimated from an emergy-based perspective by taking China as a case study. The K-means algorithm was used to identify the structural pattern of arable land input intensity. A sliding window-based partial correlation index method was proposed and applied to reveal the interaction process between input intensity and output intensity. The results show that there are two main change paths in the pattern of input intensity: one path in the western irrigation regions and the other path in the eastern northeast China Plain and middle-lower Yangtze Plain. The former path can be expressed as a small increase in fertilizer and agro-machinery input intensity with a decrease in labour force input intensity. The latter path shows a larger increase in fertilizer and pesticide input intensity. For each type of input intensity except mulching film, its correlation to output intensity has experienced a similar coupling—decoupling—recoupling process in both plain provinces and mountainous or plateau provinces. According to Landau's theory of phase transition, the complex coupling of input and output undergoes a phase transition process from order to disorder and then to order, depicted by the sliding window-based partial correlation coefficient as the order parameter from a holistic perspective. The inflection points of coupling relation changes show that the phenomenon of fertilizer and pesticide overuse has steadily occupied most provinces in eastern China and is spreading westwards. Although the “zero growth action for fertilizers and pesticides” has made considerable achievements in reducing the input intensity of fertilizer and pesticides since 2015, the situation of superfluous fertilizer and pesticide input has not changed substantially. The input intensity of fertilizer and pesticides still needs to be further reduced. This study can contribute to the estimation method system of SI. The input—output coupled method is applicable for other spatial scales and regions (or countries) to estimate the suitability of SI.

Expression levels of key immune indicators and immune checkpoints in manganese-exposed rats

Manganese is essential trace elements, to participate in the body a variety of biochemical reactions, has important physiological functions, such as stimulate the immune cell proliferation, strengthen the cellular immunity, etc. However, excessive manganese exposure can cause damage to multiple systems of the body.The immune system is extremely vulnerable to external toxicants, however manganese research on the immune system are inadequate and biomarkers are lacking. Therefore, here we applied a manganese-exposed rat model to make preliminary observations on the immunotoxic effects of manganese. We found that manganese exposure inhibited humoral immune function in rats by decreasing peripheral blood IgG (ImmunoglobulinG, IgG), IgM (ImmunoglobulinM, IgM) and complement C3 levels; It also regulates rat cellular immune activity by influencing peripheral blood, spleen, and thymus T cell numbers and immune organ ICs (Immune Checkpoints, ICs) and cytokine expression. Furthermore, it was revealed that the impact of manganese exposure on the immune function of rats exhibited a correlation with both the dosage and duration of exposure. Notably, prolonged exposure to high doses of manganese had the most pronounced influence on rat immune function, primarily manifesting as immunosuppression.The above findings suggest that manganese exposure leads to impaired immune function and related changes in immune indicators, or may provide clues for the discovery of its biomarkers.

Sociospatial relations through development projects: the alignment of Thailand’s EEC and China’s BRI

ABSTRACT The Eastern Economic Corridor (EEC) is an endeavor to promote Thailand’s development in multiple industries in its eastern coastal areas through strengthening its links with overseas. The project has unfolded through close alignment with China’s Belt and Road Initiative (BRI). This paper discusses what roles the EEC plays in economic development, and how the alignment of the EEC and the BRI reshapes brings about sociospatial changes. It is based on qualitative research, involving interviews with experts from Thailand and China and secondary data analysis. Drawing on the TPSN framework, this paper unpacks the multi-dimensional changes in sociospatial relations brought by the EEC’s alignment with the BRI, reflecting the mutual interests of and local contestations between Thailand and China. First, the flourishing of the EEC hinges upon opening up Thailand’s borders to China through new railways and new immigration rules. Second, the EEC represents a new scale of governance which allows the Thai government to negotiate with local interests in pursuing its economic vision with China. Third, the development of specific places along the EEC, such as Pattaya, has been reoriented to their new economic potential under closer Thailand-China ties. Lastly, international business networks in Thailand are reshaped as new interdependencies between Thailand and China are forged by Chinese investors in the EEC.

수중에서의 무게추 중량과 수심의 상관성 조사

This study is one of the basic experiments for the development of a weight type water level gauge. The weights are made of polyvinyl chloride (PVC) with a density of 1.1-1.35 g/cm3, in cylindrical shapes of different sizes. The weights come in different diameters: 5, 6, 7, and 8 centimeters, and two different lengths: 20 and 30 centimeters. The weight of the weights was measured using a load cell and the inverse relationship of weight change with increasing depth was investigated. Also, by adjusting the gap between the weight and the outer casing, the distance at which the error in the weight observation due to the surface tension of water of 72.75 dyne/cm (20℃) was not affected was determined. In conclusion, we found that the larger the diameter of the weight and the smaller the height, the better the correlation with the water depth. Also, considering contamination of the PVC weight and manufacturing precision, it was determined that the space between the PVC weight and the external case required more than 1cm. A buoyancy type water level gauge requires the smallest possible weight diameter and sufficient clearance.

168. “We Followed Their Lead”: Exploring Relational Change and Support Among Caregivers of Transgender and Gender Diverse Youth

168. “We Followed Their Lead”: Exploring Relational Change and Support Among Caregivers of Transgender and Gender Diverse Youth