The cooling of the Cenozoic, including the Miocene epoch, was punctuated by many geologically abrupt warming and cooling episodes— strong deviations from the cooling trend with time span of ten to hundred thousands of years. Our working hypothesis is that some of those warming episodes at least partially might have been caused by dynamics of the Antarctic Ice Sheet, which, in turn, might have caused strong changes of sea surface salinity in the Miocene Southern Ocean. Feasibility of this hypothesis is explored in a series of offline-coupled ocean-atmosphere computer experiments. The results suggest that relatively small and geologically short-lived changes in freshwater balance in the Southern Ocean could have significantly contributed to at least two prominent warming episodes in the Miocene. Importantly, the scenario-based experiments also suggest that the Southern Ocean was more sensitive to the salinity changes in the Miocene than today, which can attributed to the opening of the Central American Isthmus as a major difference between the Miocene and the present-day ocean-sea geometry.