Event Abstract Back to Event Inflammation in Major Depressive Disorder and psychophysiological correlates. Peter Goodin1, 2*, Joseph Ciorciari1* and Susan Rossell1, 2 1 Swinburne University of Technology, Australia 2 Alfred Hospital, Monash Alfred Psychiatric Research Centre, Australia Stress and non-specific immune response have been linked with Major Depressive Disorder (MDD), a condition also characterised by alterations in serotonin synthesis, brain cell density, changes in emotional processing and cognition including working memory and habituation. Despite many studies on the topics individually, none have examined how all of these factors interrelate. This study aims to explore these relationships and how the different systems interact to produce changes observed in MDD. Data collected using fMRI and MEG versions of an n-back variant and MEG only habituation data will be discussed. A sample of 12 controls and 2 MDD participants have participated so far. fMRI and MEG data is being used to examine spatial and time correlates of working memory update using a 3 back task to emotional expression. The protocols have been influenced by published behavioural studies and designed to allow for fine differentiation of emotion specific activation such as face specific activity, emotion subset activity and processing impact due to interference from previous stimuli. The goal is to examine neural correlates in emotional processing and working memory. Habituation is being examined using a visual variation of the oddball paradigm, using two oddballs consecutively to examine M300 activity. The overall aim for this section is to explore if fixation on salient emotional stimuli in depression is an automatic orientation of attention or more "top down" related mechanisms. Preliminary within groups analysis shows that even with a small sample, good discrimination between n-back conditions exist in the functional study, while MEG recordings have detected consistent activation in spatially similar areas to the fMRI, with a split in emotional amplitudes Despite being a work in progress, early results suggest this study has the potential to explore neural correlates of working memory and habituation with a level of collapsibility previously unused. Keywords: Major Depressive Disorder, working memory, Attention, habituation, Inflammation, Magnetoencephalography (MEG), fMRI BOLD Conference: ACNS-2012 Australasian Cognitive Neuroscience Conference, Brisbane, Australia, 29 Nov - 2 Dec, 2012. Presentation Type: Poster Presentation Topic: Emotion and Social Citation: Goodin P, Ciorciari J and Rossell S (2012). Inflammation in Major Depressive Disorder and psychophysiological correlates.. Conference Abstract: ACNS-2012 Australasian Cognitive Neuroscience Conference. doi: 10.3389/conf.fnhum.2012.208.00143 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 25 Oct 2012; Published Online: 17 Nov 2012. * Correspondence: Mr. Peter Goodin, Swinburne University of Technology, Melbourne, Australia, peter@hitiq.com Dr. Joseph Ciorciari, Swinburne University of Technology, Melbourne, Australia, jciorciari@swin.edu.au Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Peter Goodin Joseph Ciorciari Susan Rossell Google Peter Goodin Joseph Ciorciari Susan Rossell Google Scholar Peter Goodin Joseph Ciorciari Susan Rossell PubMed Peter Goodin Joseph Ciorciari Susan Rossell Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.