Repeated bouts of exercise in a hot environment improves the physiological capacity for heat loss, i.e., heat acclimation. This study tested the hypothesis that the time course of this adaptive response is reduced in burn survivors with well healed skin grafts. Twenty‐nine burn survivors were stratified into two groups: <40% body surface area (BSA) of grafted skin (N=13) and >40% BSA grafted (N=16). Nine similarly aged, non‐injured subjects served as controls. Subjects underwent a 7 day heat acclimation regimen wherein they exercised daily for 90 min in 40°C, 30% relative humidity. On each day, after 90 min of exercise, heart rate (HR) and the change in core (intestinal) temperature (∆TC) were measured. Despite an increased HR and ∆TC (both P<0.05) in the >40% BSA group compared to the control group, HR and ∆TC decreased (P<0.01) across the 7‐day heat acclimation regimen similarly between groups (day x group interaction: HR: P=0.76, ∆TC: P=0.11). Independent of group, in comparison to day 1, HR was reduced by day 2 (‐8 ± 14 bpm, P=0.01) through day 7 (‐17 ± 14 bpm, P<0.01) and ∆TC was attenuated by day 6 (‐0.3°C ± 0.5, P=0.02) and day 7 (‐0.3°C ± 0.4, P<0.01). These data indicate that the time course of heat acclimation in well‐healed burned survivors with grafted skin is similar to non‐burned individuals.Grant Funding Source: Supported by National Institute of General Medical Sciences GM068865