Since the 19th century, many scientists have tried to reconstruct the ground motions that occurred in the Campi Flegrei caldera, one of the most dangerous volcanos in the Mediterranean area. This study aims to assess the joint effects of vertical ground movements and anthropic forcing along the coasts of this volcanic area. A huge dataset of hundreds of archeo-stratigraphic boreholes was coupled with direct and indirect surveys of the main underwater archaeological sites scattered along the whole coastal sector and with the reinterpretation of bibliographic sources. Clear evidence of a differential volcano-tectonic behaviour (highlighted for the first time in this study) led us to divide the study area into three coastal stretches with homogeneous vertical ground movements. In each sector, a new relative sea-level (RSL) curve was reconstructed, by interpreting our stratigraphic and archaeological data in terms of SL markers covering a wider timespan compared to the previous studies, from the first Roman urbanization to the present day. The comparison between RSL curves and GIA models allowed estimating vertical ground movements (See Supplementary material 2) that occurred along the coast with decimetres accuracy. For each of the 5 recognized phase of uplift or subsidence, we also studied the subsequent effects in terms of coastal geomorphological change, and advantages or negative impacts on ancient human activities. We measured an overall subsiding trend that brought the RSL from −12 ± 1 m (4th century BC) to 7 ± 0.2 m during three different episodes between 5th and 15th centuries (1450–450 y BP), which was interrupted by short-lived falls (less of 100 years) of RSL. During the phases of RSL fall and/or volcano-tectonic stability, detected for the first time in the eastern and western part of the caldera (1st-2nd century AD and 3rd-4th century AD), a basinward shift of the coastline created newly emerged land even at the base of the local sea cliffs, where shore platforms emerged, favouring intense phases of urbanization on them along the Baia – Miseno sector and at the footslope of Rione Terra. This trend also favoured the closure of the Lucrino lagoon with an extended spit bar during the 2nd century BC, allowing the establishment of a large oyster farming system belonging to Sergio Orata. On the contrary, the subsiding phases resulted in the flooding of coastal areas and anthropic structures such as villas, nymphaea and ports inducing the construction of coastal protection structures. In the extreme case of Portus Julius, subsidence led to the abandonment of the military port and its move to nearby Miseno.