This article provides information about the nature of changes in biochemical markers on the background of stem cell therapy in patients suffering from coronary artery disease (CAD) and chronic heart failure (CHF). Methods: The study included 60 patients (54 men and 6 women) suffering from chronic heart failure and coronary artery disease. The age of patients ranged from 42 to 75 years. All patients have received medical therapy according to current clinical protocols. Patients from the 1 st group, in addition to drug therapy, have received intravenous cell therapy (culture of autologous bone marrow stromal stem cells with cellularity 50 million). The changes in hemodynamic parameters have been studied according to echocardiography and dynamics of indicators of biochemical markers of heart failure, brain natriuretic peptide (BNP) and serum lactate. Evaluating of performance has been carried out initially and at 12 and 24 weeks of observation. Results: Performance evaluation of hemodynamic parameters have shown an increase in ejection fraction to 38.6 ± 2.3% by the end of 12 weeks of observation, by the end of 24 weeks of observation also there have been registered