Shift Changes Research Articles

A H2@C601H NMR probe for sensitively detecting the supramolecular interactions between a molecular tweezer and C60.

Herein, we firstly utilized H2@C60 to monitor the supramolecular interaction between a pH-driven resorcin[4]arene molecular tweezer and C60 with a notable 1H NMR chemical shift change (ca. 0.34 ppm). This work provides a new strategy for detecting weak or complex supramolecular interactions.

Functional relationships of the cerebral cortex with subcortical structures in emotionally stressful conditions

Multidirectional and stable changes in phase shifts and cross-correlation coefficients of the cortical and subcortical stress rhythms occur under conditions of repeated irregular photostimulation, especially in the initial periods. Thus, cross-correlation functional connections, characterized by changes in the spatio-temporal relationships of the brain structures (posterior nuclei of the hypothalamus, reticular formation, and visual projection zones of the cerebral cortex), can be one of the indicators of the formation of stress. By using the parameters mentioned above, we can solve many issues related to the central mechanisms of stress. Our results show that functional connections between the cortical projection area and subcortical structures decrease under stress conditions, while connections between subcortical structures increase. We furthermore found that these EEG changes correlated with autonomic reactions in animals. Thus, these changes may lie based on central mechanisms of stress, and the results of changes in the EEG activity of the cerebral cortex and the cross-correlation parameters in the posterior nuclei of the hypothalamus and the reticular formation may allow preventive measures to be taken to affect these structures to reduce emotional stress.

Penerapan Handover Dalam Mengatasi Manajemen Konflik Untuk Menjaga Patient Safety

In Indonesia, conflict management has received less attention from organizations and governmentagencies who view conflict as bad and destructive. This begins, for example, in lessons and trainingthat is taught that life is something that is harmonious, harmonious and balanced. Handover is a wayto convey information to caregivers when changing production shifts. more easily handled by nurseup-to-date information about the patient's condition. The research objective was to determine theapplication of shift change in overcoming nurse conflict management. The research method in thisstudy was to use a literature review. Patient safety is an important element of the quality of healthservices that must be considered in all health services. The results of this study indicate that theweighing and receiving procedure is more effective in improving continuity, quality and safetybetween nurses and patients in providing quality services to patients.

교육감 권력 변동과 교육정책의 변화에 관한 연구

교육감 권력 변동과 교육정책의 변화에 관한 연구

Involving the Patient and Family in the Transfer of Information at Shift Change in a Pediatric Emergency Department

The transfer of information at the change of shift is a critical point for patient experience during the care process. The aim of this study was to evaluate caregivers' perceptions before and after the implementation of a multidisciplinary bedside handoff in a pediatric emergency department (PED). This was a quality improvement pre-post intervention, single-center study. The authors included caregivers of patients allocated in the observation unit of a PED during health care provider shift change. The study was made up of the following phases: (1) preintervention survey distribution, (2) implementation of the bedside handoff, involving all health care professionals (including nurses, nursing assistants, and pediatricians) and caregivers, and (3) postintervention survey distribution. The survey explored the three dimensions of patient experience defined as main study outcomes: information received and communication with professionals, participation, and continuity of care. A total of 102 surveys were collected (51 each in the preintervention and postintervention phases). In the preintervention phase, 94.1% of caregivers would have wished to be actively involved in the change of shift. In the postintervention phase, more caregivers felt that professionals had proper introductions (49.0% vs. 84.3%; p < 0.01), had kept them informed of the plan to be followed (58.8% vs. 84.3%; p = 0.02), and encouraged questions (45.1% vs. 82.4%; p < 0.01). Caregivers of the postintervention phase perceived less disorganization during the change of shift (25.5% vs. 5.9%; p = 0.01) and a greater sense of continuity (64.7% vs. 86.3%; p = 0.02). The bedside handoff is a useful strategy to improve patient and family perceptions of communication with professionals, information received, and continuity of care at health care providers shift change. Future lines of research and improvement include ensuring equity in participation in the bedside handoff for all caregivers, monitoring the handoffs to determine how often patients/caregivers participate and correct mistakes in information transfer. and exploring professionals' perceptions.

Innovation in Maintaining Sampyong Oral Tradition in Cijati Village, Majalengka Regency

This research is a research on Sampyong Majalengka Performing Arts which has experienced changes in form, grip, and shifts in function. Abah Uu / Ki Anom Aduy Mangkubumi is a figure of Sampyong Karang Kamuning Sirah Dayeuh Cijati Majalengka, who innovates and modifies. The innovation resulted in various reactions and responses from the community, including Sampyong players, community leaders and the government. This study explains the form of invention, Abah Uu's strategy, and the community's response to creation. The method used is the Ethnographic Method. This method is used in the data retrieval process. The result found was Abah Uu's innovative form in the central Sampyong performance with the addition of different dance moves with Authentic Sampyong. Abah Uu gave the modification a name with the term Sampyong Budaya. Other modifications are changes in the package and function. Abah Uu makes the scary Sampyong into a witty entertainment, with collaborations with other arts in the form of dangdut pop sound art, and koplo. Various responses to the innovation include from the Grumala community, Padepokan Ki Braja Manggala, Padepokan Dangiang Luhur, and several community leaders. They consider that Sampyong is preserved in authentic form. Meanwhile, Padepokan Dangiang Luhur Nini joined the Abah Uu community. Abah Wastiam invaded Sampyong with the Sampyong Ujung version.

Structural geometry and molecular dynamics by nuclear magnetic resonance of organic-inorganic perovskite [NH3(CH2)6NH3]CuBr4 crystal near phase transition temperature

The structural, thermal, and physical properties of newly developed lead-free hybrid perovskite solar cells are discussed for [NH3(CH2)6NH3]CuBr4. The hybrid material undergoes a phase transition at 269 K (TC), and is thermodynamically stable until approximately 472 K. The crystal structure determined by single-crystal X-ray diffraction is monoclinic and triclinic above and below TC, respectively. The 1H and 13C nuclear magnetic resonance spectra, recorded as a function of the temperature, revealed considerable changes in the 1H chemical shifts of NH3 and the 13C chemical shifts of the carbon atoms close to N as a result of the structural phase transition. The large difference in the activation energy, obtained from the 13C spin-lattice relaxation time above and below TC, also appears to be related to energy transfer changes in 13C. The thermal stabilities of [NH3(CH2)nNH3]CuBr4 (n = 3, 4, and 6) were compared by varying the number of methylene units, and the temperature with 2 % weight loss was shown to decrease as the number of methylene units increases. This in-depth analysis of the physical properties is expected to promote the development and application of lead-free hybrid perovskite solar cells.

Application of SBAR Communication in the Implementation of Nurse Weigh-in in the Inpatient Room of Dr. M.M Dunda Limboto Hospital

The use of good communication techniques during weigh-ins is important in improving patient safety. SBAR communication is a communication technique recommended by JCI to be used in the implementation of weigh-ins to improve patient safety in hospitals. The purpose of this study was to determine the relationship between SBAR communication and the implementation of nurse weighing in the Inpatient Room of Dr. M.M Dunda Hospital. This research method is quantitative research with a descriptive research design using a cross-sectional design. Data collection was carried out using questionnaire sheets with a population of 35 respondents. The number of respondents was taken using purposive sampling techniques. The data obtained were processed statistically using the Fisher's Exact Test. The results showed that there was a relationship between SBAR communication and the implementation of weigh-in in the Inpatient Room of Dr. M.M Dunda Limboto Hospital with a p-value result of 0.000. In conclusion, there is a relationship between SBAR communication and the implementation of nurse weighing in the Inpatient Room of Dr. M.M Dunda Limboto Hospital (p-value &lt; 0.05). Advice for nurses is expected that nurses always use complete SBAR communication in the implementation of weigh-ins at every shift change.

Effect of lateral position on rostral fluid shift and relationship to severity of Cheyne-Stokes respiration in heart failure patients.

Lateral sleep position has a significant beneficial effect on the severity of Cheyne-Stokes respiration with central sleep apnea (CSR-CSA) in patients with heart failure (HF). We hypothesized that a reduction in rostral fluid shift from the legs in this position compared with the supine position may contribute to this effect. In patients with CSR-CSA and an apnea-hypopnea index (AHI) ≥ 15/h (by standard polysomnography), uncalibrated leg fluid volume was measured in the supine, left lateral decubitus, and right lateral decubitus positions (in-laboratory assessment). The correlation between postural changes in fluid volume and corresponding changes in AHI was evaluated. Since there was no difference in both leg fluid volume and AHI between the right and left positions, measurements in these two conditions were combined into a single lateral position. In 18 patients with CSR-CSA,leg fluid volume increased by 2.7 ± 3.1% (p = 0.002) in the lateral position compared to the supine position, while AHI decreased by 46 ± 20% (p < 0.0001) with the same postural change. The correlation between postural changes in AHI and leg fluid volume was 0.22 (p = 0.42). Changes in leg fluid volume were a slow phenomenon, whereas changes in CSR-CSA severity were almost synchronous with changes in posture. Lateral position causes a reduction in rostral fluid shift compared to the supine position, but this change does not correlate with the corresponding change in CSR-CSA severity. The two changes occur on different time scales. These findings question the role of postural changes in rostral fluid shift as a determinant of corresponding changes in CSR-CSA severity.

Differential microbial composition in parasitic vs. questing ticks based on 16S next-generation sequencing.

As tick-borne diseases rise to become the second most prevalent arthropod-transmitted disease globally, the increasing investigations focus on ticks correspondingly. Factors contributed to this increase include anthropogenic influences, changes in vertebrate faunal composition, social-recreational shifts, and climatic variation. Employing the 16S gene sequence method in next-generation sequencing (NGS) allows comprehensive pathogen identification in samples, facilitating the development of refined approaches to tick research omnidirectionally. In our survey, we compared the microbial richness and biological diversity of ticks in Wuwei City, Gansu province, differentiating between questing ticks found in grass and parasitic ticks collected from sheep based on 16S NGS method. The results show Rickettsia, Coxiella, and Francisella were detected in all 50 Dermacentor nuttalli samples, suggesting that the co-infection may be linked to specific symbiotic bacteria in ticks. Our findings reveal significant differences in the composition and diversity of microorganisms, with the Friedmanniella and Bordetella genera existing more prevalent in parasitic ticks than in questing ticks (p < 0.05). Additionally, the network analysis demonstrates that the interactions among bacterial genera can be either promotive or inhibitive in ticks exhibiting different lifestyles with the correlation index |r| > 0.6. For instance, Francisella restrains the development of 10 other bacteria in parasitic ticks, whereas Phyllobacterium and Arthrobacter enhance colonization across all tick species. By leveraging NGS techniques, our study reveals a high degree of species and phylogenetic diversity within the tick microbiome. It further highlights the potential to investigate the interplay between bacterial genera in both parasitic and questing ticks residing in identical habitat environments.

Actively manipulating the temperature characteristics of photonic spin Hall effect in quasi-PT symmetric structure

The photonic spin Hall effect (PSHE) manifests itself as the spin-dependent transverse shift, and has many applications including precise metrology and optical sensing. However, some common ways to control PSHE have the limitation of less flexible and convenient manipulation. We report here an approach to actively manipulate the temperature characteristics of the PSHE in the quasi-PT symmetric structure by means of tunable graphene conductivity under optical pumping. The underlying mechanism is the flexible control of exceptional point by influencing graphene conductivity. We find that the PSHE shift is significantly enhanced near the exceptional point, and the enhanced PSHE shift can be manipulated by temperature. Moreover, the variation of temperature causes the inversion of the sign of the PSHE shift, and the temperature properties of the shift change as the optical pumping power varies. Based on the tunable PSHE shift, we design a temperature sensor with tunable sensitivity by combining weak measurement amplification techniques.

The turning of ecological change in the Yellow River Basin

AbstractThe Yellow River Basin (YRB) as a source of the oldest world cultures, flows through vast arid and semi‐arid regions of China. Its fragile vegetation is suffering the obvious effect from regional climate change, and easily turns from a critical state into qualitatively different modes of change, which implies significant impacts on humans and ecosystems. Our results show that in the period of 1982–2015, the normalized difference vegetation index (NDVI) appeared significantly discontinuous changes by stagnant warming and strengthening wetting, especially in the central YRB (104.5°–111° E, 35.5°–38° N). The NDVI in this region shifted from slowly increasing (5.42 × 10−4 a−1) to rapidly increasing (5.13 × 10−3 a−1) around 2003, called the turning point (TP). Such shift change is mainly a result of increased moderate rain, with frequency trend changed from 0.083 times·a−1 to 0.324 times·a−1. Meanwhile, these changes on vegetation led to a reversal of the gross primary productivity (GPP) from decreasing to increasing. Such results indicated the vulnerable ecosystem of the central YRB has played a positive contribution to the carbon balance, and more sustainable management of vegetation is required for the ecological development and engaging adaptive strategy.

The Influence of Capital Market Openness on the Sentiment of Chinese Investors

In recent years, China has been gradually and progressively promoting the opening of its capital markets to the outside world. In this study, a questionnaire survey and SEM (Structural Equation Modeling) model analysis were used to investigate the mechanisms and outcomes of capital market openness on Chinese investor sentiment based on the Land-Hong Kong Link Policy.The study reveals that following the opening of the capital markets, individual investor sentiment tends to become more rational due to factors such as changes in investor structure and shifts in value investment concepts. In the future, it is recommended that China's capital markets promote basic investment education and enhance the development of financial regulations to progress towards a deeper level of openness.

Abstract A041: FHD-286, a potent and selective inhibitor of BRG1 and BRM, shifts metastatic uveal melanoma tumor towards a less immunosuppressive state in patient samples

Abstract BRG1/BRM are key components of the SWI/SNF complex that are critical in regulation of transcriptional programs that control cell fate and identity. Tumor cells aberrantly hijack and upregulated BRG1 levels, hijacking “stemness features”. Furthermore, BRG1 has been shown to impact immune cell polarization, driving programs associated with T cell exhaustion and an immunosuppressive cell state. Our group previously demonstrate that the combination of FHD-286 and anti-PD-1 antibody is synergistic in syngeneic mouse models from various lineages, and substantially shifted with tumor microenvironment (TME) towards a more tumor killing state (Ichikawa, K. 2022, SITC). FHD-286 was evaluated in a phase 1 dose escalation (FHD-286-001, NCT04879017), in metastatic uveal melanoma (mUM) a tumor with low response rate to standard immune checkpoint therapy as well as high levels of immunosuppressive cell infiltration. Thus, we endeavored to determine if there was evidence of biological changes in peripheral blood and TME shifts in samples taken from our phase 1 dose escalation in patients with metastatic uveal melanoma. Subjects were on a daily dosing regimen ranging from 2.5 to 10 mg or an intermittent regimen of 1-week on/1-week-off ranging from 10 to 22.5 mg in 73 patients. RNA sequencing was performed in 46 patient blood samples collected in Paxgene tubes during dose escalation (2.5 mg- 15mg, C1D1, C1D15, C3D1 and other intermediate timepoints) and analyzed for transcriptional changes associated with shifts in immune polarization and activation. Tumor biopsies were collected at screening and either Cycle 3 or end of treatment. Biomarker changes in the tumor were quantified using multiplex IF (mIF) panel (Neogenomics) to assess co-localization and spatial orientation of 20 different immune related markers in 16 patients, 13 of which had samples from screening and on-treatment. Further changes were assessed using RNA sequencing of paired biopsies in 9 patients. Analysis of peripheral blood identified changes in expression of genes associated with a reduction in immunosuppressive signatures, particularly a dose dependent reduction of FOXP3 from baseline, as well as an increase in transcripts associated with activation of neutrophils. The mIF panel highlighted a reduction in immunosuppressive cells of multiple lineages including in on treatment samples, with 12/13 patients showing a reduction of one or more of the following: FOXP3+ Tregs (8/13), PD-L1+ Macrophages (8/13), an increase in the M2 Mf to tumor cells distance (8/13), markers of T cell exhaustion (PD1) on both CD4 (7/13) and CD8 T cells (8/13), or an increase in CD8/Treg ratio (5/13). Taken together these results suggest FHD-286 may reduce the immunosuppressive “blockade”, priming mUM patients to response in combination with an immune checkpoint inhibitor. Citation Format: Liv H Johannessen, Jessica Wan, Kim Horrigan, Mike Collins, GiNell Elliott, Kana Ichikawa, Ammar Adam, Sam Agresta, Jessica Piel, Martin Hentemann. FHD-286, a potent and selective inhibitor of BRG1 and BRM, shifts metastatic uveal melanoma tumor towards a less immunosuppressive state in patient samples [abstract]. In: Proceedings of the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; 2023 Oct 11-15; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2023;22(12 Suppl):Abstract nr A041.

HTA208 Paradigm Shift or Incremental Change? Real-World Evidence for Health Technology Assessment: A Critical Appraisal

HTA208 Paradigm Shift or Incremental Change? Real-World Evidence for Health Technology Assessment: A Critical Appraisal

From Metaphor to Metonym: Shakespearean Recognition in the United States University

This essay historicizes the Shakespeare curriculum at UC Berkeley’s English department over the last one hundred years. An elite research university in the United States, UC Berkeley’s extensive course offerings have expanded due to changes in undergraduate education and external cultural shifts. With a growing number of courses on sexuality, race, gender, etc., that became part of the purview of an English department, the teaching of Shakespeare expanded as well. I demonstrate how the emphasis on Shakespeare in the U.S. undergraduate curriculum shifts over time from one form of recognition—an acknowledgement of his value or worth—to a recognition of identifying with his work based on prior experience. Distinguishing between courses that combine “Shakespeare and” and those that combine “Literature and,” I expose the consequences each has for the canonicity of both Shakespeare and subject fields with which his works are placed in conversation, explicitly and implicitly. I argue that the expansion of Shakespeare in the American undergraduate curriculum coincides with and depends on the compression of key aspects of interpretation that pose challenges for the new knowledges it seeks to create. I illuminate how an expanded Shakespeare curriculum saw a compression of Shakespeare into metonymic mythic status, which has implications for the teaching of literature from various identity and cultural groups. I demonstrate how the origins of an expansive undergraduate Shakespeare curriculum in the United States positions Shakespeare as the interlocutor for a wide range of topics.

Highly Robust Atomic Layer Deposition‐Indium Gallium Zinc Oxide Thin‐Film Transistors with Hybrid Gate Insulator Fabricated via Two‐Step Atomic Layer Process for High‐Density Integrated All‐Oxide Vertical Complementary Metal‐Oxide‐Semiconductor Applications

Highly reliable atomic layer deposition (ALD)‐derived In‐Ga‐Zn‐O thin‐film transistors with high field‐effect mobility (μFE) and hydrogen (H) resistivity are crucial for the semiconductor industry. Herein, a hybrid Al2O3 gate insulator (GI) is proposed that is designed by controlling the plasma‐enhanced ALD and thermal ALD processes in situ to demonstrate robust characteristics. A hybrid GI is applied to the top‐gate geometry of an In0.71Ga0.08Zn0.21O active layer. The optimal device exhibits exceptional electrical characteristics, including a threshold voltage of 0.37 V, μFE of 150.7 cm2 V s−1, subthreshold swing of 64.0 mV decade−1, and hysteresis of 0.02 V. It demonstrates high resistance to H annealing and reliable positive bias temperature stress, as well as changes in VTH shifts of −0.43 and 0.00 V, respectively. The excellent electrical characteristics and high robustness of the device can be attributed to the precise control of H, oxygen, and carbon species within the upper region of the hybrid GI. The achievement of robust device characteristics enables the design of a novel vertical complementary metal‐oxide‐semiconductor inverter that exhibits a voltage gain of 44.7 V V−1 and a noise margin of 87.5% at a 10 V supply voltage.

Respiratory symptoms and pulmonary function impairment among textile industry workers in Alexandria, Egypt.

Occupational exposure to cotton dust is still an important cause of respiratory problems in textile workers particularly in less developed countries like Egypt. Evaluate respiratory symptoms and diseases, and pulmonary function pattern among Egyptian textile workers. Cross sectional comparative study was conducted from December 2019 to September 2020 in a textile factory in Egypt; 364 male workers (184 cotton dust exposed workers, and 180 unexposed workers) were included. Participants were subjected to an interviewing questionnaire, British Medical Research Council questionnaire, anthropometric measurements, pulmonary function tests, and byssinosis grading format. Descriptive and analytic statistics were conducted. Chronic cough, phlegm production, and shortness of breath grade I, II and III were more reported in cotton dust exposed workers than unexposed workers (P#x003C;0.01, P#x003C;0.01, and P=0.02, respectively). Prevalence of chronic bronchitis was significantly higher among cotton dust exposed workers (12%) than unexposed workers (3.9%) (P#x003C;0.01). The mean percent predicted values of lung function indices reflecting large-1irway function (VC, FVC, FEV1, FEV1%, PEFR, and FEF75) were significantly lower in cotton dust exposed workers (P#x003C;0.01). Prevalence of byssinosis was 22.8%. Workers with byssinosis had significantly higher prevalence of respiratory symptoms, chronic bronchitis, cross-shift reduction in PEFR and significant decrease in mean percent predicted values of FVC, FEV1, PEFR, FEF75, and FEF50 than workers without byssinosis. This study revealed a substantial association between cotton dust exposure at work and respiratory symptoms and morbidity. Regular measurement of cross shift change in PEFR is recommended among exposed workers for early diagnosis of byssinosis.

Floristic, chorological and life-form patterns at the highest summits of Mt Olympus, Greece

ABSTRACT High elevation habitats within the Mediterranean biome are expected to be disproportionally exposed to climate change impacts in comparison to the ecosystems of the lower and drier sites. The distribution and structure of alpine ecosystems greatly depend on temperature variables including growing season length. Tree-line shifts, structural change of alpine plant communities and shifts of the alpine-nival ecotone are among the most commonly observed impacts of climate change. The Global Observation Research Initiative in Alpine Environments (GLORIA) network has developed a common methodology and facilitates a global approach for studying the effects of climate change in alpine ecosystems with repeated measurements in permanent plots. Mt Olympus, Greece, was the last target region to join the network. In this study we use the vegetation data from the baseline survey on Mt Olympus to describe floristic patterns along an elevational gradient of four summits. To examine compositional, life-form and chorological differences between- and within-summits we analyzed data from 32 plots. Moreover, we fitted generalized linear models to distinguish important environmental variables for the occurrence of plant taxa. Our results demonstrate that elevation was the dominant factor influencing vegetation changes along the examined gradients. Additional, the life-form spectrum does not provide sufficient information to be used as index for monitoring climate change impacts on vegetation composition. Instead, the use of the species matrix provides enough information regarding the between-summits dissimilarities. We also identified a number of plant taxa that are highly related to either low or high elevations. These taxa could be used as early warning indices of compositional shifts.

Au coated etched FBG SPR sensor for the detection of ethanol in aqueous solution

Over the past few years, there has been a growing need for reliable ethanol sensors in the pharmaceutical and food industries. These industries require constant monitoring to ensure that the acceptable ethanol levels are maintained. This study reports a new fiber optic sensor that uses etched single mode fiber Bragg grating (FBG) coated with the thin layer of 45 nm gold to produce Surface Plasmon Resonance (SPR). A thin layer of 45 nm gold improves the sensitivity of sensor by improving the evanescent wave around the fiber, resulting in better interaction with the analyte. The sensing performance of developed structure was examined by analyzing the change in wavelength shift observed by varying ethanol concentration in aqueous solution from 0 to 100 %. The performance of developed sensor in terms of sensitivity is 20 pm/RIU. Which is expected to play an important role in food and pharmaceutical industries to protect human health from detrimental affects due to high concentration of ethanol.