Air pollution is a global issue that demands urgent attention due to its detrimental effects on human health and the environment. Land Use and Land Cover (LULC) change is an essential factor that significantly impacts ambient air quality through alterations in emission sources, vegetation cover, natural processes, and urban design. This study investigates the spatio-temporal variation of key air pollutants resulting from urban LULC changes in the Delhi region. Findings reveal a notable increase in pollutant concentrations, particularly particulate matter, in 2019 (PM10: 318.65 ± 45.80 µg/m3) and 2023 (PM10: 383.70 ± 61.49 µg/m3), compared to 2008 (PM10: 246.76 ± 30.66). LULC change analysis demonstrates a rise in built-up areas 24.59%(2008 to 2019), 33.62% (2008 to 2023) and a decline in vegetation cover 27.49% (2008 to 2019),32.37% (2008 to 2023). Correlation analysis indicates a positive correlation between PM10 and urban indices (+ 0.63) and a negative correlation between PM10 and vegetation indices (- 0.61), highlighting the impact of LULC on air quality deterioration. Subsequently, a fuzzy inference system model integrates LULC information to develop an air quality index (AQI). Incorporating LULC changes in AQI assessment offers a realistic approach to address the complexity arising from combined air pollutant effects, surpassing conventional AQI calculation methods. The findings underscore the significance of understanding the impact of Land Use and Land Cover (LULC) change on ambient air quality in formulating effective air quality management programs and policies. Integrating this knowledge into policymaking is crucial for the successful abatement of air pollution in urbanized areas.