Structural Changes Research Articles

Germination, Physiochemical, and Morphology Changes of TR10 Rice Seeds Irradiated to Filtered and Unfiltered Neutron

In 2020, Sabah’s rice production was 117, 846 metric tonnes with a planted area of 40, 446 ha is relatively low compared to other states such as Selangor, which has 36,004 ha less planted area but can produce up to 159,535 metric tonnes more than Sabah. Low rice production in Sabah has contributed to the shortage of supply. Thus, new varieties could be needed that sufficiently produce yields that comparable to the efforts and cost of rice planting. One of the methods is producing new varieties that probably produce high yields using physical mutagen. From the literature available, gamma and neutrons were found to be the most common agents to increase rice production per unit planting area but used they were used separately. Theoretically, using fast neutron irradiation was found to produce a superior mutant. Thus, this paper aims to study the effect of rice seeds irradiated to both gamma and neutron simultaneous, and compare with neutron alone on the germination rates and physiochemical of rice seeds after the irradiations at different dosages. TR10 rice seeds were irradiated simultaneously to gamma and neutrons in the nuclear reactor core using Pneumatic Transfer System–PTS facility, while irradiation to neutrons alone was performed in a neutron chamber using Beam ports–BP facility at Nuclear Malaysia. The germination study shows a linear decrease as the irradiation doses increase in BP and fail to germinate in PTS. Yet, seeds irradiated in PTS showed no hazardous compounds and a remarkable increase in mineral content in seeds, particularly potassium and magnesium at 14 Gy. Similarly, to the shape of the starch granules in both facilities, the starch structure changes after being exposed to 14 Gy in PTS and 35 Gy in BP. As a result, seeds exposed to neutron alone induced considerably more inclusive effects and may raise growth performance and improve rice quality with optimal neutron dosage range from 7 to 14 Gy.

Academic citizenship in an age of anti-intellectualism

This essay focuses on the fundamental idea that established theory can guide faculty professional service to inform and educate the general public. More specifically, we explore how faculty can use Boyer's scholarship of engagement as a framework for faculty academic citizenship and partnering with external audiences. Two recommendations are made related to intentional structural changes to universities as organizations for faculty academic citizenship to be relevant and make important contributions in the future.

Design and Development of Molecular Beacon-Based Real-Time PCR Assays to Identify Clostridioides difficile Types of Main Evolutionary Clades

C. difficile infection (CDI) has an important impact on both human and animal health. The rapid detection and monitoring of C. difficile PCR-ribotypes (RTs) cause of CDI is critical to control and prevent this infection. This study reports the first application of the Molecular Beacon (MB)-based real-time PCR method in genotyping important C. difficile RTs of the main evolutionary clades. The cdtR gene was used as target and the cdtR sequences were analyzed after extraction from deposited genomes or were obtained after sequencing from strains of different origin. cdtR alleles were identified after sequence comparisons and MB-based real-time PCR assays were developed to discriminate them. In total, 550 cdtR sequences were compared, 38 SNPs were found, and five different cdtR alleles were identified. In total, one or two alleles were associated to the RTs grouped in the same evolutionary clade. A MB-based real-time assay was designed for each allele and for optimized testing of the C. difficile strains. The results obtained demonstrated that the MB-based real-time PCR assays developed in this study represent a powerful, original, and versatile tool to identify C. difficile types/clades and to monitor changes in the population structure of this important pathogen.

A Tale of Two Divvys: The Bicycle Sharing System of Chicago

How did Chicago develop one of the largest and most successful Bicycle Sharing Systems in a very short time, what benefits does this system afford to the city and its residents, and what developments threaten this success? Urban areas benefit significantly and in a variety of ways from micromobility, which contributes to an urgently needed sustainability transformation. In this qualitative, exploratory case study, we examine the foundations of the success and types of benefits of the second largest bicycle sharing system in North America, the City of Chicago’s Divvy. We juxtapose our data, which consists of participant and non-participant observations, fieldwork, interviews, documents, and social media posts, with a typology gleaned from the academic literature on bicycle sharing systems to explore Divvy’s wide-ranging positive impact. This typology includes economic, environmental, health and safety, and quality of life benefits. In addition, we identify two further benefits from our data: modularity and zoetic capacity. Despite this impact, we show how the consequences of changes in the ownership structure since 2018 are threatening the success and benefits. The emerging service model is no longer based on the initial pillars of its success: the city’s policy and vision for Divvy, the funding and ownership structure, and the strategic deployment of bicycle stations to balance demand potential with locational equity. Based on our study, we conclude that it is unlikely that the new micromobility system, refocused on more profitable e-bike and e-scooter rentals in privileged neighborhoods, is viable in the long term because it is abandoning the core values that embedded Divvy into the fabric of the city. Worse, the emergent model may actually contribute to a systematic exclusion of poorer neighborhoods and less privileged residents of Chicago.

Tailored Micromagnet Sorting Gate for Simultaneous Multiple Cell Screening in Portable Magnetophoretic Cell‐On‐Chip Platforms

AbstractConventional magnetophoresis techniques for manipulating biocarriers and cells predominantly rely on large‐scale electromagnetic systems, which is a major obstacle to the development of portable and miniaturized cell‐on‐chip platforms. Herein, a novel magnetic engineering approach by tailoring a nanoscale notch on a disk micromagnet using two‐step optical and thermal lithography is developed. Versatile manipulations are demonstrated, such as separation and trapping, of carriers and cells by mediating changes in the magnetic domain structure and discontinuous movement of magnetic energy wells around the circumferential edge of the micromagnet caused by a locally fabricated nano‐notch in a low magnetic field system. The motion of the magnetic energy well is regulated by the configuration of the nanoscale notch and the strength and frequency of the magnetic field, accompanying the jump motion of the carriers. The proposed concepts demonstrate that multiple carriers and cells can be manipulated and sorted using optimized nanoscale multi‐notch gates for a portable magnetophoretic system. This highlights the potential for developing cost‐effective point‐of‐care testing and lab‐on‐chip systems for various single‐cell‐level diagnoses and analyses.

Cerebral Perfusion Characteristics and Dynamic Brain Structural Changes in Stroke-Prone Renovascular Hypertensive Rats: A Preclinical Model for Cerebral Small Vessel Disease.

Hypertension is a leading cause of cerebral small vessel disease (CSVD) and vascular dementia in elderly individuals. We aimed to assess cerebral perfusion and dynamic changes in brain structure in stroke-prone renovascular hypertensive rats (RHRSPs) with different durations of hypertension and to investigate whether they have pathophysiological features similar to those of humans with CSVD.The RHRSP model was established using the two-kidney, two-clip (2k2c) method, and the Morris water maze (MWM) test, MRI, immunohistochemistry, and biochemical analysis were performed at multiple time points for up to six months following the 2k2c operation.Systolic blood pressure was significantly greater in the RHRSP group than in the sham-operated group at week 4 post-surgery and continued to increase over time, leading to cognitive decline by week 20. Arterial spin labeling revealed cerebral hypoperfusion in the RHRSP group at 8 weeks, accompanied by vascular remodeling and decreased vessel density. Diffusion tensor imaging and Luxol fast blue staining indicated that white matter disintegration and demyelination gradually progressed in the corpus callosum and that myelin basic protein levels decreased. Eight weeks after surgery, blood-brain barrier (BBB) leakage into the corpus callosum was observed. The albumin leakage area was negatively correlated with the myelin sheath area (r=-0.88, p<0.001). RNA-seq analysis revealed downregulation of most angiogenic genes and upregulation of antiangiogenic genes in the corpus callosum of RHRSPs 24 weeks after surgery.RHRSPs developed cerebral hypoperfusion, BBB disruption, spontaneous white matter damage, and cognitive impairment as the duration of hypertension increased. RHRSPs share behavioral and neuropathological characteristics with CSVD patients, making them suitable animal models for preclinical trials related to CSVD.

Identification of Solvent Extraction of Au(III) by Cyanex 272 from Hydrochloric Acid Solutions

Bis(2,4,4-trimethylpentyl)phosphinic acid (Cyanex 272) is known to selectively extract Au(III) from dilute to concentrated hydrochloric acid solutions. Therefore, Cyanex 272 can be employed in the separation of Au(III) from the hydrochloric acid leaching solutions of secondary resources containing gold metal. This work identified the extraction reaction of Au(III) by Cyanex 272 from the hydrochloric acid solutions. Au(III) extraction data was obtained by varying the concentrations of HCl (1-9 M), Au(III) (0.1-1 g/L) and Cyanex 272 (0.01-0.1 M). Among the three variables, it was found that HCl concentration had the most pronounced effect on the extraction of Au(III), which increased with HCl concentration. The extraction reaction of Au(III) by Cyanex 272 is proposed by applying slope analysis method to the extraction data. Comparison of Fourier transform infrared spectroscopy results for the fresh and loaded Cyanex 272 revealed no change in the chemical structure of Cyanex 272 after the extraction. Nuclear magnetic resonance spectroscopic data showed a change in the characteristic peaks of the phosphorus atom of Cyanex 272, indicating the formation of a coordinative bond between Au(III) and Cyanex 272. FT-IR and NMR data together with application of slope analysis clearly verified that molecular Cyanex 272 takes parts in the extraction of Au(III).

MISSENSE MUTATIONS IN THE IRAK1 GENE ARE ASSOCIATED WITH AN INCREASED RISK OF SYSTEMIC LUPUS ERYTHEMATOSUS

Single nucleotide polymorphisms (SNPs) are the most common form of genetic variation in humans. Missense SNPs can change protein structure and function. This study aimed to determine missense SNPs of the IRAK1 gene that can affect the amino acid sequence and lead to changes in protein structure and function, as well as their relationship as a risk factor for SLE. In this in silico method, several bioinformatics tools have been used to identify missense SNPs, including their properties and impacts, as well as their interaction networks with proteins. The tools used were PolyPhenv2, SIFT, PhD-SNP, PROVEAN, SNAP, Panthers, I-Mutant 3.0, and GeneMania. Four missense SNPs, rs11465830, rs1059702, rs1059703, and 10127175, were obtained from the NCBI SNP database. The SIFT test results showed that all the SNPs were tolerant. In the test results obtained using PolyPhen, the four SNPs were benign. The results of the probe test indicated that the four SNPs were neutral. When tested with SNAP, one SNP was neutral, and three others had an impact. In the PhD-SNP test, all SNPs were neutral. In the panther test, all SNPs were benign. The I-mutant assay showed that the four SNPs could decrease protein stability. Tests with GeneMania have reported that most interactions between genes were between IRAK1 and MYD88, and physical interactions were the most dominant form of interaction. Conclusion. rs10127175, rs11465830, rs1059702, and rs1059703 are missense SNPs in IRAK1, which can disrupt protein stability and be a risk factor for SLE. Keywords: IRAK1, SNP, Missense, Systemic Lupus Erythematosus

Detection of ammonia mercerization in cotton textiles

AbstractCotton textiles are mercerized with anhydrous ammonia liquefied at ca. − 33 °C to improve their mechanical performance, appearance, and handle. Similar effects may also be achieved with NaOH mercerization, but goods mercerized with liquid ammonia (L-NH3) are judged qualitatively better (e.g., softer hand) and thus command a greater price. Therefore, it is of interest to be able to test and confirm whether cotton textiles labeled as L-NH3 treated are indeed so. Building on previous work, we report on tests in collaboration with a process house on identifying ammonia-mercerized fabrics from a pool of cotton textiles treated with L-NH3, NaOH, neither, or both––using FTIR-ATR spectroscopy. It is based on detecting the change in crystal lattice structure from type I (native cellulose) to type II (after NaOH mercerization) or type III (after ammonia mercerization). We could consistently differentiate the ammonia-mercerized fabrics from the untreated and those mercerized with NaOH, but the latter could not be differentiated from fabrics mercerized with both. It was also possible to detect evidence of ammonia mercerization in 4- and 14-year-old samples. Graphical abstract

Changes in soil microbial carbon fixation pathways along the oasification process in arid desert region: A confirmation based on metagenome analysis

Microbial carbon fixation has been proved to play a key role in soil carbon accumulation in arid desert oasis, but the fixation mechanism remains unclear. To solve it, we used metagenomic sequencing technology to measure the changes of soil microbial community structure, carbon fixation–related genes and carbon fixation pathway, as well as their relationships with soil properties between natural desert shrubbery (CK) and four oasis farmlands with different cultivation years (i.e., 3, 18 and 30 years) in the arid desert region of northwest China. The results showed that the contents of four soil carbon fraction (soil organic carbon/SOC, soil recalcitrant organic carbon/ROC, soil water solution carbon /WSC, and microbial biomass carbon/MBC) all significantly increased with the cultivation years (30 years ≥ 18 years > 6 years ≥ 3 years ≥ CK) (P < 0.05). Microbial composition was significant difference among CK, 3-, 6-, 18- and 30-years cultivated farmlands. Bacteria were the soil dominant taxa, and its relative abundance gradually decreased with the cultivation years. Proteobacteria, Actinobacteria, Bacteroidetes and Acidobacteria were the dominant phylum of soil microorganisms in desert shrubbery and oasis farmlands. Their relative abundance changed obviously with cultivation years. Six microbial carbon fixation pathways. i.e., the reductive tricarboxylic acid cycle (rTCA), dicarboxylate/4–hydroxybutyrate cycle (DC/4–HB cycle), 3–hydroxypropionate bicycle (3–HP bi–cycle), 3–hydroxypropionate/4–hydroxybutyrate cycle (3–HP/4–HB cycle), Calvin cycle and the Wood–Ljungdahl pathway (WL pathway), were found in all soils, but only the rTCA, DC/4–HB, 3–HP/4–HB cycles and WL pathway significantly changed with the cultivation years. The rTCA cycle was the most common fixation pathway, followed by DC/4–HB cycle and 3–HP/4–HB cycle, while WL pathway was least detected. Soil properties, especially pH, recalcitrant organic carbon, bulk density, total salinity and soil water contents, affected microbial community composition and carbon fixation–related genes in the oasification process. Our results suggested that oasification affected microbial carbon fixation by changing the soil environment due to human agricultural activities. Limited by energy supply in the nutrient–poor soils, rTCA and DC/4–HB cycles were mainly used by microorganisms to fix carbon in oasis farmlands.

Alterations in metabolic pathways: a bridge between aging and weaker innate immune response.

Aging is a time-dependent progressive physiological process, which results in impaired immune system function. Age-related changes in immune function increase the susceptibility to many diseases such as infections, autoimmune diseases, and cancer. Different metabolic pathways including glycolysis, tricarboxylic acid cycle, amino acid metabolism, pentose phosphate pathway, fatty acid oxidation and fatty acid synthesis regulate the development, differentiation, and response of adaptive and innate immune cells. During aging all these pathways change in the immune cells. In addition to the changes in metabolic pathways, the function and structure of mitochondria also have changed in the immune cells. Thereby, we will review changes in the metabolism of different innate immune cells during the aging process.

Analysis of problems and potentials for increasing pandemic resilience in public health administrations in Saxony-Anhalt, Germany—a mixed-methods approach

IntroductionThe COVID-19 pandemic has shown the importance of resilient, modern, and well-equipped public health administrations from national to communal levels. In Germany, the surveillance, contact tracing, and local adaptions went...

Neuropsychiatric and Cognitive Symptoms: Two Sides of the Same Coin?

Neuropsychiatric symptoms (NPS) are increasingly being recognized as clinical markers for incipient dementia in Alzheimer's disease (AD dementia). NPS may reinforce cognitive impairment or decline and vice versa. Although NPS are frequent already in mild cognitive impairment, their mechanisms are poorly understood. It is unclear if they share biological mechanisms with cognitive symptoms and how they are associated to structural brain changes, but evidence suggests associations of NPS to cerebral atrophy. An additional NPS dimension in AD dementia concepts might add valuable information to detect patients at risk for AD dementia.

Chromophore-Protein Interactions Affecting the Polyene Twist and π-π* Energy Gap of the Retinal Chromophore in Schizorhodopsins.

The properties of a prosthetic group are broadened by interactions with its neighboring residues in proteins. The retinal chromophore in rhodopsins absorbs light, undergoes structural changes, and drives functionally important structural changes in proteins during the photocycle. It is therefore crucial to understand how chromophore-protein interactions regulate the molecular structure and electronic state of chromophores in rhodopsins. Schizorhodopsin is a newly discovered subfamily of rhodopsins found in the genomes of Asgard archaea, which are extant prokaryotes closest to the last common ancestor of eukaryotes and of other microbial species. Here, we report the effects of a hydrogen bond between a retinal Schiff base and its counterion on the twist of the polyene chain and the color of the retinal chromophore. Correlations between spectral features revealed the unexpected fact that the twist of the polyene chain is reduced as the hydrogen bond becomes stronger, suggesting that the twist is caused by tight atomic contacts between the chromophore and nearby residues. In addition, the strength of the hydrogen bond is the primary factor affecting the color-tuning of the retinal chromophore in schizorhodopsins. The findings of this study are valuable for manipulating the molecular structure and electronic state of the chromophore by controlling chromophore-protein interactions.

Dietary Shifts in the Adaptation to Changing Marine Resources: Insights from a Decadal Study on Greater Lizardfish (Saurida tumbil) in the Beibu Gulf, South China Sea.

Understanding dietary behavior during the individual development of marine predators and its temporal variations elucidates how species adapt to changes in marine resources. This is crucial for predicting marine predators' habitat selection and the natural population's responses to environmental changes. The authors conducted a comparative analysis of dietary shift strategies and trophic level variations in Greater lizardfish (Saurida tumbil) in the Beibu Gulf during two distinct periods (2010 and 2020) using stomach content and stable isotope analysis methods. Possible driving factors for these changes were also explored. Changes in the fishery community structure and the decline in the abundance of primary prey resources have led the S. tumbil population to diversify their prey species, utilize alternative resources, and expand their foraging space. However, the species' foraging strategy, characterized by chasing and preying on schooling and pelagic prey, promoted stability in their feeding behavior across spatial and temporal scales. The main prey items remained demersal and pelagic fish species, followed by cephalopods and crustaceans. Similar to other generalist fish species, ontogenetic dietary shifts (ODSs) indicated a partial transition towards larger prey items. However, the timing and magnitude of the ODSs varied between the two periods, reflecting life-history variations and adaptive adjustments to environmental changes. In comparison to 2010, the population's mean body length (BL) increased in 2020, and the proportion of the population feeding on pelagic-neritic prey significantly increased. However, the δ15N values were lower, indicating that the shift in the ecological niche of preferred prey from demersal to pelagic-neritic was the primary cause of the decrease in trophic levels. In the future, we will conduct further quantitative research integrating the spatiotemporal data of both predators and prey to clarify the relationships between marine predators' feeding behavior, trophic levels, and changes in prey community structure.

Abstract B030: Synergistic antitumor effects of cold atmospheric plasma and temozolomide in glioblastoma: multimodal approaches integrating in-vitro, in vivo, and in silico investigations for novel and enhanced therapeutic advancements

Abstract Glioblastoma multiforme (GBM) is a common and aggressive brain cancer with a median survival rate of 12 to 18 months after diagnosis. Despite standard treatments, including surgery, radiotherapy, and Temozolomide (TMZ), GBM remains highly resistant to therapy due to its infiltrative pattern of invasion, rapid growth, and propensity to relapse [1]. While overall mortality rates remain high, there is a crucial need for a better understanding of the molecular mechanisms and gene mutations involved in GBM and the development of more effective and adaptive therapeutic approaches. Modulating reactive oxygen species (ROS) levels has been suggested as a therapeutic strategy to selectively target the destruction of cancer cells. To address this, we propose a combination therapy utilizing multi-operational plasma devices, including using cold atmospheric plasma (CAP) jet and plasma discharge tube (PDT) in conjunction with TMZ for GBM treatment. CAP functions by elevating reactive oxygen and nitrogen species (RONS) levels and specifically targeting tumor spread. We investigated various plasma devices and their characteristics using optical emission spectroscopy (OES) and measured the electromagnetic potential and emissions of the PDT. The OES of PDT displayed a similar spectrum as the CAP jet, indicating the presence of ROS. In this study, we performed transcriptomic analysis of glioblastoma cells using high throughput deep RNA-Seq with next-generation sequencing (NGS) to quantify genome-wide gene expression changes. Additionally, we examined signaling pathways and predicted structural changes in consequential proteins caused by gene spectrum up or down-regulation. Our results demonstrate that the combination treatment of CAP and TMZ downregulated vital genes involved in MAPK, P53, DNA repair, and cell cycle pathways. The combination of CAP &amp; TMZ showed a significant antitumor effect, inducing apoptosis and damaging essential proteins in GBM cells. In vitro and microscopic studies verified these results, showing nuclear and cell membrane disruption in cancer cells post-plasma treatment. Our findings demonstrate that the combination of CAP/PDT and TMZ effectively sensitizes GBM cells to TMZ, leading to apoptosis. We have previously shown a non-invasive application of CAP jet on the skull of tumor-bearing mice causing ~78% tumor inhibition [2]. Our current study highlights the potential of PDT for non-invasive treatment in vitro, offering a modality for intracranial delivery in in-vivo models. In conclusion, we propose CAP/PDT and TMZ combination therapy as novel non-invasive treatments for GBM in murine models. This approach offers a promising avenue for addressing the dire need for more effective treatments with minimal impact on normal cells. Further investigations and validation in clinical settings are warranted to significantly improve GBM management and patient outcomes.

Competition of multiphoton ionization pathways in lithium

We study the three-photon ionization of atomic lithium by intense, short light pulses, via numerically solving the time-dependent Schrödinger equation. Two-photon Rabi oscillations are induced between the 2s and 4s states, which are damped due to single-photon ionization to the p continuum. Developing a minimal three-level model, we analyze the spectral features of the Autler–Townes (AT) doublet that is formed upon the resonant coupling with the laser pulse. Furthermore, we show that this 2s→→4s→p continuum pathway is the dominant process, if the duration of the laser pulse exceeds a certain value. For shorter pulses, ionization through the 2p state ( 2s→2p→4d→f continuum ) gradually becomes the dominant process, provided that the pulse is strong enough to induce several Rabi floppings. Here, we trace the competition of these ionization pathways by observing the structural changes in the shape of the AT doublet.

Optical pH Sensor Based on a Long-Period Fiber Grating Coated with a Polymeric Layer-by-Layer Electrostatic Self-Assembled Nanofilm.

An optical fiber pH sensor based on a long-period fiber grating (LPFG) is reported. Two oppositely charged polymers, polyethylenimine (PEI) and polyacrylic acid (PAA), were alternately deposited on the sensing structure through a layer-by-layer (LbL) electrostatic self-assembly technique. Since the polymers are pH sensitive, their refractive index (RI) varies when the pH of the solution changes due to swelling/deswelling phenomena. The fabricated multilayer coating retained a similar property, enabling its use in pH-sensing applications. The pH of the PAA dipping solution was tuned so that a coated LPFG achieved a pH sensitivity of (6.3 ± 0.2) nm/pH in the 5.92-9.23 pH range. Only two bilayers of PEI/PAA were used as an overlay, which reduces the fabrication time and increases the reproducibility of the sensor, and its reversibility and repeatability were demonstrated by tracking the resonance band position throughout multiple cycles between different pH solutions. With simulation work and experimental results from a low-finesse Fabry-Perot (FP) cavity on a fiber tip, the coating properties were estimated. When saturated at low pH, it has a thickness of 200 nm and 1.53 ± 0.01 RI, expanding up to 310 nm with a 1.35 ± 0.01 RI at higher pH values, mostly due to the structural changes in the PAA.

Structural changes in Rochelle salt on phase transitions revisited in a multi-temperature single-crystal X-ray diffraction study.

Phase transitions in Rochelle salt [sodium potassium L(+)-tartrate tetrahydrate] are revisited in a single-crystal X-ray diffraction multi-temperature study on cooling from 308 to 100 K across the high-temperature paraelectric (PE) ↔ ferroelectric ↔ low-temperature PE phase transition points. The results of structure refinement using three different models (a harmonic with and without disorder, and an anharmonic) were compared. The temperature dependencies of anisotropic displacement parameters (ADPs) and Ueq, which can be calculated directly from ADPs, for the low-temperature PE phase indicate clearly the dynamic nature of disorder of the K1 atoms. The structures of the low-temperature and the high-temperature PE phases are compared for the first time at multiple temperatures for each phase based on diffraction data collected from the same single crystal. The data indicate that the high-temperature and the low-temperature paraelectric phases are probably not two different phases, as was assumed in earlier works, but are structurally the same phase at different temperatures.

Advances in Carbamazepine Cocrystals: A Review

AbstractCarbamazepine (CBZ), a widely used antiepileptic drug, is known for its therapeutic efficacy but exhibits suboptimal physicochemical characteristics, including limited bioavailability, low solubility, and poor dissolution rates. In recent years, cocrystallization has emerged as a promising approach to improve these properties and enhance the overall performance of CBZ. This review paper presents a comprehensive exploration of the advances in CBZ cocrystals, focusing on their role in enhancing bioavailability, solubility/dissolution rates, morphology, and stability compared to raw CBZ. It delves into the in‐depth examination of computational techniques, such as molecular modelling and crystal structure prediction, that play a pivotal role in the rational design and prediction of CBZ cocrystals, thereby expediting the development process. Additionally, the morphological attributes of CBZ cocrystals are discussed, shedding light on how the unique crystal structures affect their physical properties. Stability is another critical aspect addressed in this review, encompassing thermal, physical, and chemical stability. The thermal behavior of CBZ cocrystals is analyzed through differential scanning calorimetry (DSC), and their crystal structures are characterized by techniques such as X‐ray diffraction (XRD) and Fourier‐transform infrared spectroscopy (FTIR). These analyses reveal the stability and structural changes of CBZ cocrystals under various conditions, providing valuable insights for formulation and storage. In summary, this comprehensive review paper amalgamates the latest advancements in CBZ cocrystals, demonstrating their capacity to significantly improve bioavailability, solubility, dissolution rates, and stability.