Significant Changes In Amplitude Research Articles

InSAR Analysis of Partially Coherent Targets in a Subsidence Deformation: A Case Study of Maceió

Since the 1970s, extensive halite extraction in Maceió, Brazil, has resulted in significant geological risks, including ground collapses, sinkholes, and infrastructure damage. These risks became particularly evident in 2018, following an earthquake, which prompted the cessation of mining activities in 2019. This study investigates subsidence deformation resulting from these mining operations, focusing on the collapse of Mine 18 on 10 December 2023. We utilized the Quasi-Persistent Scatterer Interferometric Synthetic Aperture Radar (QPS-InSAR) technique to analyze a dataset of 145 Sentinel-1A images acquired between June 2019 and April 2024. Our approach enabled the analysis of cumulative displacement, the loss of amplitude stability, the evolution of amplitude time series, and the amplitude change matrix of targets near Mine 18. The study introduces an innovative QPS-InSAR approach that integrates phase and amplitude information using amplitude time series to assess the lifecycle of radar scattering targets throughout the monitoring period. This method allows for effective change detection following sudden events, enabling the identification of affected areas. Our findings indicate a maximum cumulative displacement of −1750 mm, with significant amplitude changes detected between late November and early December 2023, coinciding with the mine collapse. This research provides a comprehensive assessment of deformation trends and ground stability in the affected mining areas, providing valuable insights for future monitoring and risk mitigation efforts.

Fluid-Solid coupling analysis of PTFE impeller in hydraulic turbines for sewage resource utilization

Abstract Hydraulic turbines, vital energy-saving devices, convert pressure energy from liquid fluids into mechanical energy. As wastewater resource utilization and zero discharge industries proliferate, relevant research is of great interest. In order to design a suitable medium and low pressure hydraulic turbine for industrial water treatment, we conducted a study analyzing the stress and strain characteristics of a PTFE turbine impeller by means of bi-directional fluid-structure coupling numerical simulation. Our findings suggest that the impeller’s maximum equivalent stress and maximum deformation fall within acceptable material limits, with stress concentration at the blade-cover plate interface. The blade experiences maximum deformation at its midpoint due to high liquid pressure on the volute periphery. Fluid solid coupling reduces the maximum equivalent stress of the impeller by about 1.65MPa and the maximum deformation of the blade by about 0.05mm. The equivalent stress at the sampling point fluctuates periodically, with a significant change in stress amplitude at the sampling point of the cover plate on one side of the support surface, increasing susceptibility to fatigue damage.

Epidural magnetic stimulation of the motor cortex using an implantable coil

BackgroundMagnetic stimulation, represented by transcranial magnetic stimulation (TMS), is used to treat neurological diseases. Various strategies have been explored to improve the spatial resolution of magnetic stimulation. While reducing the coil size is the most impactful approach for increasing the spatial resolution, it decreases the stimulation intensity and increases heat generation. ObjectiveWe aim to demonstrate the feasibility of magnetic stimulation using an epidurally implanted millimeter-sized coil and that it does not damage the cortical tissue via heating even when a repetitive stimulation protocol is used. MethodsA coil with dimensions of 3.5 × 3.5 × 2.6 mm3 was epidurally implanted on the left motor cortex of rat, corresponding to the right hindlimb. Before and after epidural magnetic stimulation using a quadripulse stimulation (QPS) protocol, changes in the amplitude of motor evoked potentials (MEPs) elicited by a TMS coil were compared. ResultsThe experimental group showed an average increase of 88 % in MEP amplitude in the right hindlimb after QPS, whereas the MEP amplitude in the left hindlimb increased by 18 % on average. The control group showed no significant change in MEP amplitude after QPS in either hindlimb. The temperature changes at the coil surface remained <2 °C during repetitive stimulation, meeting the thermal safety limit for implantable medical devices. ConclusionThese results demonstrate the feasibility of epidural magnetic stimulation using an implantable coil to induce neuromodulation effects. This novel method is expected to be a promising alternative for focal magnetic stimulation with an improved spatial resolution and lowered stimulus current than previous magnetic stimulation methods.

The influence of menstrual phase on synaptic plasticity induced via intermittent theta-burst stimulation

BackgroundOvarian hormones influence the propensity for short-term plasticity induced by repetitive transcranial magnetic stimulation (rTMS). Estradiol appears to enhance the propensity for neural plasticity. It is currently unknown how progesterone influences short-term plasticity induced by rTMS. ObjectiveThe present research investigates whether the luteal versus follicular phase of the menstrual cycle influence short-term plasticity induced by intermittent theta-burst stimulation (iTBS). We tested the hypothesis that iTBS would increase motor evoked potentials (MEPs) during the follicular phase. Further, we explored the effects of the luteal phase on iTBS-induced neural plasticity. MethodTwenty-nine adult females participated in a placebo-controlled study that delivered real and sham iTBS to the left primary motor cortex in separate sessions corresponding to the follicular phase (real iTBS), luteal phase (real iTBS), and a randomly selected day (sham iTBS). Outcomes included corticospinal excitability as measured by the amplitude of MEPs and short-interval intracortical inhibition (SICI) recorded from the right first dorsal interosseous muscle before and following iTBS (612 pulses). ResultsMEP amplitude was increased following real iTBS during the follicular condition. No significant changes in MEP amplitude were observed during the luteal or sham visits. SICI was unchanged by iTBS irrespective of menstrual phase. ConclusionThese findings suggest women experience a variable propensity for iTBS-induced short-term plasticity across the menstrual cycle. This information is important for designing studies aiming to induce plasticity via rTMS in women.

Frequency‐Locked Wireless Multifunctional Surface Acoustic Wave Sensors

AbstractSurface acoustic waves (SAWs) have shown great potential for developing sensors for structural health monitoring (SHM) and lab‐on‐a‐chip (LOC) applications. Existing SAW sensors mainly rely on measuring the frequency shifts of high‐frequency (e.g., &gt;0.1 GHz) resonance peaks. This study presents frequency‐locked wireless multifunctional SAW sensors that enable multiple wireless sensing functions, including strain sensing, temperature measurement, water presence detection, and vibration sensing. These sensors leverage SAW resonators on piezoelectric chips, inductive coupling‐based wireless power transmission, and, particularly, a frequency‐locked wireless sensing mechanism that works at low frequencies (e.g., &lt;0.1 GHz). This mechanism locks the input frequency on the slope of a sensor's reflection spectrum and monitors the reflection signal's amplitude change induced by the changes of sensing parameters. The proof‐of‐concept experiments show that these wireless sensors can operate in a low‐power active mode for on‐demand wireless strain measurement, temperature sensing, and water presence detection. Moreover, these sensors can operate in a power‐free passive mode for vibration sensing, with results that agree well with laser vibrometer measurements. It is anticipated that the designs and mechanisms of the frequency‐locked wireless SAW sensors will inspire researchers to develop future wireless multifunctional sensors for SHM and LOC applications.

Global sensitivity analysis of water level response to harmonic aquifer disturbances through a Monte-Carlo based surrogate model with random forest algorithm

Oscillatory water levels are often observed in monitoring wells, when aquifers are disturbed by periodical pressure diffusion (PD) sources, such as oscillatory pumping and ocean tide, and by volumetric strain (VS) sources including the far-field seismic wave and earth tide. The measured water level responses are extensively utilized to interpret aquifer properties and seismic hydrological phenomena. However, owing to wellbore effects, water levels are not always truly representative of pore pressure in aquifers, and can be significantly attenuated or even unobservable in wells. To clarify how water level responds to these disturbances, this study analyzes a global parameter sensitivity of the coupled well-aquifer model based on the assumption of a confined homogeneous aquifer. Parameter uncertainties concerning aquifer properties, source characteristics, and wellbore construction are first analyzed separately for the PD and VS sources. Subsequently, Monte-Carlo based surrogate models linking parameters and response indices are developed using the random forest algorithm. For the PD source, sensitivity results indicate that hydraulic conductivity is the most influential parameter for the yes/no responses. When hydraulic conductivity exceeds 10-4 m/s, water level observations basically represent pore pressure in aquifers. Significant amplitude changes and phase delay occur when the period of disturbances is less than 50 s, majorly due to water column inertia. For VS sources, water level responses are typically observed in aquifers with hydraulic conductivity larger than 10-7 m/s and when disturbed by a source with amplitude greater than 10-3 MPa. However, pronounced amplitude changes and phase shifts occur when the source period varies within 100 s. Consideration of the impact of wellbore effects is recommended, when interpreting water level responses induced by all periodic aquifer disturbances, especially in low-conductivity aquifers with conductivities less than 10-4 m/s.

Acute Metabolic Stress Induces Lymphatic Dysfunction Through KATP Channel Activation.

Lymphatic dysfunction is an underlying component of multiple metabolic diseases, including diabetes, obesity, and metabolic syndrome. We investigated the roles of KATP channels in lymphatic contractile dysfunction in response to acute metabolic stress induced by inhibition of the mitochondrial electron transport chain. Ex vivo popliteal lymphatic vessels from mice were exposed to the electron transport chain inhibitors antimycin A and rotenone, or the oxidative phosphorylation inhibitor/protonophore, CCCP. Each inhibitor led to a significant reduction in the frequency of spontaneous lymphatic contractions and calculated pump flow, without a significant change in contraction amplitude. Contraction frequency was restored by the KATP channel inhibitor, glibenclamide. Lymphatic vessels from mice with global Kir6.1 deficiency or expressing a smooth muscle-specific dominant negative Kir6.1 channel were resistant to inhibition. Antimycin A inhibited the spontaneous action potentials generated in lymphatic muscle and this effect was reversed by glibenclamide, confirming the role of KATP channels. Antimycin A, but not rotenone or CCCP, increased dihydrorhodamine fluorescence in lymphatic muscle, indicating ROS production. Pretreatment with tiron or catalase prevented the effect of antimycin A on wild-type lymphatic vessels, consistent with its action being mediated by ROS. Our results support the conclusion that KATP channels in lymphatic muscle can be directly activated by reduced mitochondrial ATP production or ROS generation, consequent to acute metabolic stress, leading to contractile dysfunction through inhibition of the ionic pacemaker controlling spontaneous lymphatic contractions. We propose that a similar activation of KATP channels contributes to lymphatic dysfunction in metabolic disease.

Electric-field-dependent electrical properties and domain switching of 0.92BNT-0.08BT ceramic coatings

Bi0.5Na0.5TiO3-based ferroelectric materials with strong ferroelectricity and high Curie temperature have great application prospects in modern microdevices. In this paper, 0.92BNT-0.08BT ceramic coating was prepared by supersonic plasma spraying. The phase, microstructure, electrical properties and domain response of 0.92BNT-0.08BT ceramic coating were analyzed. The findings demonstrate that the 0.92BNT-0.08BT ceramic coating is without obvious structural defects and has a completely structure with good interface bonding. 0.92BNT-0.08BT ceramic coating has good electrical properties, the dielectric constant is 417, the dielectric loss is 0.3, and the remnant polarization is 16.6 μC/cm2. The piezoelectric force microscopy (PFM) results show that the 0.92BNT-0.08BT ceramic coating generally exhibits irregular and inhomogeneous striped nanodomains, with significant changes in amplitude and phase response under different electric fields. The results using switching spectroscopy-piezoresponse force microscopy (SS-PFM) show that the local piezoelectric coefficient (PRmax) of the 0.92BNT-0.08BT ceramic coating reaches 754.3 p.m./V at a voltage of 20 V, and the ferroelectric domains exhibit a clear switching behavior.

Urban micro-scale street thermal comfort prediction using a ‘graph attention network’ model

Outdoor thermal comfort (OTC) directly affects human behavior and building operations. It is also a key factor in the achievement of smart living. When modeling OTC, existing studies tend to reduce the computational burden by conceptualizing urban spatial elements (e.g., buildings, streets) as static entities without considering the intricate dynamics of their synergistic influence. This research presents an innovative network-based framework for urban micro-scale street OTC prediction. The proposed graph attention network (GAT), in conjunction with building energy modeling (BEM), treating building clusters as graph nodes and streets as edges, capturing the interrelations between urban spatial elements, and modeling the street's universal thermal climate index (UTCI) at different time periods. The GAT model is trained and tested using simulated data from representative high-density residential areas in Hong Kong. Its performance is evaluated against an artificial neural network (ANN) model that disregards interrelations among urban spatial elements. Results demonstrate that, compared to the ANN model, the GAT model achieves an improvement in overall mean absolute error (MAE) of 37.5 %, root mean square error (RMSE) of 36.07 %, and correlation coefficient (r) of 10.58 %. Furthermore, the GAT model can better predict situations with significant amplitude changes and rapid frequency variations.

Changes in corticospinal excitability during motor imagery by physical practice of a force production task: Effect of the rate of force development during practice

Transcranial magnetic stimulation studies have indicated that the physical practice of a force production task increases corticospinal excitability during motor imagery (MI) of that task. However, it is unclear whether this practice-induced facilitation of corticospinal excitability during MI depends on a repeatedly practiced rate of force development (RFD). We aimed to investigate whether corticospinal excitability during MI of an isometric force production task is facilitated only when imagining the motor task with the same RFD as the physically practiced RFD. Furthermore, we aimed to examine whether corticospinal excitability during MI only occurs immediately after physical practice or is maintained. Twenty-eight right-handed young adults practiced isometric ramp force production using right index finger abduction. Half of the participants (high group) practiced the force production with high RFD, and the other half (low group) practiced the force production with low RFD. Questionnaire scores indicating MI ability were similar in the two groups. We examined the force error relative to the target force during the force production task without visual feedback, and motor evoked potential (MEP) amplitudes of the first dorsal interosseous (FDI) and abductor pollicis brevis (APB) muscles during the MI of the force production task under practiced and unpracticed RFD conditions before, immediately after, and 20 min after physical practice. Our results demonstrated that the force error in both RFD conditions significantly decreased immediately after physical practice, irrespective of the RFD condition practiced. In the high group, the MEP amplitude of the FDI muscle during MI in the high RFD condition significantly increased immediately after practice compared to that before, whereas the MEP amplitude 20 min after practice was not significantly different from that before practice. Conversely, the MEP amplitude during MI in the high RFD condition did not change significantly in the low group, and neither group had significant changes in MEP amplitude during MI in the low RFD condition. The facilitatory effect of corticospinal excitability during MI with high RFD observed only immediately after physical practice in the high RFD condition may reflect short-term functional changes in the primary motor cortex induced by physical practice.

Quantitative evaluation of the impact of variation of optical parameters on the estimation of blood hematocrit and oxygen saturation for dual-wavelength photoacoustics

Photoacoustic (PA) spectroscopy is considered to be one of the most effective ways to measure the levels of hematocrit (H) and oxygenation saturation (SO2) of blood, which are essential for diagnosing blood-related illnesses. This simulation study aims to investigate the impact of individual optical parameters, i.e., optical absorption coefficient (μ a ), scattering coefficient (μ s ), and anisotropy factor (g), on the accuracy of this technique in estimating the blood properties. We first performed the Monte Carlo simulations, using realistic optical parameters, to obtain the fluence maps for various samples. The wavelengths of the incident light were chosen to be 532, 700, 1000, and 1064 nm. Thereafter, the k-Wave simulations were executed, incorporating those fluence maps to generate the PA signals. The blood properties were obtained using the PA signals. We introduced variations in μ a , μ s , and g ranging from −10% to +10%, −10% to +10%, and −5% to +1%, respectively, at 700 and 1000 nm wavelengths. One parameter, at both wavelengths, was changed at a time, keeping others fixed. Subsequently, we examined how accurately the blood parameters could be determined at physiological hematocrit levels. A 10% variation in μ a induces a 10% change in H estimation but no change in SO2 determination. Almost no change has been seen for μ s variation. However, a 5% (−5% to 0%) variation in the g factor resulted in approximately 160% and 115% changes in the PA signal amplitudes at 700 and 1000 nm, respectively, leading to ≈125% error in hematocrit estimation and ≈14% deviation in SO2 assessment when nominal SO2=70%. It is clear from this study that the scattering anisotropy factor is a very sensitive parameter and a small change in its value can result in large errors in the PA estimation of blood properties. In the future, in vitro experiments with pathological blood (inducing variation in the g parameter) will be performed, and accordingly, the accuracy of the PA technique in quantifying blood H and SO2 will be evaluated.

Enhancing Sleep Quantity and Quality with a Novel GABAergic Dietary Supplement

Purpose: The primary objective of this investigation was to evaluate the effects of BH_SLP_01 (Bonafide Health Sleep Product) on sleep quality and brain wave patterns using a caffeine-induced insomnia model, and on sleep duration and latency using a pentobarbital-induced sleep model. Methods: Five male BALB/c mice were allocated per treatment arm (age: 8 weeks, body mass: 180 ± 20 g). Treatment arms included control, caffeine or phenobarbital (active) control, and BH_SLP_01. Caffeine treatment model. To induce sleep disturbance, 7.5 mg/kg caffeine was injected intraperitoneally at the 15th minute (min) of recordings, and second injections (saline or combinations) were performed at the 30th minute. Brain electrical activity was monitored and recorded for a total of two hours using electrocorticography (ECoG) recording. Serum melatonin, serotonin, and dopamine were measured by ELISA. Brain levels of MDA were measured by HPLC, and protein concentrations were determined using Western Blot analysis. Phenobarbital treatment model Groups were administered saline or BH_SLP_01, and then, 45 min later, pentobarbital (42 mg/kg) was injected. After injection, sleep latency and duration were measured. Study treatments were compared using an ANOVA and Student's unpaired t-test. Significance levels were set at p&lt;0.05. Results: Analysis of ECoG recording data revealed notable findings. In the caffeine-pretreated group, a significant increase in amplitude was observed during the 30-45 min interval, compared to control. Caffeine administration also significantly increased frequency at 75-90 and 90-105 min compared to control (p&lt;0.05). Conversely, the group treated with BH_SLP_01 displayed no significant changes in amplitude and frequency, except for a significant change in frequency at 90-105 min compared to control (p&lt;0.05). Both sleep duration and sleep latency were significantly improved for BH_SLP_01 compared to control and phenobarbital control (p&lt;0.05). In addition, serotonin, dopamine, melatonin, GABAA R2, GABAB R1, GABAB R2, 5-HT1A, GluA1, GluN1, GluN2A, Bax, Bcl-2, and Caspase-3 levels were significantly improved by BH_SLP_01 compared to control and caffeine control (p&lt;0.05). Conclusion: The results of these studies provide evidence for the effcacy of BH_SLP_01 to improve impaired sleep, leading to notable enhancements in markers of deep sleep. This conclusion is supported by the significant upregulation of GABA, glutamine receptors, and endogenous melatonin, all of which collectively contribute to the augmentation of both sleep quantity and quality. These findings underscore the potential of BH_SLP_01 as a promising therapeutic intervention for optimizing sleep parameters and promoting overall sleep wellness. This research was supported by Bonafide Health, LLC. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

In vitro effects of β3-adrenoceptor agonist mirabegron on the human ureter.

This study aimed to investigate the effect of mirabegron, a β3-adrenoceptor agonist with widespread clinical use for treating overactive bladder disease, on isolated healthy human ureter strips. This was a prospective study employing a series of in vitro organ bath experiments using ureteral tissues of kidney grafts from 10 healthy donors. The ureteral strips were subjected to cumulative mirabegron concentrations (10-9-10-4.5 M). Effects on frequency or amplitude of spontaneous, 10 mM KCl- or EFS-induced contractions were evaluated. Mirabegron decreased the frequency of spontaneous ureteric contraction in a concentration-dependent manner. Statistically significant decrease in the frequency of spontaneous contraction was observed at 10-8-10-4.5 M. In 10 mM KCl medium, statistically significant change in frequency was observed at 10-9-10-4.5 M. Statistically significant decrease in the amplitudes of spontaneous contraction was observed at 10-7-10-4.5 M. In a 10 mM KCl medium, statistically significant change in amplitudes was observed at 10-8-10-4.5 M. Mirabegron reduced the amplitude and frequency of human ureter activity in in vitro organ bath studies. This effect was achieved in a dose-dependent manner on isolated tissue strips. Although monotherapy with mirabegron remains uncertain, this study has the potential to elucidate the mechanism underlying the effectiveness of mirabegron, particularly in combination therapy for ureteral stones.

VLF Signal Noise Reduction during Intense Seismic Activity: First Study of Wave Excitations and Attenuations in the VLF Signal Amplitude

This study is a continuation of pilot research on the relationships between seismic activity and changes in very low frequency (VLF) signals starting a few minutes or a few dozen minutes before an earthquake. These changes are recorded in the time and frequency domains and their duration can be influenced not only by the strongest earthquake but also by others that occur in a short time interval. This suggests that there are differences in these changes in cases of individual earthquakes and during the period of intense seismic activity (PISA). In a recent study, they were validated in the time domain by comparing the amplitude noise reductions during the PISA and before earthquakes that occurred in the analysed periods without intense seismic activity (PWISA). Here, we analyse the changes in the VLF signal amplitude in the frequency domain during the PISA and their differences are compared to the previously investigated relevant changes during PWISA. We observe the signal emitted by the ICV transmitter in Italy and received in Serbia from 26 October to 2 November 2016 when 907 earthquakes occurred in Central Italy. The study is based on analyses of the Fourier amplitude AF obtained by applying the fast Fourier transform (FFT) to the values of the ICV signal amplitude sampled at 0.1 s. The obtained results confirm the existence of one of the potential earthquake precursors observed during PWISA: significantly smaller values of AF for small wave periods (they can be smaller than 10−3 dB) than under quiet conditions (the expected values are larger than 10−2 dB). Exceptions were the values of AF for wave periods between 1.4 s and 2 s from a few days before the observed PISA to almost the end of that period. They were similar or higher than the values expected under quiet conditions. The mentioned decrease lasted throughout the observed longer period from 10 October to 10 November, with occasional normalisation. It was many times longer than the decreases in AF around the considered earthquakes during PWISA, which lasted up to several hours. In addition, no significant wave excitations were recorded at discrete small values of the wave periods during the PISA, as was the case for earthquakes during PWISA. These differences indicate the potential possibility of predicting the PISA if the corresponding earthquake precursors are recorded. Due to their importance for potential warning systems, they should be analysed in more detail in future statistical studies.

Method and system for automated detection of sleep spindles using a single EEG channels based TEO and EMD

As a hallmark of N2 sleep stage, sleep spindle detection based on electroencephalogram (EEG) recordings plays a crucial role in analyzing sleep. Hence, how to effectively automatically detect sleep spindle is crucially important. However, many automatic detection methods assume that the signal is stationary, which is inconsistent with the observation that spindle signals have a significant change in amplitude. Thus, some important non-stationary information and the presented evident dynamic characteristics has been ignored.To overcome the aforementioned shortcoming, we propose a novel methodology based on Teager Energy Operator (TEO) and Empirical Mode Decomposition (EMD) to determine the exact location of sleep spindles using single-channel EEG signals. Because the TEO is sensitive to amplitude variations and energy features, our proposed method is suitable for capturing sleep spindles. We conduct plenty of experiments to evaluate our method. The experiments are conducted to validate the effectiveness of our method. On the DREAMS Sleep Spindles Database, our method achieves 91.83% ± 1.1%, 94.12% ± 3.46%, and 83.38% ± 9.32% for accuracy, specificity, and sensitivity, respectively. Experimental results show that the performance of the proposed methodology presented herein achieves better performance as compared to other methods. Moreover, owing to its usage of a single channel of EEG signal, the proposed method will be suitable for edge-device implementation to expedite sleep disorder diagnosis.

Qualification of Austenitic Stainless Steels for the Development of Load-Sensitive Material Sensors

To detect mechanical overloads on the component directly in operation, a metastable material can be used as a load-sensitive sensor when combined with an eddy current testing system. In order to find a suitable metastable sensor material that exhibits microstructural changes at an early stage before fatigue failure, quasi-static tensile tests and cyclic rotating bending tests were carried out with the austenitic stainless steels 1.4301 (2 batches), 1.4305, 1.4541 and 1.4550. For the detection of microstructural changes, electromagnetic testing was used in-situ in the tensile test and ex-situ between the rotating bending test after a pre-defined number of cycles. The investigated materials 1.4301 batch2 and 1.4550 showed the largest signal changes and the lowest austenite stability both in the tensile test and under cyclic bending load. Due to the better mechanical properties, 1.4301 batch2 should be preferred. The order of the austenitic stainless steels tested was similar in terms of transformation behavior in both tests. Thus, the tensile test combined with in-situ electromagnetic testing appears to have potential as a suitable benchmark test for austenite stability. With regard to the cyclic bending stress, an overload of the specimens could be detected for the materials 1.4301 batch2, 1.4305, 1.4541 and for the 1.4550 on the basis of a significant amplitude change. At low bending stresses, uncritical for structural integrity, no increase in amplitude was measured. The results have shown that an early detection of overloads is possible with several materials, however, the potential for detecting overloads varies between materials and also between individual batches. In addition, it has been observed that as the bending stress increases, the gradient of the change in amplitude over the number of cycles increases as well. Thus, with a known number of cycles, it could be possible to classify the previous load spectrum based on the difference in amplitude between two measurements.

Retinal Function in Long-Term Type 1 Diabetes without Retinopathy: Insights from Pattern Electroretinogram and Pattern Visual Evoked Potentials Assessments.

To evaluate changes in pattern electroretinogram (pERG) and pattern visual evoked potentials (pVEP) in patients with long-lasting type 1 diabetes without diabetic retinopathy (DR). Prospective study involving 92 eyes divided into two groups. The diabetic group included 46 eyes of 23 patients with type 1 diabetes (T1DM); the control group included 23 age-matched healthy subjects. pERG and pVEP were assessed using the RETI-port/scan21 recording software (version 1021.3.0.0). Mean age was 48 ± 9.77 years for the diabetic group and 51.7 ± 4.75 years for the control group. The mean duration of diabetes was 28.88 ± 8.04 years. The mean HbA1c value was 7.29 ± 0.89%. There were no differences in the age or sex distribution. Regarding the pERG, T1DM patients exhibited a significant decrease in the amplitude of the P50 and N95 waves compared to the control group (p = 0.018 and p = 0.035, respectively), with no differences in the peak time of each component. pVEP showed no significant changes in either peak time or amplitude of the different components. Long-term T1DM patients without DR showed changes in the amplitude of pERG waves with preserved peak times. We did not observe modifications in pVEP. pERG may serve as a subclinical marker of ganglion cell damage in long-term T1DM patients.

An automatic arrival time picking algorithm of P-wave based on adaptive characteristic function

The accuracy of arrival time and picking speed are significant issues in terms of micro-seismic identification, location, travel-time tomography, as well as source mechanism. In order to detect small changes in signal amplitude and frequency with different signal-to-noise ratios (SNRs), the Allen's characteristic function (Allen's CF) was modified to an adaptive characteristic function (ACF) by relative time series and relative energy coefficients which was compared with the Allen's CF, Baer's CF, and Sedlak's CF. Then, an algorithm for S/L-AIC picker based on ACF for automatic P-wave arrival time picking was presented by the short-term-average to long-term-average ratios (STA/LTA) picker and the Akaike Information Criterion (AIC). In addition, the algorithm was applied to a dataset acquired by a local micro-seismic network at the Jing-Gong coal mine in Shanxi, China, which was compared with a two-step AIC picker, using the original manual selection as a reference to verify the reliability and robustness of the algorithm. Furthermore, the influence of five basic parameters on the accuracy of the S/L-AIC picker based on ACF was discussed by orthogonal tests. The results highlighted that: 81 % of the automatic picks processed by the S/L-AIC picker based on ACF were within +4 ms of deviation, while 66.3 % of the automatic picks processed by the two-step AIC picker were within the same error range; Compared with the other CFs, the ACF applied to the S/L-AIC algorithm performs better for low-SNR data and confirms more accurate and stable results. This study highlights that accurate automatic P-wave arrival time determination is feasible when using the S/L-AIC picker based on ACF.

A multi-feature-based fault diagnosis method based on the weighted timeliness broad learning system

Accurate and timely fault diagnosis is a vital task to ensure process safety of modern industrial facilities. Motivated by the complex variations of process signals and mutual coupling of faults, this paper presents a multi-feature-based fault diagnosis method based on the weighted timeliness Broad Learning System (BLS). The proposed method fuses multiple features extracted from the original process data to improve the fault diagnosis performance, and makes the diagnosis model suitable for dynamic fault diagnosis problems by incorporating the BLS. The major contributions of this study are twofolds: 1) A systematic multi-feature extraction method is proposed to extract long-term trend features, short-term trend features, and binary alarm signals, which reflect the direction and amplitude changes of process signals under faulty conditions; 2) a weighted timeliness BLS structure with multiple fault-sensitive features as the input is proposed to ensure the dynamic characteristics of the fault diagnosis model. The designed fault diagnosis model can be updated in an incremental manner, and thus can improve the model updating efficiency while ensuring accuracy. The effectiveness and superiority of the proposed method is demonstrated by a case study based on the Tennessee Eastman benchmark process.

Fibrin Glue Acutely Blocks Distal Muscle Contraction after Confirmed Polyethylene Glycol Nerve Fusion: An Animal Study.

Polyethylene glycol (PEG) is a synthetic, biodegradable, and hyperosmotic material promising in the treatment of acute peripheral nerve injuries. Our team set out to investigate the impact of fibrin glue upon PEG fusion in a rat model. Eighteen rats underwent sciatic nerve transection and PEG fusion. Electrophysiologic testing was performed to measure nerve function and distal muscle twitch. Fibrin glue was applied and testing repeated. Due to preliminary findings, fibrin glue was applied to an uncut nerve in five rodents and testing was conducted before and after glue application. Mann-Whitney U tests were used to compare median values between outcome measures. A Shapiro-Wilk test was used to determine normality of data for each comparison, significance set at a P value less than 0.05. PEG fusion was confirmed in 13 nerves with no significant change in amplitude (P = 0.054), latency (P = 0.114), or conduction velocity (P = 0.114). Stimulation of nerves following PEG fusion produced distal muscle contraction in 100% of nerves. Following application of fibrin glue, there was a significant reduction in latency (P = 0.023), amplitude (P < 0.001), and conduction velocity (P = 0.023). Stimulation of the nerve after application of fibrin glue did not produce distal muscle twitch. Five uncut nerves with fibrin glue application blocked distal muscle contraction following stimulation. Our data suggest that fibrin glue alters the nerve's function. The immediate confirmation of PEG fusion via distal muscle twitch is blocked with application fibrin glue in this experimental model. Survival and functional outcome studies are necessary to understand if this has implications on the long-term functional outcomes.