Changes In Percent Body Fat Research Articles

Strength training improves body composition, muscle strength and increases CD4+ T lymphocyte levels in people living with HIV/AIDS.

The establishment of physical training programs for people living with HIV/AIDS (PLWHA) has several benefits. The study aimed to analyze the effect of resistance training using prediction of intensity by subjective perception of effort (SPE) on body composition, muscle strength, and TCD4+ lymphocyte levels in PLWHA. This a randomized controlled trial study. Participants (11 men and 8 women), were divided in two groups: exercise group (EG) and control group (CG). The EG was submitted to 12 weeks of a resistance-training program based in the prediction of intensity by SPE. Body mass percentages were evaluated using tetrapolar bioelectrical impedance and skinfold methods. We used Flow Cytometry to quantify CD4+ T lymphocytes. Patients showed significant changes in Body Fat Percentage (Δ%=-6.23%), Lean Body Mass (Δ%=2.45%), and CD4T lymphocytes levels (Δ%=15.77%). They also showed significant increase in muscular strength presented in the test for one repetition maximum in all the evaluated exercises. Our data suggest that exercising program prescribed by SPE is capable of improving immune function, body composition, and muscular strength in PLWHA.

Seasonal changes in body composition in collegiate baseball players

Background: Body composition is a growing concern in all sports, including baseball. This study was conducted to measure changes in body composition from the beginning of the season to the end and to determine if different changes occurred in position players compared to pitchers. Methods: Participants’ (n=29; age 19.90±1.14) body mass, body mass index (BMI), and percent body fat as estimated by skinfold calipers were recorded immediately before and after the baseball season. Results: There was a significant decrease in weight of nearly 1 kg (P=0.02) with a corresponding decrease in BMI (P=0.02) without a change in percent body fat (P=0.31). When examined by position, significant change in percent body fat did occur between position players (−0.9%) and pitchers (+0.2%). Specifically, pitchers had increased body fat in the triceps (P=0.04), subscapular (P=0.03), and suprailiac (P=0.04) regions when compared to position players. Conclusions: Body composition does change during the course of a baseball season, and these changes have the potential to impact performance and outcome measures as it relates to baseball. Principles of kinesiology suggest that it could significantly influence power, speed, agility, and quickness, but further study is needed to determine the practical on-field implications of the seasonal changes in body composition observed in baseball players.

Comparison of Dual-Energy X-ray Absorptiometry (DXA) Versus a Multi-Frequency Bioelectrical Impedance (InBody 770) Device for Body Composition Assessment after a 4-Week Hypoenergetic Diet.

The purpose of this investigation was to compare two different methods of assessing body composition (i.e., a multi-frequency bioelectrical impedance analysis (MF-BIA) and dual-energy x-ray absorptiometry (DXA)) over a four-week treatment period in exercise-trained men and women. Subjects were instructed to reduce their energy intake while maintaining the same exercise regimen for a period of four weeks. Pre and post assessments for body composition (i.e., fat-free mass, fat mass, percent body fat) were determined via the MF-BIA and DXA. On average, subjects reduced their energy intake by ~18 percent. The MF-BIA underestimated fat mass and percentage body fat and overestimated fat-free mass in comparison to the DXA. However, when assessing the change in fat mass, fat-free mass or percent body fat, there were no statistically significant differences between the MF-BIA vs. DXA. Overall, the change in percent body fat using the DXA vs. the MF-BIA was −1.3 ± 0.9 and −1.4 ± 1.8, respectively. Our data suggest that when tracking body composition over a period of four weeks, the MF-BIA may be a viable alternative to the DXA in exercise-trained men and women.

Specific Collagen Peptides in Combination with Resistance Training Improve Body Composition and Regional Muscle Strength in Premenopausal Women: A Randomized Controlled Trial.

The aim was to investigate the effects of resistance exercise combined with supplementation of specific collagen peptides (SCP) on body composition and muscle strength in premenopausal women. In a double-blind, placebo-controlled, randomized trial 77 premenopausal women completed a 12-week resistance training (3 day/week) and ingested 15 g of SCP or placebo on a daily basis. Changes in body composition were determined by bioelectrical impedance analysis (BIA) and muscular strength by isometric strength testing. The treatment group (TG) significantly increased (p < 0.001) their percentage of fat-free mass. Although the control group (CG) also showed a significant (p < 0.01) gain in fat-free mass from pre- to post-training, the increase in the TG was significantly higher in an RMANOVA analysis (p < 0.05). Regarding the change in percentage body fat, a significant decline was observed in both TG (p < 0.001) and CG (p < 0.01), with a significantly higher reduction in the TG (p < 0.05). Subjects receiving 15 g of collagen peptides daily also showed a significantly higher gain in hand-grip strength compared to those performing resistance training only (p < 0.05). In both groups, the gain in leg strength (TG = p < 0.001; CG = p < 0.01) was significant after 12 weeks with a more pronounced effect in the treatment group. In conclusion, resistance training in combination with supplementation of SCP induced a significantly higher increase in fat-free mass and hand-grip strength than resistance training and placebo supplementation. In addition, there was a significantly higher loss in fat mass and a more pronounced increase in leg strength in the treatment group compared to the control group.

Effects of various interval training regimes on changes in maximal oxygen uptake, body composition, and muscular strength in sedentary women with obesity.

We determined the effects of two high-intensity interval training (HIIT) regimens [the traditional (TRAD) and periodized (PER)] on changes in maximal oxygen uptake (VO2max), body composition, and muscular strength in sedentary, obese women. Seventeen women (age and BMI = 37.5 ± 10.5year and 39.1 ± 4.3kg/m2) were randomized into a 6week regime of TRAD or PER which consisted of three sessions per week, two in the laboratory, and one on their own. Pre- and post-training, VO2max, body composition, and muscular strength of the knee extensors (KE) and flexors (KF) were assessed via ramp cycling to exhaustion, air displacement plethysmography, and isokinetic dynamometry, respectively. VO2max was increased by 4-5% in response to training (p = 0.045) with no group-by-time interaction (p = 0.79). Body mass, fat mass, and waist-to-hip ratio were unaltered (p > 0.05) in response to training, yet there was a significant change in percent body fat (p = 0.03), percent fat-free mass (p = 0.03), and absolute fat-free mass (p = 0.03) in TRAD but not PER. No change occurred in KE (p = 0.36) or KF torque (p = 0.75) in response to training and there was no group-by-time interaction (p > 0.05). Low-volume HIIT improved VO2max and body composition but did not modify muscular strength, which suggests that obese women desiring to increase strength should initiate more intense HIIT or partake in formal resistance training.

Effects of High-Intensity Interval Training on Olympic Combat Sports Athletes' Performance and Physiological Adaptation: A Systematic Review.

Franchini, E, Cormack, S, and Takito, MY. Effects of high-intensity interval training on Olympic combat sports athletes' performance and physiological adaptation: A systematic review. J Strength Cond Res 33(1): 242-252, 2019-Combat sports represent around 25% of all Olympic medals disputed, and the success in these sports are determined by technical-tactical excellence and supported by physiological and psychological development. Although the training in combat sports is intermittent training by nature, some researchers have started to focus their attention on the effects of complementary high-intensity interval training (HIIT)-coupled standard combat sports-specific training on morphological, physiological, and performance adaptations. Thus, in this systematic review, we aimed to verify the effects of this type of training on these variables. A total of 117 articles in the electronic databases Pubmed, Scopus, and Web of Science were retrieved, and 9 studies remained in the present systematic review. A total of 228 athletes (138 judo athletes, 40 taekwondo athletes, 18 boxers, 17 karate athletes, and 15 wrestlers) were investigated in these 9 studies (5 with judo athletes, 1 with boxers, 1 with karate athletes, 1 with wrestlers, and 1 with taekwondo athletes). The HIIT protocols investigated did not generate any change in body fat percentage or body mass but generally resulted in increases in (Equation is included in full-text article.)max or (Equation is included in full-text article.)peak, varying from 4.4 to 23.0%. However, the most observed benefit of HIIT protocols was an increase in anaerobic fitness, represented by improvements in anaerobic power and capacity.

Body Composition Changes of United States Smokejumpers during the 2017 Fire Season

Wildland firefighting is arduous work with extreme physical and nutritional demands that often exceeds those of athletes competing in sports. The intensity and duration of job demands, impacts the amount of calories burned, which can influence body composition. The purpose of this study was to determine if the body composition of nine wildland firefighters working as smokejumpers changed throughout the 2017 fire season. Subjects (n = 9) for the study ranged in age from 24–49 (age 30.1 ± 8.3 y). Height (177 ± 18.8 cm) and weight (81.32 ± 6.39 kg) was recorded during initial body composition testing and body fat percentage was determined pre and post-season using Lange skinfold calipers. Outcomes were evaluated using a paired t-test. Body fat percentage was significantly different between pre and post-season (average body fat percentage increase = 1.31%; t = 2.31, p = 0.04, alpha = 0.05). Body weight increased slightly from pre to post-season (average increase in body weight: 0.17 kg), although the differences were not significant (t = 2.31, p = 0.78). Change in body fat percentage without change in body weight suggest that monitoring of WLFF body composition and fitness may be needed help inform dietary and fitness interventions to insure that nutritional demands of this population are sufficient to support physical work on the fireline.

Prebiotics Reduce Body Fat and Alter Intestinal Microbiota in Children Who Are Overweight or With Obesity

Background & Aims It might be possible to manipulate the intestinal microbiota with prebiotics or other agents to prevent or treat obesity. However, little is known about the ability of prebiotics to specifically modify gut microbiota in children with overweight/obesity or reduce body weight. We performed a randomized controlled trial to study the effects of prebiotics on body composition, markers of inflammation, bile acids in fecal samples, and composition of the intestinal microbiota in children with overweight or obesity. Methods We performed a single-center, double-blind, placebo-controlled trial of 2 separate cohorts (March 2014 and August 2014) at the University of Calgary in Canada. Participants included children, 7–12 years old, with overweight or obesity (>85th percentile of body mass index) but otherwise healthy. Participants were randomly assigned to groups given either oligofructose-enriched inulin (OI; 8 g/day; n=22) or maltodextrin placebo (isocaloric dose, controls; n=20) once daily for 16 weeks. Fat mass and lean mass were measured using dual-energy-x-ray absorptiometry. Height, weight, and waist circumference were measured at baseline and every 4 weeks thereafter. Blood samples were collected at baseline and 16 weeks, and analyzed for lipids, cytokines, lipopolysaccharide, and insulin. Fecal samples were collected at baseline and 16 weeks; bile acids were profiled using high-performance liquid chromatography and the composition of the microbiota was analyzed by 16S rRNA sequencing and quantitative polymerase chain reaction. The primary outcome was change in percent body fat from baseline to 16 weeks. Results After 16 weeks, children who consumed OI had significant decreases in body weight z-score (decrease of 3.1%), percent body fat (decrease of 2.4%), and percent trunk fat (decrease of 3.8%) compared with children given placebo (increase of 0.5%, increase of 0.05%, and decrease of 0.3%, respectively). Children who consumed OI also had a significant reduction in level of interleukin 6 from baseline (decrease of 15%) compared with the placebo group (increase of 25%). There was a significant decrease in serum triglycerides (decrease of 19%) in the OI group. Quantitative polymerase chain reaction showed a significant increase in Bifidobacterium spp. in the OI group compared with controls. 16S rRNA sequencing revealed significant increases in species of the genus Bifidobacterium and decreases in Bacteroides vulgatus within the group who consumed OI. In fecal samples, levels of primary bile acids increased in the placebo group but not in the OI group over the 16-week study period. Conclusions In a placebo-controlled, randomized trial, we found a prebiotic (OI) to selectively alter the intestinal microbiota and significantly reduce body weight z-score, percent body fat, percent trunk fat, and serum level of interleukin 6 in children with overweight or obesity (Clinicaltrials.gov no: NCT02125955).

Percent Body Fat Change in Chinese Women After Adjuvant Chemotherapy for Breast Cancer.

BackgroundWeight gain is a common side effect observed in breast cancer (BC) patients undergoing adjuvant chemotherapy, although the characteristics and mechanism are not been fully understood. This study aimed to investigate percent body fat (%BF) change, and identify the associated risk factors among Chinese women receiving chemotherapy for BC.Material/MethodsA prospective longitudinal study was conducted on a cohort of 140 Chinese female patients with BC between June 2016 and October 2017. Data on demographic and clinical features were collected using a standard protocol. Anthropometric parameters including body weight and %BF were measured before and after chemotherapy. Multiple logistic analysis was performed to identify the risk factors for %BF change.ResultsA total of 52.9% and 58.6% of the 140 patients experienced gains in weight and %BF after chemotherapy, respectively, with mean increases of 2.1±1.9 kg and 1.3±2.2%, respectively. Fifty-eight patients gained %BF over 2.5% of the baseline value. Moreover, premenopausal women had a greater mean %BF gain than postmenopausal women (P=0.018). Logistic analysis showed that premenopausal status, younger age, multi-agent chemotherapy regimen, high-calorie diet, and decreased physical activity were independent variables that inducted %BF gain.Conclusions%BF gain occurred frequently in Chinese women after adjuvant chemotherapy for BC, especially in premenopausal women. An effort should be made to the management of %BF.

Rationale and Design of the STOP-OB Study for Evaluating the Effects of Tofogliflozin and Glimepiride on Fat Deposition in Type 2 Diabetes Patients Treated with Metformin/DPP-4 Inhibitor Dual Therapy.

BackgroundThe global pandemic of type 2 diabetes mellitus (T2DM) is an enormous clinical and socioeconomic burden. Biguanides and DPP-4 inhibitors (DPP-4i) are the most commonly used therapies in Japanese T2DM patients. When glycemic control is not adequate despite combination of these drugs, there is no consensus on the next step drug. Systematic reviews and meta-analyses of previous trials have indicated that glycemic control with triple combination therapies yields similar results. Thus, beneficial effects on cardiovascular risk factors may be important. The present study was designed to evaluate body fat percentage and several insulin resistance parameters after addition of tofogliflozin or glimepiride to the regimens of patients being treated with metformin and a DPP-4 inhibitor but failing to attain adequate blood glucose control.MethodsSodium glucose cotransporter-2 inhibitor, tofogliflozin versus glimepiride, comparative trial in patients with type 2 diabetes on body composition is an ongoing, multicenter, prospective, randomized, open-label, parallel-group trial. T2DM patients treated with metformin/DPP-4 inhibitor dual therapy have been recruited and randomly assigned to 20 mg/day tofogliflozin (n = 32) or 0.5 mg/day glimepiride (n = 32) groups, with either of these drugs being added to pre-existing regimens for 24 weeks.Planned OutcomesThe primary endpoint is the change in body fat percentage from baseline to 24 weeks. The secondary outcomes are changes in body composition other than fat percentage, body weight, parameters related to glycemic control and β-cell function, parameters related to lipids and arteriosclerosis, parameters related to liver function, parameters related to diabetic nephropathy, and uric acid levels. Safety parameters will also be analyzed. This is the first trial comparing the effects and safety of adding an SGLT2i and a sulfonylurea as the third-line oral agent to metformin/DPP-4i dual therapy. The results will provide valuable information for choosing third-line oral agents.Trial RegistrationUMIN000026161.FundingKowa Co. Ltd. and Kowa Pharmaceutical Co. Ltd., Tokyo, Japan.Electronic supplementary materialThe online version of this article (10.1007/s13300-018-0491-4) contains supplementary material, which is available to authorized users.

Interesterified Palm Olein (IEPalm) and Interesterified Stearic Acid-Rich Fat Blend (IEStear) Have No Adverse Effects on Insulin Resistance: A Randomized Control Trial.

Chemically-interesterified (CIE) fats are trans-fat free and are increasingly being used as an alternative to hydrogenated oils for food manufacturing industries to optimize their products’ characteristics and nutrient compositions. The metabolic effects of CIE fats on insulin activity, lipids, and adiposity in humans are not well established. We investigated the effects of CIE fats rich in palmitic (C16:0, IEPalm) and stearic (C18:0, IEStear) acids on insulin resistance, serum lipids, apolipoprotein concentrations, and adiposity, using C16:0-rich natural palm olein (NatPO) as the control. We designed a parallel, double-blind clinical trial. Three test fats were used to prepare daily snacks for consumption with a standard background diet over a period of 8 weeks by three groups of a total of 85 healthy, overweight adult volunteers. We measured the outcome variables at weeks 0, 6, and at the endpoint of 8. After 8 weeks, there was no significant difference in surrogate biomarkers of insulin resistance in any of the IE fat diets (IEPalm and IEStear) compared to the NatPO diet. The change in serum triacylglycerol concentrations was significantly lower with the IEStear diet, and the changes in serum leptin and body fat percentages were significantly lower in the NatPO-diet compared to the IEPalm diet. We conclude that diets containing C16:0 and C18:0-rich CIE fats do not affect markers of insulin resistance compared to a natural C16:0-rich fat (NatPO) diet. Higher amounts of saturated fatty acids (SFAs) and longer chain SFAs situated at the sn-1,3 position of the triacylglycerol (TAG) backbones resulted in less weight gain and lower changes in body fat percentage and leptin concentration to those observed in NatPO and IEStear.

Subjective social status is associated with compensation for large meals – A prospective pilot study

ObjectivesSubjective social status (SSS) is known to be inversely associated with obesity. Our objective was to determine if SSS is associated with eating behaviors that would predispose to weight gain, specifically, with inadequate compensation for excess energy consumed during a single large meal. Therefore, we conducted a pilot study to determine the association of SSS with 24-h energy balance, 24-h and post-lunch energy intake, changes in body composition and changes in adjusted resting energy expenditure on days when a high-energy lunch was consumed in free-living human subjects. MethodFemale participants (7 normal weight and 10 overweight) consumed 60% of’ estimated 24-h energy requirements as a lunchtime meal in the laboratory for 14 days. Subjective social status was measured at baseline using the MacArthur Scale. Remote Food Photography Method was used to record food intake outside of the lab on days 1–2, 7–8, and 12–13. Associations of 24-h energy balance, 24-h and post-lunch energy intake, changes in adjusted resting energy expenditure and changes in percent body fat (measured by dual x-ray absorptiometry) with SSS were studied. ResultsMean (standard deviation) age and BMI were 36.29 (8.25) years and 26.43 (2.32) kg/m2, respectively. Lower SSS was significantly associated with positive energy balance (p for trend 0.002), and higher post-lunch energy intake (p = 0.02) when controlled for age and initial body mass index. ConclusionsOur pilot data show that lower SSS is associated with higher post-lunch energy intake, which is indicative of poor energy compensation following a large meal. Over a longer time period, this could result in fat mass gain. Studies that are of longer duration and well-powered are warranted to confirm our findings.

Effect of Vitamin D supplementation on body composition and cardiorespiratory fitness in overweight men\u2014a randomized controlled trial

PurposeSeveral observational studies have shown an association between vitamin D deficiency and non-skeletal major health issues including impaired cardiorespiratory fitness and adiposity. Only a few studies have examined the impact of vitamin D supplementation on these conditions and the results are ambiguous. The aim of this study was to examine the effect of vitamin D supplementation on body composition and cardiorespiratory fitness in overweight/obese men with vitamin D deficiency.MethodsThis study was a prospective, placebo controlled, double blinded, randomized trial with a study period of 6 months. Forty overweight/obese men (BMI > 25 kg/m2) with vitamin D deficiency (25(OH)D ≤ 55 nmol/L) were randomized to receive either 2000 IU Cholecalciferol drops or the equivalent amount of drops of placebo. At baseline and follow up body composition and cardiorespiratory fitness were measured and blood samples were obtained. Body composition was measured using bioelectrical impedance analysis (BIA) and cardiorespiratory fitness using cardiopulmonary exercise test (CPET). The primary outcomes were changes in percentage body fat and in maximum oxygen uptake (VO2max).ResultsNo statistically significant difference between the placebo and the intervention group regarding changes in percentage body fat (p = 0.54) and VO2max (p = 0.90) was observed. Moreover, there was no statistically significant difference between the groups concerning changes in BMI (p = 0.26), maximum load (p = 0.89) and oxygen uptake at anaerobic threshold (AT) (p = 0.14).ConclusionsWe conclude that treatment with 2000 IU/d vitamin D for 6 months does not impact body composition or maximum oxygen uptake in overweight/obese men with vitamin D deficiency.

Weight maintenance diets prevent short‐term physical inactivity‐induced glycemic dysregulation in young healthy subjects

BackgroundReduced physical activity is generally associated with disruptions in glucose metabolism and increased accumulation of adiposity. However, whether these adverse effects of physical inactivity manifest when individuals are maintained in energy balance is unknown. Thus, this study examined whether weight maintenance diets prevent physical inactivity‐induced metabolic dysfunction in healthy active adults.DesignTen lean young adults (24±1 year; 25±1 kg/m2) consumed a control (64% carbohydrate, 20% fat, 16% protein) and higher‐protein diet (50% carbohydrate, 20% fat, 30% protein) during ten days of reduced ambulatory activity (&gt;10,000 → ~5,000 steps/day) in a randomized cross‐over design. To mimic the typical Western lifestyle, a subset of male subjects (n=5) completed a 3rd ten‐day physical inactivity trial while consuming 35% excess of their basal energy requirements.ResultsDuring inactivity, daily steps and activity‐associated energy expenditure were decreased by ~65% (P&lt;0.05) and this led to a reduction in maximal aerobic capacity (−1.8±0.7 ml/kg/min, P=0.004), independent of diet conditions. Fat free mass tended to decrease following inactivity (P=0.06), despite no change in body fat percentage or fat mass. Fasting glucose, but not fasting insulin levels, were lowered by physical inactivity, with no differences between diet conditions. Both diets prevented physical inactivity‐induced disruptions in postprandial glucose, insulin, and nonesterified fatty acids in response to a 75‐g oral glucose load (AUC, P&gt;0.05). Overfeeding + physical inactivity increased body weight, body fat percentage, and fat mass (P&gt;0.05). Moreover, fasting glucose, insulin, and 2‐hour postprandial glucose and insulin levels were significantly elevated (P&lt;0.05). Surrogate markers of insulin sensitivity (QUICKI) and insulin resistance (HOMA‐IR) were decreased and increased, respectively after overfeeding + inactivity, despite no changes in blood lipid concentrations.ConclusionsMetabolic disruptions associated with physical inactivity are absent in healthy subjects consuming weight maintenance diets. These findings suggest that small changes in feeding behavior aimed at preventing weight gain is a viable strategy to protect against inactivity‐induced metabolic dysfunction.Support or Funding InformationAmerican Egg Board (#00050021 to NCW; JAK, sponsor)This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.

Childhood obesity treatment; Effects on BMI SDS, body composition, and fasting plasma lipid concentrations.

ObjectiveThe body mass index (BMI) standard deviation score (SDS) may not adequately reflect changes in fat mass during childhood obesity treatment. This study aimed to investigate associations between BMI SDS, body composition, and fasting plasma lipid concentrations at baseline and during childhood obesity treatment.Methods876 children and adolescents (498 girls) with overweight/obesity, median age 11.2 years (range 1.6–21.7), and median BMI SDS 2.8 (range 1.3–5.7) were enrolled in a multidisciplinary outpatient treatment program and followed for a median of 1.8 years (range 0.4–7.4). Height and weight, body composition measured by dual-energy X-ray absorptiometry, and fasting plasma lipid concentrations were assessed at baseline and at follow-up. Lipid concentrations (total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), non-HDL, and triglycerides (TG)) were available in 469 individuals (264 girls). Linear regressions were performed to investigate the associations between BMI SDS, body composition indices, and lipid concentrations.ResultsAt baseline, BMI SDS was negatively associated with concentrations of HDL (p = 6.7*10−4) and positively with TG (p = 9.7*10−6). Reductions in BMI SDS were associated with reductions in total body fat percentage (p<2*10−16) and percent truncal body fat (p<2*10−16). Furthermore, reductions in BMI SDS were associated with improvements in concentrations of TC, LDL, HDL, non-HDL, LDL/HDL-ratio, and TG (all p <0.0001). Changes in body fat percentage seemed to mediate the changes in plasma concentrations of TC, LDL, and non-HDL, but could not alone explain the changes in HDL, LDL/HDL-ratio or TG. Among 81 individuals with available lipid concentrations, who increased their BMI SDS, 61% improved their body composition, and 80% improved their lipid concentrations.ConclusionReductions in the degree of obesity during multidisciplinary childhood obesity treatment are accompanied by improvements in body composition and fasting plasma lipid concentrations. Even in individuals increasing their BMI SDS, body composition and lipid concentrations may improve.

The effects of chronic betaine supplementation on body composition and performance in collegiate females: a double-blind, randomized, placebo controlled trial

BackgroundBetaine supplementation has been shown to improve body composition and some metrics of muscular performance in young men; but, whether betaine enhances body composition or performance in female subjects is currently unknown. Therefore, the purpose of this study was to investigate the interaction between resistance training adaptation and chronic betaine supplementation in females.MethodsTwenty-three young women (21.0 ± 1.4 years, 165.9 ± 6.4 cm, 68.6 ± 11.8 kg) without prior structured resistance training experience volunteered for this study. Body composition (BodPod), rectus femoris muscle thickness (B-mode Ultrasound), vertical jump, back squat 1RM and bench press 1RM were assessed pre- and post-training. Following 1 week of familiarization training, subjects were matched for body composition and squat strength, and randomly assigned to either a betaine (2.5 g/day; n = 11) or placebo (n = 12) group that completed 3 sets of 6–7 exercises per day performed to momentary muscular failure. Training was divided into two lower and one upper body training sessions per week performed on non-consecutive days for 8 weeks, and weekly volume load was used to analyze work capacity.ResultsSignificant main effects of time were found for changes in lean mass (2.4 ± 1.8 kg), muscle thickness (0.13 ± 0.08 cm), vertical jump (1.8 ± 1.6 cm), squat 1RM (39.8 ± 14.0 kg), and bench press 1 RM (9.1 ± 7.3 kg); however, there were no significant interactions. A trend (p = .056) was found for greater weekly training volumes for betaine versus placebo. Significant interactions were found for changes in body fat percentage and fat mass: body fat percentage and fat mass decreased significantly more in betaine (− 3.3 ± 1.7%; − 2.0 ± 1.1 kg) compared to placebo (− 1.7 ± 1.6%; − 0.8 ± 1.3 kg), respectively.ConclusionsThe results of this study indicated that betaine supplementation may enhance reductions in fat mass, but not absolute strength, that accompany a resistance training program in untrained collegiate females.

The Effects of Electrical Acupuncture and Essential Amino Acid Supplementation on Sarcopenic Obesity in Male Older Adults: A Randomized Control Study

Objective: Aging which is accompanied by loss of skeletal muscle and increase of body fat in some adults older than 60 years does not only result in remarkable influences on daily life function but also increases the risk of cardiovascular events. This study used electrical acupuncture together with essential amino acid supplementation to treat sarcopenic obesity (SO) in male older adults. Methods: A total of 48 male participants with SO (>60 years old) were randomized to electrical acupuncture with oral essential amino acids (EA + AA) or oral essential amino acids alone (AA). Acupuncture points on the limbs were punctured and stimulated electrically once every 3 days for 12 weeks. All participants received essential amino acids orally, twice per day for 28 weeks. Body fat percentage (BFP) and appendicular skeletal muscle index (ASM/H²) was determined by bioelectrical impedance analysis. Results: Both groups exhibited significant changes in BFP after 12, 20, and 28 weeks compared with baseline values; for ASM/H², there were significant differences to baseline values after 12, 20, and 28 weeks in the EA + AA group, but only after 28 weeks in the AA group. Between the two groups, there were significant differences in BFP after 12, 20, and 28 weeks, and in ASM/H² after 20 and 28 weeks. Conclusion: Both methods decrease BFP and increase ASM/H². In male older adults, electrical acupuncture with oral essential amino acids is more effective and can increase muscle mass in a shorter time than oral essential amino acids alone.

Prebiotics Reduce Body Fat and Alter Intestinal Microbiota in Children Who Are Overweight or With Obesity

It might be possible to manipulate the intestinal microbiota with prebiotics or other agents to prevent or treat obesity. However, little is known about the ability of prebiotics to specifically modify gut microbiota in children with overweight/obesity or reduce body weight. We performed a randomized controlled trial to study the effects of prebiotics on body composition, markers of inflammation, bile acids in fecal samples, and composition of the intestinal microbiota in children with overweight or obesity. We performed a single-center, double-blind, placebo-controlled trial of 2 separate cohorts (March 2014 and August 2014) at the University of Calgary in Canada. Participants included children, 7-12 years old, with overweight or obesity (>85th percentile of body mass index) but otherwise healthy. Participants were randomly assigned to groups given either oligofructose-enriched inulin (OI; 8 g/day; n=22) or maltodextrin placebo (isocaloric dose, controls; n=20) once daily for 16 weeks. Fat mass and lean mass were measured using dual-energy-x-ray absorptiometry. Height, weight, and waist circumference were measured at baseline and every 4 weeks thereafter. Blood samples were collected at baseline and 16 weeks, and analyzed for lipids, cytokines, lipopolysaccharide, and insulin. Fecal samples were collected at baseline and 16 weeks; bile acids were profiled using high-performance liquid chromatography and the composition of the microbiota was analyzed by 16S rRNA sequencing and quantitative polymerase chain reaction. The primary outcome was change in percent body fat from baseline to 16 weeks. After 16 weeks, children who consumed OI had significant decreases in body weight z-score (decrease of 3.1%), percent body fat (decrease of 2.4%), and percent trunk fat (decrease of 3.8%) compared with children given placebo (increase of 0.5%, increase of 0.05%, and decrease of 0.3%, respectively). Children who consumed OI also had a significant reduction in level of interleukin 6 from baseline (decrease of 15%) compared with the placebo group (increase of 25%). There was a significant decrease in serum triglycerides (decrease of 19%) in the OI group. Quantitative polymerase chain reaction showed a significant increase in Bifidobacterium spp. in the OI group compared with controls. 16S rRNA sequencing revealed significant increases in species of the genus Bifidobacterium and decreases in Bacteroides vulgatus within the group who consumed OI. In fecal samples, levels of primary bile acids increased in the placebo group butnot in the OI group over the 16-week study period. In a placebo-controlled, randomized trial, we found a prebiotic (OI) to selectively alter the intestinal microbiota and significantly reduce body weight z-score, percent body fat, percent trunk fat, and serum level of interleukin 6 in children with overweight or obesity (Clinicaltrials.gov no:NCT02125955).

Newborn insula gray matter volume is prospectively associated with early life adiposity gain.

BackgroundThe importance of energy homeostasis brain circuitry in the context of obesity is well established, however, the developmental ontogeny of this circuitry in humans is currently unknown. Here, we investigate the prospective association between newborn gray matter (GM) volume in the insula, a key brain region underlying energy homeostasis, and change in percent body fat accrual over the first six months of postnatal life, an outcome that represents among the most reliable infant predictors of childhood obesity risk.Methods52 infants (29 male, 23 female, gestational age at birth=39[1.5] weeks) were assessed using structural MRI shortly after birth (postnatal age at MRI scan=25.9[12.2] days), and serial Dual X-Ray Absorptiometry shortly after birth (postnatal age at DXA scan 1=24.6[11.4] days) and at six months of age (postnatal age at DXA scan 2=26.7[3.3] weeks).ResultsInsula GM volume was inversely associated with change in percent body fat from birth to six-months postnatal age and accounted for 19% of its variance (β=-3.6%/S.D., p=0.001). This association was driven by the central-posterior portion of the insula, a region of particular importance for gustation and interoception. The direction of this effect is in concordance with observations in adults, and the results remained statistically significant after adjusting for relevant covariates and potential confounding variables.ConclusionsTogether, these findings suggest an underlying neural basis of childhood obesity that precedes the influence of the postnatal environment. The identification of plausible brain-related biomarkers of childhood obesity risk that predate the influence of the postnatal obesogenic environment may contribute to an improved understanding of propensity for obesity, early identification of at-risk individuals, and intervention targets for primary prevention.

Relationship Between Physiological Load, Body Composition, And Performance Across Season In Female Soccer Athletes

Body composition has been widely recognized as one of the many factors that could affect performance in the collegiate athlete, including body fat percentage and its changes across the competitive season. Zephyr Performance Systems have been used as a tool to measure physiological load in competitive athletes. Changes in body composition and fitness measures have been reported in female soccer athletes, but few have examined the relationship between them across the season, and their potential effect on post-season fitness measures. PURPOSE: The purpose of this study was to determine the relationship between physiological load and body composition across the season on the post-season performance of the Yo-Yo Intermittent Recovery Test 2 in Division I Female Soccer Athletes. METHODS: Thirty female soccer athletes, age (19.4 ± 1 year) with preseason body fat percentage (22.7 ± 5.3%), participated in the Yo-Yo Intermittent Recovery Test 2 (YYIR2) prior to their fall pre-season conditioning period. Body fat percentage was assessed pre and post-season using BodPod assessment. Zephyr Performance Systems were worn during home season games to quantify and record the athletes’ physiological load, which was averaged over the season (AVEPL). Athletes completed a second YYIR2 at the conclusion of their post-season play and the change in the distance covered on this assessment from pre to post-season was recorded (ChangeDist). RESULTS: No differences were observed in YYIR2 or body fat percentage between pre and post-season. However, AVEPL was negatively correlated with pre to post-season change in distance covered (ChangeDist), r = -0.489, p =0.040. Linear regression analysis also revealed ChangeDist was inversely related to AVEPL (β = -0.448, p =0.048). When adjusted for age and pre to post-season change in body fat percentage (ChangeBF), AVEPL remained inversely related to ChangeDist (β = -0.446, p =0.037). CONCLUSIONS: Athletes with higher average physiological load across the season exhibited a decrease in performance on the post-season Yo-Yo Intermittent Recovery Test 2 when compared to pre-season, regardless of change in body fat percentage. Further research should be done to determine whether these results are due to a true decline in fitness levels or a decline in motivation to perform on the post-season assessment.