Physical activity may be difficult for survivors with poorer functioning following primary treatment. The study examined whether late symptoms of breast cancer treatment impact PA adoption (0-6months) and maintenance (6-18months) during a weight management intervention, and whether late symptoms influence PA when accounting for overall functioning. Secondary analyses were conducted using a sample of survivors participating in a weight management intervention and who provided valid weight and accelerometer data at baseline and 6months (N=176). The Breast Cancer Prevention Trial Symptom Checklist (BCPT) assessed late treatment-related symptoms. SF-12 Physical Component Scale (PCS) and Mental Component Scale (MCS) scores assessed functioning. Change in bouted moderate to vigorous physical activity (MVPA) min/week from baseline to 6months was not associated with BCPT scales (all p values>0.05). When adding SF-12 scores to the model, change in bouted MVPA min/week was significantly associated with the PCS (p=0.045). Change in MVPA min/week from 6 to 18months was significantly associated with cognitive symptoms (p=0.004), but not musculoskeletal or vasomotor symptoms (p values>0.05). When adding 6-month SF-12 scores to the model, MVPA min/week was significantly associated with PCS (p=0.001) and MCS (p=0.028); however, BCPT cognitive problems score became non-significant (p>0.05). Poorer physical functioning was associated with lower PA adoption, and poorer mental and physical functioning was associated with lower maintenance of PA, while late symptoms generally were not. Interventionists should consider level of functioning when identifying individual PA goals during weight management interventions.
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