To analyse cases with a diagnosis of isolated major congenital heart diseases (MCHDs) in terms of gestational age (GA) at the suspicion, GA at the diagnosis, the management and the outcome of the pregnancy. This is a multicentre retrospective analysis of cases with isolated MCHDs in four tertiary centres from 2010 to 2016. In the study period, in over 36 hundred pregnancies, 105 cases of isolated MCHDs were diagnosed in these centres. The time of positive diagnosis was 16+6 weeks of amenorrhea (range: 12+6 – 36+1weeks of gestation). 60 couples (57.14%) chose first and second trimester termination of pregnancy. The median time interval between the diagnosis and the termination procedure was 3.5 days (range: 1-7 days). In 36 cases (60%), termination of pregnancy took place in or after the 18th week of gestation. In this study group we had: cases of tricuspid atresia with ventricular septal defect (TrAVSD), cases tetralogy of Fallot (TOF), cases of critical aortic stenosis (AoSt), cases of atrioventricular septal defect - AVSD (partial and complete), and cases of cardiac tumours. We may hypothesise that the diagnosis could have been made earlier in few of them. Most couples (54/60 - 90%) requested for repeated multidisciplinary counselling before termination and only one couple expressed the intention of engaging in a medical litigation for a delayed diagnosis. In our country many parents experience difficulties in coping with the severe prenatal diagnosis of MCHD. Implementation of a uniform prenatal care including first-trimester cardiac screening could lead to an earlier accurate diagnosis in a reduced number of cases. There is need for cost-analysis studies and ethics debates before changing health policies. The additional minor risk due to medical second trimester termination and litigation must be balanced against incomplete counselling after FT suspicion and against the disadvantages of FT surgical terminations request.